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| 1 | Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate显示文摘 | Huarong Nie Aihua He Wanling Wu Jianfen Zheng Shanshan Xu Junxing Li Charles C. Han | 2009 | Polymer2009，，20： | 2 |
| 2 | Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres显示文摘 | Wujun Xu Qiang Gao Yao Xu Dong Wu Yuhan Sun Wanling Shen Feng Deng | 2008 | Powder Technology2008，，1： | 1 |
| 3 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells显示文摘 | Shuguang Zuo Chang Liu Jianguo Wang Fuqing Wang Wanling Xu Shao Cui Lei Yuan Xudong Chen Wenjuan Fan Mingchen Cui Guohua Song | 2012 | Journal of Cancer Research and Clinical Oncology2012，，6： | 1 |
| 4 | The influence of immunosuppressants on the fertility of males who undergo renal transplantation and on the immune function of their offspring显示文摘 | Longgen Xu Shu Han Yong Liu Hongwei Wang Yirong Yang Feng Qiu Wanling Peng Ligong Tang Jing Fu Xiao-Feng Zhu Xianfan Ding Youhua Zhu | 2009 | Transplant Immunology2009，，： | 1 |
| 5 | 新型可遗传编码的荧光探针实现在果蝇、斑马鱼和小鼠中快速特异地示踪多巴胺显示文摘文章简介多巴胺是神经系统中一种重要的单胺类神经递质,它介导了一系列重要的生理、病理过程。如何在自由活动的动物脑中特异、精准地示踪特定时间、区域的多巴胺释放是长期以来困扰神经科学家的技术难题。 | 孙芳妙 曾健智 井淼 Jingheng Zhou 冯杰思 Scott F.Owen 骆奕辰 Funing Li 王欢 Takashi Yamaguchi 雍自昊 Yijing Gao Wanling Peng Lizhao Wang Siyu Zhang Jiulin Du Dayu Lin Min Xu Anatol C.Kreitzer Guohong Cui 李毓龙 | 2019 | 科学新闻2019，0，2： | 1 |
| 6 | Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy显示文摘With tremendous research advances in biomedical application,liquid metals(LM)also offer fantastic chemistry for synthesis of novel nano-composites.Herein,as a pioneering trial,litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles(EGaIn-Au NPs),served as effective radiosensitizer and photothermal agent for radio-photothermal cancer therapy,have been successfully prepared using in situ interfacial galvanic replacement reaction.The enhanced photothermal conversion efficiency and boosted radio-sensitization effect could be achieved with the reduction of Au nanodots onto the eutectic gallium indium(EGaIn)NPs surface.Most importantly,the growth of tumor could be effectively inhibited under the combined radio-photothermal therapy mediated by EGaIn-Au NPs.Inspired by this approach,in situ interfacial galvanic replacement reaction may open a novel strategy to fabricate LM-based nano-composite with advanced multi-functionalities. | Zhenhu Guo Jingsong Lu Dan Wang Wensheng Xie Yongjie Chi Jianzhong Xu Nonaka Takuya Junxin Zhang Wanling Xu Fei Gao Hong Wu Lingyun Zhao | 2021 | Bioactive Materials2021，6，3： | 0 |
| 7 | Retrieving chlorophyll content and equivalent water thickness of Moso bamboo(Phyllostachys pubescens) forests under Pantana phyllostachysae Chao-induced stress from Sentinel-2A/B images in a multiple LUTs-based PROSAIL framework显示文摘Biochemical components of Moso bamboo(Phyllostachys pubescens)are critical to physiological and ecological processes and play an important role in the material and energy cycles of the ecosystem.The coupled PROSPECT with SAIL(PROSAIL)radiative transfer model is widely used for vegetation biochemical component content inversion.However,the presence of leaf-eating pests,such as Pantana phyllostachysae Chao(PPC),weakens the performance of the model for estimating biochemical components of Moso bamboo and thus must be considered.Therefore,this study considered pest-induced stress signals associated with Sentinel-2A/B images and field data and established multiple sets of biochemical canopy reflectance look-up tables(LUTs)based on the PROSAIL framework by setting different parameter ranges according to infestation levels.Quantitative inversions of leaf area index(LAI),leaf chlorophyll content(LCC),and leaf equivalent water thickness(LEWT)were derived.The scale conversions from LCC to canopy chlorophyll content(CCC)and LEWT to canopy equivalent water thickness(CEWT)were calculated.The results showed that LAI,CCC,and CEWT were inversely related with PPC-induced stress.When applying multiple LUTs,the p-values were<0.01;the R2 values for LAI,CCC,and CEWT were 0.71,0.68,and 0.65 with root mean square error(RMSE)(normalized RMSE,NRMSE)values of 0.38(0.16),17.56μg cm-2(0.20),and 0.02 cm(0.51),respectively.Compared to the values obtained for the traditional PROSAIL model,for October,R2 values increased by 0.05 and 0.10 and NRMSE decreased by 0.09 and 0.02 for CCC and CEWT,respectively and RMSE decreased by 0.35μg cm-2 for CCC.The feasibility of the inverse strategy for integrating pest-induced stress factors into the PROSAIL model,while establishing multiple LUTs under different pest-induced damage levels,was successfully demonstrated and can potentially enhance future vegetation parameter inversion and monitoring of bamboo forest health and ecosystems. | Zhanghua Xu Anqi He Yiwei Zhang Zhenbang Hao Yifan Li Songyang Xiang Bin Li Lingyan Chen Hui Yu Wanling Shen Xuying Huang Xiaoyu Guo Zenglu Li | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 8 | Recent advances for liquid metals:Synthesis,modification and bio-applications显示文摘Considering the application requirements for modern biomedicine,research into novel biomaterials with unusual functions is highly desired.As an alternative,liquid metals(LMs),a nontraditional family of metal materials,have piqued the interest of biomedical researchers and made significant advances in biomed-ical areas,owing to their shape transformability,self-healing capability,excellent electrical,and thermal conductivities.In particular,many functionalized strategies for the preparation and modification of LMs or LMs-based composites to achieve extended biomedical applications have been investigated in recent years.These findings provided inspiring while constructive reference for the fabrication and engineering of novel LMs-based composites.Herein,in this topic review,we elaborate on the recent advances of LMs-based functional materials,with particular focuses on the synthesis,modification,and bio-applications,especially in antitumor therapy,antibacterial,contrast agent for imaging,bone repair,electronic skin sen-sor,and nerve connection agent.Further on,the current challenges and future prospects of LMs-based composites are carefully discussed. | Zhenhu Guo Xiaohan Gao Jingsong Lu Wanling Xu Jielin Ye Ying Li Wensheng Xie Lingyun Zhao | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 9 | Necroptosis-elicited host immunity:GOx-loaded MoS_(2) nanocatalysts for self-amplified chemodynamic immunotherapy显示文摘Nanoparticles induced potent antitumor immunotherapy plays a significant role for enhancing conventional therapeutic effectiveness.However,revealing the pathway of how nanoagents themselves trigger the host immunity or how to maximize the immunotherapy efficacy still needs further exploration.Herein,rose-like MoS2 nanoflowers modified with 2-deoxy-D-glucose(2-DG)and glucose oxidase(GOx)(MPGGFs)have been successfully fabricated via a one-pot hydrothermal reaction and following one-by-one surface modification as a multifunctional nanocatalyst for photothermal therapy enhanced self-amplified chemodynamic immunotherapy(PTT-co-CDT).By introducing GOx,the obtained MPGGFs exhibited self-amplified chemodynamic therapeutic efficacy under hypoxia tumor microenvironment(TME)because of the raised intracellular H2O2 level via enzyme-catalysis of oxygen.Furthermore,combined with the intrinsic excellent photothermal conversion efficiency of MoS2 nanoflowers,PTT-co-CDT performances by MPGGFs could effectively induce the necroptosis of tumor cells both in vitro and in vivo.Then the induced necroptosis via PTT-co-CDT by MPGGFs could directly trigger host immunity by activating the antigen-specific T-cells(CD4^(+) and CD8^(+)).Finally,the excellent in vivo safety of MPGGFs makes us believe that the successful construction of rose-like multifunctional nanocatalyst not only has great potentials for self-amplified chemodynamic immunotherapy,but also provides a paradigm for exploring necroptosis triggered host immunity for cancer treatment. | Wensheng Xie Jingsong Lu Zhenhu Guo Xiaoxiao Guo Yongjiu Chi Jieling Ye Junxin Zhang Wanling Xu Lingyun Zhao Yen Wei | 2022 | Nano Research2022，15，3： | 0 |
| 10 | Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal显示文摘Intestinal organoids,derived from intestinal stem cell self-organization,recapitulate the tissue structures and behav-iors of the intestinal epithelium,which hold great potential for the study of developmental biology,disease modeling,and regenerative medicine.The intestinal epithelium is exposed to dynamic mechanical forces which exert profound effects on gut development.However,the conventional intestinal organoid culture system neglects the key role of mechanical microenvironments but relies solely on biological factors.Here,we show that adding cyclic stretch to intestinal organoid cultures remarkably up-regulates the signature gene expression and proliferation of intestinal stem cells.Furthermore,mechanical stretching stimulates the expansion of SOX9+progenitors by activating the Wnt/β-Catenin signaling.These data demonstrate that the incorporation of mechanical stretch boosts the stemness of intestinal stem cells,thus benefiting organoid growth.Our findings have provided a way to optimize an organoid generation system through understanding cross-talk between biological and mechanical factors,paving the way for the application of mechanical forces in organoid-based models. | Fanlu Meng Congcong Shen Li Yang Chao Ni Jianyong Huang Kaijun Lin Zanxia Cao Shicai Xu Wanling Cui Xiaoxin Wang Bailing Zhou Chunyang Xiong Jihua Wang Bing Zhao | 2022 | Cell Regeneration2022，11，1： | 0 |
| 11 | Expert recommendations on data collection and annotation of two dimensional ultrasound images in azoospermic males for evaluation of testicular spermatogenic function in intelligent medicine显示文摘Testicular two-dimensional ultrasound is a testing modality that is often used to evaluate azoospermia and other related diseases.With the continuous development of deep learning in recent years,the combination of deep learning and testicular ultrasound appears unstoppable despite a lack of relevant standards.One of the major problems associated with the digitization of ultrasound images is the uneven quality of data however,and a standardized data source and acquisition process has not yet been developed.Such a standard could fill the current gap,and establish acquisition criteria for ultrasound images of testes during the male reproductive period,including grayscale ultrasound,shear wave elastography,and contrast-enhanced ultrasound.By following these guidelines the quality of testicular ultrasound images would be improved and standardized,which would lay a solid foundation for the standardization of testicular ultrasound images,and assist automated evaluation of testicular spermatogenic function of whole testis in azoospermic males. | Wanling Huang Yifan Xiang Yahan Yang Qing Tang Guangjian Liu Hong Yang Erjiao Xu Huitong Lin Zhixing Zhang Zhe Ma Zhendong Li Ruiyang Li Anqi Yan Haotian Lin Zhu Wang Chinese Association of Artificial Intelligence Medical Artificial Intelligence Branch of the Guangdong Medical Association | 2022 | Intelligent Medicine2022，2，2： | 0 |
| 12 | Overcoming Debye length limitations:Three-dimensional wrinkled graphene field-effect transistor for ultra-sensitive adenosine triphosphate detection显示文摘Adenosine triphosphate(ATP)is closely related to the pathogenesis of certain diseases,so the detection of trace ATP is of great significance to disease diagnosis and drug development.Graphene field-effect transistors(GFETs)have been proven to be a promising platform for the rapid and accurate detection of small molecules,while the Debye shielding limits the sensitive detection in real samples.Here,a three-dimensional wrinkled graphene field-effect transistor(3D WG-FET)biosensor for ultra-sensitive detection of ATP is demonstrated.The lowest detection limit of 3D WG-FET for analyzing ATP is down to 3.01 aM,which is much lower than the reported results.In addition,the 3D WG-FET biosensor shows a good linear electrical response to ATP concentrations in a broad range of detection from 10 aM to 10 pM.Meanwhile,we achieved ultra-sensitive(LOD:10 aM)and quantitative(range from 10 aM to 100 fM)measurements of ATP in human serum.The 3D WG-FET also exhibits high specificity.This work may provide a novel approach to improve the sensitivity for the detection of ATP in complex biological matrix,showing a broad application value for early clinical diagnosis and food health monitoring. | Yue Ding Chonghui Li Meng Tian Jihua Wang Zhenxing Wang Xiaohui Lin Guofeng Liu Wanling Cui Xuefan Qi Siyu Li Weiwei Yue Shicai Xu | 2023 | Frontiers of physics2023，18，5： | 0 |
| 13 | Parallel aligned Nickel Nanocone Arrays for Multi-band Microwave Absorption显示文摘Magnetic nanostructures with conical shape are highly desired for pursuing extraordinary magnetic properties and microwave absorption.For a soft magnetic nanocone. | Zhang Wanling Zhang Jiaming Huang Ran Xu Fangfang Cheng Hongwei Liu Jie Yao Huijun Mo Dan Chen Yonghui Duan Jinglai | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 14 | Genetic Improvement of Betula platyphylla Suk.in China:A Review显示文摘Birch(Betula platyphylla Suk.),distributed in Eurasia,North America,and Australia,is a kind of cold-resistant,fast-growing,and vital pulpwood tree species.It is also one of the most important ecological restoration tree species with high values of economic benefits in Northeast China.To improve the genetic gain and expand the economic benefit of B.platyphylla,many genetic improvements have been carried out.In China,B.platyphylla is widely distributed and varied,and there are many varieties with excellent genetic characteristics.In this paper,the genetic improvement of B.platyphylla was reviewed,and the previous research results were discussed from two aspects:conventional breeding and molecular breeding.Some problems and corresponding solutions in the genetic improvement were put forward to provide ideas for B.platyphylla breeding in the future. | Qinhui Zhang Xiaona Pei Lianfeng Xu Xianbo Lu Baoyang Wen Yanlong Li Liankui Wang Guangzhi Dong Wanling Shi Xiaoqing Hu Xiyang Zhao | 2022 | Phyton-International Journal of Experimental Botany2022，91，8： | 0 |
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