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| 1 | 全球慢性疾病流行和疾病管理方案国际拓展显示文摘从海啸、HIV/AIDS危机、战争的创伤和发展中国家的饥饿来看,全球的医院正在努力应付对其能力要求日益增长的需求。另一种全球性危机正迅速来临,世界卫生组织建议,慢性疾病可能成为“21世纪的流行病”。 | Warren E Todd | 2006 | 中国卫生产业2006，，7： | 8 |
| 2 | Therapeutic induction of autophagy to modulate neurodegenerative disease progression显示文摘 | Warren E HOCHFELD Shirley LEE David C RUBINSZTEIN | 2013 | Acta Pharmacologica Sinica2013，34，5： | 6 |
| 3 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 4 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 5 | Hyperspectral versus multispectral data for estimating leaf area index in four different biomes显示文摘 | Kyu-Sung Lee Warren B Cohen Robert E Kennedy Thomas K Maiersperger Stith T Gower | 2004 | Remote Sensing of Environment2004，，3： | 2 |
| 6 | Luminescent quantum dots for multiplexed biological detection and imaging显示文摘 | Warren C.W Chan Dustin J Maxwell Xiaohu Gao Robert E Bailey Mingyong Han Shuming Nie | 2002 | Current Opinion in Biotechnology2002，，1： | 2 |
| 7 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 8 | Qiamtofuomg augmentation gluteoplasty outcomes:a comparison of three instruments used to measure gluteal projection显示文摘 | FERREIRA D M WARREN S M | 2007 | Aesthetic Plast Surg2007，21，： | 1 |
| 9 | A histological evaluation of peritoneal injury and repair: implications for adhesion formation 显示文摘 | Elkins T E Stovall T G Warren J | 1987 | Obstet Gynecol1987，70，2： | 1 |
| 10 | Safe mycobacterium tuberculo- sis DNA extraction method that does not compromise integrity显示文摘 | Warren R De-Kock M Engelke E | 2006 | Jour- nal of Clinical Microbiology2006，44，1： | 1 |
| 11 | Constructive and destructive deviance in organi- zations显示文摘 | Warren D E | 2003 | Academy of Management Review2003，28，4： | 1 |
| 12 | The effects of loading and unloading treadmill walking on balance,gait,fall risk and daily function in Parkinsonism显示文摘 | Toole T Maitland CG Warren E | 2005 | Neurorehabilitation2005，20，： | 1 |
| 13 | Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones显示文摘 | Dollins D E Warren J J Immormino R M | 2007 | Mol Cell2007，28，1： | 1 |
| 14 | Relationships between Leaf Area Index and Landsat TM Spectral Vegetation Indices across Three Temperate Zone Sites 显示文摘 | David PT Warren B C Robert E K | 1999 | Remote Sensing of Environment1999，70，： | 1 |
| 15 | Outcomes of methotrexate therapy for psoriasis and rela- tionship to genetic polymorphisms 显示文摘 | Warren RB Smith RL Campalani E Eyre S Smith CH Barker JN | 2009 | Br J Dermatol2009，160，2： | 1 |
| 16 | Observations of Col- letotrichum graminicola on sweet corn in Indiana 显示文摘 | Warren H Nicholson R Ullstrup A Sharvelle E | 1973 | Plant Disease Re- port1973，，57： | 1 |
| 17 | An antigen produced by splicing of noncontiguous peptides in the reverse order 显示文摘 | Warren E H Vigneron N J Gavin M A | 2006 | Science2006，313，5792： | 1 |
| 18 | Seed hydration using the drum priming system显示文摘 | Warren J E Bennett M A | 1997 | Horticulture Science1997，32，7： | 1 |
| 19 | The application of neutron activation analysis to the measurement of the wear of a friction material 显示文摘 | Bush H D Rowson D M Warren S E | 1972 | Wear1972，20，2： | 1 |
| 20 | Modeling the impact of summer temperatures on national electricity consumption显示文摘 | Le Comte D M Warren H E | 1981 | J Appl Meteor1981，20，12： | 1 |
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