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| 1 | Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study显示文摘NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response.Meanwhile,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members.Since the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune response.The activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these pathways.Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of diseases.This review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases. | Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 35 |
| 2 | Molybdenum sulfide/graphene-carbon nanotube nanocomposite material for electrocatalytic applications in hydrogen evolution reactions显示文摘我们报导铝二硫化物合成的一个三维的层次第三的混血儿(瞬间 2), 减少了 graphene 氧化物(去) ,并且碳 nanotubes (CNT ) 由一个二拍子的圆舞过程准备了。第一,与三维的 microstructuresare 减少了 GOCNT composites 由水的分散的热水的处理综合了去并且经由相互作用形成合成结构的 CNT。然后,瞬间 2 nanoparticles 热水地在 GOCNT 的表面上被种合成。在氢进化反应的这项第三的合成表演上级 electrocatalytic 活动和稳定性与仅仅 35 mV 的一个低发作潜力,~的一个 Tafel 斜坡 38 mVor AuCuFeCo ),并且优化 AuCuFeCo 0.8相应于 134.4 食火鸟的浸透的磁化的 Ni 0.2性能????愠汬祯湩?? | Majid Khan Ammar Bin Yousaf Mingming Chen Chengsha Wei Xibo Wu Ningdong Huang Zemin Qi Liangbin Li | 2016 | Nano Research2016，9，3： | 7 |
| 3 | Novel Co-free high performance TRIP and TWIP medium-entropy alloys at cryogenic temperatures显示文摘Recently,high-and medium-entropy alloys(HEAs and MEAs) have been found to exhibit excellent cryogenic mechanical properties,but most of them contain high-priced Co element.Therefore,developing HEAs or MEAs with high strength and ductility and relatively low cost is urgent.In this work,novel Cofree Fex Mn(75-x) Ni(10)Cr(15)(x=50 and 55 at.%) MEAs were developed,which exhibit a good combination of low cost,high strength and ductility at cryogenic temperature.It was found that the Fe(50)Mn(25)Ni(10)Cr(15)MEA exhibits a combination of cryogenic tensile strength of^0.98 GPa and ductility of^83 %.The excellent cryogenic mechanical properties were attributed to joint of twinning-induced plasticity(TWIP) and transformation-induced plasticity(TRIP) effects.The present study sheds light on developing low cost MEAs with high perfo rmance for cryogenic-tempe rature applications. | Ran Wei Kaisheng Zhang Liangbin Chen Zhenhua Han Tan Wang Chen Chen Jianzhong Jiang Tingwei Hu Fushan Li | 2020 | Journal of Materials Science & Technology2020，54，22： | 6 |
| 4 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 5 | Daifan San intervenes in forkhead box P3 and the interleukin(IL)-23/IL-17A signaling pathway to help prevent and treat primary biliary cirrhosis显示文摘OBJECTIVE:To investigate the mechanism by which Daifan San(DFS)prevents and treats primary biliary cirrhosis(PBC)via the forkhead box P3(FoxP3)and interleukin(IL)-23/IL-17A signaling pathways.METHODS:Ninety C57BL/6 mice were randomly divided into the control,model,DFS low-dose,DFS middle-dose,DFS high-dose and ursodeoxycholic acid(UDCA)groups(n=15 per group).A mouse model of PBC was induced using polyinosinic polycytidylic acids(poly I:C).Lymphocyte subset expression in the peripheral blood was analyzed via flow cytometry.The inflammatory cytokines and antimitochondrial autoantibody(AMA)levels were detected via enzyme-linked immunosorbent assays.The expressions and location of typeⅠcollagen,typeⅢcollagen,cytokeratin 19 and FoxP3 in the liver tissue were evaluated via immunohistochemistry.FoxP3,IL-23 and IL-17 expressions in the peripheral blood and liver tissue were evaluated via real-time polymerase chain reaction and western blotting.RESULTS:IL-17,IL-23,IL-8,IL-33,TNF-α,and AMA expressions were significantly increased in the model group and decreased in the DFS and UDCA groups.Conversely,Treg cell and FoxP3 expressions were significantly decreased in the model group and increased in the DFS and UDCA groups.The IL-23/IL-17A signaling pathway was closely correlated with chronic inflammation of the bile duct in PBC and functional deletion of Treg cells,leading to reduced FoxP3 levels and mediating the loss of tolerance in PBC.CONCLUSION:DFS may delay the occurrence and relieve the symptoms of PBC by downregulating IL-23/IL-17A signaling pathway expression and upregulating FoxP3 expression. | Zhan Kai Xu Yan Han Mengling Cheng Liangbin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 6 | An Approach to Enforcing Clark-Wilson Model in Role-based Access Control Model显示文摘Using one security model to enforce another is a prospective solution to multi-policy support. In this paper, an approach to the enforcing Clark-Wilson data integrity model in the Role-based access control (RBAC) model is proposed. An enforcement construction with great feasibility is presented. In this construction, a direct way to enforce the Clark-Wilson model is provided, the corresponding relations among users, transformation procedures, and constrained data items are strengthened; the concepts of task and subtask are introduced to enhance the support to least-privilege. The proposed approach widens the applicability of RBAC. The theoretical foundation for adopting Clark-Wilson model in a RBAC system with small cost is offered to meet the requirements of multi-policy support and policy flexibility. | LIANGBin SHIWenchang SUNYufang SUNBo | 2004 | Chinese Journal of Electronics2004，13，4： | 2 |
| 7 | 中国西南地区2007年-2011年男性乳腺癌发生率(英文)显示文摘Objective: Male breast cancer is a rare disease with an incidence of about 1% of breast cancers in USA, but relatively lack of the information of male breast cancer in China, especially in Southwest of China, led us to study its incidence trends. Methods: Chongqing is one of the biggest and the most important areas that is located in Southwest of China. There are around 31.4 million people who live in approximate 82 402.95 km2area of Chongqing. Data about breast cancer patients registered in the Center for Disease Prevention and Control of Chongqing(China) were statistically collected from 187 hospitals, about 58 hospitals in city and 129 hospitals in country, and over 6.2 million people were studied every year. It was tried to represent all the people in villages and cities in Chongqing, China. Results: The incidence of male breast cancer in Southwest of China ranged from 0.34/100 000 to 1.45/100 000 between 2007 and 2011, while the incidence of female breast cancer ranged from 15.40/100000 to 21.66/100000 at the same time. The rate of male breast cancer to female breast cancer ranged from 0.02:1 to 0.07:1, male breast cancer accounted for 1.96% to 6.5%(with the mean value of 2.9%) of breast cancers in Southwest of China from 2007 to 2010. Conclusion: In Southwest of China male breast cancer accounts for about 2.9% of breast cancers which is higher than that in United States. It is important for policy makers and health manager to seriously consider breast cancer in future plan in Southwest of China. | Liangbin Jin Linjie Lu Lingquan Kong Yang Bai Zixiang Yao Guangyan Ji Shengchun Liu Guosheng Ren Kainan Wu Hua Tang Deqiang Mao | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，11： | 2 |
| 8 | Ecological stoichiometry and biomass response of Agropyron michnoi Roshev.under simulated N deposition in a sandy grassland,China显示文摘Sandy grassland in northern China is a fragile ecosystem with poor soil fertility.Exploring how plant species regulate growth and nutrient absorption under the background of nitrogen(N)deposition is crucial for the management of the sandy grassland ecosystem.We carried out a field experiment with six N levels in the Hulunbuir Sandy Land of China from 2014 to 2016 and explored the Agropyron michnoi Roshev.responses of both aboveground and belowground biomasses and carbon(C),N and phosphorus(P)concentrations in the plant tissues and soil.With increasing N addition,both aboveground and belowground biomasses and C,N and P concentrations in the plant tissues increased and exhibited a single-peak curve.C:N and C:P ratios of the plant tissues first decreased but then increased,while the trend for N:P ratio was opposite.The peak values of aboveground biomass,belowground biomass and C concentration in the plant tissues occurred at the level of 20 g N/(m2•a),while those of N and P concentrations in the plant tissues occurred at the level of 15 g N/(m2•a).The maximum growth percentages of aboveground and belowground biomasses were 324.2%and 75.9%,respectively,and the root to shoot ratio(RSR)decreased with the addition of N.N and P concentrations in the plant tissues were ranked in the order of leaves>roots>stems,while C concentration was ranked as roots>leaves>stems.The increase in N concentration in the plant tissues was the largest(from 34%to 162%),followed by the increase in P(from 10%to 33%)and C(from 8%to 24%)concentrations.The aboveground biomass was positively and linearly correlated with leaf C,N and P,and soil C and N concentrations,while the belowground biomass was positively and linearly correlated with leaf N and soil C concentrations.These results showed that the accumulation of N and P in the leaves caused the increase in the aboveground biomass,while the accumulation of leaf N resulted in the increase in the belowground biomass.N deposition can alter the allocation of C,N and P stoichiometry in the plant tissues and has a high potential for increasing plant biomass,which is conducive to the restoration of sandy grassland. | JIN Xiaoming YANG Xiaogang ZHOU Zhen ZHANG Yingqi YU Liangbin ZHANG Jinghua LIANG Runfang | 2020 | Journal of Arid Land2020，12，5： | 2 |
| 9 | Genetic Fingerprint Concerned with Lymphatic Metastasis of Human Lung Squamous Cancer显示文摘背景与目的筛选肺鳞癌患者淋巴转移差异表达基因群。方法原发癌组织及区域淋巴结取自10例接受完全性肺癌切除手术的肺鳞癌患者。根据组织来源将标本分为三组:不伴淋巴转移的肺鳞癌组织(TxN-,n=5)、伴有淋巴转移的肺鳞癌组织(TxN+,n=5)及相应转移淋巴结中的肺鳞癌细胞(N+,n=5)。对各组进行激光显微切割以获得纯净癌细胞,T7RNA线性扩增获取足够量的RNA,实验通道和参照通道分别标记以后与含6000个已知人类基因或表达序列标签的cDNA基因芯片杂交,扫描荧光信号以后进行数据分析。结果共有37个基因可将TxN+组与TxN-组区分开,其中在TxN+组高表达的基因有8个,主要涉及蛋白合成、信号传导、伴侣蛋白和酶等。有29个基因在TxN-组高表达,这些基因主要编码细胞周期调节子、转导子、信号传导蛋白以及细胞凋亡调节蛋白。比较N+组与TxN+组却没有发现具有显著性的差异表达基因。结论肺鳞癌的淋巴转移表型的获得可能是早期事件。这些差异基因的发现有助于阐明肺鳞癌淋巴转移的分子机制和寻找新的治疗靶点。 | Mingjian GE Mei WANG Qingchen WU Zhiming QIN Li CHEN Liangbin LI Li LI Xiaolong ZHAO | 2009 | 中国肺癌杂志2009，12，9： | 2 |
| 10 | Crystalline morphology of isotactic polypropylene(iPP) in injection molded poly (ethylene terephthalate)(PET)/iPP microfibrillar blends 显示文摘 | Zhong Ganji Li Zhongming Li Liangbin | 2007 | Polymer2007，48，6： | 1 |
| 11 | Antifungal compounds from Bacillus subtilis B-FS06 inhibiting the growth of Aspergillus flavus显示文摘 | Zhang Ting Shi Zhiqi Hu Liangbin | 2008 | World Journal of Microbiology and Biotechnology2008，24，6： | 1 |
| 12 | Functionalized Hydrogels for Articular Cartilage Tissue Engineering显示文摘Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints.AC defects are common in the knees of young and physically active individuals.Because of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage adequately.With rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating behaviors.They can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of cartilage.This article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC repair.Finally,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation. | Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin | 2022 | Engineering2022，8，6： | 1 |
| 13 | Bifunctional photocatalysis of TiO 2 /Cu 2 O composite under visible light: Ti 3+ in organic pollutant degradation and water splitting显示文摘 | Liangbin Xiong Fan Yang Lili Yan Nannan Yan Xi Yang Mingqiang Qiu Ying Yu | 2011 | Journal of Physics and Chemistry of Solids2011，，： | 1 |
| 14 | Crystal structure and morphology of poly(L-lactide-b-d-lactide) diblock copolymers 显示文摘 | Li Liangbin Zhong Zhiyuan Wim H de Jeu | 2004 | Macromolecules2004，37，23： | 1 |
| 15 | Hydrothermal preparation and luminescence property of MWO 4 :Sm 3+ (M=Ca, Sr, Ba) red phosphors显示文摘 | Jinsheng Liao Liangbin Liu Hangying You Haiping Huang Weixiong You | 2011 | Optik - International Journal for Light and Electron Optics2011，，10： | 1 |
| 16 | Analysis of inductor current sharing in nonisolated and isolated multiphase DC-DC converters显示文摘 | MAO Hong YAO Liangbin WANG Caisheng | 2007 | IEEE Transactions on Industrial Electronics2007，54，6： | 1 |
| 17 | Morphology and nonisothermal crystallization of in situ microfibrillar poly-(ethylene terephthalate)/polypropylene blend fabricated through slit-extrusion, hot-stretch quenching 显示文摘 | Li Zhongming Yang Wei Li Liangbin | 2004 | J Polym Sci Part B:Polym Phys2004，42，： | 1 |
| 18 | A New Mechanism in the Formation of PET Extended-Chain Crystals显示文摘 | Liangbin L Rui H Ling Z | 2001 | Polymer2001，42，： | 1 |
| 19 | A Study of fractal image com- pression based on an improved genetic algorithm 显示文摘 | Lifeng Xi Liangbin Zhang | 2007 | In- temational Journal of Nonlinear Science2007，3，2： | 1 |
| 20 | Optimization of Douch fibrinolytic enzyme production by statistical experimental methods显示文摘 | ZHANG Xu YUN Luojia PENG Liangbin | 2013 | Journal of Huazhong University of Science and Technology2013，33，1： | 1 |
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