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| 1 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 2 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 3 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 4 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 5 | Evolution of kaolinite subgroup minerals and mixed-layer illite/smectite in the Paleogene Damintun Depression in Liaohe Basin of China and its implication for paleotemperature显示文摘The oil-rich Damintun Depression is located in the Liaohe Basin, Northeast China, and was formed during the Paleogene. The major oil-producing strata in the depression are mudstone and shale. To explore the burial diagenetic history of the basin and the formation thresholds of hydrocarbons, the characters of the kaolinite subgroup minerals and mixed-layer illite/smectite in the mudstone and the shale are studied by using X-ray diffraction, electron probe, scanning electron microscope, and Fourier infrared spectrum. The kaolinite subgroup consists of kaolinite and halloysite. The kaolinite is flake-like or vermiform-like. The halloysite is in long tubular shape and its length is related to its iron content. A longer tube has lower iron content. The crystallinity of kaolinite is 0.40 °2θ, and its degree of order increases from 0.03 to 1.17 with the burial depth. Kaolinite is in disorder when the buried depth is less than or equal to 2479 m , and it is partially ordered when the buried depth is greater than 2479 m. Kaolinite is supposed to turn into dickite when the depth is greater than 2550 m, but low penetrability and low porosity of the shale and mudstone prevent such a change. The mixed-layer illite/smectite changes from disorder to order continually as the buried depth increases. Its disorder (R0I/S), as defined by illite layer content (I%), is smaller than 50% at depths less than 2550.25 m. Based on Hoffman & Hower’s model, the paleo-geothermal gradients of 3.37–3.76°C/100 m (3.57°C /100 m on average) can be derived in the Paleocene Damintun Depression, which is significantly higher than the present geothermal gradient (2.9°C/100 m). The threshold depth of the oil formation in the depression is about 2550 m. | ZHAO Ming JI JunFeng CHEN ZhenYan CHEN XiaoMing CUI XiangDong WANG YanShan | 2011 | Science China Earth Sciences2011，54，1： | 3 |
| 6 | Mechanical property of U-Shaped 65Mn steel bumpers for seismic base isolation显示文摘This study proposes a novel U-shaped 65Mn steel bumper as the displacement restraining device for base-isolated structures with laminated elastomeric rubber bearings.A series of bumpers with different geometric parameters were designed and tested under monotonic and cyclic quasi-static loading protocols.The experimental results from a total of 232 specimens were analyzed to develop an analytical model to calculate the backbone curve and the maximum elastic restoring force for U-shaped 65Mn bumpers.Thus,the analytical equations to calculate the elastic,hardening,and unloading stiffness of U-shaped 65Mn bumpers,as well as their maximum elastic restoring force,are validated by using an additional ten groups of bumpers with varying radiuses.These analytical equations can accurately predict the mechanical parameters of U-shaped 65Mn steel bumpers for a design purpose. | Han Miao Wang Yuandong Du Hongkai Cui Xiangdong | 2021 | Earthquake Engineering and Engineering Vibration2021，20，3： | 2 |
| 7 | Experimental Study of Partially Demineralized Bone Matrix as Bone Tissue Engineering Scaffold显示文摘 | Lei Cui Dong Li Xiangdong Liu Fanfan Chen Wei Liu Yilin Cao | 2005 | 中国生物学文摘2005，19，10： | 2 |
| 8 | Freeze-drying of human red blood cells: influence of carbohydrates and their concentrations显示文摘 | Yu Jianping Liu J H Pu L Q Cui Xiangdong Wang Changzheng Ouyang S L Gao Dayong | 2004 | Cell Preservation Technology2004，2，4： | 1 |
| 9 | Adipose Aspirates as a Source for Human Processed Lipoaspirate Cells after Optimal Cryopreservation显示文摘 | Lee L. Q. Pu Xiangdong Cui Betsy F. Fink Dayong Gao Henry C. Vasconez | 2006 | Plastic and Reconstructive Surgery2006，，6： | 1 |
| 10 | Mechanical properties and deformation mechanisms of a novel fine-grained Mg-Gd-Y-Ag-Zr-Ce alloy with high strength-ductility synergy显示文摘Grain boundary precipitation and segregation play an important role in determining mechanical properties of Mg alloys. In the present work, we studied work focuses on the strengthening and deformation mechanism of coarse-grained(CG) and fine-grained(FG) Mg-Gd-Y-Ag-Zr-Ce alloy. The CG alloy is strengthened by means of age-strengthening with the formation of both basal plate γ' and prismatic plate β’ precipitates in the grain interior. While the strengthening of FC alloy is completed by intergranular alloying segregation and intragranular precipitates γ' and β’. The segregation of alloying elements at the grain boundary and formation of sub-micron particles can stabilize the grain boundary and suppress the intergranular deformation. Consequently, dislocations could be trapped near γ' and β’ precipitates in the grain interior. Unlike CG alloys, the FG alloys exhibit a heterogeneous transition from elastic to plastic deformation via the Lüders plateau. The rapid gliding dislocation multiplications and fine-grained size are necessary and sufficient conditions for the Lüders strains. Our work provides the insights on the evolution of fine-grained microstructure and helps for the design of Mg alloys with good mechanical properties. | Xiaofei Cui Wei Fu Daqing Fang Guangli Bi Zijun Ren Shengwu Guo Suzhi Li Xiangdong Ding Jun Sun | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 11 | Cryopreservation of composite tissues and transplantation: Preliminary studies显示文摘 | Xiangdong Cui Dayong Y Gao | 2007 | Cryobiology2007，55，29： | 1 |
| 12 | Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex显示文摘Currently,the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide.COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon(IFN-I)signal,along with limited activation of antiviral immune responses as well as enhanced viral infectivity.Dramatic progresses have been made in revealing the multiple strategies employed by SARS-CoV-2 in impairing canonical RNA sensing pathways.However,it remains to be determined about the SARS-CoV-2 antagonism of cGAS-mediated activation of IFN responses during infection.In the current study,we figure out that SARS-CoV-2 infection leads to the accumulation of released mitochondria DNA(mtDNA),which in turn triggers cGAS to activate IFN-I signaling.As countermeasures,SARS-CoV-2 nucleocapsid(N)protein restricts the DNA recognition capacity of cGAS to impair cGAS-induced IFN-I signaling.Mechanically,N protein disrupts the assembly of cGAS with its co-factor G3BP1 by undergoing DNA-induced liquid-liquid phase separation(LLPS),subsequently impairs the double-strand DNA(dsDNA)detection ability of cGAS.Taken together,our findings unravel a novel antagonistic strategy by which SARS-CoV-2 reduces DNA-triggered IFN-I pathway through interfering with cGAS-DNA phase separation. | Sihui Cai Chenqiu Zhang Zhen Zhuang Shengnan Zhang Ling Ma Shuai Yang Tao Zhou Zheyu Wang Weihong Xie Shouheng Jin Jincun Zhao Xiangdong Guan Jianfeng Wu Jun Cui Yaoxing Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 13 | Fabrication of the beam splitters for soft X-ray laser application显示文摘The soft X-ray interferometry is completed by the Mach-Zehnder interferometer using a soft X-ray laser, and it is also an important method to measure the electron densities of a laser-produced plasma near the critical surface. It is apparently demonstrated in this paper that the incident angle of each optical element in the soft X-ray Mach- Zehnder interferometer should be near normal incidence based on the polarized characteristics of the soft X-ray mul-tilayers, and the product of reflectivity and transmission of the beam splitter should be taken as a standard of design according to the structure of the soft X-ray Mach-Zehnder interferometer. The beam splitters used in the soft X-ray interferometry at 13.9 nm are fabricated using the ion beam sputtering. The figure error of the beam splitter has reached the nanometer magnitude, in which the product of reflectiv-ity and transmission of the beam splitter is more than 1.6%. | WANG Zhanshan WU Yonggang TANG Weixing QIN Shuji CHEN Lingyan XU Xiangdong HONG Yilin FU Shaojun ZHU Jie CUI Mingqi | 2003 | Chinese Science Bulletin2003，48，18： | 1 |
| 14 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 15 | Cryopreservation and microsurgical implantation of rabbit carotid arteries 显示文摘 | Xiangdong CUI Carlos L Liqun HE | 2002 | Cell Preservation Technology2002，2，： | 1 |
| 16 | Biodegradation kinetics of phthalate esters by Pseudomonas fluoresences FS1显示文摘 | CUI Kunyan LI Xiangdong | 2004 | Rrocess Biochemistry2004，39，： | 1 |
| 17 | A non-contact flexible pyroelectric sensor for wireless physiological monitoring system显示文摘Recently,human physiological information wireless monitoring in real-time is particularly important in health analysis.As a solution,a non-contact wireless physiological monitoring system based on pyroelectric generator(Py G),whose core part consists of a wireless circuit processing module and a polyvinylidene fluoride(PVDF)film,has been successfully designed.Owing to the temperature change under the stimulation of an external heat source,the output voltage of the Py G self-powered flexible sensor increases with the heat source temperature variation in the range of 295–355 K.Furthermore,based on the natural temperature oscillation between the living body and surrounding environment,the sensor can realize human physiological information assessment,for example,temperature monitoring of the palms,fingers,respiratory heat signals from mouth or nose or non-contact spatial heat mapping recognition of finger movement via sensor array.On this basis,a portable wireless monitoring system was designed by integrating the intelligent sensor with a signal conditioning circuit,data conversion storage module,Bluetooth module,and power module.This system can acquire real-time human oral or nasal breathing signals in the personal mobile app to evaluate the physiological state of individuals.Additionally,the wireless monitoring system can be activated within 10 m,demonstrating the application of Py G sensors in remote data transmission. | Jian HE Sen LI Xiaojuan HOU Yongjun ZHOU Hao LI Min CUI Tao GUO Xiangdong WANG Jiliang MU Wenping GENG Xiujian CHOU | 2022 | Science China(Information Sciences)2022，65，2： | 0 |
| 18 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 19 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 20 | Experimental Investigations on Fiber Motion within Rotor Spinning Unit显示文摘An experimental platform is constructed to photograph fibers' motion within rotor spinning unit, which is mainly composed of a transparent rotor and a transport channel based on the similarity theory. The fibers will stretch and gather into a fiber bundle in the transport channel. The velocity of fibers is increasing along the inlet to the outlet of the transport channel, and the fibers' maximum velocity appears at the outlet of transport channel. The straightness of the fiber bundle is related to the convergence degree of the transport channel, and the greater the convergence degree is, the straighter the fiber bundle stretches. The results will provide a useful insight to the yarn-forming mechanism of rotor spinning. | JIN Yuzhen LI Xiangdong JIANG Shunwei CUI Jingyu ZHU Zuchao | 2017 | Journal of Thermal Science2017，26，4： | 0 |
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