2篇
您的检索式：作者名="Cechuan Deng"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Acylations in cardiovascular diseases:advances and perspectives显示文摘Cardiovascular diseases(CVD)have become..the leading cause of morbidity and mortality worldwide.Duringthe past two,decades,many experimental and preclinical studies have highlighted the critical roles of histone modifications(eg,acetylations and methylations)in regulating cardiovas-cular development,homeostasis,and disease progression by regulating gene transcription.The well studied histone acetylations such as H3K9ac and H3K27ac activate gene transcription and have shown critical functions in cardio-vascular homeostasis and remodeling. For instance,while class Ⅰ and Ⅱ histone deacetylases(HDACs)generally promote the development of cardiac hypertrophy and diabetic cardiomyopathy,most class Ⅱ HDACs(Sirtuins)exhibit cardioprotective capacity.The inhibitors of class Ⅲ HDACs have been proven to repress cardiac remodeling and heart failure. | Xiaofeng Chen Cechuan Deng Han Wang Xiaoqiang Tang | 2022 | Chinese Medical Journal2022，，13： | 1 |
| 2 | Histone crotonylation in neurobiology:to be or not to be?显示文摘Epigenetic regulation is a pivotal mechanism that controls gene transcription and cell fate.During the past decades,it has been observed that histone,DNA,and RNA modifications participate in determining the fate of neural stem cells(NSCs).These modifications include histone acetylation and methylation,as well as DNA and RNA methylation.Of note,non-coding RNAs also participate in neural differentiation.[1]In addition to acetylation,many other types of acylations to histone lysines,including crotonylation,propionylation,succinylation,and malonylation,have been identified.[2]The roles of these histone acylations in neuroscience remain elusive. | Cechuan Deng Jia-Hua Qu InKyeom Kim Xiaoqiang Tang | 2022 | Chinese Medical Journal2022，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员