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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Different patterns of angiotensin II and atrial natriuretic peptide secretion in a sheep model of atrial fibrillation显示文摘 | WILLEMS R SIPIDO K R HOLEMANS P | 2001 | J Cardiovasc Electrophysiol2001，12，12： | 2 |
| 3 | Itraconazole oral solution and intravenous formulations:a review of pharmacokinetics and pharmacodynamics显示文摘 | Willems L van der Geest R de Beule K | | 0，，： | 2 |
| 4 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 5 | 'Edge effect' of (32)P radioactive stents is caused by the combination of chronic stent injury and radioactive dose falloff显示文摘 | Willem J Evelyn R Miranda S | 2001 | Circulation2001，104，： | 1 |
| 6 | Azithromycin reduces pul- monary fibrosis in a bleomycin mouse model显示文摘 | Wuyts WA Willems S Vos R | 2010 | Exp Lung Res2010，36，： | 1 |
| 7 | Selective dorsal rhizotomy in cerebral palsy to improve functional abilities:evaluation of criteria for selection显示文摘 | PETRA E M JEROEN V WILLEM J R | 2005 | Childs Nerv Syst2005，21，6： | 1 |
| 8 | Study on the transformation of intact yeast cells by LiAc/SS-DNA/ PEG procedure 显示文摘 | Gietz R D Schiestl R H Willems A R | 1995 | Yeast1995，11，4： | 1 |
| 9 | A two-step method for forecasting spare parts demand using information on component repairs显示文摘 | Ward R Ruud T Willem V J | 2012 | Eu- ropean Journal of Operational Research2012，220，2： | 1 |
| 10 | An integrated approachfor visual analysis of a multisource moving objectsknowledge base 显示文摘 | Willems N van Hage W R de Vries G | 2010 | International Journal of Geographical InformationScience2010，24，10： | 1 |
| 11 | GPIAG national primary care conference:delivering optimal respiratory care显示文摘 | Willem R Pietersa E Williams B | 2005 | Prim Care Respir J2005，14，： | 1 |
| 12 | Surfactant protein A influences reepithelialization in an alveolocapillary model system显示文摘 | Willems C H Zimmermann L J Langen R M | 2012 | Lung2012，190，6： | 1 |
| 13 | Nonsyndromic hearing impairment:Unpairalleled heterogeneity显示文摘 | Willems P J Smith R J H | 1997 | Am J Hum Genet1997，60，： | 1 |
| 14 | Fermentation of Nondigestible Oligosaccharides by Human Colonic Bacteria显示文摘 | Gibson G R Willems A Readings S | 1996 | Proceeding of the Nutrition Soc-ity1996，55，： | 1 |
| 15 | One ring to rule a superfamily of E3 ubiqnitin ligases显示文摘 | Tyers M Willems A R | 1999 | Science1999，284，5414： | 1 |
| 16 | Immunological biomark- ers of tuberculosis显示文摘 | Gerhard W Katharina R Willem H | 2011 | Nat Rev Immunol2011，5，11： | 1 |
| 17 | Cellulase Production from Spent Lignocellulose Hydrolysates by Recombinant Aspergillus niger显示文摘 | Bjorn A Shaunita H R Willem H Z | 2009 | Applied and Environmental Microbiology2009，，4： | 1 |
| 18 | Repeated tilt testing in patients with tilt-positive neurally mediated syncope显示文摘 | Ector H Willems R Heidbuchel H | 2005 | Europace2005，7，6： | 1 |
| 19 | High occurrence of esp among ampicillin-resistant and vancomycin-susceptible Enterococcus faecium clones from hospitalized patients显示文摘 | Willems R Canton R | 2002 | J Antimicrob Chemother2002，50，8： | 1 |
| 20 | Comparison of impedance minute ventilation and direct measured minute ventilation in a rate adaptive pacemaker显示文摘 | Simon R Ni Q Willems R | | 0，，11： | 1 |
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