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| 1 | Blood glucose response after oral intake of lactulose in healthy volunteers:A randomized,controlled,cross-over study显示文摘AIM To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects.METHODS The study was performed as prospective, randomized, two-part study with 4-way cross-over design with n = 12 in each study arm. Capillary blood glucose levels were determined over a time period of 180 min after intake of a single dose of 10 g or 20 g lactulose provided as crystal or liquid formulation. During the manufacturing process of lactulose, impurities with sugars(e.g., lactose, fructose, galactose) occur. Water and 20 g glucose were used as control and reference. Because lactulose is used as a functional food ingredient, it may also be consumed by people with impaired glucose tolerance, including diabetics. Therefore, it is of interest to determine whether the described carbohydrate impurities may increase blood glucose levels after ingestion. RESULTS The blood glucose concentration-time curves after intake of 10 g lactulose, 20 g lactulose, and water were almost identical. None of the three applications showed any changes in blood glucose levels. After intake of 20 g glucose, blood glucose concentration increased by approximately 3 mmol/L(mean Cmax = 8.3 mmol/L), reaching maximum levels after approximately 30 min and returning to baseline within approximately 90 min, which was significantly different to the corresponding 20 g lactulose formulations(P < 0.0001). Comparing the two lactulose formulations, crystals and liquid, in the dosage of 10 g and 20 g, there was no difference in the blood glucose profile and calculated pharmacokinetic parameters despite the different amounts of carbohydrate impurities(1.5% for crystals and 26.45% for liquid). Anyhow, the absolute amount of single sugars was low with 0.3 g in crystals and 5.29 g in liquid formulation in the 20 g dosages. Lactulose was well tolerated by most volunteers, and only some reported mild to moderate mainly gastrointestinal side effects. CONCLUSION The unchanged blood glucose levels after lactulose intake in healthy subjects suggest its safe use in subjects with impaired glucose tolerance. | Jasmin Steudle Christiane Schon Manfred Wargenau Lioba Pauly Susann Schwejda-Güttes Barbara Gaigg Angelika Kuchinka-Koch John F Stover | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，3： | 4 |
| 2 | Contemporary view on neuromonitoring following severe traumatic brain injury显示文摘Evolving brain damage following traumatic brain injury(TBI) is strongly influenced by complex pathophysiologic cascades including local as well as systemic influences. To successfully prevent secondary progression of the primary damage we must actively search and identify secondary insults e.g. hypoxia, hypotension, uncontrolled hyperventilation, anemia, and hypoglycemia, which are known to aggravate existing brain damage. For this, we must rely on specific cerebral monitoring. Only then can we unmask changes which otherwise would remain hidden, and prevent adequate intensive care treatment. Apart from intracranial pressure(ICP) and calculated cerebral perfusion pressure(CPP), extended neuromonitoring(Sjv O2, pti O2, microdialysis, transcranial Doppler sonography, electrocorticography) also allows us to define individual pathologic ICP and CPP levels. This, in turn, will support our therapeutic decision-making and also allow a more individualized and flexible treatment concept for each patient. For this, however, we need to learn to integrate several dimensions with their own possible treatment options into a complete picture. The present review summarizes the current understanding of extended neuromonitoring to guide therapeutic interventions with the aim of improving intensive care treatment following severe TBI, which is the basis for ameliorated outcome. | John F Stover | 2012 | World Journal of Critical Care Medicine2012，1，1： | 3 |
| 3 | MODIFIED MELT TEXTURING PROCESS FOR YBCO BASED ON THE POLYTHERMIC SECTION YO1.5-BA0.4CU0.6O IN THE Y-BA-CU-O PHASE DIAGRAM AT 0.21 BAR OXYGEN PRESSURE显示文摘 | Krabbes G Schatzle P Bieger W Wiesner U Stover G Wu M Strasser T Litzkendorf D Fischer K Gornert P | | 0，，： | 2 |
| 4 | Comparative transcriptome analysis during early fruit development between three seedy citrus genotypes and their seedless mutants显示文摘Identification of genes with differential transcript abundance(GDTA)in seedless mutants may enhance understanding of seedless citrus development.Transcriptome analysis was conducted at three time points during early fruit development(Phase 1)of three seedy citrus genotypes:Fallglo(Bower citrus hybrid(Citrus reticulata×C.reticulata×C.paradisi)×Temple(C.reticulata×C.sinensis)),grapefruit(C.paradisi),Pineapple sweet orange(C.sinensis),and their seedless mutants.Seed abortion in seedless mutants was observed at 26 days post anthesis(Time point 2).Affymetrix transcriptomic analysis revealed 359 to 1077 probe sets with differential transcript abundance in the comparison of seedless versus seedy fruits for each citrus genotypes and time points.The GDTA identified by 18 microarray probe sets were validated by qPCR.Hierarchical clustering analysis revealed a range of GDTA associated with development,hormone and protein metabolism,all of which may reflect genes associated with seedless fruit development.There were 14,9 and 12 genes found exhibiting similar abundance ratios in all three seedless versus seedy genotype comparisons at time point 1,2 and 3,respectively.Among those genes were genes coding for an aspartic protease and a cysteine protease,which may play important roles in seedless fruit development.New insights into seedless citrus fruit development may contribute to biotech approaches to create seedless cultivars. | Shujian Zhang Qingchun Shi Ute Albrecht Robert G Shatters Jr Ric Stange Greg McCollum Shuo Zhang Chengming Fan Ed Stover | 2017 | Horticulture Research2017，4，1： | 2 |
| 5 | Polymer mierocapsules by interfacial polyaddition between styrene-maleic anhydride copolymers and amines显示文摘 | Harald D H Stover | 2002 | Journal of Membrane Science2002，209，2： | 1 |
| 6 | Low dose spiral CT: applicability to pediatric chest imaging 显示文摘 | Rogolla P Stover B Scheer I | 1999 | Pediatr Radiol1999，29，： | 1 |
| 7 | Convergence of genetic,nutritional and inflammatory factors in gastrointestinal cancers显示文摘 | MACFARLANEA J STOVER P J | 2007 | Nutr Rev2007，65，12： | 1 |
| 8 | A second serine protease associated with mannan-binding lectin that activates complement显示文摘 | Thiel S Vorup-Jensen T Stover CM | 1997 | Nature1997，386，6624： | 1 |
| 9 | Gender and lung cancer 显示文摘 | Rivera MP Stover DE | 2004 | Clin Chest Med2004，25，： | 1 |
| 10 | Evaluation of commercial alloys as cathode current collector for metal-supported tubular solid oxide fuel cells显示文摘 | Montero X Tieta F Stover D | | 0，，： | 1 |
| 11 | A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis显示文摘 | Stover CK Warrener P VanDevanter DR | | 0，，6789： | 1 |
| 12 | A longitudinal evaluation of baccalaureate nursing students' critical thinking abihties 显示文摘 | Adams M Stover LM Whitlow JF | 1999 | Journal of Nursing Education1999，38，3： | 1 |
| 13 | Effects of particle shape on particle identification and scatter predictions 显示文摘 | Scheer C A Ivakhnenko V Stover J C | 2001 | Intl Soc Optical Eng2001，4449，： | 1 |
| 14 | Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures显示文摘 | Weresh MJ Hakanson R Stover MD | 2000 | J Orthop Trauma2000，14，5： | 1 |
| 15 | Evaluation of metals in wastewater studge显示文摘 | STOVER R C SOMMERS L E SILVIERA D J | 1976 | Water Pollution Control Federation1976，48，50： | 1 |
| 16 | Age-related changes in visual acui-ty, learning and memory in the APPswe/PSldE9 mousemodel of Alzheimer's disease 显示文摘 | Stover KR Brown RE | 2012 | Behav Brain Res2012，231，1： | 1 |
| 17 | Statistical quality control applied to ion chromatography calibrations 显示文摘 | Stover F S BriU R V | 1998 | Journal of Chromatography A1998，804，12： | 1 |
| 18 | Does screw configuration affect subtrochanteric fracture after femoral neck fixation 显示文摘 | OAKEY J W STOVER M D SUMERS H D | 2006 | Clin Orthop Relat Res2006，443，： | 1 |
| 19 | A onepass thinning algorithm and its parallel implementation显示文摘 | CHIN R T WAN G H K Stover D L | 1987 | Computer Vision Graphics Image Process-ing1987，40，1： | 1 |
| 20 | Knowledge, resilience, and effectiveness of education in a young teen asthma camp 显示文摘 | Buckner EB Hawkins AM Stover L | 2005 | Pediatric Nuts2005，31，20： | 1 |
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