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| 1 | Decline of semen quality during IVF is not associated with subjective male stress显示文摘如果精液质量衰退在期间,现在的学习的目的是估计在 vitro 授精(IVF ) 并且这现象是否被长期的男应力触发。以便测试这个假设,我们首先调查了 155 个男 IVF 病人(严峻的队) 的一个回顾的队。随后,我们在经历他们的第一 IVF 的人开始了未来的队研究并且用一个验证工具估计了精液质量和主观男长期的应力,即富饶问题库存(FPI ) 问询表。在应力和精子质量衰落之间的协会在 IVF (T1 ) 的开始前是 4-6 星期,在卵母细胞的日子,检索(T2 ) 是主要结果。实时出生率,第一三个月流产和差的应答者的率是第二等的结果。在严峻的队,吝啬的进步活动性,然而并非吝啬的精子密度显著地衰退了。有 78/154 (51%) 人和在进步活动性显示出衰落的 50/154 (32%) 人,在精液密度看了衰落。在确认队,进步活动性衰退了,而,从 T1 增加到 T2 的精子密度。78 个人, 27 个人增加了应力(FPI 分数 >146 ) 。精子密度和进步活动性不在有或没有应力的人是显著地不同的。面对男应力,然而,夫妇们有差的应答者,流产和实时出生的更低的率的更高的率。主观应力没在在 IVF 期间观察的精液质量与衰落被联系,但是可以与不利怀孕结果被联系。 | Kazem Nouri Brigitte Litschauer Michael Sator Denise Tiringer Johannes Ott Katherina Walch Lukas A Hefler Clemens B Tempfer | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 2 | Serologic markers of autoimmunity in women with polycystic ovary syndrome显示文摘 | Katrin Hefler-Frischmuth Katharina Walch Wolfgang Huebl Konstantin Baumuehlner Clemens Tempfer Lukas Hefler | 2010 | Fertility and Sterility2010，，7： | 2 |
| 3 | Fibrinogen plasma levels are an independent prognostic parameter in patients with cervical cancer显示文摘 | Stephan Polterauer Veronika Seebacher Katrin Hefler-Frischmuth Christoph Grimm Georg Heinze Clemens Tempfer Alexander Reinthaller Lukas Hefler | 2009 | American Journal of Obstetrics and Gynecology2009，，6： | 2 |
| 4 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 5 | hnmunohistochemi- eal detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP-2) in stage Ⅰ and Ⅱ endometrial cancer 显示文摘 | Moser PL Hefler L Tempfer C | 1999 | Anticancer Res1999，19，3： | 1 |
| 6 | Vascular endothelial growth factor gene polymorphisms are associated with prognosis in Ovarian cancer显示文摘 | Hefler LA Mustea A Konsgen D | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 7 | Periurethral connective tissue status of post menopausal women with genital prolapse with and without stress incontinence显示文摘 | Goepel C Hefler L Methfessel H | 2003 | Acta Obstet Gynecol Scand2003，82，7： | 1 |
| 8 | The correlation between immunohistochemically-detected markers of angiogenesis and serum vascular endothelial growth factor in patients with breast cancer显示文摘 | Lantzsch T Hefler L Kranse U | 2002 | Antieancer Res2002，22，3： | 1 |
| 9 | Tumor anemia and thrombocytosis in patients with vulvar cancer显示文摘 | Hefler L Mayerhofer K Leibman B | 2000 | Tumour Biol2000，21，5： | 1 |
| 10 | Vascular endothelial growth factor serum levels in pregnancy and preeclampsia 显示文摘 | Hefler L Obermair A Husslein P | 2000 | Acta Obstet Gynecol Scand2000，79，1： | 1 |
| 11 | The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma:a multicenter study显示文摘 | Hefler LA Rosen AC Graf AH | 2000 | Cancer2000，89，7： | 1 |
| 12 | The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma: a multicenter study 显示文摘 | Hefler LA Rosen AC Graf AH | 2000 | Cancer2000，89，7： | 1 |
| 13 | Vascular endothelial growth factor in the serum concentration in ovarian cancer显示文摘 | Tempfer C Obermair A Hefler L | 1998 | Obstet Gynecol1998，92，1： | 1 |
| 14 | Serum vascular endothelial growth factor serum concentrations in ovarian cancer显示文摘 | Obermair A Hefler L | 1998 | Obstet Gynecol1998，92，3： | 1 |
| 15 | Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 ( TIMP 2) in stage IB cervical cancer显示文摘 | Moser PL Kieback DG Hefler L | 1999 | Anticancer Res1999，19，5： | 1 |
| 16 | Vascular endothelial growth factor serum levels in pregnancy and preeclampsia 显示文摘 | Hefler L Obermair A Husslein P et aI | 2000 | Acta Obstet Gynecol Scand2000，11，1： | 1 |
| 17 | The prognostic value of immunohisochemically detected CD44v3 and CD44v6 expression in patients with surgically staged vulvar carcinoma : a multieenter study显示文摘 | HEFLER L A CONCIN N MINCHAM D | 2002 | Cancer2002，94，： | 1 |
| 18 | The prognostic value of immunohistochemicalty detected CD44v3 and CD44v6 expression in patients with surgically staged vulvar carcinoma: a muhicenter study 显示文摘 | Hefler LA Concin N Mincham D | 2002 | Cancer2002，94，1： | 1 |
| 19 | The prognostic value of immunohistochemically detected CD44v3 and CD44v6 expression in patients with surgically staged vulvar carcinoma: a multicenter study 显示文摘 | Hefler LA Concin N Mincham D | 2002 | Cancer2002，94，1： | 1 |
| 20 | Periurethral connective tissue status of postmenopausal women with genital prolapse with and without stress incontinence显示文摘 | Goepel C Hefler L Methfessel HD | 2003 | Acta Obstet Gynecol Scand2003，82，7： | 1 |
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