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| 1 | Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?显示文摘The molecular basis for enhanced chemosensitivity of testicular germ cell tumors(GCT)has been an area of great interest,as it could potentially give us therapeutic leads in other resistant malignancies.Thus far,however,the increased sensitivity of GCT has been variously attributed to multiple factors—an inability to detoxify cisplatin,a lack of export pumps,an inability to repair the DNA damage,an intact apoptotic cascade and lack of p53 mutation;but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive.Herein,we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α(HIF-1α)expression in mediating the general exquisite chemosensitivity of testicular GCT,through the aforementioned processes.This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies. | niraj shenoy roxana dronca fernando quevedo stephen a boorjian john cheville brian costello manish kohli thomas witzig lance pagliaro | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Performance of a bioreactor with submerged membranes for aerobic treatment of municipal waste water显示文摘 | Rosenberger S Kriiger U Witzig R | 2002 | Wat Res2002，36，： | 2 |
| 5 | Review of 1027 Patients With Newly Diagnosed Multiple Myeloma显示文摘 | Robert A. Kyle Morie A. Gertz Thomas E. Witzig John A. Lust Martha Q. Lacy Angela Dispenzieri Rafael Fonseca S. Vincent Rajkumar Janice R. Offord Dirk R. Larson Matthew E. Plevak Terry M. Therneau Philip R. Greipp | 2003 | Mayo Clinic Proceedings2003，，1： | 2 |
| 6 | Review of 1027 patients with newly diagnosed multiple myeloma显示文摘 | KYLE R A GERTZ M A WITZIG T E | 2003 | Mayo Clin Proc2003，78，1： | 1 |
| 7 | Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma显示文摘 | Kumar S Witzig T E Dispenzieri A | | 0，，： | 1 |
| 8 | Review of 1027 Patients With Newly Diagnosed Multiple Myeloma显示文摘 | Kyle RA Gertz MA Witzig TE | | 0，，： | 1 |
| 9 | Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma显示文摘 | Witzig TE Geyer SM Ghobrial I | 2005 | J Clin Oncol2005，23，23： | 1 |
| 10 | Safety of yttrium-90 ibritumomab tiuxetan radioimmunotherapy for relapsed low-grade,follicular,or transformed non-Hodgkin's lymphoma显示文摘 | Witzig TE White CA Gordon LI | 2003 | J Clin Oncol2003，21，7： | 1 |
| 11 | Introduction of apoptosis in malignant B cells by phenylbutyrate or phenylacetate in combination with chemotherapeutic agents显示文摘 | Witzig T E Timm M Stenson Mary | 2000 | Clinical Cancer Research2000，6，2： | 1 |
| 12 | Treatment with ibritumomab tiuxetan radioimmunotherapy in patients with rituximab-refractory follicular non-Hodgkin's lymphoma显示文摘 | Witzig TE Flinn IW Gordon LI | 2002 | J Clin Oncol2002，20，15： | 1 |
| 13 | Clinicopathological correlates of CD56 expression in multiple myeloma: a unique entity显示文摘 | Mathew P Ahmann G J Witzig T E | 1995 | Br J Haematol1995，90，： | 1 |
| 14 | An international phase II trial of single - agent lenalidomide for relapsed or refractory aggressive B - cell non - Hodgkin's lympho- ma显示文摘 | Witzig TE Vose JM Zinzani PL | 2011 | Ann Oncol2011，，： | 1 |
| 15 | Induction of Apoptosis in Malignant B Cells by Phenylbutyrate or Phenylacetate in Combination with Chemotherapeutic Agents显示文摘 | THOMAS E WITZIG MICHAEL TIMM | 2000 | Clinical Cancer Res2000，6，： | 1 |
| 16 | Phase 1] trial of single - agent temsirolimus( CC! - 779 ) for relapsed mantle cell lymphoma显示文摘 | Witzig TE Geyer SM Ghobrial I | 2005 | J Clin Oncol2005，23，： | 1 |
| 17 | Expression of VEGF and its receptors by myeloma cells 显示文摘 | Kumar S Witzig TE Timm M | 2003 | Leukemia2003，17，10： | 1 |
| 18 | Carcinoid tumor of the rectum显示文摘 | S. D. Fitzgerald M.D. A. P. Meagher M.B. M.S. F.R.A.C.S. P. Moniz-Pereira M.D. G. M. Farrow M.D. T. E. Witzig M.D. B. G. Wolff M.D | 1996 | Diseases of the Colon & Rectum1996，，6： | 1 |
| 19 | Targeting apoptosis pathways in cancer therapy显示文摘 | Ghobrial IM Witzig TE Adjei AA | 2005 | CA Cancer J Clin2005，55，3： | 1 |
| 20 | Review of 1027 patients with newly diagnosed multiple myeloma 显示文摘 | Kyle RA Gertz MA Witzig TE | 2003 | Mayo Clin Proc2003，78，1： | 1 |
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