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| 1 | Biliary complications in liver transplantation: Impact of anastomotic technique and ischemic time on short- and long-term outcome显示文摘AIM: To elucidate the impact of various donor recipient and transplant factors on the development of biliary complications after liver transplantation.METHODS: We retrospectively reviewed 200 patients of our newly established liver transplantation(LT) program, who received full size liver graft. Biliary reconstruction was performed by side-to-side(SS), end-to-end(EE) anastomosis or hepeaticojejunostomy(HJ). Biliary complications(BC), anastomotic stenosis, bile leak, papillary stenosis, biliary drain complication, ischemic type biliary lesion(ITBL) were evaluated by studying patient records, corresponding radiologic imaging and reports of interventional procedures [e.g., endoscopic retrograde cholangiopancreatography(ERCP)]. Laboratory results included alanine aminotransferase(ALT), gammaglutamyltransferase and direct/indirect bilirubin with focus on the first and fifth postoperative day, six weeks after LT. The routinely employed external bile drain was examined by a routine cholangiography on the fifth postoperative day and six weeks after transplantation as a standard procedure, but also whenever clinically indicated. If necessary, interventional(e.g., ERCP) or surgical therapy was performed. In case of biliary complication, patients were selected, assigned to different complication-groups and subsequently reviewed in detail. To evaluate the patients outcome, we focussed on appearance of postoperative/post-interventional cholangitis, need for rehospitalisation, retransplantation, ITBL or death caused by BC.RESULTS: A total of 200 patients [age: 56(19-72), alcoholic cirrhosis: n = 64(32%), hepatocellular carcinoma: n = 40(20%), acute liver failure: n = 23(11.5%), cryptogenic cirrhosis: n = 22(11%), hepatitis B virus /hepatitis C virus cirrhosis: n = 13(6.5%), primary sclerosing cholangitis: n = 13(6.5%), others: n = 25(12.5%) were included. The median follow-up was 27 mo until June 2015. The overall biliary complication rate was 37.5%(n = 75) with anastomotic strictures(AS): n = 38(19%), bile leak(BL): n = 12(6%), biliary drain complication: n = 12(6%); papillary stenosis(PS): n = 7(3.5%), ITBL: n = 6(3%). Clinically relevant were only 19%(n = 38). We established a comprehensive classification for AS with four grades according to clinical relevance. The reconstruction techniques [SS: n = 164, EE: n = 18, HJ: n = 18] showed no significant impact on the development of BCs in general(all n < 0.05), whereas in the HJ group significantly less AS were found(P = 0.031). The length of donor intensive care unit stay over 6 d had a significant influence on BC development(P = 0.007, HR = 2.85; 95%CI: 1.33-6.08) in the binary logistic regression model, whereas other reviewed variables had not [warm ischemic time > 45 min(P = 0.543), cold ischemic time > 10 h(P = 0.114), ALT init > 1500 U/L(P = 0.631), bilirubin init > 5 mg/d L(P = 0.595), donor age > 65(P = 0.244), donor sex(P = 0.068), rescue organ(P = 0.971)]. 13%(n = 10) of BCs had no therapeutic consequences, 36%(n = 27) resulted in repeated lab control, 40%(n = 30) received ERCP and 11%(n = 8) surgical therapy. Fifteen(7.5%) patients developed cholangitis [AS(n = 6), ITBL(n = 5), PS(n = 3), biliary lesion BL(n = 1)]. One patient developed ITBL twelve months after LT and subsequently needed retransplantation. Rehospitalisation rate was 10.5 %(n = 21) [AS(n = 11), ITBL(n = 5), PS(n = 3), BL(n = 1)] with intervention or reinterventional therapy as main reasons. Retransplantation was performed in 5(2.5%) patients [ITBL(n = 1), acute liver injury(ALI) by organ rejection(n = 3), ALI by occlusion of hepatic artery(n = 1)]. In total 21(10.5%) patients died within the follow-up period. Out of these, one patient with AS developed severe fatal chologenic sepsis after ERCP.CONCLUSION: In our data biliary reconstruction technique and ischemic times seem to have little impact on the development of BCs. | Stefan Kienlein Wenzel Schoening Anne Andert Daniela Kroy Ulf Peter Neumann Maximilian Schmeding | 2015 | World Journal of Transplantation2015，5，4： | 14 |
| 2 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 3 | 定常吹/吸气控制凸包分离的数值研究显示文摘针对凸包流动分离主动控制开展了参数化数值研究。凸包模型为NA SA设计用于流动分离主动控制的内外流通用模型。重点研究运行参数变化时定常吹/吸气影响。首先采用试验数据标定了所开发程序,然后进行了一系列参数化数值模拟。结果显示:定常吸气作用明显不同于定常吹气。对于所给定几何模型,不管吸气流量增加到多大,吸气都无法消除分离,而吹气可以做到。详细展示流动结构并讨论了流动机理。 | 季路成 林峰 Marco P Schoen | 2006 | 航空动力学报2006，21，1： | 5 |
| 4 | Paleoarchean bedrock lithologies across the Makhonjwa Mountains of South Africa and Swaziland linked to geochemical,magnetic and tectonic data reveal early plate tectonic genes flanking subduction margins显示文摘The Makhonjwa Mountains, traditionally referred to as the Barberton Greenstone Belt, retain an iconic Paleoarchean archive against which numerical models of early earth geodynamics can be tested. We present new geologic and structural maps, geochemical plots, geo- and thermo-chronology, and geophysical data from seven silicic, mafic to ultramafic complexes separated by major shear systems across the southern Makhonjwa Mountains. All reveal signs of modern oceanic back-arc crust and subductionrelated processes. We compare the rates of processes determined from this data and balance these against plate tectonic and plume related models. Robust rates of both horizontal and vertical tectonic processes derived from the Makhonjwa Mountain complexes are similar, well within an order of magnitude, to those encountered across modern oceanic and orogenic terrains flanking Western Pacific-like subduction zones. We conclude that plate tectonics and linked plate-boundary processes were well established by 3.2-3.6 Ga. Our work provides new constraints for modellers with rates of a 'basket' of processes against which to test Paleoarchean geodynamic models over a time period close to the length of the Phanerozoic. | Maarten de Wit Harald Furnes Scott MacLennan Moctar Doucouré Blair Schoene Ute Weckmann Uma Martinez Sam Bowring | 2018 | Geoscience Frontiers2018，9，3： | 4 |
| 5 | 生物材料引起的感染、肿瘤和钙化显示文摘生物材料与宿主组织的相互作用是相当复杂的病理过程,远远超出了生物材料植入硬组织或软组织而引起的血栓形成和炎症反应。虽然这些现象的临床结果是重要的,并已广为传播,但对其机理的了解却非常浅薄。本文的目的是总结临床病理损伤和当今对生物材料与组织相互作用,以及由生物材料引起的感染、肿瘤和钙化的病理变化的解释。一、感染 1. | Schoen F J 奚廷斐 王春仁 | 1989 | 国外医学(生物医学工程分册)1989，12，1： | 4 |
| 6 | Obesity, weight change, and risk of adenoma recurrence: a prospective trial显示文摘 | A. Laiyemo C. Doubeni D. Badurdeen G. Murphy P. Marcus R. Schoen E. Lanza D. Smoot A. Cross | 2012 | Endoscopy2012，，09： | 2 |
| 7 | Transcatheter closure of patent foramen ovale in patients with cerebral ischemia显示文摘 | Braun MU Fassbender D Schoen SP | 2002 | J Am Coll Cardiol2002，39，12： | 2 |
| 8 | 生物材料的钙化—病理学、机理和预防措施显示文摘在心血管体系和非心血管体系的医用装置都可产生不同程度的钙化(即磷灰石矿物)。钙化造成目前的生物瓣失效,钙化也限制了试验性的机械血泵和临床长期使用的全人工心脏的功能寿命。目前的研究旨在阐明生物材料钙化的宿主、植入物和周围环境之间复杂的关系,并探讨有效的预防治疗方法。 | F J Schoen 奚廷斐 | 1989 | 国外医学(生物医学工程分册)1989，12，5： | 2 |
| 9 | 哥伦比亚河玄武岩的快速喷发造成了中新世的适宜气候显示文摘作为地球历史上最大的火山事件,大陆溢流玄武岩的喷发能在短时间内释放大量的CO2和SO2,因此被普遍认为可以引起全球气候变化。在中中新世气候适宜期,哥伦比亚河溢流玄武岩(CRBG)的喷发被认为与大气中CO2的升高及全球变暖有着直接的联系。然而,由于CRBG的时空分布不是很明确,关于火山作用与气候变暖的关系仍是推测。 | 夏群科 Jennifer Kasbohn Blair Schoene | 2018 | 矿物岩石地球化学通报2018，37，5： | 2 |
| 10 | Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study显示文摘 | Keith Leung Paul Pinsky Adeyinka O. Laiyemo Elaine Lanza Arthur Schatzkin Robert E. Schoen | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 11 | Pancreatic duct stones in chronic pancreatitis: Criteria for treatment intensity and success显示文摘 | Michael J. Farnbacher Christoph Schoen Thomas Rabenstein Johannes Benninger Eckhart G. Hahn H.Thomas Schneider | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 12 | 医学图书馆是超越文献的知识连接者显示文摘美国大型学术型医疗中心的图书馆正在经历从传统知识存储库到知识连接者这一新角色的转变。这种转变的推动力源于研究者、临床医生和学生使用的主要信息来源已经不再是以往图书馆的纸质资源。当前对实现学术型医疗中心使命至关重要的知识资源现在包括在线书籍和期刊、大型数据集、软件工具和远远超出图书馆壁垒的专业知识。阐述了华盛顿大学一圣路易斯Bernard Becker医学图书馆如何抓住机会,重塑自己作为超越文献而存在的知识纽带作用,并加强其在大学中作为学习和发现的催化剂的重要作用。 | Paul Schoening | 2018 | 中华医学图书情报杂志2018，27，1： | 2 |
| 13 | Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation显示文摘BACKGROUND: Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus,improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.METHODS: Male inbred Wistar rats(weighing 230-260 g) served as donors and recipients(n=6/group). Donors of treatment groups received i.v. 0.01 m L/g body weight(BW) warm(21 ℃) HTK systemically 15 minutes prior to cold perfusion. Control groups received 0.01 m L/g BW warm(21 ℃) Na Cl 0.9%. Following pretreatment,donors were flushed with 4 ℃ cold HTK,livers were explanted and stored in 4 ℃ HTK for six hours. Thereafter orthotopic liver transplantation was performed. Recipients were harvested four hours,two and five days after reperfusion and blood and liver tissue samples were obtained. Blood samples were analyzed for AST,ALT,lactate dehydrogenase and bilirubin. Liver histological analysis as well as tissue analysis for pro-MMP2,MMP2 and pro-MMP9 using zymography was conducted.RESULTS: Treatment groups showed significantly lower ALT and lactate dehydrogenase levels as well as significantly lower activities of pro-MMP2,MMP2 and pro-MMP9. Histological analysis revealed only minor damage in all groups.CONCLUSIONS: The new concept of warm HTK pretreatment significantly reduced ischemia-reperfusion injury. The reduced ischemia-reperfusion injury was due to MMP inhibition. Warm HTK donor pretreatment is easy to handle and could further improve HTK's potency in liver preservation. | Wenzel Schoening Veeravorn Ariyakhagorn Thomas Schubert Peter Olschewski Andreas Andreou Peter Neuhaus Johann Pratschke Gero Puhl | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 2 |
| 14 | The pathologic measurement of polyp size is preferable to the endoscopic estimate显示文摘 | Robert E. Schoen Lawrence D. Gerber Craig Margulies | 1997 | Gastrointestinal Endoscopy1997，，6： | 2 |
| 15 | Z-Bunionectomy:retrospective long-term study显示文摘 | Schoen NS Zygmunt K Gudas C | 1996 | J Foot Ankle Surg1996，35，： | 1 |
| 16 | A nonpeptidyl growthhormone secretagogue显示文摘 | Smith RG Cheng K Schoen WR | 1993 | Science1993，260，5114： | 1 |
| 17 | Absorptiometric determination of acid-soluble lignin in semichemical bisulfite pulps and in some woods and plants显示文摘 | SCHOENING A G JOHANSSON G | 1965 | Svensk Papperstidning1965，68，18： | 1 |
| 18 | Evolving concepts of cardiac valve dynamics:the continuum of development,functional structure,pathobiology,and tissue engineering显示文摘 | Schoen FJ | | 0，，18： | 1 |
| 19 | Comprehensive Identification of Proteins from MALDI Imaging显示文摘 | Stefan K. Maier Hannes Hahne Amin Moghaddas Gholami Benjamin Balluff Stephan Meding Cédrik Schoene Axel K. Walch Bernhard Kuster | 2013 | Molecular & Cellular Proteomics2013，，10： | 1 |
| 20 | Motor bearing damage detection using stator current monitoring 显示文摘 | Schoen R R Habetler T G Kamran F | 1995 | IEEE Transactions on Industry Applications1995，31，6： | 1 |
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