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| 1 | Flow Characteristics Diagnosis and Optimization for Dust Collectors Inflow Duct in Thermal Power Plants显示文摘火电厂烟风道用于输送烟气、冷风等介质,其设计优化水平不但影响火电厂烟风系统阻力的大小,而且影响与烟风道直接相连的各个设备的运行状态。某600MW机组除尘器前烟道设计不合理,存在磨损严重、进入除尘器烟气分配不均等问题,文中采用标准缸￡模型,利用Fluent求解器对该部分烟道的流场进行数值计算,诊断分析其存在的主要问题,提出的3个改造方案均可使烟道阻力大幅度下降、烟道磨损减轻、进入除尘器烟气分配均匀。同时,研究了缓转半径及烟气流速对该段烟道阻力和烟气分配的影响情况,计算结果表明该段烟道缓转半径宜选在0.875以上,烟气流速对该段烟道的性能基本没有影响。 | LIU Ming MENG Guixiang YAN Junjie CHEN Weixiong LI Weidong CHONG Daotong LIU Jiping | 2013 | 中国电机工程学报2013，33，11： | 22 |
| 2 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 3 | Reduced order model for unsteady aerodynamic performance of compressor cascade based on recursive RBF显示文摘Based on Recursive Radial Basis Function(RRBF)neural network,the Reduced Order Model(ROM)of compressor cascade was established to meet the urgent demand of highly efficient prediction of unsteady aerodynamics performance of turbomachinery.One novel ROM called ASA-RRBF model based on Adaptive Simulated Annealing(ASA)algorithm was developed to enhance the generalization ability of the unsteady ROM.The ROM was verified by predicting the unsteady aerodynamics performance of a highly-loaded compressor cascade.The results show that the RRBF model has higher accuracy in identification of the dimensionless total pressure and dimensionless static pressure of compressor cascade under nonlinear and unsteady conditions,and the model behaves higher stability and computational efficiency.However,for the strong nonlinear characteristics of aerodynamic parameters,the RRBF model presents lower accuracy.Additionally,the RRBF model predicts with a large error in the identification of aerodynamic parameters under linear and unsteady conditions.For ASA-RRBF,by introducing a small-amplitude and highfrequency sinusoidal signal as validation sample,the width of the basis function of the RRBF model is optimized to improve the generalization ability of the ROM under linear unsteady conditions.Besides,this model improves the predicting accuracy of dimensionless static pressure which has strong nonlinear characteristics.The ASA-RRBF model has higher prediction accuracy than RRBF model without significantly increasing the total time consumption.This novel model can predict the linear hysteresis of dimensionless static pressure happened in the harmonic condition,but it cannot accurately predict the beat frequency of dimensionless total pressure. | Jiawei HU Hanru LIU Yan'gang WANG Weixiong CHEN Yan MA | 2021 | Chinese Journal of Aeronautics2021，34，4： | 7 |
| 4 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 5 | Application of response surface methodology to the chemical cleaning process of ultrafiltration membrane显示文摘A numerical model was established to predict and optimise the chemical cleaning process of Polyvinylidene Fluoride(PVDF)Ultra filtration(UF)membranes with the results from the experiment that applied the Response Surface Method(RSM)and Central Composite Design(CCD).The factors considered in the experimental design were sodium hydroxide(NaOH)concentration,sodium hypochlorite concentration(NaClO),citric acid concentration and cleaning duration.The interactions between the factors were investigated with the numerical model.Humic acid(20 mg·L-1)was used as the model foulant,and chemical enhanced back flush(CEB)was employed to simulate the chemical cleaning process.The concentrations of sodium hydroxide,sodium hypochlorite,citric acid and cleaning duration tested during the experiments were in the range of 0.1%–0.3%,100–300 mg·L-1,1%–3%and 0.5–1.5 h,respectively.Among the variables,the sodium hypochlorite concentration and the cleaning duration showed a positive relationship involving the increased ef ficiency of the chemical cleaning.The chemical cleaning ef ficiency was hardly improved with increasing concentrations of sodium hydroxide.However,the data was sharply decreased when at a low level of sodium hydroxide concentration.In total,54 sets of cleaning schemes with 80%to 100%cleaning ef ficiency were observed with the RSM model after calibration. | Caihong Wang Aishu Wei Hao Wu Fangshu Qu Weixiong Chen Heng Liang Guibai Li | 2016 | Chinese Journal of Chemical Engineering2016，24，5： | 4 |
| 6 | Effects of Ginsenoside Rg1 on nuclear factor-kappa B activity in beta amyloid protein-treated neural cells显示文摘BACKGROUND:Modern pharmacological studies have shown that Ginsenoside Rg1 is one of the active components of ginseng that promote intelligence in the nervous system.Ginsenoside Rg1 can improve memory and learning in mouse models ofβ-amyloid protein(Aβ)-induced dementia. OBJECTIVE:To investigate whether effects of Ginsenoside Rg1 against Aβare associated with activity of nuclear factor-kappa B(NF-κB). DESIGN,TIME AND SETTING:The randomized,controlled,cell biological experiment was performed at the DME Center,Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,China from July 2005 to May 2006. MATERIALS:Beta-amyloid fragment 25-35(Aβ_(25-35)) was supplied by the Neural Biochemical Laboratory,Xuanwu Hospital,Capital Medical University,China.Ginsenoside Rg1 was obtained from National Institute for the Control of Pharmaceutical and Biological Products,China.Rabbit anti-rat NF-κB p65 antibody was purchased from Santa Cruz Biotechnology,USA. METHODS:Hippocampal neurons and cortical astrocytes of neonatal Sprague Dawley rats were harvested and treated with various concentrations(0,5,10,20,and 40μmol/L) of Aβfor 6,12,and 24 hours to establish cellular models of Alzheimer's disease.Cellular models were pretreated with various concentrations of Ginsenoside Rg1(1,2,4,8,and 16μmol/L).According to cell morphology and activity,the following conditions were selected:40μmol/L Aβfor 24 hours,as well as 2,4,and 8μmol/L Ginsenoside Rg1.NF-κB activity was observed using immunofluorescence and cytochemical staining. MAIN OUTCOME MEASURES:Morphology and viability of hippocampal neurons and cortical astrocytes,and activities of NF-κB were measured. RESULTS:Hippocampal neuron activity was significantly greater in the normal and 2 and 4μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.05).Astrocyte activity was significantly greater in the normal,1,2,4,8,and 16μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.05).NF-κB activity of hippocampal neurons was significantly greater in the normal,2,4,and 8μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.01). NF-κB activity of astrocytes was significantly less in the normal,2,4,and 8μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.01 or P<0.05).No significant difference in NF-κB activity was determined between the 2μmol/L Ginsenoside Rg1 and normal groups(P>0.05). CONCLUSION:Ginsenoside Rg1 protected neural cells by upregulating NF-κB activity in neurons and downregulating NF-κB activity in astrocytes.Ginsenoside Rg1(2μmol/L) maintained cell activity and NF-κB activity at normal levels. | Yunbo Chen Dapeng Zhang Mei Feng Qi Wang Shuyi Cheng Weixiong Liang Zehuai Wen | 2009 | Neural Regeneration Research2009，4，8： | 2 |
| 7 | The origin and evolution of the diosgenin biosynthetic pathway in yam显示文摘Diosgenin,mainly produced by Dioscorea species,is a traditional precursor of most hormonal drugs in the pharmaceutical industry.The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants remain unclear.After sequencing the whole genome of Dioscorea zingiberensis,we revealed the evolutionary trajectory of the diosgenin biosynthetic pathway in Dioscorea and demonstrated the de novo biosynthesis of diosgenin in a yeast cell factory.First,we found that P450 gene duplication and neofunctionalization,driven by positive selection,played important roles in the origin of the diosgenin biosynthetic pathway.Subsequently,we found that the enrichment of diosgenin in the yam lineage was regulated by CpG islands,which evolved to regulate gene expression in the diosgenin pathway and balance the carbon flux between the biosynthesis of diosgenin and starch.Finally,by integrating genes fromplants,animals,and yeast,weheterologously synthesized diosgenin to 10mg/l in genetically-engineered yeast.Our study not only reveals the origin and evolutionary mechanisms of the diosgenin biosynthetic pathway in Dioscorea,but also introduces an alternative approach for the production of diosgenin through synthetic biology. | Jian Cheng Jing Chen Xiaonan Liu Xiangchen Li Weixiong Zhang Zhubo Dai Lina Lu Xiang Zhou Jing Cai Xueli Zhang Huifeng Jiang Yanhe Ma | 2021 | Plant Communications2021，2，1： | 2 |
| 8 | Investigation of the Unsteady Disturbance in Tip Region of a Contra-Rotating Compressor near Stall显示文摘The present study investigated the spectrum characteristics of unsteady disturbance and the tip leakage vortex evolution during pre-stall process for a contra-rotating axial compressor(CRAC). Transient numerical simulation was carried out in a single passage of the CRAC. The original transient fluctuation and oscillation of the tip leakage vortex structure with varying flow capacity of the CRAC were revealed using circle-like pattern figure and phase-locked root mean square(PLRMS). Additionally, the tip leakage flow in terms of vortex structure evolution was visualized for the sake of revealing the flow mechanism during pre-stall process. Results show that the unsteady fluctuation first appears at φ=0.3622, and the fluctuation frequency is 2.86 BPF. Unsteady disturbance source is mainly located at the tip side of the downstream rotor leading edge. From the choking point to the near stall condition, tip leakage vortex is always found in the tip leading edge of the upstream rotor. In addition, the tip leakage vortex of upstream rotor remains in the same place over time, i.e., no fluctuation, even when the downstream rotor entered into stall state. Such a phenomenon indicates that the stall point of the contra-rotating compressor is determined by the downstream rotor. Moreover, the maximum fluctuation position is mainly concentrated on the interface between the mainstream and the tip leakage vortex of the downstream rotor. By throttling the compressor, the angle between the main leakage vortex and the circumferential direction decreases gradually. When the main leakage vortex touches and continuously impacts on the leading edge of the adjacent blade, the unsteady disturbance, which is different from that of BPF, appears firstly. | CHEN Weixiong WANG Yangang WANG Hao | 2019 | Journal of Thermal Science2019，28，5： | 2 |
| 9 | Comparison of Lipid Levels, Hyperlipidemia Prevalence and Its Risk Factors between Guangxi Hei Yi Zhuang and Han Populations显示文摘 | Yin Ruixing Chen Yuming Pan Shangling He Fengping Liu Tangwei Yang Dezhai Wu Jinzhen Yao Limei Lin Weixiong Li Rongshan Huang Jiandong | 2006 | Archives of Medical Research2006，，6： | 1 |
| 10 | Bacteria-responsive microRNAs regulate plant innate immunity by modulating plant hormone networks显示文摘 | Weixiong Zhang Shang Gao Xiang Zhou Padmanabhan Chellappan Zheng Chen Xuefeng Zhou Xiaoming Zhang Nyssa Fromuth Gabriela Coutino Michael Coffey Hailing Jin | 2011 | Plant Molecular Biology (-)2011，，1： | 1 |
| 11 | The numerical analysis of the effect of geometrical factors on natural gas ejector performance显示文摘 | WeiXiong Chen DaoTong Chong JunJie Yan JiPing Liu | 2013 | Applied Thermal Engineering . 2013 (1-2)2013，，1： | 1 |
| 12 | Energy transfer and luminescence properties of Eu 3+ -doped NaTb(WO 4 ) 2 phosphor prepared by a facile hydrothermal method显示文摘 | Jinsheng Liao Shaoan Zhang Hangying You He-Rui Wen Jing-Lin Chen Weixiong You | 2010 | Optical Materials2010，，6： | 1 |
| 13 | A VUV photoionization mass spectrometric study on the OH-initiated photooxidation of isoprene with synchrotron radiation显示文摘The gas-phase organic compounds resulting from OH-initiated photooxidation of isoprene have been investigated on-line by VUV photoionization mass spectrometry based on synchrotron radiation for the first time.The photoionization efficiency curves of the corresponding gaseous products as well as the chosen standards have been deduced by gating the interested peaks in the photoionization mass spectra while scanning the photon energy simultaneously,which permits the identification of the pivotal gaseous products of the photooxidation of isoprene,such as formaldehyde(10.84eV),formic acid(11.38eV),acetone(9.68eV),glyoxal(9.84eV),acetic acid(10.75eV),methacrolein(9.91eV),and methyl vinyl ketone(9.66eV).Proposed reaction mechanisms leading to the formation of these key products were discussed,which were completely consistent with the previous works of different groups.The capability of synchrotron radiation photoionization mass spectrometry to directly identify the chemical composition of the gaseous products in a simulation chamber has been demonstrated,and its potential application in related studies of atmospheric oxidation of ambient volatile organic compounds is anticipated. | Gang Pan Changjin Hu Mingqiang Huang Zhenya Wang Yue Cheng Zhi Liu Weixiong Zhao Weijun Zhang Jun Chen Fuyi Liu Xiaobin Shan Liusi Sheng | 2012 | Journal of Environmental Sciences2012，24，12： | 1 |
| 14 | Synthesis process and luminescence properties of Tm 3+ in AWO 4 (A显示文摘 | Jinsheng Liao Bao Qiu Herui Wen Jinglin Chen Weixiong You Liangbin Liu | 2009 | Journal of Alloys and Compounds2009，，1： | 1 |
| 15 | Energy transfer and luminescence properties of Eu 3+ -doped NaTb(WO 4 ) 2 phosphor prepared by a facile hydrothermal method显示文摘 | Jinsheng Liao Shaoan Zhang Hangying You He-Rui Wen Jing-Lin Chen Weixiong You | 2010 | Optical Materials2010，，6： | 1 |
| 16 | Experimental and numerical analysis of supersonic air ejector显示文摘 | Chong Daotong Hu Mengqi Chen Weixiong | 2014 | Applied Energy2014，130，： | 1 |
| 17 | Design,Characterization and Optimization of Multi-directional Bending Pneumatic Artificial Muscles显示文摘Bending Pneumatic Artificial Muscles(PAMs)are particularly attractive and extensively applied to the soft grasper,snake-like robot,etc.To extend the application of PAMs,we fabricate a Multi-directional Bending Pneumatic Artificial Muscle(MBPAM)that can bend in eight directions by changing the pressurized chambers.The maximum bending angle and output force are 151°and 0.643 N under the pressure of 100 kPa,respectively.Additionally,the Finite Element Model(FEM)is established to further investigate the performance.The experimental and numerical results demonstrate the nonlinear relationship between the pressure and the bending angle and output force.Moreover,the effects of parameters on the performance are studied with the validated FEM.The results reveal that the amplitude of waves and the thickness of the base layer can be optimized.Thus,multi-objective optimization is performed to improve the bending performance of the MBPAM.The optimization results indicate that the output force can be increased by 7.8%with the identical bending angle of the initial design,while the bending angle can be improved by 8.6%with the same output force.Finally,the grasp tests demonstrate the grip capability of the soft four-finger gripper and display the application prospect of the MBPAM in soft robots. | Wei Xiao Dean Hu Weixiong Chen Gang Yang Xu Han | 2021 | Journal of Bionic Engineering2021，18，6： | 1 |
| 18 | Research progress of functional near-infrared spectroscopy in patients with psychiatric disorders显示文摘Functional near-infrared spectroscopy(fNIRS)is a technique of detecting cerebral cortical function by using near-infrared light,which is a multifunctional neuroimaging technique and provides a convenient and efficient detection method in neuroscience.In consideration of acceptability,safety,high spatial and temporal resolutions compared with electroencephalogram(EEG)and functional magnetic resonance imaging(fMRI),fNIRS is widely used to study different psychiatric disorders,most prominently affective disorders,schizophrenic illnesses,brain organic mental disorders and neurodevelopmental disorders,etc.The article focuses on the latest research progress and practical application of fNIRS in psychiatric disorders,especially traumatic brain,including studies on the characterization of phenomenology,treatment effects and descriptions of neuroimaging data. | Fan Chang Haozhe Li Shengyu Zhang Chen Chen Chao Liu Weixiong Cai | 2021 | Forensic Sciences Research2021，6，2： | 1 |
| 19 | Polarized spectroscopy of Er 3+ ions in YAl 3 (BO 3 ) 4 crystal显示文摘 | Weixiong You Yanfu Lin Yujin Chen Zundu Luo Yidong Huang | 2005 | Optical Materials2005，，： | 1 |
| 20 | A Review on Thermal Design of Liquid Droplet Radiator System显示文摘Liquid Droplet Radiator (LDR) system is regarded as a quite promising waste heat rejection system for aerospace engineering.A comprehensive review on the state-of-the-art of LDR system was carried out.The thermal design considerations of crucial components such as working fluid,droplet generator and collector,intermediate heat exchanger,circulating pump and return pipe were reviewed.The state-of-the-art of existing mathematical models of radiation and evaporation characteristics of droplet layer from literatures were summarized.Furthermore,thermal designs of three LDR systems were completed.The weight and required planform area between the rectangular and triangular LDR systems were respectively compared and the evaporation models for calculating the mass loss were evaluated.Based on the review,some prospective studies of LDR system were put forward in this paper. | CHONG Daotong ZHU Maoguo ZHAO Quanbin CHEN Weixiong YAN Junjie | 2021 | Journal of Thermal Science2021，30，2： | 1 |
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