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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The large increase of δ^(13)C_(carb)-depth gradient and the end-Permian mass extinction显示文摘Carbonate carbon isotope δ(13Ccarb) has received considerable attention in the Permian-Triassic transition for its rapid negative shift coinciding with the great end-Permian mass extinction event.The mechanism has long been debated for such a δ13Ccarb negative excursion through the end-Permian crisis and subsequent large perturbations in the entire Early Triassic.A δ13Ccarb depth gradient is observed at the Permian-Triassic boundary sections of different water-depths,i.e.,the Yangou,Meishan,and Shangsi sections,and such a large δ13Ccarb-depth gradient near the end-Permian mass extinction horizon is believed to result from a stratified Paleotethys Ocean with widespread anoxic/euxinic deep water.The evolution of δ13Ccarb-depth gradient combined with paleontological and geochemical data suggests that abundant cyanobacteria and vigorous biological pump in the immediate aftermath of the end-Permian extinction would be the main cause of the large δ13Ccarb-depth gradient,and the enhanced continental weathering with the mass extinction on land provides a mass amount of nutriment for the flourishing cyanobacteria.Photic zone anoxia/euxinia from the onset of chemocline upward excursion might be the direct cause for the mass extinction whereas the instability of chemocline in the stratified Early Triassic ocean would be the reason for the delayed and involuted biotic recovery. | SONG HaiJun TONG JinNan XIONG YanLin SUN DongYing TIAN Li SONG HuYue | 2012 | Science China Earth Sciences2012，55，7： | 11 |
| 3 | The microfacies and sedimentary responses to the mass extinction during the Permian-Triassic transition at Yangou Section, Jiangxi Province, South China显示文摘A Permian-Triassic(P-Tr) boundary section of continuous carbonate facies, which well recorded the biotic and environmental processes through the great P-Tr transition in the shallow non-microbialite carbonate facies, has been studied in Yangou, Leping County, Jiangxi Province. The P-Tr sequence is well correlated with the Meishan section according to the conodont biostratigraphy and the excursion of carbon isotopes. A series of high-resolution thin-sections from the P-Tr boundary carbonate rocks at the Yangou section are studied to explore the interrelation between environmental change and biological evolution during the transitional time. Six microfacies have been identified based upon the observation of the thin-sections under a microscope on the grains and matrix and their interrelation. Combined with the data of fossils and carbon isotopes, Microfacies 4(MF-4), coated-grain-bearing foraminifer oolitic sparitic limestone, and Microfacies 6(MF-6), dark shelly micritic limestone, should be the different responses to the two episodes of mass extinction and environmental events that can be correlated throughout South China and even over the world. The oolitic limestone of MF-4 is the first finding from the latest Permian strata in South China and it might be a proxy of an unusual environmental condition of high pCO2, low sulfate concentration and of microbial blooming in the aftermath of the latest Permian mass extinction. The micritic limestone of MF-6 containing rich micro-gastropods and ostracods probably represents the blooming event of disaster taxa in the earliest Triassic environment. The microfacies analysis at the Yangou section can well reveal the episodic process of the biological evolution and environmental change in the shallow non-microbialite carbonate facies throughout the great P-Tr transition, thus the Yangou section becomes an important complement to the Meishan section. | TIAN Li TONG JinNan SUN DongYing XIONG YanLin WANG ChengGang SONG HaiJun SONG HuYue HUANG YunFei | 2014 | Science China Earth Sciences2014，57，9： | 4 |
| 4 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 5 | Molten steel yield optimization of a converter based on constructal theory显示文摘Constructal theory is introduced into the molten steel yield maximization of a converter in this paper. For the specific total cost of materials, generalized constructal optimization of a converter steel-making process is performed. The optimal cost distribution of materials is obtained, and is also called as 'generalized optimal construct'. The effects of the hot metal composition contents, hot metal temperature, slag basicity and ratio of the waste steel price to the sinter ore price on the optimization results are analyzed.The results show that the molten steel yield after optimization is increased by 5.48% compared with that before optimization when sinter ore and waste steel are taken as the coolants, and the molten steel yield is increased by 6.84% when only the sinter ore is taken as the coolant. It means that taking sinter ore as coolant can improve the economic performance of the converter steelmaking process. Decreasing the contents of the silicon, phosphorus and manganese in the hot metal can increase the molten steel yield. The change of slag basicity affects the molten steel yield a little. | CHEN LinGen LIU Xiong FENG HuiJun GE YanLin XIE ZhiHui | 2018 | Science China(Technological Sciences)2018，61，4： | 2 |
| 6 | Plant target of rapamycin signaling network:Complexes,conservations,and specificities显示文摘Target of rapamycin(TOR)is an evolutionarily conserved protein kinase that functions as a central signaling hub to integrate diverse internal and external cues to precisely orchestrate cellular and organismal physiology.During evolution,TOR both maintains the highly conserved TOR complex compositions,and cellular and molecular functions,but also evolves distinctive roles and strategies to modulate cell growth,proliferation,metabolism,survival,and stress responses in eukaryotes.Here,we review recent discoveries on the plant TOR signaling network.We present an overview of plant TOR complexes,analyze the signaling landscape of the plant TOR signaling network from the upstream signals that regulate plant TOR activation to the downstream effectors involved in various biological processes,and compare their conservation and specificities within different biological contexts.Finally,we summarize the impact of dysregulation of TOR signaling on every stage of plant growth and development,from embryogenesis and seedling growth,to flowering and senescence. | Yanlin Liu Yan Xiong | 2022 | Journal of Integrative Plant Biology2022，64，2： | 1 |
| 7 | Identification of novel human glioblastoma-specific transcripts byserial analysis of gene expression data mining显示文摘 | Yanlin Su Jie Xiong Zhitong Bing Xiaomin Zeng Yong Zhang Xiaohua Fu Xiaoning Peng | 2013 | Cancer Biomarkers2013，，5： | 1 |
| 8 | Numerical simulation of zonal disintegration of surrounding rock in the deep-buried chamber显示文摘Zonal disintegration is the phenomenon of cyclical rupture zone and nonrupture zone in the surrounding rock of a deep-buried chamber,which is different from that of a shallow chamber.Based on the finite difference software FLAC3D,the numerical simulation of surrounding rock with different mechanical parameters was conducted by using the SU model(Bilinear Strain-Softening Ubiquitous-Joint).The influences of buried depth,cohesion,and internal friction angle of surrounding rock on zonal disintegration were analyzed to reveal the influence law.The results show that:(1)after the chamber excavation,multiple rupture zones gradually extend from the chamber surface or adjacent periphery to the deep surrounding rock.In the extension process,a single rupture zone may be forked into two or even multiple rupture zones,which cross each other and form the zonal disintegration zone.(2)Zonal disintegration is affected by bothσ(in situ stress)and U_(cs)(uniaxial compression strength).Smaller U_(cs)and largerσwill lead to zonal disintegration.(3)The zoning fracture is not obvious in the case ofσ≤U_(cs).In the reverse case,zoning fracture appears remarkably in the surrounding rock around the chamber.These results reveal the influence law of zonal disintegration and provide theoretical support for the design of deep-buried chambers. | Yukai Wang Xiaoli Liu Yanlin Xiong | 2022 | Deep Underground Science and Engineering2022，1，2： | 0 |
| 9 | Efficient conversion of lignin to alkylphenols over highly stable inverse spinel MnFe_(2)O_(4) catalysts显示文摘The aromatic properties of lignin make it a promising source of valuable chemicals and fuels.Developing efficient and stable catalysts to effectively convert lignin into high-value chemicals is challenging.In this work,MnFe_(2)O_(4) spinel catalysts with oxygen-rich vacancies and porous distribution were synthesized by a simple solvothermal process and used to catalyze the depolymerization of lignin in an isopropanol solvent system.The specific surface area was 110.5 m^(2)∙g^(–1),which substantially increased the active sites for lignin depolymerization compared to Fe3O4.The conversion of lignin reached 94%,and the selectivity of alkylphenols exceeded 90% after 5 h at 250℃.Underpinned by characterizations,products,and density functional theory analysis,the results showed that the catalytic performance of MnFe_(2)O_(4) was attributed to the composition of Mn and Fe with strong Mn–O–Fe synergy.In addition,the cycling experiments and characterization showed that the depolymerized lignin on MnFe_(2)O_(4) has excellent cycling stability.Thus,our work provides valuable insights into the mechanism of lignin catalytic depolymerization and paves the way for the industrial-scale application of this process. | Yi Qi Xuezhi Zeng Lingyingzi Xiong Xuliang Lin Bowen Liu Yanlin Qin | 2023 | Frontiers of Chemical Science and Engineering2023，17，8： | 0 |
| 10 | Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage显示文摘The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange, respectively. However, the regulation of proximal–distal patterning at the embryonic stage of human lung development is largely unknown. Here we investigated the early lung development of human embryos at weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, and obtained a transcriptomic atlas of 169,686 cells. We observed discernible gene expression patterns of proximal and distal epithelia at week 4, upon the initiation of lung organogenesis. Moreover, we identified novel transcriptional regulators of the patterning of proximal (e.g., THRB and EGR3) and distal (e.g., ETV1 and SOX6) epithelia. Further dissection revealed various stromal cell populations, including an early-embryonic BDNF+ population, providing a proximal–distal patterning niche with spatial specificity. In addition, we elucidated the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development. Together, our study expands the scope of human lung developmental biology at early embryonic stages. The discovery of intrinsic transcriptional regulators and novel niche providers deepens the understanding of epithelial proximal–distal patterning in human lung development, opening up new avenues for regenerative medicine. | Shangtao Cao Huijian Feng Hongyan Yi Mengjie Pan Lihui Lin Yao Santo Zhang Ziyu Feng Weifang Liang Baomei Cai Qi Li Zhi Xiong Qingmei Shen Minjing Ke Xing Zhao Huilin Chen Qina He Mingwei Min Quanyou Cai He Liu Jie Wang Duanqing Pei Jiekai Chen Yanlin Ma | 2023 | Cell Research2023，33，6： | 0 |
| 11 | The Evaluation of Visual Cadavers in Medical Laboratory: from Teaching to Practical Applications显示文摘Visual Cadavers is anemerging study method which promotes medical education and practical applications.It is benefited from other techniques and evaluated as having huge advantages,which is not only accelerating teaching and learning,but also improving scientific study,nevertheless,with limited cons. | Xinbozi XIONG Yanlin CHEN Zeping LI Xuezhong XIONG | 2018 | 国际感染病学(电子版)2018，7，4： | 0 |
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