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| 1 | Significance of Axial Length Monitoring in Children with Congenital Cataract and Update of Measurement Methods显示文摘Congenital cataract is the main cause of blindness in children, with significantly varying treatment effects. The development of axial length is an important factor that affects the prognosis of these children.However,when compared with the eyes of normal children,the mechanism of growth of the axial length is so complicated that the reported findings differ significantly in terms of the measuring apparatus,assessment methods,and statistical outcome,making the rule of axial length development still unclear. In this paper, we first review the process of axial length development in normal healthy children and compare different hypotheses about certain factors that could affect the development of axial length. The results of some current research about the characteristics of axial length development in congenital cataract children are then reviewed. Lastly, the advantages and disadvantages of current axial length measurements methods are compared and analyzed.The purpose of this review is to improve our understanding of the complexity and importance of axial length development and to suggest better use of axial length monitoring measurements in congenital cataract children for pediatric ophthalmologists,with the hope of offering assistance that will enhance long-term therapeutic effects for these children. | Jiao Zhan Haotian Lin Xinyu Zhang Weirong Chen Yizhi Liu | 2013 | Eye Science2013，28，2： | 11 |
| 2 | Progress of Application of Sedation Technique in Pediatric Ocular Examination显示文摘Pediatric ophthalmic test requires meticulous observation and precise measurement..However, children are unable to actively cooperate with the test...If they were forced to receive the examinations,.it is difficult to deliver accurate diagnosis and treatment, and cause negative influence upon physical and mental health. Consequently, sedation technique plays an extremely vital role in pediatric eye examinations..This study was designed to summarize the application of chloral hydrate in pediatric eye examination and propose different methods of medicine administration for children of varying ages, aiming to improve the effect of sedation. In addition, the feasibility of use of dexmedetomidine,.which had been proven to be effective in pediatric sedation examination,.into pediatric ophthalmic sedation examination was evaluated,.thereby offering more options for the development of pediatric ocular sedation test. | Jingjing Chen Zhuoling Lin Haotian Lin | 2014 | Eye Science2014，29，3： | 7 |
| 3 | Engineering the surface of LiCoO2 electrodes using atomic layer deposition for stable high-voltage lithium ion batteries显示文摘 | Jin Xie Jie Zhao Yayuan Liu Haotian Wang Chong Liu Tong Wu Po-Chun Hsu Dingchang Lin Yang Jin Yi Cui | 2017 | Nano Research2017，10，11： | 6 |
| 4 | Progress in Screening and Treatment of Common Congenital Eye Diseases显示文摘Congenital eye illnesses are caused by congenital ocular malformations and are a primary cause of poor visual acuity and blindness in infants. Early diagnosis and treatment of congenital eye illnesses are of great significance for affected infants, their families, and even society as a whole. This study describes the current situation for prenatal and infant screening for congenital eye diseases and briefly summarizes novel progress in the treatment of the five most common eye diseases(congenital dacryocystitis, congenital cataract, retinopathy of prematurity, congenital glaucoma and retinoblastoma).Current programs are now aimed at improvements in the prevention and treatment of congenital eye diseases in China. | Yan Li Haotian Lin | 2013 | Eye Science2013，28，3： | 4 |
| 5 | Decoding Cortical Glial Cell Development显示文摘Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late embryogenesis.There are fundamental gaps in understanding how these diverse cell subtypes are generated.Here,by combining single-cell RNA-Seq with intersectional lineage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OLIG2,and MKI67.These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons.Finally,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.Taken together,this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes. | Xiaosu Li Guoping Liu Lin Yang Zhenmeiyu Li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang Yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen Zhengang Yang | 2021 | Neuroscience Bulletin2021，37，4： | 2 |
| 6 | Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy显示文摘One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors.Tumor cells generally display the higher oxidative level than normal cells,and also displayed the heterogeneity in terms of redox homeostasis level.We previously found that the disulfide bond-linkage demonstrates surprising oxidationsensitivity to form the hydrophilic sulfoxide and sulphone groups.Herein,we develop oxidation-strengthened prodrug nanosystem loaded with pyropheophorbide a(PPa)to achieve light-activatable cascade drug release and enhance therapeutic efficacy.The disulfide bond-driven prodrug nanosystems not only respond to the redox-heterogeneity in tumor,but also respond to the exogenous oxidant(singlet oxygen)elicited by photosensitizers.Once the prodrug nanoparticles(NPs)are activated under irradiation,they would undergo an oxidative self-strengthened process,resulting in a facilitated drug cascade release.The IC50 value of the PPa@PTX-S-S NPs without irradiation was 2-fold higher than those of NPs plus irradiation.In vivo,the PPa@PTX prodrug NPs display prolonged systemic circulation and increased accumulation in tumor site.The PPa@PTXS-S NPs showed much higher efficiency than free PTX or the PPa@PTX-C-C NPs to suppress the growth of 4 T1 tumors.Therefore,this novel oxidation-strengthened disulfide-bridged prodrug-nanosystem has a great potential in the enhanced efficacy of cancer synergetic photochemotherapy. | Bin Yang Lin Wei Yuequan Wang Na Li Bin Ji Kaiyuan Wang Xuanbo Zhang Shenwu Zhang Shuang Zhou Xiaohui Yao Hang Song Yusheng Wu Haotian Zhang Qiming Kan Tao Jin Jin Sun | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 2 |
| 7 | Pattern of Refractive Correction and Timing of Stage Ⅱ IOL Implantation after Congenital Cataract Extraction显示文摘Congenital cataract occurs during infancy when the axial length and corneal and visual function are in the sensitive stages of rapid development..Inappropriate surgical intervention not only fails to restore visual function,.but also causes irreversible serious influences upon eyeball development in children diagnosed with congenital cataract. At present, the uncertainty of selection of intraocular lens(IOL) degrees during the eyeball development period is averted by using a main treatment of congenital cataract that includes two-stage surgery:.stage I cataract extraction and stage II IOL implantation. However, the accurate selection of a refractive correction method and the timing of IOL implantation during stage II surgery for aphakic eyes remains controversial following stage I cataract extraction..This review retrospectively summarizes the current progress and existing problems indicated by related recent studies focusing on refractive correction pattern and IOL implantation timing. | Yan Li Haotian Lin | 2014 | Eye Science2014，29，4： | 2 |
| 8 | Unique strength-ductility balance of AlCoCrFeNi_(2.1)eutectic high entropy alloy with ultra-fine duplex microstructure prepared by selective laser melting显示文摘As a typical dual-phase eutectic high entropy alloy(EHEA),AlCoCrFeNi_(2.1)can achieve the fair matching of strength and ductility,which has attracted wide attention.However,the engineering applications of as-cast AlCoCrFeNi_(2.1)EHEAs still face challenges,such as coarse grain and low yield strength resulting from low solidification rate and temperature gradient.In this study,selective laser melting(SLM)was introduced into the preparation of AlCoCrFeNi_(2.1)EHEA to realize unique strength-ductility balance,with emphasis on investigating the effects of processing parameters on its eutectic microstructure and properties.The results show that the SLM-ed samples exhibit a completely eutectic structure consisting of ultra-fine face-centered cubic(FCC)and ordered body-centered cubic(B2)phases,and the duplex microstructure undergoes a morphological evolution from lamellar structure to cellular structure as laser energy input reducing.The SLM-ed AlCoCrFeNi_(2.1)EHEA presents an excellent match of high tensile strength(1271 MPa),yield strength(966 MPa),and good ductility(22.5%)at room temperature,which are significantly enhanced by the ultra-fine grains and heterogeneous structure due to rapid solidification rate and high temperature gradient during SLM.Especially,the yield strength increment of~50%is realized with no loss in ductility as compared with the as-cast samples with the same composition.On this basis,the precise complex component with excellent mechanical properties is well achieved.This work paves the way for the performance improvement and complex parts preparation of EHEA by microstructural design using laser additive manufacturing. | Yinuo Guo Haijun Su Haotian Zhou Zhonglin Shen Yuan Liu Jun Zhang Lin Liu Hengzhi Fu | 2022 | Journal of Materials Science & Technology2022，，16： | 2 |
| 9 | Construction of databases:advances and significance in clinical research显示文摘Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials(RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research. | Erping Long Bingjie Huang Liming Wang Xiaoyu Lin Haotian Lin | 2015 | Eye Science2015，30，4： | 1 |
| 10 | Intervention Strategies for Improving Patient Adherence to Follow-Up in the Era of Mobile Information Technology :A Systematic Review and Meta-Analysis 显示文摘 | Haotian Lin Xiaohang Wu | 2014 | PLoS One2014，69，8： | 1 |
| 11 | Clinical Evaluation of Three Incision Size–Dependent Phacoemulsification Systems显示文摘 | Lixia Luo Haotian Lin Mingguang He Nathan Congdon Ye Yang Yizhi Liu | 2012 | American Journal of Ophthalmology2012，，5： | 1 |
| 12 | Exploration of Management Workflow of Cataract Surgery in an Impoverished Population in Urban China显示文摘Purpose:.To explore and establish a rational management workflow for a free cataract surgery program for the poor population in urban China, aiming to improve surgical efficiency.Methods:.Establishment of a management workflow mainly includes system design and an auxiliary facility. System design procedures consist of outpatient screening, outpatient physical examination,.surgical procedures,.and postoperative clinic visits. After establishing the management workflow of cataract surgery, a free cataract surgery program was conducted for 15 months.Results: Based upon the established management mode, 9003 patients received preoperative screening and 2358 underwent cataract surgery..During the 15-month investigation,.each procedure was successfully conducted,.the efficiency of screening and operation attained the highest standards in China,.and no surgical malpractice occurred intraoperatively.Conclusion:.In this study,.a management workflow for cataract surgery was designed for a poverty relief project in urban China. During the 15-month project, the degree of patient satisfaction was enhanced without disrupting the normal practice and safety of the sponsor hospital. | Haofeng Jiang Haotian Lin Bo Qu Weirong Chen | 2014 | Eye Science2014，29，2： | 1 |
| 13 | Clinical and Experimental Research of Corneal Lymphangiogenesis after Keratoplasty显示文摘 | Ling Shiqi Lin Haotian Xiang Daoman Feng Guangqiang Zhang Xuefei | 2008 | Ophthalmologica2008，，5： | 1 |
| 14 | Eye can see a nest of worms显示文摘 | Haotian Lin Xiaoling Liang | 2012 | Lancet2012，379，9820： | 1 |
| 15 | A Prussian blue route to nitrogen-doped graphene aerogels as efficient electrocatalysts for oxygen reduction with enhanced active site accessibility显示文摘为氧减小反应(ORR ) 开发高效的 nonprecious 金属 electrocatalysts 为许多可更新的精力变换和存储系统是关键的。近那结束,导致高度活跃的催化中心和提高的活跃地点可接近性的合理催化剂设计原则无疑具有首要的重要性。这里,我们使用了普鲁士的蓝 nanoparticles 到锚 Fe/Fe 3 C 种类到做氮的减少的 graphene 氧化物 aerogels 作为 ORR 催化剂。在 nanosized Fe 3 C 和 graphitic 碳壳在 ORR 导致了 synergistic 效果,并且碳壳的保护保证了催化剂的稳定性。作为结果, aerogel electrocatalyst 在在碱的媒介,在酸的媒介的好表演,和匹敌 ORR electrocatalysts 迄今为止报导了的最好的 nonprecious 金属的优秀稳定性和转线路忍耐装载的一样的团与最先进的 Pt/C 催化剂同样在 ORR 显示了突出的活动。 | Yayuan Liu Haotian Wang Dingchang Lin Jie Zhao Chong Liu Jin Xie Yi Cui | 2017 | Nano Research2017，10，4： | 1 |
| 16 | Genus Tetrastigma:A review of its folk uses,phytochemistry and pharmacology显示文摘The genus Tetrastigma belongs to the Vitaceae family and contains over 100 species.This paper reviewed folk uses,chemical constituents,pharmacological activities,and clinical applications of the medicinal plants in the genus Tetrastigma.In addition,the paper also discussed the current problems for the further studies.Up to now,more than 240 compounds were reported from the genus Tetrastigma,covering 74 flavonoids,14 terpenoids,19 steroids,21 phenylpropanoids,14 alkaloids and others constituents.Among them,flavonoids are the major and the characteristic chemical constituents in this genus.Modern pharmacological studies and clinical practice showed that the extracts and chemical constituents of Tetrastigma species possessed wide pharmacological activities including antitumor,antioxidative,hepatoprotective,antiviral,anti-inflammatory,and analgesic activities.The information summarized in this paper provides valuable clues for new drug discovery and an incentive to expand the research of genus Tetrastigma. | Lizhi Zhang Bin Li Mengyun Wang Haotian Lin Yilin Peng Xudong Zhou Caiyun Peng Jixun Zhan Wei Wang | 2022 | Chinese Herbal Medicines2022，14，2： | 1 |
| 17 | Unbiased transcriptomic analyses reveal distinet effects of immune deficiency in CNS function with and without injury显示文摘The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI, which was confirmed by immunohistochemical analysis and was consistent with better functional recovery. Transcriptomic analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced inflammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation. | Dandan Luo Weihong Ge Xiao Hu Chen Li Chia-Ming Lee Liqiang Zhou Zhourui Wu Juehua Yu Sheng Lin Jing Yu Wei Xu Lei Chen Chong Zhang Kun Jiang Xingfei Zhu Haotian Li Xinpei Gao Yanan Geng Bo Jing Zhen Wang Changhong Zheng Rongrong Zhu Qiao Yan Quan Lin Keqiang Ye Yi E. Sun Liming Cheng | 2019 | Protein & Cell2019，10，8： | 1 |
| 18 | The national multi-center artificial intelligent myopia prevention and control project显示文摘In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results. | Xun Wang Yahan Yang Yuxuan Wu Wenbin Wei Li Dong Yang Li Xingping Tan Hankun Cao Hong Zhang Xiaodan Ma Qin Jiang Yunfan Zhou Weihua Yang Chaoyu Li Yu Gu Lin Ding Yanli Qin Qi Chen Lili Li Mingyue Lian Jin Ma Dongmei Cui Yuanzhou Huang Wenyan Liu Xiao Yang Shuiming Yu Jingjing Chen Dongni Wang Zhenzhe Lin Pisong Yan Haotian Lin Chinese Association of Artificial Intelligence,Medical Artificial Intelligence Branch of Guangdong Medical Association | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 19 | Development of Super-Synchronization Speed Control Assembly in Two 80 MVA Motor Generators of HL-2A Tokamak显示文摘 | LI Huajun DU Chang XUAN Weimin PEN Jianfei HU Haotian LIU Lin KANG Li XU Lirong HUANG Zhaorong WANG Fen WANG Xiaoping WANG Haibing | 2005 | Southwestern Institute of Physics Annual Report2005，，1： | 0 |
| 20 | Application of artifcial intelligence in cataract management:current and future directions显示文摘The rise of artifcial intelligence(AI)has brought breakthroughs in many areas of medicine.In ophthalmology,AI has delivered robust results in the screening and detection of diabetic retinopathy,age-related macular degeneration,glaucoma,and retinopathy of prematurity.Cataract management is another feld that can beneft from greater AI application.Cataract is the leading cause of reversible visual impairment with a rising global clinical burden.Improved diagnosis,monitoring,and surgical management are necessary to address this challenge.In addition,patients in large developing countries often sufer from limited access to tertiary care,a problem further exacerbated by the ongoing COVID-19 pandemic.AI on the other hand,can help transform cataract management by improving automation,efcacy and overcoming geographical barriers.First,AI can be applied as a telediagnostic platform to screen and diagnose patients with cataract using slit-lamp and fundus photographs.This utilizes a deep-learning,convolutional neural network(CNN)to detect and classify referable cataracts appropriately.Second,some of the latest intraocular lens formulas have used AI to enhance prediction accuracy,achieving superior postoperative refractive results compared to traditional formulas.Third,AI can be used to augment cataract surgical skill training by identifying diferent phases of cataract surgery on video and to optimize operating theater workfows by accurately predicting the duration of surgical procedures.Fourth,some AI CNN models are able to efectively predict the progression of posterior capsule opacifcation and eventual need for YAG laser capsulotomy.These advances in AI could transform cataract management and enable delivery of efcient ophthalmic services.The key challenges include ethical management of data,ensuring data security and privacy,demonstrating clinically acceptable performance,improving the generalizability of AI models across heterogeneous populations,and improving the trust of end-users. | Laura Gutierrez Jane Sujuan Lim Li Lian Foo Wei Yan Ng Michelle Yip Gilbert Yong San Lim Melissa Hsing Yi Wong Allan Fong Mohamad Rosman Jodhbir Singth Mehta Haotian Lin Darren Shu Jeng Ting Daniel Shu Wei Ting | 2024 | Eye and Vision2024，10，1： | 0 |
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