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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Effects of Machine Tool Configuration on Its Dynamics Based on Orthogonal Experiment Method显示文摘In order to analyze the influence of configuration parameters on dynamic characteristics of machine tools in the working space, the configuration parameters have been suggested based on the orthogonal experiment method. Dynamic analysis of a milling machine, which is newly designed for producing turbine blades, has been conducted by utilizing the modal synthesis method. The finite element model is verified and updated by experimental modal analysis (EMA) of the machine tool. The result gained by modal synthesis method is compared with whole-model finite element method (FEM) result as well. According to the orthogonal experiment method, four configuration parameters of machine tool are considered as four factors for dynamic characteristics. The influence of configuration parameters on the first three natural frequencies is obtained by range analysis. It is pointed out that configuration parameter is the most important factor affecting the fundamental frequency of machine tools, and configuration parameter has less effect on lower-order modes of the system than others. The combination of configuration parameters which makes the fundamental frequency reach the maximum value is provided. Through demonstration, the conclusion can be drawn that the influence of configuration parameters on the natural frequencies of machine tools can be analyzed explicitly by the orthogonal experiment method, which offers a new method for estimating the dynamic characteristics of machine tools. | GAO Xiangsheng ZHANG Yidu ZHANG Hongwei WU Qiong | 2012 | Chinese Journal of Aeronautics2012，25，2： | 11 |
| 3 | Constitutive modeling of flow behavior and processing maps of Mg-8.1 Gd-4.5Y-0.3Zr alloy显示文摘High temperature deformation behavior and workability of Mg-8.1 Gd-4.5Y-0.3Zr alloy were studied by compression tests.Arrhenius equation with strain compensation and processing maps were established.The results show that the activation energy Q,structure factor a,n and In A varies with the strain,its relationship fit well by fifth order polynomial.The flow stresses predicted by the extracted model are in good agreement with the experimental results.There are five typical domains in the processing map,and the deformation mechanisms in different domains were determined by microstructure analysis.The feasible processing window of the alloy is in the areas of 400-500℃/0.001-0.1 s^(-1). | Xiangsheng Xia Kui Zhang Minglong Ma Ting Li | 2020 | Journal of Magnesium and Alloys2020，8，3： | 9 |
| 4 | Correlation of the quantifiable parameters of blood flow pattern derived with dynamic CT in solitary bronchogenic adenocarcinoma显示文摘Objective:To evaluate the correlation of the quantifiable parameters of blood flow pattern derived with dynamic CT in solitary bronchogenic adenocarcinoma(SBA).Methods:46 patients with solitary bronchogenic adenocarcinomas (SBA)(diameter≤4 cm)underwent multi-location dynamic contrast material-enhanced(nonionic contrast material was administrated via the antecubital vein at a rate of 4 mL/s by using an autoinjector 90 mL,4×5 mm or 4×2.5 mm scanning mode with stable table were performed)serial CT.Precontrast and postcontrast attenuation on every scan was recorded.Perfusion (PBA),peak height(PHBA),ratio of peak height of the SPN to that of the aorta(BA-to-A ratio)and mean transit time(MTT)were calculated.The correlation between peak height of the aorta(PHA)and parameters of the SBA(PHBA,BA-to-A ratio,PBA,and MTT)and those among parameters of the SBA were assessed by means of linear regression analysis.Regression equation among parameters of the SBA were obtain by means of stepwise regression.Results:The correlation between the SBA peak height(PHBA,36.78 HU±12.02)and the aortic peak height(PHA)was significant(r=0.506,P<0.0001).No significant cor- relation was found between the BA-to-Apeak height ratio(15.33%±4.55)and the aortic peak height(r=0.130,P=0.388> 0.05)as it was between the SBA perfusion(PBA,31.86 mL/min/100 g±9.74)and the aortic peak height(r=0.049,P=0.749 >0.05).The SBA perfusion correlated with the PHBA and the BA-to-A peak height ratio(r=0.394,P=0.007<0.05;r=0.407, P=0.005<0.05).The PHBA correlated positively with the BA-to-A peak height ratio(r=0.781,P<0.0001).Mean transit time was 14.84 s±5.52.PBA=18.500+0.872×BA-to-A ratio.BA-to-A ratio=4.467+0.295×PHBA.Conclusion:The linear correlation between the SBA perfusion and BA-to-Aratio and that between BA-to-Aratio and PHBA can be expressed by equation. It is possible to design a simpler scanning procedure of investigation of bronchogenic adenocarcinoma angiogenesis. | Shenjiang Li Xiangsheng Xiao Shiyuan Liu Huimin Li Chengzhou Li Chenshi Zhang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 8 |
| 5 | Genotypic variation in phosphorus acquisition from sparingly soluble P sources is related to root morphology and root exudates in Brassica napus显示文摘Genotypic variations in the adaptive response to low-phosphorus(P) stress and P-uptake efficiency have been widely reported in many crops.We conducted a pot experiment to evaluate the P-acquisition ability of two rapeseed(Brassica napus) genotypes supplied with two sparingly soluble sources of P,Al-P and Fe-P.Then,the root morphology,proton concentrations,and carboxylate content were investigated in a solution experiment to examine the genotypic difference in P-acquisition efficiency.Both genotypes produced greater biomass and accumulated more P when supplied with Al-P than when supplied with Fe-P.The P-efficient genotype 102 showed a significantly greater ability to deplete sparingly soluble P from the rhizosphere soil because of its greater biomass and higher P uptake compared with those of the P-inefficient genotype 105.In the solution experiment,the P-efficient genotype under low-P conditions developed dominant root morphological traits,and it showed more intensive rhizosphere acidification because of greater H+ efflux,higher H+-ATPase activity,and greater exudation of carboxylates than the P-inefficient genotype.Thus,a combination of morphological and physiological mechanisms contributed to the genotypic variation in the utilization of different sparingly soluble P sources in B.napus. | ZHANG HaiWei HUANG Yu YE XiangSheng XU FangSen | 2011 | Science China(Life Sciences)2011，54，12： | 6 |
| 6 | Microstructures and strengthening mechanisms of Mg-8.2Gd-4.6Y-1.5Zn-0.4Zr alloy containing LPSO,β’ and γ type phases显示文摘The microstructures and strengthening mechanisms of the Mg-8.2 Gd-4.6 Y-1.5 Zn-0.4 Zr(wt%) alloy with long-period stacking ordered(LPSO),β’ and γ type phases were systematically studied.The results show that the LPSO with lamellar and block structures forms near the grain boundaries.The grains are clearly refined,and the 18 R LPSO phase is oriented along the extrusion direction after extrusion.Some particles also precipitate from the Mg matrix dynamically.The extruded alloy exhibits a remarkable agehardening response,and mechanical properties,with a tensile strength(TS) of 449 MPa,yield strength(YS) of 362 MPa,and elongation of 7.9% obtained in the peak-aged alloy.The strengthening mechanisms of the alloy in different states are discussed.Grain boundary and precipitation strengthening are the main strengthening mechanisms for the peak-aged alloy. | Xiangsheng Xia Kui Zhang Minglong Ma Ting Lie | 2020 | Journal of Rare Earths2020，38，10： | 5 |
| 7 | Correlation between the quantifiable parameters of blood flow pattern derived with dynamic CT in malignant solitary pulmonary nodules and tumor size显示文摘Objective: To evaluate the correlation between the quantifiable parameters of blood flow pattern derived with dy- namic CT in malignant solitary pulmonary nodules and tumor size. Methods: Sixty-eight patients with malignant solitary pulmo- nary nodules (SPNs) (diameter ≤4 cm) underwent multi-location dynamic contrast material-enhanced (nonionic contrast material was administrated via the antecubital vein at a rate of 4mL/s by using an autoinjector, 4×5 mm or 4×2.5 mm scanning mode with stable table were performed). Precontrast and postcontrast attenuation on every scan was recorded. Blood flow (BF), peak, height (PHSPN), ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio) and mean transit time (MTT) were calculat- ed. The correlation between the quantifiable parameters of blood flow pattern derived with dynamic CT in malignant solitary pul- monary nodules and tumor size were assessed by means of linear regression analysis. Results: No significant correlations were found between the tumor size and each of the peak height (PHSPN) (35.79±10.76 Hu), ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio), (14.27%±4.37) and blood flow (BF) (30.18 mL/min/100 g±9.58) (r=0.180, P=0.142>0.05; r=0.205, P=0.093>0.05; r=0.008, P=0.947>0.05). Conclusion: No significant correlations were found between the tumor size and each of the quantifiable parameters of blood flow pattern derived with dynamic CT in malignant solitary pulmonary nodules. | Shenjiang Li Xiangsheng Xiao Shiyuan Liu Huimin Li Chengzhou Li Chenshi Zhang | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，5： | 3 |
| 8 | Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function显示文摘Enteroviral 感染能导致扩大心肌症(DCM ) ,它是世界范围的心血管的死亡的一个主要原因。然而,病原的机制充分没被阐明。浆液反应因素(SRF ) 是控制许多目标基因的表示的一个心脏充实抄写管理者,包括涉及可收缩的仪器和立即的早反应的那些,以及 microRNAs 那沉默心脏的规章的因素的表示。在心的 SRF 的大美人导致心脏的可收缩的基因表示的 downregulation 和 DCM 的开发。这研究的目标是在导致 enterovirus 的心脏的机能障碍和前进理解 SRF 的角色到 DCM。这里,我们报导 SRF 被劈开跟随老鼠心和有教养的 cardiomyocytes 的 enteroviral 感染。这劈开被心脏特定的可收缩、规章的基因的损害心脏的功能和 downregulation 伴随。由印射的抗体 epitope 和指导地点的 mutagenesis 的进一步的调查证明那 SRF 劈开通过编码病毒的朊酶 2A 的行动发生在它的 transactivation 领域的区域。而且,我们证明 SRF 的那劈开分裂它从 DNA 有约束力的领域的 transactivation 领域,导致调停 SRF 的基因 transactivation 的混乱。除了功能的 SRF 的损失,最后,我们报导 SRF 劈开产品的 N 终端碎片能也充当一个主导否定的抄写因素,它多半为 DNA 绑定与本国的 SRF 竞争。我们的结果建议病毒感染由损害心功能的机制并且可以提供新治疗学的策略改善 DCM 的心肌的损坏和前进。 | Jerry Wong Jingchun Zhang Bobby Yanagawa Zongshu Luo Xiangsheng Yang Jiang Chang Bruce McManus Honglin Luo | 2012 | Cell Research2012，22，2： | 3 |
| 9 | Laboratory Investigation into the Evaporation of Natural-Gas Condensate Oils: Hints for the Sanchi Oil Spill显示文摘The Sanchi oil tanker collision in the East China Sea on January 6th, 2018 has caused worldwide attention due to its uniqueness. A considerable amount of highly volatile natural-gas condensate oil was spilled, burned and sank with the Sanchi tanker, this entirely new kind of maritime disaster has posed massive unknowns to the public. In this study, for better understanding of the evaporative behavior of condensate oils, two condensate oils were investigated under various laboratory conditions. The overall result demonstrates that the evaporation of condensate oils is highly dependent on the air-exposed time and the total loss of condensate oils could be more than 90% within a short time. However, a certain amount of the high-molecular weight and toxic oil contents such as phenanthrenes still highly remain in the aquatic system even after a long evaporation process, indicating their detrimental potentials to the aquatic organisms. Based on these data, for the Sanchi oil spill accident, it is assumed that although the evaporation weathering of the total condensate oil mass is probably tremendous, the long-term ecological risks of the remaining oil components in the marine environment are strongly recommended to be carefully evaluated. | ZHANG Yong YANG Tao ZHANG Junbo LV Baoyi CHENG Xiangsheng FANG Yin | 2020 | Journal of Ocean University of China2020，19，3： | 2 |
| 10 | Hot deformation behavior and processing map of coarse-grained Mg–Gd–Y–Nd–Zr alloy显示文摘 | Xiangsheng Xia Qiang Chen Kui Zhang Zude Zhao Minglong Ma Xinggang Li Yongjun Li | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 11 | Classification of facial wrinkles among Chinese women显示文摘It is generally recognized that Caucasians and Asians have different skin aging features.The aim of this study was to develop a facial wrinkle grading scale for Chinese women.Standard photographs were taken of 242 Chinese women.Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected,including grading scales for resting and hyperkinetic crow's feet,frontalis lines,glabellar frown lines,and nasolabial folds.To identify the scale by objective quantitative measurement,skin surface measurements from the Visioscan~ VC98 were used.To test the reliability and validity of our wrinkle scale,a multi-rater consensus method was used.A double-blind,randomized,vehicle-controlled 12-week study was conducted to use this clinical photo-score to evaluate the efficacy and safety of Centella triterpenes cream~ in treating crow's feet.A newly developed 10-point photographic and descriptive scale emerged from this study.The final atlas of these photographs contained a total of 6 sets with 10 pictures each.From 0 to 9,surface evaluation of smoothness(SEsm) parametric measurements decreased progressively,indicating that the scale increased inversely.Weighted kappa coefficients for intra-assessor were between 0.75-0.87.The overall Kendall's coefficient is 0.86 on the first rating and 0.87 on the second rating.Thirtysix volunteers were recruited and 35 subjects completed a 12-week trial.Clinical photo-score by investigator showed a significant difference(P < 0.05) between the treatment side and control side after 4 weeks.Use of these scales in clinical settings to evaluate facial wrinkles in Asians individuals is recommended. | Jiechen Zhang Wei Hou Suying Feng Xiangsheng Chen Hongwei Wang | 2017 | The Journal of Biomedical Research2017，31，2： | 2 |
| 12 | Isolation and identification of biosurfactant producing and crude oil degrading Pseudomonas aeruginosa strains显示文摘 | Xiangsheng Zhang Dejun Xu Chunyan Zhu Tserennyam Lundaa Kerstin E. Scherr | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 13 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 14 | Fabrication of photonic crystals with functional defects by one-step holographic lithography显示文摘 | Juntao Li Yikun Liu Xiangsheng Xie Peiqing Zhang Bing Liang Li Yan Jianying Zhou Gershon Kurizki Daniel Jacobs Kam Sing Wong and Yongchun Zhong | 2008 | Optics Express2008，16，12： | 1 |
| 15 | 明显强化孤立肺结节血流模式(英文)显示文摘Objective: To evaluate the efficacy of dynamic multi-slice spiral computed tomography (MSCT) for providing quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs). Methods: Seventy-eight patients with SPNs (diameter ≤ 4 cm; 68 malignant; 10 active inflammatory) were underwent multi-location dynamic contrast mate-rial-enhanced serial CT (nonionic contrast material was administrated via the antecubital vein at a rate of 4 mL/s by using an autoinjector, 4 × 5 mm or 4 × 2.5 mm transverse scanning mode with stable table were performed). Sixteen series CT scans (16 scans each for the first and second series and one scan each for the rest series) were obtained during 9 min scanning period. Precontrast and postcontrast attenuation on every scan was recorded. Perfusion, peak height and ratio of peak height of the SPN to that of the aorta were calculated. Perfusion was calculated from the maximum gradient of the time-attenuation curve and the peak height of the aorta. Results: No statistically significant difference in the peak height was found between malignant (35.79 ± 10.76 Hu) and active inflammatory (39.76 ± 4.59 Hu) (t = 1.148, P = 0.255 > 0.05). SPN-to-aorta ratio (14.27% ± 4.37) and perfusion value (30.18 mL/min/100 g ± 9.58) in malignant SPNs were significantly lower than those of active inflammatory (18.51% ± 2.71, 63.44 mL/min/100 g ± 43.87) (t = 2.978, P = 0.004 < 0.05; t = 5.590, P < 0.0001). Conclusion: The quantitative information about blood flow patterns of malignant and active inflammatory SPNs is different . SPN-to-aorta ratio and perfusion value are helpful in differentiating malignant nodules from active inflammatory. | Shenjiang Li Xiangsheng Xiao Shiyuan Liu Huimin Li Chengzhou Li Chenshi Zhang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，5： | 1 |
| 16 | End End-to to-End Chinese Entity Recognition Based on BERT BERT-BiLSTM BiLSTM-ATT ATT-CRF显示文摘Traditional named entity recognition methods need professional domain knowl-edge and a large amount of human participation to extract features,as well as the Chinese named entity recognition method based on a neural network model,which brings the prob-lem that vector representation is too singular in the process of character vector representa-tion.To solve the above problem,we propose a Chinese named entity recognition method based on the BERT-BiLSTM-ATT-CRF model.Firstly,we use the bidirectional encoder representations from transformers(BERT)pre-training language model to obtain the se-mantic vector of the word according to the context information of the word;Secondly,the word vectors trained by BERT are input into the bidirectional long-term and short-term memory network embedded with attention mechanism(BiLSTM-ATT)to capture the most important semantic information in the sentence;Finally,the conditional random field(CRF)is used to learn the dependence between adjacent tags to obtain the global optimal sentence level tag sequence.The experimental results show that the proposed model achieves state-of-the-art performance on both Microsoft Research Asia(MSRA)corpus and people’s daily corpus,with F1 values of 94.77% and 95.97% respectively. | LI Daiyi TU Yaofeng ZHOU Xiangsheng ZHANG Yangming MA Zongmin | 2022 | ZTE Communications2022，20，S01： | 1 |
| 17 | Isola- tion and Identification of Biosurfactant Producing and Crude Oil Degrading Pseudomonas Aeruginosa Strains显示文摘 | Zhang Xiangsheng Xu Dejun Zhu Chunyan | 2012 | Chemical Engineering Journal2012，209，： | 1 |
| 18 | Response Surface Analysis of Rhamnolipid Production by Pseudomonas Aeruginosa Strain Z41 with Two Response Values显示文摘 | Zhang Xiangsheng Lu Dequan | 2013 | African Journal of Microbiology Research2013，7，22： | 1 |
| 19 | Isolation and identification of biosurfactant producing and crude oil degrading Pseudomonas aeruginosa strains 显示文摘 | ZHANG Xiangsheng XU Dejun ZHU Chunqyan | 2012 | Chemical Engineering Journal2012，209，： | 1 |
| 20 | Scattering Window Material:Transparent A1_(2)O_(3)Ceramics and Its Fabrication显示文摘A kind of highly transparent A1_(2)O_(3)ceramics is fabricated in a way of reducing the scattering origins such as the boundary scattering and the facies-difference scattering.The ceramics is a hopeful substitute of the optoelectronic detector windows made of crystalline A1_(2)O_(3)with several advantages such as lower cost,improvement of detecting accuracy and increase of the damage threshold etc. | LI Yi SU Xiyu SONG Lianke ZHANG Binglin MENG Xiangsheng | 1995 | Chinese Physics Letters1995，12，7： | 1 |
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