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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 3 | Heat to light energy conversion by emitters doped with rare-earth metal ions显示文摘 | WINSTON C GARRETT W R | 1996 | Appl Phys Lett1996，69，2： | 1 |
| 4 | The bromodomain:a conserved sequence found in human,Drosophila and yeast proteins显示文摘 | Haynes S R bollard C Winston F | 1992 | Nucleic Acids Res1992，20，： | 1 |
| 5 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 6 | The bromodomain: a chromatin- targeting module显示文摘 | Winston F Allis C D | 1999 | Nat Struct Biol1999，6，7： | 1 |
| 7 | Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain显示文摘 | Winston - Salem N C Deer T R Charleston W V | 2011 | Pain Physician2011，14，： | 1 |
| 8 | Systemic RNAi in Caenorhabditis elegans显示文摘 | Hunter CP Winston WM Molodowitch C | 2006 | Cold Spring Harbor symposia on quantitative biology2006，71，： | 1 |
| 9 | Comparison of runoff quality and quantity from a commercial low impact and conventional development in Raleigh, North Carolina显示文摘 | WILSON C E HUNT W F WINSTON R J | 2015 | Journal of Environmental Engineering2015，141，2： | 1 |
| 10 | A generalized decision support system using predicate calculus and network data base management 显示文摘 | Holsapple C W Winston A B | 1981 | Operations Research1981，29，2： | 1 |
| 11 | Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits 显示文摘 | REBEKAH L C WINSTON S C STEVEN C E | 2007 | Molecular Genetics & Metabolism2007，90，3： | 1 |
| 12 | Quinupristin Dalfopristin therapy for infections due to vaneomycin - resistm Enterococcus faecium显示文摘 | Winston D J Emmanouilides C Kroeber A | 2000 | Clin Infect Dis2000，30，79： | 1 |
| 13 | A Functional Magnetic Resonance Imaging Study Mapping the Episodic Memory Encoding Network in Temporal Lobe Epilepsy显示文摘 | Sidbu M K Stretton J Winston G P Bonelli S Centeno M Vollmar C | 2013 | Brain2013，136，6： | 1 |
| 14 | Periphery resort tourism and tourist-resident stress: An example from Barbados 显示文摘 | Husbands Winston C | 1986 | Leisure Studies1986，5，2： | 1 |
| 15 | An analyti- cal framework for science parks and technology dis- tricts with an a:p!ication to Singapore 显示文摘 | Francis'C K Winston T K Feichin TT | 2005 | Journal of Business Venturing2005，20，2： | 1 |
| 16 | Sliding mode predictive control of a solar air conditioning plant显示文摘 | Winston G G Darine Z Eduardo F C | 2009 | Control Engineering Practice2009，17，2： | 1 |
| 17 | An analytic framework for science parks and technology districts with an application to singapore显示文摘 | FRANCIS C C Koh WINSTON T H Koh FEICHIN Ted Tschang | 2005 | Journal of business venturing2005，20，2005： | 1 |
| 18 | Efticient Transportation Infrastructure Policy显示文摘 | Winston C | 1991 | Journal of Economic Perspectives1991，，5： | 1 |
| 19 | Hilar cholangiocarcinoma: diagnosis and staging显示文摘 | Jarnagin W Winston C | 2005 | HPB(Oxford)2005，7，4： | 1 |
| 20 | The dynamics of airline pricing and competition显示文摘 | orrison S A Winston C | 1990 | American Economic Review1990，80，2： | 1 |
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