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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocar- dial infarction 显示文摘 | Chaudhuri A Janicke D Wilson MF | 2004 | Circulation2004，109，7： | 1 |
| 4 | Antiinflammatory and profibfinolytic effect of insulin in acute STsegment-elevation myocardial infarction显示文摘 | CHAUDHURI A JANICKE D WILSON MF et ol | 2004 | Circulation2004，109，7： | 1 |
| 5 | procalcitonin increase after endotoxin injection in normal subjects显示文摘 | DANDONA P NIX D WILSON MF et a1 | 1994 | J Clin Endocinol Metab1994，79，6： | 1 |
| 6 | Procalcitonin increase aftex endotoain injection in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，： | 1 |
| 7 | Procalcitonin increase after endotoxin injection in normal subjects 显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，5： | 1 |
| 8 | Comparative effective- ness of advanced wound dressings for patients with chronic venous leg ulcers: A systematic review 显示文摘 | Valle MF Maruthur NM Wilson LM | 2014 | Wound Repair Regen2014，22，2： | 1 |
| 9 | Mitochondrial DNA and aging显示文摘 | Alexeyev MF Ledoux SP Wilson GL | 2004 | Clin Sci (Lond)2004，107，4： | 1 |
| 10 | Procalcitonin increase after endotoxin injection in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol1994，79，6： | 1 |
| 11 | Mitochondrial DNA and aging显示文摘 | Alexeyev MF Ledoux SP Wilson GL | 2004 | Clin Sci(Lond)2004，107，4： | 1 |
| 12 | Procalcitonin increase after endotoxin inject ion in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，6： | 1 |
| 13 | Procalcition increase after en- doloxin injection in normal subjects 显示文摘 | Dandona P Nix D Wilson MF | 1994 | Clin Endocrinaol Metab1994，79，6： | 1 |
| 14 | Procalcitonin increase after endotoxin injection in normal subjects 显示文摘 | Dandona P Nix D Wilson MF | 1994 | Clin Endocrinol1994，79，： | 1 |
| 15 | Procalcitonin increase after endotoxin injection in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，6： | 1 |
| 16 | Procalcitonin increase after endotoxin injection in normal subjects 显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，6： | 1 |
| 17 | Procalcitonin increase after endotoxin injection in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，5： | 1 |
| 18 | Procalcitonin increase after endotoxi injection in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，6： | 1 |
| 19 | Procalcitonin increase after endotoxin injection in normal subjects显示文摘 | Dandona P Nix D Wilson MF | 1994 | J Clin Endocrinol Metab1994，79，6： | 1 |
| 20 | Cardiac, Pulmonary and neuromuscular effects of clenbuterol and terbutaline compared with placebo显示文摘 | Whitsett TL Manion CV Wilson MF | 1981 | Br J Clin Pharmacol1981，12，2： | 1 |
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