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| 1 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 2 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 3 | Medusoid Fossils from the Sinian Xingmincun Formation of Southern Liaoning Province显示文摘Abundant medusoid soft-bodied metazoan fossils have been found in the Sinian Xingmincun Formation(with an isotopic age of 650 Ma) at Qipanmo, Qidingshan and Yangtun of the Dalian-Jinzhou area, southern Liaoning Province; in addition, a number of macroscopic algal fossils have been discovered for the first time in the Getun Formation overlying the Xingmincun Formation. Medusoid fossils include 3 genera and 6 species(all of which are new). Judging from their biological characters, these medusoid fossils are considered to have an intimate affinity with the Ediacara fauna in the terminal Precambrian of Australia, as their characters are close to each other. The authors suggest that these medusoids and the Edicara fauna might be the products of the same period. The discovery of the medusoid fauna in the Xingmincun Formation marks an important event in the evolution of the terminal Precambrian organisms in China, and it is of major practical significance in the study of the Sinian System of China and the correlation of the Sinian strata of northern and southern China. | Hong Zuomin, Huang Zhenfu, Yang Xinde, Lan Jing, Xian Bingcai, Yang Yajun, Regional Geological Survey Party, Bureau of Geology and Mineral Resources of Liaoning Province, Jinzhou, Liaoning and Liu Xiaoliang Shenyang Institute of Geology and Resources, Chinese Academy of Geological Sciences, Shenyang, Liaoning Fang Xinzhong | 1989 | Acta Geologica Sinica(English Edition)1989，63，1： | 20 |
| 4 | China's Opening up after 40 Years: Standing at a Historic Turning Point显示文摘 | Jiandong Ju Xinding Yu | 2018 | China & World Economy2018，26，2： | 9 |
| 5 | A Pseudo Arc-Length Method for Numerical Simulation of Shock Waves显示文摘 | WANG Xind MA Tian-Bao NING Jian-Guo | 2014 | Chinese Physics Letters2014，31，3： | 8 |
| 6 | Microstructure and properties of as-cast Cu-Cr-Zr alloys with lanthanum addition显示文摘Cu-0.45 Cr-0.2 Zr-xLa(x = 0-0.48) alloys were prepared by vacuum casting. The effects of La addition and orientation on the microstructure and properties of the as-cast alloy were investigated by an optical microscope, a scanning electron microscope with an energy dispersive X-ray spectrometer, a tensile testing machine and an electrical conductivity tester. The result shows that the addition of La significantly refines the columnar grainsize and decreases the secondary dendrite arm spacing. Trace addition of La improves the room temperature ultimate tensile strength,elongation and electrical conductivity mainly by purifying during melting and casting. The ultimate tensile strength, elongation and electrical conductivity significantly decrease with the increase of La content due to formation of coarse particles and oxides, which severely harm the performance of the Cu-0.45 Cr-0.2 Zr-xLa alloys. The Cu-0.45 Cr-0.2 Zr-0.13 La alloy possesses a good combination of room temperature ultimate tensile strength, elongation and electrical conductivity. In addition, room temperature ultimate tensile strength and electrical conductivity along transverse direction of the ingot are higher than that along longitudinal direction,which is mainly ascribed to different distribution of grain boundary and grain orientation. | Jilin Li Lili Chang Shengli Li Xinde Zhu Zhongxin An | 2018 | Journal of Rare Earths2018，36，4： | 6 |
| 7 | Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism显示文摘Pink1, mitochondrial kinase,和 Parkin, E3 ubiquitin ligase,在 mitochondrial 工作维护。Pink1 在动摇线粒体上积累,在它招募的地方主要导致外部膜蛋白质并且最后的连接 K63 的链 ubiquitination 的 Parkin mitophagy。Parkin 属于 RBR E3 ligase 家庭。最近, RBR 领域经由 cysteine^ubiquitin 酶中介把 ubiquitin 转移到目标,这被建议了,以类似于 HECT 领域 E3 ligases 的一种方式。然而,在 vivo 为 Parkin 的家为 ubiquitin 转移机制和它的重要性指导证据功能仍然是失踪的。这里,我们报导那项 Parkin E3 活动在 mitophagy 期间依靠调停半胱氨酸的 ubiquitin 转移。变异到丝氨酸(Parkin C431S ) 的通常认为的催化半胱氨酸套住 ubiquitin,并且令人惊讶地,也废除 Parkin mitochondrial translocation,显示那项 E3 活动为 Parkin translocation 是必要的。我们发现 Parkin 能绑在连接 K63 的 ubiquitin 链,并且那指向的 K63-mimicking ubiquitin 锁住到线粒体恢复 Parkin C431S 本地化。我们建议 Parkin translocation 通过一项新奇催化活动被完成联合机制。 | Xinde Zheng Tony Hunter | 2013 | Cell Research2013，23，7： | 6 |
| 8 | MOF-derived Co-MOF,O-doped carbon as trifunctional electrocatalysts to enable highly efficient Zn-air batteries and water-splitting显示文摘Development of high-efficiency non-noble electrocatalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is urgently needed for high-performance Zn-air batteries and overall water splitting.Here,a facile strategy to synthesize novel Co-MOF,O-doped carbon(Co-MOF-T)based on Zn,Co-doped glucosamine and ZIF-8 by pyrolysis at temperature T was demonstrated.The prepared Co-MOF-800 showed a superior oxygen reduction reaction(ORR)activity comparable to that of commercial Pt/C catalyst.In addition,this catalyst shows great potential in the overall water splitting due to the excellent oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)activities.Based on the trifunctional activity,the primary Zn-air batteries using a Co-MOF-800 air electrode achieved a high open-circuit voltage of 1.38 V,a specific capacity of 671.6 mAh g^(-1) Zn,and a prominent peak power density of 144 mW cm^(-2).Also,the rechargeable Zn-air batteries based on CoMOF-800 air electrode could be smoothly run for 510 cycles with a low voltage gap of 0.58 V.Finally,the trifunctional Co-MOF-800 catalyst was applied to boost the electrochemical water splitting,demonstrating its promising potential as a green energy material for practical applications. | Xinde Duan Na Pan Can Sun Kexin Zhang Xukun Zhu Mingdao Zhang Li Song Hegen Zheng | 2021 | Journal of Energy Chemistry2021，30，5： | 5 |
| 9 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 10 | Mechanisms of lead, copper, and zinc retention by phosphate rock显示文摘 | Xinde Cao Lena Q. Ma Dean R. Rhue Chip S. Appel | 2004 | Environmental Pollution2004，，3： | 4 |
| 11 | Phosphate-induced lead immobilization from different lead minerals in soils under varying pH conditions显示文摘 | Xinde Cao Lena Q. Ma Satya P. Singh Qixing Zhou | 2007 | Environmental Pollution2007，，1： | 3 |
| 12 | Petroleum Origins and Accumulation Patterns in the Weixinan Sag in the Beibu Gulf Basin,Using Subsag B as an Example显示文摘Crude oil has been discovered in the Paleogene and Neogene units of the Weixinan Sag in the Beibu Gulf Basin.To determine the source and accumulation mode of this crude oil,12 crude oil samples and 27 source rock samples were collected and an extensive organic geochemical analysis was conducted on them.Based on the geological conditions and the analytical results,the types,origins and accumulation patterns of crude oil in the study area were elucidated.Except for a shallowly-buried and biodegraded crude oil deposit in Neogene rocks,the crude oil samples in the study area were normal.All of the crude oils were derived from lacustrine source rocks.According to biomarker compositions,the crude oils could be divided into two families,A and B,distinctions that were reinforced by differences in carbon isotope composition and spatial distribution.Oil-source correlation analysis based on biomarkers revealed that Family A oils were derived from the mature oil shale at the bottom of the second member of the Liushagang Formation,while the Family B oils formed in the mature shale of the Liushagang Formation.The Family A oils,generated by oil shale,mainly migrated laterally along sand bodies and were then redistributed in adjacent reservoirs above and below the oil shale layer,as well as in shallow layers at high structural positions,occupying a wide distribution range.The Family B oils were generated by other shale units before migrating vertically along faults to form reservoirs nearby,resulting in a narrow distribution range. | GAO Gang XU Xinde QU Tong GAN Jun DANG Wenlong ZHOU Xiaoxiao LIU Fengyan | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 3 |
| 13 | Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice显示文摘Dear Editor,Hearing loss is the most common sensory disorder in the world.Among cases of non-syndromic hearing loss,which account for 70%of all cases of genetic hearing loss,around 80%of cases arise from autosomal recessive loss-of-function mutations that require repair,rather than disruption,of the mutant allele.1 CRISPR/Cas9-mediated homology-directed repair(HDR)-based therapies have the potential to cure many genetic diseases because this class of therapeutics can achieve arbitrary base changes as well as the insertion or deletion of DNA fragments/However. | Xi Gu Xinde Hu Daqi Wang Zhijiao Xu Fang Wang Di Li Geng-lin Li Hui Yang Huawei Li Erwei Zuo Yilai Shu | 2022 | Cell Research2022，32，7： | 3 |
| 14 | AN APPROXIMATE REASONING METHOD IN DEZERT-SMARANDACHE THEORY显示文摘With the increment of focal elements number in discernment framework,the computation amount in Dezert-Smarandache Theory (DSmT) will exponentially go up. This has been the bottleneck problem to block the wide application and development of DSmT. Aiming at this difficulty,in this paper,a kind of fast approximate reasoning method in hierarchical DSmT is proposed. Presently,this method is only fit for the case that there are only singletons with assignment in hyper-power set. These singletons in hyper-power set are forced to group through bintree or tri-tree technologies. At the same time,the assignments of singletons in those different groups corresponding to each source are added up respectively,in order to realize the mapping from the refined hyper-power set to the coarsened one. And then,two sources with the coarsened hyper-power set are combined together according to classical DSm Combination rule (DSmC) and Proportional Conflict Redistribution rule No. 5 (PCR5). The fused results in coarsened framework will be saved as the connecting weights between father and children nodes. And then,all assignments of singletons in different groups will be normalized respectively. Tree depth is set,in order to decide the iterative times in hierarchical system. Finally,by comparing new method with old one from different views,the superiority of new one over old one is testified well. | Li Xinde Wu Xuejian Sun Jiaming Meng Zhengda | 2009 | Journal of Electronics(China)2009，26，6： | 3 |
| 15 | Properties of dairy-manure-derived biochar pertinent to its potential use in remediation显示文摘 | Xinde Cao Willie Harris | 2010 | Bioresource Technology2010，，14： | 2 |
| 16 | Mechanisms of lead, copper, and zinc retention by phosphate rock显示文摘 | Xinde Cao Lena Q. Ma Dean R. Rhue Chip S. Appel | 2004 | Environmental Pollution2004，，3： | 2 |
| 17 | Field assessment of lead immobilization in a contaminated soil after phosphate application显示文摘 | Ricardo Melamed Xinde Cao Ming Chen Lena Q. Ma | 2002 | Science of the Total Environment2002，，1： | 2 |
| 18 | 公司欺诈与审计对策显示文摘本文是深圳天健信德会计师事务所“公司欺诈与审计对策”专题研究小组的报告该报告根据朱基总理“诚信为本、操守为重、坚持准则、不做假账”的指示精神,按照《独立审计具体准则第8号—错误与舞弊》等准则的要求,研究了针对国内外的公司欺诈,并结合我国的实际情况提出了相应的审计对策。 | Shenzhen Xinde Pan-China Certified Public Accountants | 2002 | 中国注册会计师2002，，6： | 2 |
| 19 | Cambrian Sequence Stratigraphy and Sea Level Cycles of North China Platform显示文摘TheNorthChinaplatformisoneofthemostimportantcratonicbasinsinChina.SinceitwasupliftedattheearlyNeoproterozoic,theplatformhadbe... | Shi Xiaoying Mei Shilong Chen Jianqiang Yang Xinde Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 | 1999 | Journal of Earth Science1999，18，2： | 2 |
| 20 | Corticofugal modulation of frequency tuning of inferior collicular neurons in big brown bat,Eptesicus fuscus显示文摘In order to explore the possible mechanism of corticofugal modulation of excitatory frequency tuning curves (EFTCs) of midbrain neurons, we examined the change of sharpness, frequency-intensity response area, minimum threshold of both EFTCs and inhibitory frequency tuning curves (IFTCs) of inferior collicular neurons during corticofugal modulation using two-tone inhibition paradigm and micro-electrical stimulation technique. Our data showed that corticofugal inhibition increased sharpness, minimum threshold, and decreased the frequency-intensity response area of EFTCs, at the same time it decreased the sharpness, minimum threshold but increased the frequency-intensity response area of IFTCs. The opposite results were observed for EFTCs and IFTCs of corticofugally facilitated inferior collicular neurons. During corticofugal inhibition, the percent change of frequency-intensity response area of EFTCs had significant correlation with the percent change of that of IFTCs. These data suggest that cortical | ZHANG Jiping SUN Xinde Philip H.-S.Jen | 2001 | Chinese Science Bulletin2001，46，10： | 2 |
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