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| 1 | Modeling and optimal energy management of a power split hybrid electric vehicle显示文摘With the combination modes of engine and two electric machines,the power split device allows higher efficiency of the engine.The operation and of a power split HEV are analyzed,and the system dynamic model HEV is established event-driven for HEV forward system simulation dynamics controller design.Considering the mode,the fact the mode that the operation modes of is the are and the the is continuous theory.time-driven this for each structure selection of the controller built and the described finite with hybrid automaton control In control structure,process is depicted by the state mode machine(FSM).The multi-mode switch controller is designed to realize power distribution.Furthermore,vehicle operations programming are optimized,and finite the prediction nonlinear model horizon.predictive control(NMPC)strategy is applied by that implementing the dynamic(DP)and in the Comparative simulation The results optimal demonstrate strategy hybrid in control structure is effective feasible for HEV energy management design.NMPC is superior improving fuel economy. | SHI DeHua WANG ShaoHua Pierluigi Pisu CHEN Long WANG RuoChen WANG RenGuang | 2017 | Science China(Technological Sciences)2017，60，5： | 14 |
| 2 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 3 | Partial discharge measurement and analysis under lightning impulse superimposed DC voltage in SF6 gas显示文摘The presence of lightning impulses(LIs)on the DC waveform can seriously influence the insulation performance of a GIL system.The waveshape can be a superposition of the DC and impulse waveform.In this study,the behaviour of partial discharge(PD)on an epoxy surface is investigated under DC and LI superimposed voltage in SF6.The lightning impulses with different polarities are superimposed on the epoxy surface under both positive and negative DC voltages,respectively.Positive lightning impulses are superimposed on a negative DC voltage with a 90%of the partial discharge inception voltage(PDIV)magnitude.The number and amplitude of the PDs are used to evaluate the insulation performance.The experimental results show that the LI with a different polarity applied to DC can excite the PDs on the epoxy surface.The excitation effect of positive LI superimposed on negative DC is more significant.According to the impulse amplitude and PD characteristics,the influence of superimposed LI on PD excitation can be divided into three stages.As the superimposed LI increases,the amplitude of the excited PD increases gradually,while the PD number first increases and then decreases.This study is expected to provide reference for manufacture and protection of power equipment. | Haotian Wang Cong He Ruochen Guo Xuan Meng Wenze Yuan Junhao Li | 2022 | High Voltage2022，7，4： | 3 |
| 4 | Drift potential of UAV with adjuvants in aerial applications显示文摘The reduction of pesticide aerial spraying drift is still one of the major challenges in modern agriculture.The aim of this study was to evaluate the drift potential of different types of unmanned aerial vehicle(UAV)and adjuvant products for reducing spray drift in aerial applications.Three types of UAV(3WQF120-12 and 3CD-15 fuel oil powered single-rotor UAV and HY-B-15L battery powered single-rotor UAV)were selected in this study with regular application parameters to compare each spray drift,and 3WQF120-12 fuel oil powered UAV was selected to quantify spray drift of 6 adjuvants dissolved in water under field conditions.Solutions were marked with brillant sulfoflavin dye(BSF)at 0.1%.Petri dishes and rotary impactors were used to collect airborne and sediment drift,respectively.Drift deposits were evaluated by spectrophotometry in order to quantify deposits.The results showed that when the flight height was 1.5-2.0 m above the crop at the flight speed of 4-5 m/s and the average wind speed of 1.63-1.73 m/s,3WQF120-12 fuel oil powered UAV had lower drift potential than the other two types;DV0.5 and percentage of droplets with diameter≤75μm had very significant effects on spray drift percentage(p=0.01);the risk of drift in agricultural spraying could be significantly decreased not only by reducing the percentage of fine droplets but also by changing droplet spectra.Compared to water,Silwet DRS-60,ASFA+B,T1602,Break-thru Vibrant,QF-LY and Tmax could reduce by 65%,62%,59%,46%,42%,and 19%spray drift,respectively.when water without adjuvants were sprayed,90%of drift droplets were located within a range of 10.1 m of the target area while with 0.8%Silwet DRS-60 adjuvant in water,the distance was shortened to 6.4 m. | Xiaonan Wang Xiongkui He Jianli Song Zhichong Wang Changling Wang Shilin Wang Ruochen Wu Yanhua Meng | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 3 |
| 5 | Modeling and test on height adjustment system of electrically-controlled air suspension for agricultural vehicles显示文摘To reduce the damages of pavement,vehicle components and agricultural product during transportation,an electric control air suspension height adjustment system of agricultural transport vehicle was studied by means of simulation and bench test.For the oscillation phenomenon of vehicle height in driving process,the mathematical model of the vehicle height adjustment system was developed,and the controller of vehicle height based on single neuron adaptive PID control algorithm was designed.The control model was simulated via Matlab/Simulink,and bench test was conducted.Results show that the method is feasible and effective to solve the agricultural vehicle body height unstable phenomenon in the process of switching.Compared with other PID algorithms,the single neuron adaptive PID control in agricultural transport vehicle has shorter response time,faster response speed and more stable switching state.The stability of the designed vehicle height adjustment system and the ride comfort of agricultural transport vehicle were improved. | Chen Yuexia Chen Long Wang Ruochen Xu Xing Shen Yujie Liu Yanling | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 3 |
| 6 | S4Net: Single stage salient-instance segmentation显示文摘In this paper, we consider salient instance segmentation. As well as producing bounding boxes,our network also outputs high-quality instance-level segments as initial selections to indicate the regions of interest. Taking into account the category-independent property of each target, we design a single stage salient instance segmentation framework, with a novel segmentation branch. Our new branch regards not only local context inside each detection window but also the surrounding context, enabling us to distinguish instances in the same scope even with partial occlusion.Our network is end-to-end trainable and is fast(running at 40 fps for images with resolution 320 × 320). We evaluate our approach on a publicly available benchmark and show that it outperforms alternative solutions. We also provide a thorough analysis of our design choices to help readers better understand the function of each part of our network. Source code can be found at http://gffzz188fe103f8f1460askqk59v55wxun6c6v.ffgz.tsg.suse.edu.cn/Ruochen Fan/S4 Net. | Ruochen Fan Ming-Ming Cheng Qibin Hou Tai-Jiang Mu Jingdong Wang Shi-Min Hu | 2020 | Computational Visual Media2020，6，2： | 2 |
| 7 | 近年中国北方草地变绿受降水增加的驱动显示文摘中国北方的暖湿化是近期的热点话题,然而其对植被生长的影响仍不清楚。本研究基于长时间序列(1982–2018年)数据,研究了归一化植被指数(NDVI)的时间动态及其气候驱动因子之间的关系,以探索近年来气候的暖湿化是否会导致该区植被变绿。我们采用分段回归探测了NDVI的变化趋势是否存在转变点,用Pearson相关分析描述了植被指数与气候因子的关系。最后,采用逐步多元回归方法研究了气候因子对NDVI时间变化的贡献率。研究结果表明,NDVI时间变化趋势的转变点出现在2008年,GIMMS NDVI在1982–2008年略有增加,上升速率为0.00022 yr?1,在2008–2015年上升速率达到0.002 yr?1,MODIS NDVI在2008–2018年上升速率为0.0018 yr?1。降水是NDVI变化的主要驱动因子,气温和饱和水汽压差(VPD)对NDVI的变化影响较小。总体看来,NDVI时间序列变化趋势存在转变点,并且近期气候的暖湿化主导了中国北方草地植被变绿,这为今后更好地预测该地区气候变化下的植被覆盖变化提供了依据。 | Kai Di Zhongmin Hu Mei Wang Ruochen Cao Minqi Liang Genan Wu Ruru Chen Guangcun Hao Yaolong Zhao | 2021 | Journal of Plant Ecology2021，14，5： | 2 |
| 8 | Investigation on hierarchical control for driving stability and safety of intelligent HEV during car-following and lane-change process显示文摘The longitudinal and lateral coordinated control for autonomous vehicles is fundamental to achieve safe and comfortable driving performance.Aiming at this for hybrid electric vehicles(HEV)during the car-following(CF)and lane-change(LC)process while accelerating,a hierarchical control strategy for vehicle stability control is proposed.This new approach is different from the conventional hierarchical control.On the basis of model predictive control(MPC)theory,a two-layer MPC controller is designed at the top level of the control structure.The upper layer is a linear time-varying MPC(LTV-MPC),while the lower layer is a hybrid MPC(HMPC).For the LTV-MPC controller,a control-oriented linear discrete model for HEV is established,which integrates the dynamic model with three degrees of freedom(DOF)and the car-following model.The lower-layer HMPC controller is designed on the basis of the analysis for HEV hybrid characteristics and the modelling for the mixed logic dynamic(MLD)model of the HEV powertrain.As for the bottom level,a control plant including the HEV powertrain model and the 7 DOF nonlinear dynamics of the vehicle body is established.In addition,the system stability is proven.A deep fusion of vehicle dynamics control and energy management is achieved.Compared with LC-ACC control and conventional ACC control,the simulation and the hardware-in-the-loop(HIL)test results under different driving scenarios show that the proposed hierarchical control strategy can effectively maintain lateral stability and safety under severe driving conditions.Additionally,the HEV powertrain output torque and the gear-shift point are coordinated and controlled by the HMPC controller. | ZHOU YaZhou WANG RuoChen DING RenKai SHI DeHua YE Qing | 2022 | Science China(Technological Sciences)2022，65，1： | 1 |
| 9 | Chaotic Motion in a Nonlinear Car Model Excited by Multi-frequency Road Surface Profile显示文摘In order to solve the problem that existing nonlinear suspension models have not considered chaotic motion in primary and other resonances, and numerical calculation model is too simplified to capture the accurate critical conditions for the chaotic motion, a nonlinear suspension model and its new paths of chaos are investigated. Primary resonances, secondary resonances, and combined resonances are performed using multiple-time scales method. Based on the Melnikov functions, the critical conditions for the chaotic motion of the nonlinear system are found, which is 0.246 7 for the primary resonance, and 0.338 8 for the secondary resonance. The effects of parameters on chaotic range are considered, and results show that nonlinear stiffness of suspension k2 has the largest impact on the chaotic range while damping coefficient C1 has the smallest one. The chaotic responses on the area of the primary and secondary resonances are discussed via Lyapunov exponents and numerical integration of the equations of motion. It is found from Lyapunov exponents and Poincare′ maps that motions are chaos over critical conditions, and has shown two very different paths of chaos on the primary and secondary resonances. Chaotic motion patterns in the primary and secondary resonances are obtained with more accurate critical conditions, which is a necessary complement to nonlinear study in nonlinear suspension mode. | Yuexia CHEN Long CHEN King XU Ruochen WANG Xiaofeng YANG | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 1 |
| 10 | A facile method for the fabrication of IM-5 hollow zeolite sphere in emulsion system显示文摘 | Lei Wang Weiya Yang Fengxiang Ling Zhiqi Shen Ruochen Yang Wanfu Sun Xiangchen Fang Honghai Ji | 2012 | Microporous and Mesoporous Materials2012，，： | 1 |
| 11 | SRSF1通过调控DBF4B的可变剪接来阻断DNA损伤和促进肿瘤的形成显示文摘文章简介DBF4B是细胞周期S期促进激酶Cdc7的调控因子,与Cdc7激酶一起参与并调控DNA复制的起始与进程,在细胞周期中发挥重要的调控作用。本研究报道了细胞周期相关蛋白DBF4B剪接异构体及剪接调控因子SRSF1在结直肠癌发生发展中的调控作用。 | Linlin Chen Chunling Luo Lei Shen Yuguo Liu Qianqian Wang Chang Zhang Ruochen Guo Yanan Zhang Zhiqin Xie Ning Wei Wenwu Wu 韩军 冯英 | 2018 | 科学新闻2018，0，4： | 0 |
| 12 | Correlating the electronic structures of metallic/semiconducting MoTe_(2)interface to its atomic structures显示文摘Contact interface properties are important in determining the performances of devices that are based on atomically thin two-dimensional(2D)materials,especially for those with short channels.Understanding the contact interface is therefore important to design better devices.Herein,we use scanning transmission electron microscopy,electron energy loss spectroscopy,and first-principles calculations to reveal the electronic structures within the metallic(1T)-semiconducting(2H)MoTe_(2)coplanar phase boundary across a wide spectral range and correlate its properties to atomic structures.We find that the 2 H-MoTe_(2)excitonic peaks cross the phase boundary into the 1 T phase within a range of approximately 150 nm.The1 T-MoTe_(2)crystal field can penetrate the boundary and extend into the 2H phase by approximately two unit-cells.The plasmonic oscillations exhibit strong angle dependence,that is a red-shift ofπ+σ(approximately 0.3–1.2 e V)occurs within 4 nm at 1 T/2 H-MoTe_(2)boundaries with large tilt angles,but there is no shift at zero-tilted boundaries.These atomic-scale measurements reveal the structure–property relationships of the 1 T/2 H-MoTe_(2)boundary,providing useful information for phase boundary engineering and device development based on 2 D materials. | Bo Han Chen Yang Xiaolong Xu Yuehui Li Ruochen Shi Kaihui Liu Haicheng Wang Yu Ye Jing Lu Dapeng Yu Peng Gao | 2021 | National Science Review2021，8，2： | 0 |
| 13 | Mesenchymal stem cells:As a multi-target cell therapy for clearingβ-amyloid deposition in Alzheimer’s disease显示文摘Extracellularβ-amyloid(Aβ)plaques and neurofibrillary tangles(NFTs)are the pathological hallmarks of Alzheimer’s disease(AD).Studies have shown that aggregates of extracellular Aβcan induce neuroinflammation mediated neurotoxic signaling through microglial activation and release of pro-inflammatory factors.Thus,modulation of Aβmight be a potential therapeutic strategy for modifying disease progression.Recently,a large number of reports have confirmed the beneficial effects of mesenchymal stem cells(MSCs)on AD.It is believed to reduce neuroinflammation,reduce Aβamyloid deposits and NFTs,increase acetylcholine levels,promote neurogenesis,reduce neuronal damage,and improve working memory and cognition.In this review,we focus on the role of MSCs in clearing Aβdeposition.MSCs have the potential to modulate Aβ-related microenvironments via enhancement of autophagy,proteolysis of Aβaggregates,phagocytic clearance of Aβby microglial M2 polarization,decrease oxidative stress(OS),and correction of abnormal sphingolipid(SL)metabolism.With advantages in clinical applications,these data suggest that the use of MSCs as a multi-target modulator of Aβwould be an effective therapeutic approach in AD. | RUXIN ZHANG CHENGGANG LI RUOCHEN DU YITONG YUAN BICHUN ZHAO YUJUAN ZHANG CHUNFANG WANG | 2022 | BIOCELL2022，46，3： | 0 |
| 14 | Numerical investigation of co-flow jet airfoil with parabolic flap显示文摘Both the Active Flow Control(AFC)and the variable-camber technology are considered as efficient ways to enhance the aerodynamic performance of an aircraft.The present study investigated the feasibility of the combination of a Co-Flow Jet(CFJ)airfoil and a parabolic flap,where the Reynolds Average Navier-Stokes(RANS)equations and the Spalart-Allmaras(S-A)turbulence model were exploited for the numerical simulation.Several significant geometric parameters,including the injection slot location,the suction slot location,the injection slot angle,the suction slot angle and the airfoil Suction Surface Translation(SST),were selected to study their effects on the aerodynamics of the proposed configuration.Then,an optimized design was created and compared with the baseline airfoil.The results show that the CFJ airfoil combined with the parabolic flap is more beneficial to the aerodynamic performance enhancement at small angles of attack.It is preferable to locate the injection slot at a 2%chord-wise location and the suction slot at a 75%chord-wise location.Both the decrease of the injection slot angle and the augmentation of the suction slot angle could reduce the drag.Furthermore,the SST of 0.5%chord is selected due to its high gain in the corrected aerodynamic efficiency at small angles of attack.Compared with the baseline,the optimized design could increase the lift coefficient and the corrected lift-to-drag ratio by 32.1%and 93.8%respectively at the angle of attack a=4°. | Ruochen WANG Xiaoping MA Guoxin ZHANG Pei YING Xiangyu WANG | 2023 | Chinese Journal of Aeronautics2023，36，5： | 0 |
| 15 | Gene expression of granulosa and cumulus cells: The prospect inpredicting the quality and developmental competence of oocytesin vitro maturation显示文摘In vitro maturation(IVM),a promising assisted reproductive technology(ART),has been evolving in clinical trials and applications.There is a huge potential demand for IVM in clinical practice because it reduces the stimulation of gonadotropins to patients and provides evidence for the safety of neonatal birth.Unfortunately,the maturation rate of oocytes in vitro is not as high as it is in vivo due to a different microenvironment.Moreover,there are still controversies in predicting the developmental capability of oocytes in IVM.The granulosa cells(GCs)and cumulus cells(CCs),closely surrounding the oocytes,play a critical role in oocytes development,while some studies have shown that they can reflect the quality of oocytes.Many studies have been conducted in terms of oocyte quality in transcriptional level in GCs and CCs of mice,Xenopus africanus,and Homo sapiens,which provides important enlightenment for the successful clinical application of IVM.However,no comprehensive reviews about how gene expression profiles affect oocytes quality have been reported.This review aimed to elucidate the gene expression profiles of GCs and CCs that have effects on the quality and developmental competence of oocytes maturation in vitro.And we also put forward a possible idea for ART in the future,integrating all gene expression profiles of GCs and CCs and predicting the quality of the oocytes. | BICHUN ZHAO XUEQING WU YITONG YUAN YUANTAO GAO XIAO LI RUOCHEN DU SUMING XU RUXIN ZHANG CHUNFANG WANG | 2020 | BIOCELL2020，44，4： | 0 |
| 16 | CCDC25:precise navigator for neutrophil extracellular traps on the prometastatic road显示文摘The dissemination of cancer cells called metastasis accounts for the majority of deaths of cancer patients.Neutrophil extracellular traps(NETs)released by neutrophils to fight pathogens have been shown to promote metastasis in mouse models.However,the mechanism behind how NETs boost metastasis remains elusive.In a recent study in Nature,1 Yang et al reported that NETs are abundant in the liver metastases of patients with breast and colon cancers,and that the risk of liver metastasis in patients with earlystage breast cancer can be predicted by monitoring the levels of serum NETs.Furthermore,Yang et al.1 elucidated that the DNA component of NETs(NET-DNA)acts as a chemotactic factor that is recognized by coiled-coil domain containing protein 25(CCDC25),a cytoplasmic membrane-localized extracellular DNA sensor of cancer cells,which in turn activates the integrin-linked kinase(ILK)–β-parvin–RAC1–CDC42 cascade to promote metastasis(Fig.1).The clinical importance of CCDC25 was confirmed by Yang et al.,1 and targeting CCDC25 inhibits NET-mediated metastasis in mouse models,suggesting a potential therapeutic strategy to halt the metastasis. | Ruochen Liu Erhu Zhao Feng Wang Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 17 | Improving the Accuracy of Vegetation Index Retrieval for Biomass by Combining Ground-UAV Hyperspectral Data-A New Method for Inner Mongolia Typical Grasslands显示文摘Grassland biomass is an important parameter of grassland ecosystems.The complexity of the grassland canopy vegetation spectrum makes the long-term assessment of grassland growth a challenge.Few studies have explored the original spectral information of typical grasslands in Inner Mongolia and examined the influence of spectral information on aboveground biomass(AGB)estimation.In order to improve the accuracy of vegetation index inversion of grassland AGB,this study combined ground and Unmanned Aerial Vehicle(UAV)remote sensing technology and screened sensitive bands through ground hyperspectral data transformation and correlation analysis.The narrow band vegetation indices were calculated,and ground and airborne hyperspectral inversion models were established.Finally,the accuracy of the model was verified.The results showed that:(1)The vegetation indices constructed based on the ASD FieldSpec 4 and the UAV were significantly correlated with the dry and fresh weight of AGB.(2)The comparison between measured R^(2) with the prediction R^(2) indicated that the accuracy of the model was the best when using the Soil-Adjusted Vegetation Index(SAVI)as the independent variable in the analysis of AGB(fresh weight/dry weight)and four narrow-band vegetation indices.The SAVI vegetation index showed better applicability for biomass monitoring in typical grassland areas of Inner Mongolia.(3)The obtained ground and airborne hyperspectral data with the optimal vegetation index suggested that the dry weight of AGB has the best fitting effect with airborne hyperspectral data,where y=17.962e^(4.672x),the fitting R^(2) was 0.542,the prediction R^(2)was 0.424,and RMSE and REE were 57.03 and 0.65,respectively.Therefore,established vegetation indices by screening sensitive bands through hyperspectral feature analysis can significantly improve the inversion accuracy of typical grassland biomass in Inner Mongolia.Compared with ground monitoring,airborne hyperspectral monitoring better reflects the inversion of actual surface biomass.It provides a reliable modeling framework for grassland AGB monitoring and scientific and technological support for grazing management. | Ruochen Wang Jianjun Dong Lishan Jin Yuyan Sun Taogetao Baoyin Xiumei Wang | 2024 | Phyton-International Journal of Experimental Botany2024，93，2： | 0 |
| 18 | Context-Based AI Translation From a Globalization Perspective:A Case Study of ChatGPT显示文摘The trend of globalization has brought new requirements to existing translation industry.Need for flexibility calls for contextualized translation that can be applied to various scenarios.This is an exploratory case study of ChatGPT,aiming at discovering potential of artificial intelligence(AI)translation tools.ChatGPT is compared with machine-aided translation tools like Google Translate,Microsoft Translate,Youdao Translate,and Baidu Translate.Data were collected based on accuracy of terminologies in the fields of economy,politics,and arts.This study found that ChatGPT translation has more contextual understanding that makes the generative translation more accurate and more relevant to specific fields.This study also analyzes its economic and cultural benefits to the process of globalization. | CHENG Yuxin WANG Ruochen CHEN Jiawei CHAO Yijun Aliye Maimaitili ZHANG Haoruo | 2023 | Sino-US English Teaching2023，20，9： | 0 |
| 19 | The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants显示文摘Coronavirus disease 2019(COVID-19),the disease caused by infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients. | Ben Hu Ran Liu Xiaolu Tang Yuchen Pan Ming Wang Yongqing Tong Guangming Ye Gaigai Shen Ruochen Ying Aisi Fu Di Li Wanxu Zhao Jing Peng Jie Guo Dong Men Xinmin Yao Yirong Wang Hong Zhang Zhihui Feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping Zhang Yirong Li Bende Liu Lilei Yu Yan Li Jian Lu Tiangang Liu | 2021 | National Science Review2021，8，8： | 0 |
| 20 | Comparison of intestinal absorption characteristics between rhubarb traditional Chinese medicine preparation and activity ingredients using in situ and in vitro model显示文摘Objective: The intestinal absorption characteristics of active ingredients are very important for oral administration of traditional Chinese medicine(TCM) to achieve the desired therapeutic effect.However, a deeper understanding about active ingredients absorption characteristics is still lack. The aim of this study was to investigate the absorption properties and mechanism of rhubarb active ingredients in TCM preparation and pure form.Methods: The intestinal absorption behavior of active ingredients in Shenkang extract(SKE) and rhubarb anthraquinone ingredients(RAI) were investigated by in situ single-pass intestinal perfusion model. And the bidirectional transport characteristics of these active ingredients were assessed by in vitro Caco-2 cell monolayer model.Results: In situ experiment on Sprague-Dawley rats, the effective permeability coefficient values of aloeemodin, emodin and chrysophanol in RAI were higher than those in SKE, and the value of rhein in RAI was lower than that in SKE. But the easily absorbed segments of intestine were consistent for all ingredients,whether in SKE or in RAI. In vitro experiment, the apparent permeability coefficient values of rhein, emodin and chrysophanol in RAI were higher than those in SKE, and this value of aloe-emodin in RAI was lower than that in SKE. But their efflux ratio(ER) values in SKE and RAI were all similar.Conclusion: Four rhubarb anthraquinone ingredients in SKE and RAI have similar absorption mechanism and different absorption behavior, and the microenvironment of the study models influenced their absorption behavior. The results may provide an aid for understanding of the absorption characteristics of the TCM active ingredients in complex environments and the complementarities of different research models. | Wenjing Ta Xiaoying Yang Jie Wang Chengkun Han Ruochen Hua Wen Lu | 2023 | Chinese Herbal Medicines2023，15，1： | 0 |
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