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| 1 | Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma显示文摘瞄准:在食道的有鳞的房间癌(ESCC ) 寻找病毒(HPV ) 感染人的乳突淋瘤的证据并且在河南省移民在食道的癌的致病调查 HPV 感染的潜在的角色和传染病学。方法:乳突淋瘤病毒(PV ) 和 HPV 被 Ultrasensive S-P 免疫组织化学(IHC ) 和原位杂交(ISH ) 在食道的癌纸巾(82 个案例) 和正常粘膜(40 个案例) 决定。结果:当时, IHC 表明 PV 的积极的率分别地是 75.0% , 68.18% 和 72.5% 积极的率是的 HPV (16/18-E6 )45.0%,36.36% , 37.5% ,分别地在从在湖北癌症的河南省移民,本地公民和病人的食道的癌组织标本医院。PV 和 HPV (16/18-E6 ) 在所有正常食道的粘膜标本是否定的。没有关联在食道的有鳞的房间癌纸巾并且在等级 1-3 在 HPV 之间被发现食道的有鳞的房间癌房间。原位杂交证明 HPV (16/18 ) DNA 积极的率是 30.0% , 31.8% , 25.0% ,分别地在 3 组样品。没有积极杂交信号在 40 个正常食道的粘膜标本被发现。在食道的癌标本的 HPV (16/18 ) DNA 的积极的率在正常粘膜标本(P<0.05 ) 比那显著地高。积极的率不在 3 组食道的癌组织标本(P>0.05 ) 之中是不同的。结论:HPV 感染在在湖北癌症 Hospital.HPV 的河南省移民,本地居民和病人的食道的癌高仔细与食道的有鳞的房间癌被联系。HPV 感染可以在食道的有鳞的房间癌起一个重要作用。 | Pin-Fang Yao Guang-Can Li Jin Li He-Shun Xia Xiao-Ling Yang Huan-Yuan Huang You-Gao Fu Rui-Qin Wang Xi-Yin Wang Ju-Wei Sha | 2006 | World Journal of Gastroenterology2006，12，9： | 15 |
| 2 | Effect of replacing antibiotics using multi-enzyme preparations on production performance and antioxidant activity in piglets显示文摘The study was conducted to investigate the effects of replacing antibiotics using multi-enzyme preparations on growth performance,coefficient of total tract apparent digestibility,digestive enzyme activity,and antioxidant property in piglets.A total of 160 piglets((21.35±0.22)kg)were randomly assigned to five dietary treatments:1)basal diet supplemented with antibiotics(AC),2)antibiotic diet supplemented with 0.5 g kg^(–1) multi-enzyme preparations(AC+0.5EP),3)antibiotic diet supplemented with 1.5 g kg^(–1) multi-enzyme preparations(AC+1.5EP),4)basal diet supplemented with a half dosage of antibiotics and 1.5 g kg^(–1) multi-enzyme preparations(AH+1.5EP),and 5)basal diet supplemented with 1.5 g kg^(–1) multienzyme preparations(BC+1.5EP).The results showed that AC+1.5EP significantly improved the feed efficiency,apparent digestibility of ether extract(EE)and crude ash(CA),lipase activity in pancreas and duodenum content,maltase and lactase activity in jejunum and ileum mucosa,glutathione peroxidase(GSH-Px)concentration in serum and liver,and decreased malondialdehyde(MDA)concentration in serum and liver compared with piglets receiving AC(P<0.05).Piglets receiving BC+1.5EP showed no significant difference in growth performance(P>0.05)but had lower MDA concentration than piglets receiving AC(P<0.05).The apparent digestibility of EE and crude fiber(CF),duodenal lipase activity,jejunum mucosa maltase,and ileum mucosa lactase activity of piglets receiving AH+1.5EP or BC+1.5EP were significantly improved compared with piglets receiving AC(P<0.05).These results indicated an additive growth promotion effect between antibiotics and multi-enzyme preparations on piglets,and the multi-enzyme preparations may be used as substitutes for antibiotics for improving piglet production performance and health status. | HAN Xin-yan YAN Feng-ying NIE Xin-zheng XIA Wei CHEN Sha ZHANG Xiao-xu QIAN Li-chun | 2017 | Journal of Integrative Agriculture2017，16，3： | 9 |
| 3 | Combined small bowel and reduced auxiliary liver transplantation:case report显示文摘AIM: To present a case of combined small bowel andreduced auxiliary liver transplantation.METHODS: A 55-year-old patient with short bowelsyndrome and TPN-related liver dysfunction received smallbowel transplantation combined with a reduced auxiliaryliver graft. A liver was added to restore the patient′s liverfunction and to protect the intestinal allograft from rejection.His own liver was not removed.RESULTS: Without donor pretreatment and by conventionalimmunosuppresive therapy following transplantation, thepatient experienced had only one episode of mild intestinalrejection, which was easily reversed by treatment withMethylprednisolone. No liver rejection occurred.Unfortunately, the patient died of heart and lung failure30d after transplantation, despite successful graftreplacement. Histopathologic examination of specimens afterdeath demonstrated normal structure in both intestinal andliver grafts.CONCLUSION: The auxiliary liver graft might play a role inpreventing intestinal allograft rejection. However, theobservation period in this case is short. Further study isneeded to determine the risks, effect on the protecting thesmall-bowel from rejection, and feasibility of generalapplication of this procedure. | Wei-Jie Zhang Dun-Gui Liu Qi-Fa Ye Bo Sha Fan-Jun Zhen Hui Gun Sui-Sheng Xia Institute of Organ Transplantation,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China | 2002 | World Journal of Gastroenterology2002，8，5： | 6 |
| 4 | Wnt3a:functions and implications in cancer显示文摘Wnt3a,one of Wnt family members,plays key roles in regulating pleiotropic cellular functions,including self-renewal,proliferation,differentiation,and motility.Accumulating evidence has suggested that Wnt3 a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.In addition,the roles of Wnt3 a signaling can be inhibited by multiple proteins or chemicals.Herein,we summarize the latest findings on Wnt3 a as an important therapeutic target in cancer. | Sha He Yi Lu Xia Liu Xin Huang Evan T.Keller Chao-Nan Qian Jian Zhang | 2015 | Chinese Journal of Cancer2015，34，12： | 5 |
| 5 | LIN28A inhibits DUSP family phosphatases and activates MAPK signaling pathway to maintain pluripotency in porcine induced pluripotent stem cells显示文摘LIN28A,an RNA-binding protein,plays an important role in porcine induced pluripotent stem cells(piPSCs).However,the molecular mechanism underlying the function of LIN28A in the maintenance of pluripotency in piPSCs remains unclear.Here,we explored the function of LIN28A in piPSCs based on its overexpression and knockdown.We performed total RNA sequencing(RNA-seq)of piPSCs and detected the expression levels of relevant genes by quantitative real-time polymerase chain reaction(qRT-PCR),western blot analysis,and immunofluorescence staining.Results indicated that piPSC proliferation ability decreased following LIN28A knockdown.Furthermore,when LIN28A expression in the shLIN28A2 group was lower(by 20%)than that in the negative control knockdown group(shNC),the pluripotency of piPSCs disappeared and they differentiated into neuroectoderm cells.Results also showed that LIN28A overexpression inhibited the expression of DUSP(dual-specificity phosphatases)family phosphatases and activated the mitogen-activated protein kinase(MAPK)signaling pathway.Thus,LIN28A appears to activate the MAPK signaling pathway to maintain the pluripotency and proliferation ability of piPSCs.Our study provides a new resource for exploring the functions of LIN28A in piPSCs. | Xiao-Long Wu Zhen-Shuo Zhu Xia Xiao Zhe Zhou Shuai Yu Qiao-Yan Shen Ju-Qing Zhang Wei Yue Rui Zhang Xin He Sha Peng Shi-Qiang Zhang Na Li Ming-Zhi Liao Jin-Lian Hua | 2021 | Zoological Research2021，42，3： | 5 |
| 6 | A Rapid and Effective HPLC Method for Identification of Bovis Calculus in Chinese Patent Medicines显示文摘Objective Due to the limited resource and the large demand,many kinds of Bovis Calculus(BC)including artificial Bovis Calculus(ABC),in vivo cultured Bovis Calculus(in vivo CBC),and in vitro cultured Bovis Calculus(in vitro CBC)were used in Chinese patent medicines(CPMs).Previous studies have shown that the chemical constituents of ABC and their properties were different from other BC.The two types of CBC with much higher price than ABC were approximately equivalent with natural Bovis Calculus in quality and clinical effect.The aim of the study is to establish a rapid and effective method for the identification of BC in CPMs.Methods An HPLC method with the higher specificity for analyzing bilirubin was established to distinguish ABC from other three kinds of BC by comparing the change of bilirubin content with the addition of EDTA-2Na as the extraction solvent and stabilizer.Results The bilirubin content in CPMs containing ABC was basically unchanged,while that in CPMs containing other kinds of BC showed significant difference.The proposed method was employed to analyze a variety of CPMs containing Bovis Calculus(CPMBCs)and proven to be universal.Conclusion An effective analytical method is established for the quality control of CPMBCs and further ensures the safety and efficacy of these drugs in clinical practice. | XIA Jing XIA Li WANG Wei-yi SHA Yi-wei WANG Ke JI Shen | 2013 | Chinese Herbal Medicines2013，5，3： | 3 |
| 7 | Microstructure of nano precursors of La-Mg hydrogen storage alloy synthesized by sol-gel technology at different pH values显示文摘Sol-gel technology was employed to synthesize nanosized precursors of La-Mg hydrogen storage alloy at different pH values (0.5,1.5,8.0 and 9.0) of reaction solution.The effect of pH value on microstructure of the nano precursors of La-Mg hydrogen storage alloy was studied by infrared radiation (IR),thermo-gravimetric and differential thermal analysis (TG/DTA),X-ray diffraction analyzer (XRD) and transmission electron microscopy (TEM).IR results indicate that the chelating agent,citric acid,is not fully ionized,and carboxyl groups are not entirely used to complex metal ions in acidic solutions.The efficiency of complexing metal ions is enhanced in basic solutions.TG/DTA results show that the combustion may take place with low rate of the flame propagation that causes the longer combustion time when pH<1.5.On the contrary,the dry gel synthesized in basic solution combusts at low ignition temperature and combustion reaction is violent; it is easy to form fine particles.XRD and TEM results reveal that the precursor powders are mainly two-phase mixture of La2O3 and MgO.The morphology of the particles is almost flake with the size of~30 nm when pH is 8.0. | WANG Dahui XIA Jihong ZHANG Sha | 2012 | Rare Metals2012，31，5： | 3 |
| 8 | SAR Image Despeckling Using Scale Mixtures of Gaussians in the Nonsubsampled Contourlet Domain显示文摘The edge and contour details in SAR images are important for subsequent processing tasks. The multiscale geometric analysis method — Nonsubsampled contourlet transform(NSCT) is able to capture the geometric information of SAR images effectively. Describing the aggregation behavior of the neighborhoods coefficients, the scale mixtures of Gaussians model has exhibited favorable performances. A novel SAR image despeckling method is presented by constructing the scale mixtures of Gaussians model of NSCT. This method models the SAR images using the multiscale and multidirection information in NSCT domain. The dependency relationship of NSCT neighborhoods coefficients are also taken into consideration in our model. The speckle noise coefficients are shrinkaged by statistical prior estimation based on SAR image model constructed. Experimental results demonstrate that our method is advantageous at directional information preservation and the speckle restraint. | CHANG Xia JIAO Licheng LIU Fang SHA Yuheng | 2015 | Chinese Journal of Electronics2015，24，1： | 2 |
| 9 | Impact of Smoking Status on Lipoprotein Subfractions: Data from an Untreated Chinese Cohort显示文摘Objective Cigarette smoking is one of the established risk factors of atherosclerotic cardiovascular disease,however,its impact on lipids is not completely understood,especially in the Chinese population.Therefore,this study evaluated the impact of smoking status(non,former,and current smoking) on the distribution of lipoprotein subfractions in untreated patients with angina-like chest pain.Methods A total of 877 patients were consecutively enrolled and divided into nonsmoking(n = 518),former smoking(n = 103),and current smoking(n = 256) groups.Both low-and high-density lipoprotein cholesterol(LDL-C and HDL-C) subfractions were measured using the Quantimetrix Lipoprint System.The distributions of lipoprotein subfractions were evaluated among the groups.Results Compared with nonsmoking subjects,the current smoking group had significantly lower large/medium HDL-C(both P < 0.001) concentration and large HDL subfraction percentage but higher small HDL-C and medium LDL-C concentrations as well as medium LDL subfraction percentage.Importantly,former smoking subjects showed elevated levels of large HDL-C concentration,large HDL particle percentage,and mean LDL particle size and attenuation in small HDL/LDL percentages and small LDL-C concentration,but these levels did not reach the optimal status compared with those of the non-smoking group(data not shown).Conclusion Smoking has an adverse impact on the lipoprotein subfractions,presented as lower large HDL particles besides higher small HDL and medium LDL particles,whereas smoking cessation could reverse these change to a certain degree. | ZHAO Xi ZHANG Hui Wen ZHANG Yan LI Sha XU Rui Xia SUN Jing ZHU Cheng Gang WU Na Qiong GAO Ying GUO Yuan Lin LIU Geng DONG Qian LI Jian Jun | 2017 | Biomedical and Environmental Sciences2017，30，4： | 2 |
| 10 | Genome-wide identification of chitin-binding proteins and characterization of BmCBP1 in the silkworm, Bombyx mori显示文摘The insect cuticle plays important roles in numerous physiological functions to protect the body from invasion of pathogens, physical injury and dehydration. In this report, we conducted a comprehensive genome-wide search for genes encoding proteins with peritrophin A-type (ChtBD2) chitin-binding domain (CBD) in the silkworm, Bombyx mori. One of these genes, which encodes the cuticle protein BmCBP1, was additionally cloned, and its expression and location during the process of development and molting in B. mori were investigated. In total, 46 protein-coding genes were identified in the silkworm genome, including those encoding 15 cuticle proteins analogous to peritrophins with one CBD (CPAP1s), nine cuticle proteins analogous to peritrophins with three CBD (CPAP3s), 15 peritrophic membrane proteins (PMPs), four chitinases, and three chitin deacetylases, which contained at least one ChtBD2 domain. Microarray analysis indicated that CPAP-encoding genes were widely expressed in various tissues, whereas PMP genes were highly expressed in the midgut. Quantitative polymerase chain reaction and western blotting showed that the cuticle protein BmCBP1 was highly expressed in the epidermis and head, particularly during molting and metamorphosis. An immunofluorescence study revealed that chitin co-localized with BmCBP1 at the epidermal surface during molting. Additionally, BmCBP1 was notably up-regulated by 20-hydroxyecdysone treatment. These results provide a genome-level view of the chitin-binding protein in silkworm and suggest that BmCBP1 participates in the formation of the new cuticle during molting. | Zhi-Lang Li Sha Tian Huan Yang Xia Zhou Shu-Ping Xu Zi-Yu Zhang Jing Gong Yong Hou Qing-You Xia | 2019 | Insect Science2019，26，3： | 2 |
| 11 | Protection of retinal ganglion cells against optic nerve injury by induction of ischemic preconditioning显示文摘AIM: To explore if ischemic preconditioning(IPC) can enhance the survival of retinal ganglion cells(RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60 min or axotomy, IPC was applied for ten minutes in groups of(n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27(HSP27) and heat shock protein 70(HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14 d post-injury. The cellular expression of HSP27 and HSP70 and changes in the numbers of retinal microglia were quantified to detect the possible mechanism of the protection of the IPC. RESULTS: Ten minutes of IPC promoted RGC survival in both the optic nerve injury(IPC-ONT) and the retinal ischemia 60min(IPC-IR60) groups, examined at 7d and 14 d post-injury. Microglial proliferation showed little correlation with the extent of benefit effects of IPC on the rescue of RGCs. The number of HSP27-positive RGCs was significantly higher in the IPC-ONT group than in the sham IPC-ONT group, although the percentage of HSP27-positive RGCs did not significantly differ between groups. For the IPC-IR60 group, neither the number nor the percentage of the HSP27-positive RGCs differed significantly between the IPC and the sham-operated groups. The number of HSP70-positive RGCs was significantly higher for both the IPC-ONT and the IPC-IR60 experimental groups, but the percentages did not differ. CONCLUSION: The induction of IPC enhances the survival of RGCs against both axotomy and retinal ischemia. | Xia Liu Jiu-Ping Liang Ou Sha Song-Juan Wang Heng-Guo Li Eric Y.P.Cho | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 2 |
| 12 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 13 | Utility of in vitro interferon‐γ release assay in differential diagnosis between intestinal tuberculosis and C rohn’s disease显示文摘 | Yuan Lei Feng Ming Yi Jie Zhao Rishi Vishal Luckheeram Sha Huang Min Chen Mei Fang Huang Jin Li Rui Zhou Gui Fang Yang Bing Xia | 2013 | Journal of Digestive Diseases2013，，2： | 2 |
| 14 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 15 | Distribu- tion of phthalic acid esters in Wuhan section of the yangtze river, ehina显示文摘 | WANG Fan XIA Xing-hui SHA Yu-juan | 2008 | Journal of Hazardous Mate- rials2008，154，13： | 1 |
| 16 | Band-gap-tailored random laser显示文摘A band-gap-tailored random laser with a wide tunable range and low threshold through infrared radiation is demonstrated. When fluorescent dyes are doped into the liquid crystal and heavily doped chiral agent system,we demonstrate a wavelength tuning random laser instead of a side-band laser, which is caused by the combined effect of multi-scattering of liquid crystal(LC) and band-gap control. Through rotating the infrared absorbing material on the side of the LC cell, an adjustable range for random lasing of 80 nm by infrared light irradiation was observed. | HONGBO Lu JIAN XING CHENG WEI JIANGYING XIA JUNQING SHA YUNSHENG DING GUOBING ZHANG KANG XIE LONGZHEN QIU ZHIJIA Hu | 2018 | Photonics Research2018，6，5： | 1 |
| 17 | Distribution of phthalic acid esters in wuhan section of the Yangtze river, China 显示文摘 | Wang F Xia X H Sha Y J | 2008 | Journal of Hazardous Materials2008，154，13： | 1 |
| 18 | Utility of in vitro interferon‐γ release assay in differential diagnosis between intestinal tuberculosis and C rohn’s disease显示文摘 | Yuan Lei Feng Ming Yi Jie Zhao Rishi Vishal Luckheeram Sha Huang Min Chen Mei Fang Huang Jin Li Rui Zhou Gui Fang Yang Bing Xia | 2013 | Journal of Digestive Diseases2013，，2： | 1 |
| 19 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor显示文摘Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels. | Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li Heidi Qunhui Xie Naijun Tang Bin Zhao | 2019 | Journal of Environmental Sciences2019，31，2： | 1 |
| 20 | Rethinking China’s urbanization: an institutional innovation perspective显示文摘 | Kaixun Sha Tao Song Xia Qi Nengjun Luo | 2006 | Building Research & Information2006，，6： | 1 |
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