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| 1 | Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 prototypic 自体免疫的疾病。天生、适应的免疫合作地贡献 SLE 的发展。介绍抗原的房间(APC ) 被建议了连接天生、适应的免疫。T 房间 immunoglobulin-domain-containing 和 mucin-domain-containing molecule-4 (Tim-4;另外作为 Timd4 知道) ,首先在 APC 的表面上表示了,是 TIM 家庭,的一个成员作为免疫系统的潜在的管理者收到了许多注意的分子的一个最近描述的组。在这研究,我们使用了量的即时反向的抄写聚合酶链反应从 SLE 病人在外部血 mononuclear 房间( PBMC )检验 Tim-4 的 mRNA 表示并且进一步在 PBMC 和浆液肿瘤坏死因素( TNF )分析了在 Tim-4 和 Tim-1 (为 Tim-4 的潜在的 ligand )的表示之间的关联-伪层次。结果证明在 PBMC 的那个 Tim-4 mRNA 表达式比在健康控制在 SLE 病人是显著地更高的,特别在疾病的活跃阶段的那些病人。而且, Tim-4 mRNA 层次密切在 SLE 病人然而并非在控制组在 PBMC 并且与浆液 TNF- 伪层次与 Tim-1 mRNA 层次被相关。一起拿,这些结果证明 Tim-4 可以涉及 SLE 的致病。 | Peiqing Zhao Liyun Xu Piming Wang Xiaohong Liang Jianni Qi Peng Liu Chun Guo Lining Zhang Chunhong Ma Lifen Gao | 2010 | Cellular & Molecular Immunology2010，7，2： | 11 |
| 2 | Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism显示文摘The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes.Progestin and adipoQ receptor 3(PAQR3),a key regulator of inflammation and metabolism,can negatively regulate the PI3 K/AKT signaling pathway.Here,we report that gentiopicroside(GPS),the main bioactive secoiridoid glycoside of Gentiana manshurica Kitagawa,decreased lipid synthesis and increased glucose utilization in palmitic acid(PA) treated HepG2 cells.Additionally,GPS improved glycolipid metabolism in streptozotocin(STZ) treated high-fat diet(HFD)-induced diabetic mice.Our findings revealed that GPS promoted the activation of the PI3 K/AKT axis by facilitating DNA-binding protein 2(DDB2)-mediated PAQR3 ubiquitinated degradation.Moreover,results of surface plasmon resonance(SPR),microscale thermophoresis(MST) and thermal shift assay(TSA) indicated that GPS directly binds to PAQR3.Results of molecular docking and cellular thermal shift assay(CETSA) revealed that GPS directly bound to the amino acids of the PAQR3 NH2-terminus including Leu40,Asp42,Glu69,Tyr125 and Ser129,and spatially inhibited the interaction between PAQR3 and the PI3 K catalytic subunit(P110α) to restore the PI3 K/AKT signaling pathway.In summary,our study identified GPS,which inhibits PAQR3 expression and directly targets PAQR3 to restore insulin signaling pathway,as a potential drug candidate for the treatment of diabetes. | Haiming Xiao Xiaohong Sun Zeyuan Lin Yan Yang Meng Zhang Zhanchi Xu Peiqing Liu Zhongqiu Liu Heqing Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 7 |
| 3 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 4 | MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B显示文摘Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs(miRNAs) play multiple roles in biological processes and participate in cardiovascular diseases. In the present research, we investigate the impact of miRNA-34 c-5 p on cardiac hypertrophy and the mechanism involved. The expression of miR-34 c-5 p was proved to be elevated in heart tissues from isoprenaline(ISO)-infused mice. ISO also promoted miR-34 c-5 p level in primary cultures of neonatal rat cardiomyocytes(NRCMs). Transfection with miR-34 c-5 p mimic enhanced cell surface area and expression levels of foetal-type genes atrial natriuretic factor(Anf) and β-myosin heavy chain(β-Mhc) in NRCMs. In contrast, treatment with miR-34 c-5 p inhibitor attenuated ISO-induced hypertrophic responses. Enforced expression of miR-34 c-5 p by tail intravenous injection of its agomir led to cardiac dysfunction and hypertrophy in mice, whereas inhibiting miR-34 c-5 p by specific antagomir could protect the animals against ISO-triggered hypertrophic abnormalities. Mechanistically, miR-34 c-5 p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, the autophagy-related gene 4 B(ATG4 B) was identified as a direct target of miR-34 c-5 p, and miR-34 c-5 p was certified to interact with 3’untranslated region of Atg4 b mRNA by dual-luciferase reporter assay. miR-34 c-5 p reduced the expression of ATG4 B, thereby resulting in decreased autophagy activity and induction of hypertrophy. Inhibition of miR-34 c-5 p abolished the detrimental effects of ISO by restoring ATG4 B and increasing autophagy. In conclusion, our findings illuminate that miR-34 c-5 p participates in ISO-induced cardiac hypertrophy, at least partly through suppressing ATG4 B and autophagy. It suggests that regulation of miR-34 c-5 p may offer a new way for handling hypertrophy-related cardiac dysfunction. | Yuhong Zhang Yanqing Ding Min Li Jing Yuan Youhui Yu Xueying Bi Huiqi Hong Jiantao Ye Peiqing Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 5 | 6 DOF long- range precision tracking system显示文摘 | Lin Qi Hui Zhang Peiqing Ye | 2004 | IEEE International Conference on Systems Man and Cybernetics2004，，6： | 1 |
| 6 | Effects of canard sweep and canard-spanwise blowing magnitude on lift increment 显示文摘 | Liu Peiqing Wen Ruiying Zhang Guowei | 2006 | Journal of Aircraft2006，43，5： | 1 |
| 7 | The knot factor method and its applications in blade measurement显示文摘 | YE Peiqing ZHANG Hui | 2006 | Aerospace Science and Technology2006，10，5： | 1 |
| 8 | Ponicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosis 显示文摘 | Zhang Junfeng Liu Peiqing Chen Guihua | 2007 | Dig Liver Dis2007，39，2： | 1 |
| 9 | Study of the per- formance of modified nano-scale ZSM-5 zeolite on olefins reduction in FCC gasoline 显示文摘 | Zhang Peiqing Guo Xinwen Guo Hongchen | 2007 | Journal of Molecular Catalysis A : Chemical2007，261，： | 1 |
| 10 | Anatase Ti()2 hollow spheres embedded Ti()2 nanocrystalline photoa node for dyesensitized solarcells 显示文摘 | Zhang Yanwei Zhang Jing Wang Peiqing | 2010 | Mater Chem Phys2010，123，： | 1 |
| 11 | Fabrication of photonic crystals with functional defects by one-step holographic lithography显示文摘 | Juntao Li Yikun Liu Xiangsheng Xie Peiqing Zhang Bing Liang Li Yan Jianying Zhou Gershon Kurizki Daniel Jacobs Kam Sing Wong and Yongchun Zhong | 2008 | Optics Express2008，16，12： | 1 |
| 12 | WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC显示文摘Cancer stem cells(CSCs)are a small population of stem cell-like cancer cells that can initiate tumors in vivo,and are the major source of cancer initiation,relapse,and drug resistance.We previously reported that the p38 MAPK,through its downstream effectors MK2 and HSP27,suppressed CSC properties by downregulating the expression of transcription factors that mediate stemness in non-small-cell lung cancer(NSCLC)cells,and that despite unaltered total expression of total p38 proteins,the levels of activated p38 were reduced in NSCLC tissues.However,the mechanism underlying the reduced levels of activated p38 in NSCLC is unknown.In this study,we identified WIP1,a p38 phosphatase frequently overexpressed in cancer,as a suppressor of p38 in a pathway that regulates CSC properties in NSCLC.Increased WIP1 expression correlated with reduced levels of activated p38,and with increased levels of a CSC marker in NSCLC tissues.Further investigation revealed that WIP1 promoted stemness-related protein expression and CSC properties by inhibiting p38 activity in NSCLC cells.WIP1 inhibitors are currently under development as anticancer drugs based on their ability to reactivate p53.We found that a WIP1 inhibitor suppressed stemness-related protein expression and CSC properties by activating p38 in NSCLC cells in vitro and in vivo.These studies have identified the WIP1–p38–MK2–HSP27 cascade as a novel signaling pathway that,when altered,promotes CSC properties in NSCLC development,and have defined novel mechanisms underlying the oncogenic activity of WIP1 and the anticancer efficacy of WIP1 inhibitors. | Kaiyuan Deng Liang Liu Xiaoming Tan Zhen Zhang Jianjun Li Yang Ou Xin Wang Shuang Yang Rong Xiang Peiqing Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 13 | Effects of CeO2 on friction and wear characteristics of Fe-Ni-Cr alloy coatings 显示文摘 | Zhang Zhenyu Wang Zhiping Liang Bunv La Peiqing | 2006 | Tribalogy Intemational2006，，39： | 1 |
| 14 | Study of the performance of modified nano-scale ZSM-5 zeolite on olefins reduction in FCC gasoline 显示文摘 | Zhang Peiqing Guo Xinwen Guo Hongchen | 2007 | Journal of Molecular Catalysis A : Chemical2007，261，2： | 1 |
| 15 | Noble gas isotopic constraints on the origin and evolution of the Jinchuan Ni-Cu-(PGE) sulfide ore-bearing ultramafic intrusion, Western China 显示文摘 | Zhang Mingjie Tang Qingyan Hu Peiqing | 2013 | Chemical Geology2013，339，： | 1 |
| 16 | Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway显示文摘 | Yingxia Bao Ruifang Li Jianmin Jiang Birong Cai Jie Gao Kang Le Fangyan Zhang Shaorui Chen Peiqing Liu | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 17 | The knot factor method and its applications in blade measurement显示文摘 | Ye Peiqing Zhang Hui | 2006 | Aerospace Science and Technology2006，10，5： | 1 |
| 18 | Catalytic denitrogenation of hydrocarbons through partial oxidation in supercritical water显示文摘 | Yuan Peiqing Cheng Zhenmin Zhang Xiangyang | 2006 | Fuel2006，85，3： | 1 |
| 19 | 显示文摘 | Wang Xiangsheng Guo Hongchen | 2003 | Chin J Catal2003，24，3： | 1 |
| 20 | Study of the performance of modified nano-scale ZSM-5 zeolite on ole- fins reduction in FCC gasoline显示文摘 | Zhang Peiqing Guo Xinwen Guo Hongchen | 2007 | J Mol Catal A2007，26，2： | 1 |
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