|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 3 | Inertia Match of a 3-RRR Reconfigurable Planar Parallel Manipulator显示文摘Inertia match of the parallel manipulator means the ratio of the inertial load of the parallel manipulator converted to each actuator shaft and the moment of inertia of the actuator is kept within a reasonable range. Currently there are many studies on parallel manipulators, but few mention inertia parameters and inertia match of parallel manipulators. This paper focuses on the inertia characteristics of the 3-RRR reconfigurable planar parallel manipulator. On the basis of the inverse dynamic formulations deduced with the principle of virtual work, the inertia matrix of the 3-RRR planar parallel manipulator in the actuator space is obtained in algebraic form. Then, by unifying the dimension and averaging diagonal elements of the inertia matrix, the equivalent inertia of the parallel manipulator, which is the inertial load of the parallel manipulator converted to each actuator shaft, is determined. By transforming the inertia problem of the 3-RRR parallel manipulator into that of the serial multi-bar manipulator, the practicality of the equivalent inertia deduced by inverse dynamics is demonstrated. According to the physical meaning of the inertia equation, the manipulator is divided in to three parts. Further analysis is carried out on the contribution of each part to the equivalent inertia and their distributions in the required workspace, revealing that the passive links cannot ignored in calculating the equivalent inertia of the parallel manipulator. Finally, the inertia match for the 3-RRR reconfigurable parallel manipulator under three configurations is accomplished, and reducers are selected. The equivalent inertia calculation and the inertial match results illustrate that the inertia math is a necessary step to the design of the parallel manipulator, and inertia parameters dramatically affect dynamic performances of parallel manipulators. Besides, the equivalent inertia and inertial match principles, proposed in the paper, can be widely applied in the dynamic analysis and servomotors selecting for the parallel manipulator. | SHAO Zhufeng TANG Xiaoqiang CHEN Xu WANG Liping | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 7 |
| 4 | Atlas Based Kinematic Optimum Design of the Stewart Parallel Manipulator显示文摘Optimum design is a key approach to make full use of potential advantages of a parallel manipulator. The optimum design of multi-parameter parallel manipulators(more than three design parameters), such as Stewart manipulator, relies on analysis based and algorithm based optimum design methods, which fall to be accurate or intuitive. To solve this problem and achieve both accurate and intuition, atlas based optimum design of a general Stewart parallel manipulator is established, with rational selection of design parameters. Based on the defined spherical usable workspace(SUW), primary kinematic performance indices of the Stewart manipulator, involving workspace and condition number are introduced and analyzed. Then, corresponding performance atlases are drawn with the established non-dimensional design space, and impact of joint distribution angles on the manipulator performance is analyzed and illustrated. At last, an example on atlas based optimum design of the Stewart manipulator is accomplished to illustrate the optimum design process, considering the end-effector posture. Deduced atlases can be flexibly applied to both quantitative and qualitative analysis to get the desired optimal design for the Stewart manipulator with respect to related performance requirements. Besides, the established optimum design method can be further applied to other multi-parameter parallel manipulators. | SHAO Zhufeng TANG Xiaoqiang WANG Liping SUN Dengfeng | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 6 |
| 5 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 6 | Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR显示文摘 | Yanwei Zhong Jiaqi Han Zhengsheng Zou Shuhong Liu Bo Tang Xiaoqiang Ren Xiaodong Li Yulai Zhao Yan Liu Dongqing Zhou Weijie Li Jingmin Zhao Dongping Xu | 2011 | Clinica Chimica Acta2011，，21： | 2 |
| 7 | A comparison study of two Tricept units for reconfigurable parallel kinematic machines显示文摘This paper presents a comparison study of workspace and dexterity of two Tricept units for Reconfigurable Parallel Kinematic Machines (RPKMs). The modular leg of RPKMs is designed and the RPKMs can be built by changing the setting of modules. A compositive kinematic model is developed accordingly. The inverse kinematics and Jacobian of these two Tricept units are analyzed. Considering workspace volume and dexterity, the effects of geometric size of some modules on the two Tricept units are discussed. In the end, comparison results of these two Tricept units are given. The comparison of two kinds of Parallel Kinematic Machines (PKMs) can be of help in the design and configuration planning of the RPKMs. | 石俊山 Tang Xiaoqiang Lin Chunshen Wang Liping | 2005 | High Technology Letters2005，11，4： | 2 |
| 8 | Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice显示文摘Cardiac hypertrophy is the strongest predictor of the development of heart failure, and anti-hypertrophic treatment holds the key to improving the clinical syndrome and increasing the survival rates for heart failure. The paraoxonase(PON) gene cluster(PC) protects against atherosclerosis and coronary artery diseases. However, the role of PC in the heart is largely unknown. To evaluate the roles of PC in cardiac hypertrophy, transgenic mice carrying the intact human PON1, PON2, and PON3 genes and their flanking sequences were studied. We demonstrated that the PC transgene(PC-Tg) protected mice from cardiac hypertrophy induced by Ang II; these mice had reduced heart weight/body weight ratios, decreased left ventricular wall thicknesses and increased fractional shortening compared with wild-type(WT) control. The same protective tendency was also observed with an Apoe^(-/-)background. Mechanically, PC-Tg normalized the disequilibrium of matrix metalloproteinases(MMPs)/tissue inhibitors of MMPs(TIMPs) in hypertrophic hearts, which might contribute to the protective role of PC-Tg in cardiac fibrosis and, thus, protect against cardiac remodeling. Taken together, our results identify a novel anti-hypertrophic role for the PON gene cluster, suggesting a possible strategy for the treatment of cardiac hypertrophy through elevating the levels of the PON gene family. | Jian-Fei Pei Yun-Fei Yan Xiaoqiang Tang Yang Zhang Shen-Shen Cui Zhu-Qin Zhang Hou-Zao Chen De-Pei Liu | 2016 | Science China(Life Sciences)2016，59，11： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | A review of CO2 se- questration projects and application in china显示文摘 | Yong Tang Ruizhi Yang Xiaoqiang Bian | 2014 | The Scientific World Journal2014，，： | 1 |
| 11 | Dimensional optimization design of the four-cable-drivenparallel manipulator in FAST显示文摘 | YAO Rui TANG Xiaoqiang WANG Jinsong | 2010 | IEEE/ASME Transactions on Mechatronics2010，15，6： | 1 |
| 12 | Analysis and Dimensional Design of a Novel Hybrid Machine Tool显示文摘 | Wang Jinsong Tang Xiaoqiang | 2003 | International Journal of Machine Tools & Manufacture2003，43，7： | 1 |
| 13 | Acylations in cardiovascular diseases:advances and perspectives显示文摘Cardiovascular diseases(CVD)have become..the leading cause of morbidity and mortality worldwide.Duringthe past two,decades,many experimental and preclinical studies have highlighted the critical roles of histone modifications(eg,acetylations and methylations)in regulating cardiovas-cular development,homeostasis,and disease progression by regulating gene transcription.The well studied histone acetylations such as H3K9ac and H3K27ac activate gene transcription and have shown critical functions in cardio-vascular homeostasis and remodeling. For instance,while class Ⅰ and Ⅱ histone deacetylases(HDACs)generally promote the development of cardiac hypertrophy and diabetic cardiomyopathy,most class Ⅱ HDACs(Sirtuins)exhibit cardioprotective capacity.The inhibitors of class Ⅲ HDACs have been proven to repress cardiac remodeling and heart failure. | Xiaofeng Chen Cechuan Deng Han Wang Xiaoqiang Tang | 2022 | Chinese Medical Journal2022，，13： | 1 |
| 14 | Green tea polysaccharide-conjugates protect human umbilical vein endothelial cells against impairments triggered by high glucose显示文摘 | Xiaoqiang Chen Yuefei Wang Yalin Wu Baoyu Han Yuejin Zhu Xiaolin Tang Qinglei Sun | 2011 | International Journal of Biological Macromolecules2011，，1： | 1 |
| 15 | Histone crotonylation in neurobiology:to be or not to be?显示文摘Epigenetic regulation is a pivotal mechanism that controls gene transcription and cell fate.During the past decades,it has been observed that histone,DNA,and RNA modifications participate in determining the fate of neural stem cells(NSCs).These modifications include histone acetylation and methylation,as well as DNA and RNA methylation.Of note,non-coding RNAs also participate in neural differentiation.[1]In addition to acetylation,many other types of acylations to histone lysines,including crotonylation,propionylation,succinylation,and malonylation,have been identified.[2]The roles of these histone acylations in neuroscience remain elusive. | Cechuan Deng Jia-Hua Qu InKyeom Kim Xiaoqiang Tang | 2022 | Chinese Medical Journal2022，，9： | 1 |
| 16 | Geometric error modeling of machine tools based on screw theory显示文摘 | Zhao Yu Li Tiemin Tang Xiaoqiang | 2011 | Procedia Engineering2011，，24： | 1 |
| 17 | Fe2O3–TiO2 Nanocomposites for Enhanced Charge Separation and Photocatalytic Activity显示文摘 | Savio J. A. Moniz Stephen A. Shevlin Xiaoqiang An Zheng‐Xiao Guo Junwang Tang | 2014 | Chem. Eur. J2014，，47： | 1 |
| 18 | Dimensional design on the six-cable driven parallel manipulator of FAST显示文摘 | TANG Xiaoqiang YAO Rui | 2011 | ASME Journal of Mechanical Design2011，133，11： | 1 |
| 19 | Measurement and correlation of compressibility factor of high CO2-content natural gas显示文摘 | Bian Xiaoqiang Du Zhimin Tang Yong | 2012 | Journal of Petroleum Science and Engineering2012，8283，： | 1 |
| 20 | Dynamic modeling and wind vibration control of the feedsupport system in FAST 显示文摘 | SHAO Zhufeng TANG Xiaoqiang WANG Liping | 2012 | Nonlinear Dynamics2012，67，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员