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| 1 | Integrated contra‑directionally coupled chirped Bragg grating waveguide with a linear group delay spectrum显示文摘Due to the advantages of low propagation loss,wide operation bandwidth,continuous delay tuning,fast tuning speed,and compact footprints,chirped Bragg grating waveguide has great application potential in wideband phased array beamforming systems.However,the disadvantage of large group delay error hinders their practical applications.The nonlinear group delay spectrum is one of the main factors causing large group delay errors.To solve this problem,waveguides with nonlinear gradient widths are adopted in this study to compensate for the nonlinear efect of the grating apodization on the mode efective index.As a result,a linear group delay spectrum is obtained in the experiment,and the group delay error is halved. | Xudong Gao Zhenzhu Xu Yupeng Zhu Chengkun Yang Shoubao Han Zongming Duan Fan Zhang Jianji Dong | 2023 | Frontiers of Optoelectronics2023，16，1： | 0 |
| 2 | SupraBiology 2014: Promoting UK-China collaboration on Systems Biology and High Performance Computing显示文摘 | Ettore Murabito Riccardo Colombo Chengkun Wu Malkhey Verma Samrina Rehman Jacky Snoep Shao-Liang Peng Naiyang Guan Xiangke Liao Hans V. Westerhoff | 2015 | Frontiers of Electrical and Electronic Engineering in China2015，10，1： | 0 |
| 3 | Comparison of intestinal absorption characteristics between rhubarb traditional Chinese medicine preparation and activity ingredients using in situ and in vitro model显示文摘Objective: The intestinal absorption characteristics of active ingredients are very important for oral administration of traditional Chinese medicine(TCM) to achieve the desired therapeutic effect.However, a deeper understanding about active ingredients absorption characteristics is still lack. The aim of this study was to investigate the absorption properties and mechanism of rhubarb active ingredients in TCM preparation and pure form.Methods: The intestinal absorption behavior of active ingredients in Shenkang extract(SKE) and rhubarb anthraquinone ingredients(RAI) were investigated by in situ single-pass intestinal perfusion model. And the bidirectional transport characteristics of these active ingredients were assessed by in vitro Caco-2 cell monolayer model.Results: In situ experiment on Sprague-Dawley rats, the effective permeability coefficient values of aloeemodin, emodin and chrysophanol in RAI were higher than those in SKE, and the value of rhein in RAI was lower than that in SKE. But the easily absorbed segments of intestine were consistent for all ingredients,whether in SKE or in RAI. In vitro experiment, the apparent permeability coefficient values of rhein, emodin and chrysophanol in RAI were higher than those in SKE, and this value of aloe-emodin in RAI was lower than that in SKE. But their efflux ratio(ER) values in SKE and RAI were all similar.Conclusion: Four rhubarb anthraquinone ingredients in SKE and RAI have similar absorption mechanism and different absorption behavior, and the microenvironment of the study models influenced their absorption behavior. The results may provide an aid for understanding of the absorption characteristics of the TCM active ingredients in complex environments and the complementarities of different research models. | Wenjing Ta Xiaoying Yang Jie Wang Chengkun Han Ruochen Hua Wen Lu | 2023 | Chinese Herbal Medicines2023，15，1： | 0 |
| 4 | A broadband integrated microwave photonic mixer based on balanced photodetection显示文摘An integrated microwave photonic mixer based on silicon photonic platforms is proposed,which consist of a dual-drive Mach–Zehnder modulator and a balanced photodetector.The modulated optical signals from microwave photonic links can be directly demodulated and down-converted to intermediate frequency(IF)signals by the photonic mixer.The converted signal is obtained by conducting of-chip subtraction of the outputs from the balanced photodetector,and subsequent fltering of the high frequency items by an electrical low-pass flter.Benefting from balanced detection,the conversion gain of the IF signal is improved by 6 dB,and radio frequency leakage and common-mode noise are suppressed signifcantly.System-level simulations show that the frequency mixing system has a spurious-free dynamic range of 89 dB·Hz^(2/3),even with deteriorated linearity caused by the two cascaded modulators.The spur suppression ratio of the photonic mixer remains higher than 40 dB when the IF varies from 0.5 to 4 GHz.The electrical-electrical 3 dB bandwidth of frequency conversion is 11 GHz.The integrated frequency mixing approach is quite simple,requiring no extra optical flters or electrical 90°hybrid coupler,which makes the system more stable and with broader bandwidth so that it can meet the potential demand in practical applications. | Zhenzhu Xu Li Mei Yuhua Chong Xudong Gao Shoubao Han Chengkun Yang Lin Li | 2023 | Frontiers of Optoelectronics2023，16，2： | 0 |
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