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| 1 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 2 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bdds5kqbww6nufc06fwx.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 3 | Late Holocene mangrove development and response to sea level change in the northwestern South China Sea显示文摘Mangroves,widely distributed along the coasts of tropical China,are influenced by Asia monsoon,relative sea level change and enhanced human activity.To predict the impacts of future climate change on mangrove ecosystems,it can be understood by reconstructing past mangrove dynamics using proxies preserved in coastal sediments.In this study,we quantitatively partitioned buried organic matter(OM)sources,collected from a vulnerable mangrove swamp in the Qinzhou Bay of northwestern South China Sea,using a ternary end-member mixing model of δ^13C and C:N values.Mangrove-derived OM(MOM)contribution was used as a tracer for mangrove development since 2.34 cal ka BP.This information,together with paleoclimate records(i.e.,speleothem δ^18O values,sea level change,grain size parameters)and human activity,was used to divide mangrove development into three stages during the late Holocene:relative flourish(2.34-1.13 cal ka BP),relative degradation(1.13-0.15 cal ka BP)and further degradation(0.15-0 cal ka BP).Before 1.13 cal ka BP,mangroves flourished with a high MOM contribution((88.9±10.6)%),corresponding to stable and high sea level under a warm and humid climate.After 1.13 cal ka BP,rapid fall in relative sea level coupled with the strengthening of the Asian winter monsoon,resulted in mangrove degradation and MOM reduction((62.4±18.9)%).Compared with air temperature and precipitation,the relative sea level fall was the main controlling factor in mangrove development before entering the Anthropocene(the time of the Industrial Revolution).After^150 cal a BP,reclamation of mangrove swamps to shrimp ponds is the main factor causing mangrove degradation and MOM reduction. | Peng Xia Xianwei Meng Zhen Li Pengyao Zhi Mengwei Zhao Enkang Wang | 2019 | Acta Oceanologica Sinica2019，38，11： | 4 |
| 4 | Spatial variation in grain-size population of surface sediments from northern Bering Sea and western Arctic Ocean: Implications for provenance and depositional mechanisms显示文摘In general,sediments in nature comprise populations of various diameters.Accurate information regarding the sources and depositional mechanisms of the populations can be obtained through their temporal and spatial comparisons.In this study,the grain size distribution of surface sediments from the Bering Sea and western Arctic Ocean were fitted and partitioned into populations using a log-normal distribution function.The spatial variations in the populations indicate differences in their sources and deposition mechanisms.The sediments on most of the Bering Sea Shelf originated from the Yukon River,and were transported westward by waves and currents.However,the presence of a coarser population outside Anadyr Bay was the result of Anadyr River transport.Additionally,a northward transport trend of fine suspended particles was observed on the west side of the Bering Sea Shelf.The sediments in Hope Valley in the south Chukchi Sea also originated from the Yukon River.The coarser population on the central Chukchi Sea Shelf originated from coast of Alaska to the east,not the Yukon River,and was transported by sea ice and bottom brine water.The populations of sediments from the Chukchi Basin and the base of the Chukchi Sea Slope are the result of sea ice and eddy action.Surface sediments from the western high Arctic Ocean predominantly comprised five populations,and two unique populations with mode diameters of 50–90μm and 200–400μm,respectively,were ubiquitous in the glacial and interglacial sediments.It was difficult to distinguish whether these two populations originated from sea ice or icebergs.Therefore,caution should be exercised when using either the>63μm or>250μm fractions in sediments as a proxy index for iceberg and ice sheet variation in the high Arctic Ocean. | WANG Weiguo YANG Jichao ZHAO Mengwei DONG Linsen JIANG Min HUANG Erhui | 2020 | Advances in Polar Science2020，31，3： | 2 |
| 5 | Thermal and tectonic history of the Ordos Basin, China: evidence from apatite fission track analysis, vitrinite reflectance, and K-Ardating显示文摘 | Zhao Mengwei Hans - Jurgen Behr Hans Ahrendt | 1996 | AAPG1996，80，7： | 1 |
| 6 | Thermal and tectonic history of the Ordos Basin, China: evidence from apitite fission track analysis, vitrinite reflectance and K--At dating 显示文摘 | Zhao Mengwei Behr H J Ahrendt H | 1996 | AAPG Bulletin1996，80，7： | 1 |
| 7 | Thermal and tectonic history of the Ordos Basin, China:Evidence apitite fission track analysis,vitrinite reflectance and K-Ar dating显示文摘 | Zhao Mengwei Hans J B Hans A | 1996 | AAPG Bulletin1996，80，7： | 1 |
| 8 | Thermal and tectonic histo- ry of the Ordos Basin,China: Evidence apitite fission t rack analysis, vitrinite reflectance and K-Ar dating显示文摘 | Zhao Mengwei Behr H J A HRENDT H | 1996 | AAPG Bu111996，80，7： | 1 |
| 9 | Thermal and tectonic history of the Ordos Basin,China: evidence apitite fission track analysis,vitrinite reflectance and K-Ar dating显示文摘 | Zhao Mengwei Hans J B Hans A | 1996 | AAPG Bulletin1996，80，： | 1 |
| 10 | Optimization of COVID-19 prevention and control measures during the Beijing 2022 Winter Olympics:a model-based study显示文摘Background:The continuous mutation of severe acute respiratory syndrome coronavirus 2 has made the coronavirus disease 2019(COVID-19)pandemic complicated to predict and posed a severe challenge to the Beijing 2022Winter Olympics and Winter Paralympics held in February and March 2022.Methods:During the preparations for the Beijing 2022 Winter Olympics,we established a dynamic model with pulsedetection and isolation efect to evaluate the efect of epidemic prevention and control measures such as entry policies,contact reduction,nucleic acid testing,tracking,isolation,and health monitoring in a closed-loop managementenvironment,by simulating the transmission dynamics in assumed scenarios.We also compared the importance ofeach parameter in the combination of intervention measures through sensitivity analysis.Results:At the assumed baseline levels,the peak of the epidemic reached on the 57th day.During the simulationperiod(100 days),13,382 people infected COVID-19.The mean and peak values of hospitalized cases were 2650and 6746,respectively.The simulation and sensitivity analysis showed that:(1)the most important measures to stopCOVID-19 transmission during the event were daily nucleic acid testing,reducing contact among people,and dailyhealth monitoring,with cumulative infections at 0.04%,0.14%,and 14.92%of baseline levels,respectively(2)strictlyimplementing the entry policy and reducing the number of cases entering the closed-loop system could delay thepeak of the epidemic by 9 days and provide time for medical resources to be mobilized;(3)the risk of environmentaltransmission was low.Conclusions:Comprehensive measures under certain scenarios such as reducing contact,nucleic acid testing,health monitoring,and timely tracking and isolation could efectively prevent virus transmission.Our research resultsprovided an important reference for formulating prevention and control measures during the Winter Olympics,andno epidemic spread in the closed-loop during the games indirectly proved the rationality of our research results. | Lingcai Kong Mengwei Duan Jin Shi Jie Hong Xuan Zhou Xinyi Yang Zheng Zhao Jiaqi Huang Xi Chen Yun Yin Ke Li Yuanhua Liu Jinggang Liu Xiaozhe Wang Po Zhang Xiyang Xie Fei Li Zhaorui Chang Zhijie Zhang | 2022 | Infectious Diseases of Poverty2022，11，5： | 0 |
| 11 | Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model显示文摘Current therapies for obesity and related complications have been shown to have limited benefits,including unsatisfactory weight loss and poor metabolic improvement.With recent developments in bariatric surgery,promising advancements have been made in clinical and scientific research,particularly in the management of obesity and diabetes.Vertical sleeve gastrectomy(VSG)has become increasingly popular due to its safety,simplicity, | Qiwei Shen Yeping Yang Wenjuan Liu Meng Wang Yikai Shao Bo Xu Xiaolong Zhao Jinxing Zhu Rong Hua Wanzhu Jin Zhiyu Hu Jae Bum Kim Qinghua Wang Yiming Li Mengwei Zang Qiyuan Yao Zhaoyun Zhang | 2017 | Science Bulletin2017，62，7： | 0 |
| 12 | Columnar Liquid Crystalline Corannulenes: Synthesis, Assembly and Charge-Carrier Transport Properties显示文摘Two discotic liquid crystalline(LC)molecules consisting of a bowl-shaped corannulene core and five-fold photoactive azobenzene branches with differe nt pa raff i nk side chai ns were developed.Their self-assembly,photo-resp on sive behavior and charge-carrier tran sport properties were investigated in detail.A wider mesophase temperature range was achieved when utilizi ng Ion ger and furcal flexible side chai n substituti on.2D XRD measureme nts revealed the n-packed cora nnulen e-ce ntered lb(i.e.,with furcal side alkoxy I chains)exhibited helical columnar LC phase.This packing structure also led to a higher hole charge carrier mobility of 7.07 ×1O^(-2) cm^(2)-V^(-1)s^(-1) compared to that of the counterpart la with linear side chain substitutions. | Yang Li Zunzhi Wang Mengwei Li Feiyi Chen Yang Zhao Qi Wang Fanli Lu Yi Liu Xiang-Kui Ren Long Chen | 2021 | Chinese Journal of Chemistry2021，39，9： | 0 |
| 13 | The marine environmental evolution in the northern Norwegian Sea revealed by foraminifera during the last 60 ka显示文摘Both planktonic and benthic foraminifera were identified in a sediment core collected from the northern Norwegian Sea to reconstruct the paleoceanographic evolution since the last glaciation.The assemblages and distribution patterns of dominant foraminiferal species with special habitat preferences indicated that three marine environments occurred in the northern Norwegian Sea since 62 ka BP:(1)an environment controlled by the circulation of the North Atlantic Current(NAC);(2)by polynya-related sinking of brines and upwelling of intermediate water surrounding the polynya;(3)by melt-water from Barents Sea Ice Sheet(BSIS).At 62-52.5 ka BP,a period with the highest summer insolation during the last glaciatial period,intensification of the NAC led to higher absolute abundances and higher diversity of foraminiferal faunas.The higher abundance of benthic species Cibicidoides wuellerstorfi indicates bottom water conditions that were well-ventilated with an adequate food supply;however,higher abundances of polar planktonic foraminiferal species Neogloboquadrina pachyderma(sin.)indicate that the near-surface temperatures were still low.During mid-late Marine Isotope Stage(MIS)3(52.5-29 ka BP),the marine environment of the northern Norwegian Sea alternately changed among the above mentioned three environments.At 29-17ka BP during the last glacial maximum,the dominant benthic species Bolivina arctica from the Arctic Ocean indicates an extreme cold bottom environment.The BSIS expanded to its maximum extent during this period,and vast polynya formed at the edge of the ice sheet.The sinking of brines from the formation of sea ice in the polynyas caused upwelling,indicated by the upwelling adapted planktonic species Globigerinita glutinata.At 17-10 ka BP,the northern Norwegian Sea was controlled by melt-water.With the ablation of BSIS,massive amounts of melt water discharged into the Norwegian Sea,resulting in strong water column stratification,poor ventilation,and an oligotrophic bottom condition,which ledto a drastic decline in the abundance and diversity of foraminifera.At 10-0 ka BP,the marine environment was transformed again by the control of the NAC,which continues to modern day.The abrupt decrease in relative abundance of Neogloboquadrina pachyderma(sin.)indicates a rise in near-surface temperature with the strengthening of the NAC and without the influence of the BSIS. | WANG Weiguo ZHAO Mengwei YANG Jichao XIAO Wenshen WANG Haoyin LIU Yang | 2021 | Advances in Polar Science2021，32，3： | 0 |
| 14 | Evolution of the North Atlantic Current and Barents Ice Sheet as revealed by grain size populations in the northern Norwegian Sea during the last 60 ka显示文摘The grain size distribution of bulk sediment samples was decomposed in a core to reconstruct paleoceanographic evolution over the past 60 ka in the northern Norwegian Sea.The results show that sediments consisted of 3–4 grain populations derived from the North Atlantic Current(NAC)and Barents Ice Sheet(BIS).The grain size data suggest three palaeoceanographic evolution stages:(1)an environment affected by BIS and NAC and changed with the interstadial/stadial transition in phase with the Greenland ice-core record at 60–31 ka BP,during which discharge of icebergs and the content of the coarsest population containing ice-rafted debris(IRD)in the sediments increased significantly during stadial,while the fine silt population containing volcanic glasses increased with the enhancement of NAC during the interstadial;(2)an extreme environment controlled by BIS at31–13 ka BP.BIS reached to its maximum at about 31 ka BP and the turbid plumes that formed at the leading edge of BIS contributed to a significant increase in the clayey population in sediments.Icebergs drained into the northern Norwegian Sea with periodical calving of the BIS at 31–19 ka BP.Subsequently,the ablation of the BIS discharged massive floods with clayey sediments and icebergs into the Norwegian Sea at 19–13 ka BP,resulting in a constant increase in clay and IRD in sediments;and(3)a marine environment similar to the present one under the strong influence of NAC following the complete melting of the BIS after 13 ka BP,NAC is the dominant transport agent and no IRD occurred in sediments.The fine silt populations containing volcanic glasses transported by NAC significantly increased. | Weiguo Wang Mengwei Zhao Yanguang Liu Min Jiang Chengqiang Wu Yang Liu | 2021 | Acta Oceanologica Sinica2021，40，10： | 0 |
| 15 | Diagnostic diversity and heterogeneity of tumors: a real-world study of metastasis re-biopsy in advanced breast cancer显示文摘Background::Re-biopsy of metastasis in advanced breast cancer(ABC)has become an international convention to assist the diagnosis and evaluation of tumor heterogeneity.This study aimed to detect diagnostic diversity and inconsistencies among estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER2)expression levels between primary and metastatic lesions.Methods::We conducted a retrospective analysis of 1670 cases of ABC patients who had undergone at least one lesion re-biopsy from January 2010 to December 2018.The pathological diagnosis of biopsies,distribution of biopsy sites,and severe puncture complications at each site were collected.In addition,the inconsistency rates and related factors of ER,PR,and HER2 expression between primary and metastatic lesions were analyzed fully considering patients’demographic profiles and disease characteristics.Results::In total,1670 cases of breast cancer(BC)patients diagnosed by pathology underwent one to four biopsies of recurrences or metastases in different sites or at different stages during the rescue treatment,producing 2019 histopathological specimens which were analyzed in the study.Pathological diagnosis showed that eight patients had benign pathological diagnoses,11 patients had second primary malignant tumors but without recurrences of breast cancer,and 17 patients had pathologically confirmed breast cancer recurrences combined with second primary cancer.In 1173 patients who presented ER,PR,and HER2 expressions in primary and metastatic lesions,the inconsistency rates of ER,PR,and HER2 were 17.5%(205/1173),31.3%(367/1173),and 13.9%(163/1173),respectively.The multivariate analysis showed that the age at the onset of breast cancer or adjuvant endocrine therapy was an independent factor affecting changes in PR expression level.Except one liver puncture with local hemorrhage and two lung punctures with hemopneumothorax,no other severe puncture complications occurred in 1950 non-surgical rebiopsies.Conclusions::The pathological diagnosis of metastasis re-biopsy of ABC was diverse,and the ER,PR,and HER2 expression levels were inconsistent between primary and metastatic lesions.Therefore,more attention should be paid to perform biopsies of relapsed and metastatic breast cancers routinely in clinical practice. | Huimin Lv Limin Niu Mengwei Zhang Huiai Zeng Shengnan Zhao Min Yan | 2022 | Chinese Medical Journal2022，135，17： | 0 |
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