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1篇 您的检索式：作者名="Eric Y.P.Cho"

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		题名	作者	年代	出处	被引量
	1	Protection of retinal ganglion cells against optic nerve injury by induction of ischemic preconditioning显示文摘AIM: To explore if ischemic preconditioning(IPC) can enhance the survival of retinal ganglion cells(RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60 min or axotomy, IPC was applied for ten minutes in groups of(n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27(HSP27) and heat shock protein 70(HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14 d post-injury. The cellular expression of HSP27 and HSP70 and changes in the numbers of retinal microglia were quantified to detect the possible mechanism of the protection of the IPC. RESULTS: Ten minutes of IPC promoted RGC survival in both the optic nerve injury(IPC-ONT) and the retinal ischemia 60min(IPC-IR60) groups, examined at 7d and 14 d post-injury. Microglial proliferation showed little correlation with the extent of benefit effects of IPC on the rescue of RGCs. The number of HSP27-positive RGCs was significantly higher in the IPC-ONT group than in the sham IPC-ONT group, although the percentage of HSP27-positive RGCs did not significantly differ between groups. For the IPC-IR60 group, neither the number nor the percentage of the HSP27-positive RGCs differed significantly between the IPC and the sham-operated groups. The number of HSP70-positive RGCs was significantly higher for both the IPC-ONT and the IPC-IR60 experimental groups, but the percentages did not differ. CONCLUSION: The induction of IPC enhances the survival of RGCs against both axotomy and retinal ischemia.	Xia Liu Jiu-Ping Liang Ou Sha Song-Juan Wang Heng-Guo Li Eric Y.P.Cho	2017	International Journal of Ophthalmology(English edition)2017，10，6：	2

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