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101篇 您的检索式:作者名="WATKINS DN"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Epigenetic inactivation of SFRP gene allows constitutive WNT signaling in colorectal cancer 显示文摘Suzuki H Watkins DN Jair KW 2004Nat Genet2004,36,4:1
3Hedgehog signalling within airway epithelial progenitors and in small-cell lung Cancer显示文摘Watkins DN Berman DM Burkholder SG 0,,6929:1
4Mechanisms of Hedgehog signalling in cancer 显示文摘Marini KD Payne BJ Watkins DN 2011Growth Factors2011,29,6:1
5Developmental signaling pathways in lung cancer显示文摘Daniel VC Peacock CD Watkins DN 0,,03:1
6Sonic hedgehog signaling in- hibition provides opportunities for targeted therapy by sulfora- phane in regulating pancreatic cancer stem cell self-renewal显示文摘Rodova M FuJ Watkins DN 2012PLoS One2012,7,46:1
7Hedgehog signaling within airway epithelial progenitors and in small cell lung cancer显示文摘Watkins DN Berman DM Burkholder SG 2003Nature2003,422,6929:1
8Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer 显示文摘Watkins DN Berman DM Burkholder SG 2003Nature2003,422,6929:1
9Hedgehog signaling within airway epithelial progenitors and in small - cell lung cancer 显示文摘Watkins DN Berman DM Burkholder SG 2003Nature2003,422,20:1
10Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal显示文摘Rodova M Fu J Watkins DN 2012PLo S One2012,7,46:1
11The Hedgehog signalling pathway in breast development,carcinogenesis and cancer therapy显示文摘Hui M Cazet A Nair R Watkins DN O'Toole SA Swarbrick A 2013Breast Cancer Res2013,15,2:1
12Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer显示文摘WATKINS DN BERMAN DM BURKHOLDER SG 2003Nature2003,422,:1
13Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer显示文摘 Berman DM Burkholder SG 2003Nature2003,422,6929:1
14Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer 显示文摘Watkins DN Berman DM Burkholder SG 2003Nature2003,422,6929:1
15Developmental signaling pathways in lung cancer显示文摘Daniel VC Peacock CD Watkins DN 2006Respirology2006,11,3:1
16显示文摘Ray S Watkins DN Misso NL 2002Clin Exp Allergy2002,32,4:1
17Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer 显示文摘Watkins DN Berman DM Burkholder SG 2003Nature2003,422,6929:1
18Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition显示文摘Ko GJ Grigoryev DN Linfert D Jang HR Watkins T Cheadle C Racusen L Rabb H 2010Am J Physiol Renal Physiol2010,298,6:1
19Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer显示文摘Suzuki H Watkins DN Jair KW 2004Nat Genet2004,36,4:1
20Hedgehog signalling wthin airway epithelial progenitors and in small - cell lung cancer 显示文摘Watkins DN Berman DM Burkholder SG 2003Nature2003,422,:1
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