|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | 对比增强超声显示的颈动脉斑块新生血管与临床症状的相关性显示文摘目的采用微气泡对比剂.评价颈动脉粥样硬化病人斑块的强化程度与临床症状的相关性。方法本研究得到医院伦理委员会批准,所有病人均签署知情同意书。104例颈动脉粥样斑块的病人[男性83例,平均年龄(64±9)岁;女件21例,平均年龄(61-10)岁]行普通超声和对比增强超声检查。采用视觉和定量分析评价斑块的强化程度。结果在104例病人中,35例(34%)有一过性缺血发作和(或)脑血管缺血性卒中。35例有症状和69例无症状的病人中,分别有28例(80%)和21例(30%)病人可见斑块强化(P〈0.001)。 | L. Xiong Y.B. Deng Y. Zhu Y.N. Liu X.J. Bi 郑梅竹(译) 夏爽(校) | 2009 | 国际医学放射学杂志2009，32，4： | 65 |
| 3 | Effects of dietary protein/energy ratio on growth performance,carcass trait,meat quality,and plasma metabolites in pigs of different genotypes显示文摘Background:The protein/energy ratio is important for the production performance and utilization of available feed resources by animals.Increased protein consumption by mammals leads to elevated feed costs and increased nitrogen release into the environment.This study aimed to evaluate the effects of dietary protein/energy ratio on the growth performance,carcass traits,meat quality,and plasma metabolites of pigs of different genotypes.Methods:Bama mini-pigs and Landrace pigs were randomly assigned to two dietary treatment groups(Chinese conventional diet with low protein/energy ratio or National Research Council diet with high protein/energy ratio;n = 24 per treatment) in a 2x2 factorial arrangement.Blood and muscle samples were collected at the end of the nursery,growing,and finishing phases.Results:We observed significant interactions(P< 0.05) between breed and diet for total fat percentage,intramuscular fat(IMF) content,protein content in biceps femoris(BF) muscle,and plasma urea nitrogen(UN) concentration in the nursery phase;for average daily gain(ADG),average daily feed intake(ADFI),dry matter,IMF content in psoas major(PM) muscle,and plasma total protein and albumin concentrations in the growing phase;and for drip loss and plasma UN concentration in the finishing phase.Breed influenced(P < 0.05) growth performance,carcass traits,and meat quality,but not plasma metabolites.Throughout the trial,Landrace pigs showed significantly higher(P < 0.05) ADG,ADFI,dressing percentage,lean mass rate,and loin-eye area than did Bama mini-pigs,but significantly lower(P< 0.05)feed/gain ratio,fat percentage,backfat thickness,and IMF content.Dietary protein/energy ratio influenced the pH value,chemical composition of BF and PM muscles,and plasma activities of glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase,and plasma concentration of UN.Conclusions:Compared with Landrace pigs,Bama mini-pigs showed slower growth and lower carcass performance,but had better meat quality.Moreover,unlike Landrace pigs,the dietary protein/energy ratio did not affect the growth performance of Bama mini-pigs.These results suggest that,in swine production,low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. | Yingying Liu Xiangfeng Kong Guoli Jiang Bi'e Tan Jinping Deng Xiaojian Yang Fengna Li Xia Xiong Yulong Yin | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 37 |
| 4 | Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction显示文摘Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction,but whether major ozonated autohemotherapy affects remote injury remains poorly understood.Here,we assumed that major ozonated autohemotherapy contributes to recovery of clinical function,possibly by reducing remote injury after acute cerebral infarction.Sixty acute cerebral infarction patients aged 30–80 years were equally and randomly allocated to ozone treatment and control groups.Patients in the ozone treatment group received medical treatment and major ozonated autohemotherapy(47 mg/L,100 m L ozone) for 10 ± 2 days.Patients in the control group received medical treatment only.National Institutes of Health Stroke Scale score,modified Rankin scale score,and reduced degree of fractional anisotropy values of brain magnetic resonance diffusion tensor imaging were remarkably decreased,brain function improved,clinical efficiency significantly increased,and no obvious adverse reactions detected in the ozone treatment group compared with the control group.These findings suggest that major ozonated autohemotherapy promotes recovery of neurological function in acute cerebral infarction patients by reducing remote injury,and additionally,exhibits high safety. | Xiao-na Wu Tao Zhang Jun Wang Xiao-yan Liu Zhen-sheng Li Wei Xiang Wei-qing Du Hong-jun Yang Tie-gen Xiong Wen-ting Deng Kai-run Peng Su-yue Pan | 2016 | Neural Regeneration Research2016，11，7： | 32 |
| 5 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 6 | Review of actuators for high speed active flow control显示文摘Actuators are one of the key points for the development of active flow control technology.Efficient methods of high speed flow control can provide enhanced propulsive efficiency and at the same time enable safe and maneuverable high speed flight.The development of high speed flight technology promotes the emergence of novel and robust actuators.This review introduces the state of the art in the development of actuators that can be used in high speed active flow control.The classification and different operation criteria of the actuators are discussed.The specifications,mechanisms and applications of various popular actuator types including fluidic,mechanical,and plasma actuators are described.Based on the realistic need of high speed flow control and the existing results of actuators,a new actuator design method is proposed.At last,the merits and drawbacks of the actuators are summarized and some suggestions on the development of active flow control technology are put forward. | WANG Lin LUO ZhenBing XIA ZhiXun LIU Bing DENG Xiong | 2012 | Science China(Technological Sciences)2012，55，8： | 21 |
| 7 | Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists显示文摘BACKGROUND:Organ fibrosis has been viewed as one of the major medical problems, which can lead to progressive dysfunction of the liver, lung, kidney, skin, heart, and eventually death of patients. Fibrosis is initiated by a variety of pathological, physiological, biochemical, and physical factors. Regardless of their different etiologies, they all share a common pathogenetic process: excessive activation of the key profibrotic cytokine, transforming growth factor-β (TGF-β). Peroxisome proliferator-activated receptor γ (PPARγ), a ligand-activated transcription factor of the nuclear receptor superfamily, has received particular attention in recent years, because the activation of PPARγ by both natural and synthetic agonists could effectively inhibit TGF-β-induced profibrotic effects in many organs. DATA SOURCES: The English-language medical databases, PubMed, Elsevier and SpringerLink were searched for articles on PPARγ, TGF-β, and fibrosis, and related topics. RESULTS: TGF-β is recognized as a key profibrotic cytokine. Excessive activation of TGF-β increases synthesis of extracellular matrix proteins and decreases their degradation, associated with a gradual destruction of normal tissue architecture and function, whereas PPARγ agonists inhibit TGF-β signal transduction and are effective antifibrogenic agents in many organs including the liver, lung, kidney, skin and heart. CONCLUSIONS: The main antifibrotic activity of PPARγ agonists is to suppress the TGF-β signaling pathway by so-called PPARγ-dependent effect. In addition, PPARγ agonists, especially 15d-PGJ2, also exert potentially antifibrotic activity independent of PPARγ activation. TGF-β1/Smads signaling not only plays many essential roles in multiple developmental processes, butalso forms cross-talk networks with other signal pathways, and their inhibition by PPARγ agonists certainly affects the cytokine networks and causes non-suspected side-effects. Anti-TGF-β therapies with PPARγ agonists may have to be carefully tailored to be tissue-and target gene-specific to minimize side-effects, indicating a great challenge to the medical research at present. | Yi-Lei Deng, Xian-Ze Xiong, Nan-Sheng Cheng Department of General Surgery, West China Hospital,Sichuan University, Chengdu 610041, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 20 |
| 8 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 9 | Sandwich-Like Fe&TiO2@C Nanocomposites Derived from MXene/Fe-MOFs Hybrids for Electromagnetic Absorption显示文摘Electromagnetic pollution has been causing a series of problems in people’s life,and electromagnetic absorbers with lightweight and broad absorbing bandwidth properties are widely desired.In this work,novel sandwich-like 2D laminated Fe&TiO2 nanoparticles@C nanocomposites were rationally designed and successfully developed from the MXene–MOFs hybrids.The formation of Fe and rutile-TiO2 nanoparticles sandwiched by the two-dimensional carbon nanosheets provided strong electromagnetic energy attenuation and good impedance matching for electromagnetic wave(EMW)absorption.As expected,the nanocomposites achieved a broad effective absorption bandwidth of 6.5 GHz at a thickness of only 1.6 mm and the minimum reflection loss(RL)value of−51.8 dB at 6.6 GHz with a thickness of 3 mm.This work not only provides a good design and fabricating concept for the laminated metal and functional nanoparticles@C nanocomposites with good EMW absorption,but also offers an important guideline to fabricate various two-dimensional nanocomposites derived from the MXene precursors. | Baiwen Deng Zhen Xiang Juan Xiong Zhicheng Liu Lunzhou Yu Wei Lu | 2020 | Nano-Micro Letters2020，12，4： | 16 |
| 10 | Prevalence and risk factors of postpartum depression in a populationbased sample of women in Tangxia Community,Guangzhou显示文摘Objective:To investigate the prevalence and analyze the risk factors of postpartum depression(PPD)in Tangxia Community.Guangzhou,a community representative of the process of urbanization in China.Methods:A total of 1 823 delivery women in Tangxia Community.Guangzhou were screened with the Chinese Version of Edinburgh Postnatal Depression Scale,Hamilton Depression Scale and Social Support Rating Scale.The risk factors were evaluated by self-made questionnaire based on literature interview combined with expert consultation.The data collected were analyzed using Student's t test and logistic regression in SPSS16.0.Results:The prevalence of PPD in Tangxia Community,Guangzhou was 27.37%.Mutivariant logistic regression analysis identified mode of delivery,puerperanl from one-child family,relationship between mother-in-law atul daughter-in-law and fetus gender as the risk factors of PPD while housing condition was negatively correlated with the incidence of PPD with OR value of 0.82.The the total score of social support rating scale,the score of objective support,subjective support and social utilization degree were significantly reduced in women with PPD in contrast with women without PPD.Conclusions:The incidence of PPD was slightly higher than other regions of China.It's of great importance to distinguish risk factors in regional culture context and develop health promotion program in order to enhance the well-being of delivery women. | Ai-Wen Deng Ri-Bo Xiong Ting-Ting Jiang Ying-Ping Luo Wang-Zhong Chen | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，3： | 14 |
| 11 | Hyperparameter Optimization for Machine Learning Models Based on Bayesian Optimization显示文摘Hyperparameters are important for machine learning algorithms since they directly control the behaviors of training algorithms and have a significant effect on the performance of machine learning models. Several techniques have been developed and successfully applied for certain application domains. However, this work demands professional knowledge and expert experience. And sometimes it has to resort to the brute-force search.Therefore, if an efficient hyperparameter optimization algorithm can be developed to optimize any given machine learning method, it will greatly improve the efficiency of machine learning. In this paper, we consider building the relationship between the performance of the machine learning models and their hyperparameters by Gaussian processes. In this way, the hyperparameter tuning problem can be abstracted as an optimization problem and Bayesian optimization is used to solve the problem. Bayesian optimization is based on the Bayesian theorem. It sets a prior over the optimization function and gathers the information from the previous sample to update the posterior of the optimization function. A utility function selects the next sample point to maximize the optimization function.Several experiments were conducted on standard test datasets. Experiment results show that the proposed method can find the best hyperparameters for the widely used machine learning models, such as the random forest algorithm and the neural networks, even multi-grained cascade forest under the consideration of time cost. | Jia Wu Xiu-Yun Chen Hao Zhang Li-Dong Xiong Hang Lei Si-Hao Deng | 2019 | Journal of Electronic Science and Technology2019，17，1： | 14 |
| 12 | Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C显示文摘We have previously reported that Cystatin C(CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen(HBO) preconditioning; however,the underlying mechanism and how CysC changes after stroke are not clear. In the present study, we demonstrated that CysC expression was elevated as early as 3 h after reperfusion, and this was further enhanced by HBO preconditioning. Concurrently, LC3-II and Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of CysC blocked these elevations. As a marker of autophagy inhibition, p62 was downregulated by HBO preconditioning and this was blocked by CysC knockdown. Besides, the beneficial effects of preserving lysosomal membrane integrity and enhancing autolysosome formation induced by HBO preconditioning were abolished in CysC-/-rats.Furthermore, we demonstrated that exogenous CysC reduced the neurological deficits and infarct volume after brain ischemic injury, while 3-methyladenine partially reversed this neuroprotection. In the present study, we showed that CysC is biochemically and morphologically essential for promoting autophagic flux, and highlighted the translational potential of HBO preconditioning and CysC for stroke treatment. | Zongping Fang Yun Feng Yuheng Li Jiao Deng Huang Nie Qianzhi Yang Shiquan Wang Hailong Dong Lize Xiong | 2019 | Neuroscience Bulletin2019，35，2： | 14 |
| 13 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 14 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 15 | Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)显示文摘In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this journal.With accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition recently.The current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in children.In the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is highlighted.The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice.This version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide. | Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang | 2020 | World Journal of Pediatrics2020，16，3： | 9 |
| 16 | Identification of a Differentially Expressed Gene PPP1CB between Porcine Longissimus dorsi of Meishan and Large White×Meishan Hybrids显示文摘To study the molecular basis of heterosis,suppression subtractive hybridization was used toinvestigate the differences in gene expression between porcine Longissimus dorsi of F1 hybrids LargeWhite×Meishan and their female parents Meishan.From two specific subtractive cDNA libraries,the clonesselected by reverse Northern high-density blot screening were chosen to clone full-length cDNA by rapidamplification of cDNA ends.An expression-upregulated gene for Meishan skeletal muscle,designated proteinphosphatase 1,catalytic subunit,beta isoform(PPPICB),was identified.Porcine PPPICB contains an openreading frame encoding 327 amino acid residues with 13 and 1763 nucleotides in the 5′ and 3′ untranslatedregions,respectively.A DNA fragment of 721 nucleotides was amplified and a mutation that creates/disruptsa restriction site for endonuclease RsaI was found.The derived amino acid sequence of PPPICB has highhomology with the PPPICB of three species,Mus musculus(99%),human(99%)and mouse(100%).Thetissue expression analysis indicated that the swine PPP1CB gene is generally expressed in most tissues.Thepossible role of PPP1CB and its relation to porcine heterosis are discussed. | Tao HUANG Yuan-Zhu XIONG Ming-Gang LEI De-Quan XU Chang-Yan DENG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，7： | 9 |
| 17 | Experimental characteristics of a two-electrode plasma synthetic jet actuator array in serial显示文摘Plasma Synthetic Jet(PSJ) actuators have shown wide and promising application prospects in high-speed flow control, due to their advantages including high exhaust speed, wide frequency band, rapid response, and non-moving components. Although previous studies on PSJ actuators are abundant, most of them have focused on the performance of a single actuator. However, in practice, an actuator array is very necessary for large-scale aerodynamic actuation on account of the small affected area of a single PSJ. In this paper, the characteristics of a twoelectrode plasma synthetic jet actuator array in serial are investigated experimentally. Compared to a parallel actuator array, the serial actuator array requires simpler power supply design and is much easier to realize. High-speed photography of the discharge evolution, voltage-current measurement, and shadowgraphy visualization are used in the investigation. Experimental results show that, for the serial actuator array, weak discharges happen firstly between energized and suspending electrodes, and then a strong pulse arc discharge is triggered. The breakdown voltage in serial is irrelevant to such factors as the number of actuators, the maximum or minimum gap in serial,the connection sequence, etc. It is mainly determined by the sum of gaps. For serial actuators with the same anode-to-cathode spacing, the energy deposition is the same, and the jet is synchronous and similar. Because of the entrainment and merging of adjacent jet vortices, the jet front speed of an aligned synchronous jet array increases as the orifice distance decreases. To achieve the highest jet front velocity, the orifice of the actuator has an optimal diameter. | Yan ZHOU Zhixun XIA Zhenbing LUO Lin WANG Xiong DENG | 2018 | Chinese Journal of Aeronautics2018，31，12： | 9 |
| 18 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 19 | Analysis of the clinical characteristics and refraction state in premature infants: a 10-year retrospective analysis显示文摘AIM: To report the visual outcomes and refractive status in premature infants with and without retinopathy of prematurity(ROP) who were or not treated. METHODS: The clinical records of all premature infants with or without ROP and with or without treatment between 2007 and 2017 were retrospectively reviewed. Basic demographic data, serial changes in ROP incidence, treatment and outcomes, and the refractive states were analyzed. Correlations among myopia and astigmatism progression, birth weight, gestational age, and treatment methods were also analyzed.RESULTS: A total of 562 screened premature infants(all Chinese, 1124 eyes), were recruited with a 378:184 maleto-female ratio. Birth weight did not directly influence ROP incidence. The overall ROP incidence was 16.55%(93/562 cases). The incidences in boys and girls were 16.14%(33/378 cases) and 17.39%(32/184 cases), respectively, and this difference was not significant. However, all infants with serious ROP(stage IV and V) were male. Myopia combined with astigmatism was common in premature infants with and without ROP(30.99%, 172/555 cases), and myopic refraction(including myopia and myopia combined with astigmatism) was more common in premature infants with ROP(48.84%, 42/86 cases). In the >8.00 diopter group, there were significantly more ROP infants than without ROP. Myopic refraction(including myopia and myopia combined with astigmatism) was most common in infants with ROP after treatment(63.63%, 7/11 cases). CONCLUSION: The refractive state is different between premature infants and mature infants. Those treated for ROP had a higher chance of developing myopia, astigmatism, and higher diopter. | Yan Deng Chun-Hong Yu Yun-Tao Ma Yang Yang Xiao-Wei Peng Yu-Jun Liao Wei-Wei Xiong Jin-Song Wu Huan-Wen Mao Xiao-Long Yin | 2019 | International Journal of Ophthalmology(English edition)2019，12，4： | 8 |
| 20 | A novel alkenoic acid ester and a new benzophenone from Ranunculus ternatus显示文摘新奇 alkenoic 酸酉旨,(E)-4-hydroxy-dodec-2-enedioic acid-12-O-methyl 酉旨和新 benzophenone,和已知的混合物的乙醇(S)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate, ,(E)-4-hydroxy-dodec-2-enedioic 酸从毛莨属 ternatus 的根被孤立。他们的结构被分光镜的方法阐明。 | Ying Xiong Ke Zhong Deng Wen Yuan Gao Yuan Qiang Guo Tie Jun Zhang | 2007 | Chinese Chemical Letters2007，18，11： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员