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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 3 | Investigation of precipitation in an Al-Zn-Mg alloy after twostep ageing treatment at 100 ℃ and 150 ℃显示文摘 | Warren P J Hansen V | 1999 | Material Science and Engineering A1999，270，： | 1 |
| 4 | A retrospective radiographic analysis of bone loss following placement of TiO2 grit-blasted implants in the posterior maxilla mid mandible 显示文摘 | Warren P Chaffee N Fehon DA | 2002 | The International Journal of Oral & Maxillofacial Implants2002，17，3： | 1 |
| 5 | Comparison of in vitro and in vivo efficieneies of a novel unit-dose liquid aerosol generator and a pressurized metered dose inhaler显示文摘 | Farr SJ Warren SJ Lloyd P | 2000 | Int J Pharm2000，198，： | 1 |
| 6 | Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse显示文摘 | Golshani P Warren RA Jones EG | 1998 | J Neurophysiol1998，80，1： | 1 |
| 7 | Investigation of precipitation in an Al-Zn-Mg alloy after two-step aging treatment at 100℃ and 150 ℃显示文摘 | Stiller K Warren P J Hansen V | 1999 | Mater Sci Eng A1999，270，： | 1 |
| 8 | The influence of temperature and NaCl on cadmium,copper and zinc partitioning among suspended particulate and dissolved phases in an urban river显示文摘 | Warren L A Zimmerman A P | 1994 | Wat Res1994，28，19： | 1 |
| 9 | Testing predictive validity of the communication composite of the communication and symbolic behavior scales显示文摘 | McCathren R B Yoder P J Warren S F | | 0，，01： | 1 |
| 10 | A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis显示文摘 | Stover CK Warrener P VanDevanter DR | | 0，，6789： | 1 |
| 11 | Investigation of precipitation in an AI-Zn-Mg alloy aftcr two-step ageing treatment at 100 C and 150 C 显示文摘 | STILLER K WARREN P HANSEN V ANGENETE J GJNNES J | 1999 | Mater Sci Eng A1999，270，1： | 1 |
| 12 | Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells:implications for fracture healing显示文摘 | Bouletreau P J Warren S M Spector J A | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 13 | Bone density is compromised in amenorrheic women despite return of menses:a 2-year study显示文摘 | Jonnavithula S Warren M P Fox R P | 1993 | Obstet Gynecol1993，81，： | 1 |
| 14 | Abnormal intra-QRS potentials associated with percutaneous trasluminal coronary angiography-inducd transient myocardial ischemis显示文摘 | Lander P Gomis P Warren S | 2006 | J Electrocardiol2006，39，3： | 1 |
| 15 | Dissipative particle dy- namics:bridging the gap between atomistic and meso- scopic simulation显示文摘 | GROOT R D WARREN P B | 1997 | J Chem Phys1997，107，11： | 1 |
| 16 | Maternal responsivity predicts the prelinguistic communication intervention that facilitates generalized intentional communication显示文摘 | Yoder P Warren S | | 0，，： | 1 |
| 17 | Growth and form of spherulites 显示文摘 | Granasy L P T Tegze G Warren J A | 2005 | Physical Review E2005，72，1： | 1 |
| 18 | Ginkgo biloba: A living fossil 显示文摘 | Btadly P Warren S | 2000 | Am J Med2000，108，4： | 1 |
| 19 | Dissipative particle dynamics:Bridging the gap between atomistic and mesoscopic simulation显示文摘 | Groot R D Warren P B J | 1997 | Chem Phys1997，107，11： | 1 |
| 20 | Geological controls on porosity and permeability in reservoir sands, Goodwyn Field, Rankin Trend, northern Barrow-Dampier Subbasin, Northwest Shelf, Australia显示文摘 | Warren J K Tingate P Tarabbia P | 1993 | AAPG Bulletin1993，77，9： | 1 |
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