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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Modeling of liquefied petroleum gas Spray development,evaporation and combustion显示文摘 | Watkins A P | 2004 | Int J Engine Res2004，5，6： | 1 |
| 3 | Assessment of terminal effects of high velocity projectiles using tissue simulants显示文摘 | WATKINS F P PEARCE B P STAINER M C | 1982 | Acta Chir Scand1982，508，： | 1 |
| 4 | Modelling of Liquefied Petroleum Gas Spray Development,Evaporation and Combustion显示文摘 | Yoong A P F Watkins A P | 2004 | International Journal of Engine Research2004，5，6： | 1 |
| 5 | Associa- tion of phosphatidylinositol 3-kinase with nuclear tran- scription sites in higher plants显示文摘 | Bunney T D Watkins P A Beven A F | 2000 | The Plant Cell2000，12，9： | 1 |
| 6 | Cytochrome P4501A1 expression in human small bowel:interindividual variation and inhibition by ketoconazole显示文摘 | Paine M F Schmiedlin-Ren P Watkins P B | 1999 | Drug Metab Dispos1999，27，3： | 1 |
| 7 | Status of the GRACE Follow-on Mission显示文摘 | FLECHTNER F MORTON P WATKINS M | 2014 | Gravity Geoid and Height Systems2014，141，： | 1 |
| 8 | New insights into drug absorption studieswith sirolimus 显示文摘 | PAINE M F LEUNG L Y WATKINS P B | 2004 | Ther Drug Monit2004，26，5： | 1 |
| 9 | Genetic analysis of cytokine promoters in nonhuman primates:implications for Th1/Th2profile characteristics and SIV disease pathogenesis显示文摘 | Bostik P Watkins M Villinger F | 2004 | Clinical and Development Immunology2004，11，1： | 1 |
| 10 | Amyloid β protein gene:cDNA,mRNA distribution,and ge-netic linkage near the Alzheimer locus显示文摘 | TANZI R E GUSELLA J F WATKINS P C | | 0，，4791： | 1 |
| 11 | Assessment of terminal effects of high velocity projectiles using tissue stimulants显示文摘 | F P Watkins B P Pearce M C Stainer | | 0，，： | 1 |
| 12 | Cultivar and growing region in uenceefcacy of warming treatments for amelioration of super cial scalddevelopment on apples after storage显示文摘 | WATKINS C B BRAMLAGE W J BROOKFIELD P L REID S J WEISS S A ALWAN T F | 2000 | Postharvest Biology andTechnology2000，19，： | 1 |
| 13 | Studies of zinc transport into brush-border membranevesicles isolated from pig small intestine显示文摘 | Tacnet F Watkins DW Ripoche P | 1990 | Biochim BiophysActa1990，，2： | 1 |
| 14 | Modeling of liquefied petroleum gas spray development,evaporation and combustion显示文摘 | YOONG A P F WATKINS A P | 2004 | Engine Res2004，5，6： | 1 |
| 15 | Superficial scald, carbon dioxide injury, and changes of fermentation products and organic acids in 'Cortland' and 'Law Rome' apples after high carbon dioxide stress treatment显示文摘 | FERNANDEZ-TRUJILLO J P NOCK J F WATKINS C B | 2001 | Journal of the American society for horticultural science2001，126，2： | 1 |
| 16 | Amyloid beta protein gene:cDNA,mRNA distribution,and genetic linkage near the Alzheimer locus显示文摘 | Tanzi R E Gusella J F Watkins P C | | 0，，4791： | 1 |
| 17 | Dramatic decrease in brain reward function during nictin withdraw显示文摘 | WATKINS S S KOOB G F | 1998 | Nature1998，39，3： | 1 |
| 18 | Nitrate and periplasmic nitrate reductases 显示文摘 | Watkins C S Stolz J F Basu P | 2014 | The Royal Societ of Chemistry2014，43，： | 1 |
| 19 | Development of maturity indices for the ‘Fuji' apple cultivar in relation to watercore incidence显示文摘 | Brookfield P L Harber F R | 1993 | Acta Hort1993，326，： | 1 |
| 20 | Dramatic decreases in brain reward function during nicotine withdrawal显示文摘 | EPPING-JORDAN M P WATKINS S S KOOB G F | 1998 | Nature1998，393，： | 1 |
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