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    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Induction of the PAOhl/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells 显示文摘DEVEREUX W WANG Y STEWART TM 2003Cancer Chemother Pharmacol2003,52,5:1
3Risk of adverse outcomes as- seeiated with concomitant use of clopidogrel and proton pump inhibi- tors following acute coronary syndrome 显示文摘Ho PM Maddox TM Wang L 2009JAMA2009,301,9:1
4Functional difference of the PDS gene product are associated c phenotypic variation in patients c pendred syndrome & non-syndromic hearing loss (DFNB4) 显示文摘Scott DA Wang R Kreman TM 2000Hum Mol Genet2000,9,11:1
5Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism显示文摘Wang A Holcslaw T Bashore TM 2000Kidney Int2000,57,4:1
6Glucose downregulation of PKG-I protein mediates increased thrombospondinl-dependent TGF-{beta} activity in vascular smooth muscle cells 显示文摘Wang S Lincoln TM Murphy-Ullrich JE 2010Am J Physiol Cell Physiol2010,298,5:1
7Rapid determination of gefitinib and its main metabolite, O-desmethyl gefitinib in human plasma using liquid chromatography-tandem mass spectrometry显示文摘Wang LZ Lim MY Chin TM 2011J Chromatogr B Analyt Technol Biomed Life Sci2011,879,22:1
8Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome显示文摘HO PM MADDOX TM WANG L et ol 2010JAMA2010,301,9:1
9SLOOP dissociates myosin IIA fila- ments and focal adhesion sites to reduce cell adhesion and enhance cell migration显示文摘Du M Wang G Ismail TM 2012J Biol Chem2012,287,15:1
10Effect of schisandrin B on lipoperoxidative damage to plasma membrane of rat liver in vitro 显示文摘Zhang TM Wang BN Liu G 1992Acta Pharma col Sin1992,13,:1
11Squamous cell carcinoma of the bladder:a ten-year retrospective study显示文摘Wang TM Chang PL Huang ST 1998Changgeng Yi Xue Za Zhi1998,21,4:1
12Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome显示文摘Ho PM Maddox TM Wang L et a1 0,,:1
13Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome显示文摘Ho PM Maddox TM Wang L 0,,09:1
14Type I interferons protect mice against enterovirus 71 infection 显示文摘Liu ML Lee YP Wang YF Lei HY Liu CC Wang SM Su IJ Wang JR Yeh TM Chen SH Yu CK 2005J Gen Virol2005,86,12:1
15Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome显示文摘Ho PM Maddox TM Wang L 2009JAMA2009,301,9:1
16On graphical and numerical representation of protein sequences 显示文摘Bai FL Wang TM 2006Journal of Biomolecular Structure & Dynamics2006,23,5:1
17Surgical management of carotid body tumors otolaryngology 显示文摘Wang SJ Wang MB Barauskas TM 2000Head Neck Surg2000,123,:1
18Increasing damage to tu- mor blood vessels during motexafin lutetium-PDT through use of low fluence rate显示文摘Busch TM Wang HW Wileyto EP 2010Radiat Res2010,174,3:1
19A new mapping rule for RNA secondary structures with its applications显示文摘BAI FL LI DC WANG TM 0,,:1
20Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute conary syndrome显示文摘Ho PM Maddox TM wang L 2009JAMA2009,301,9:1
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