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| 1 | Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocompetent rats显示文摘AIM: To characterize the host response to hepatitis B virus (HBV) infection in human hepatocytes transplanted into immunocompetent rodent rats tolerized by, and transplanted with primary human hepatocytes.METHODS: One week after the transplantation, rats were inoculated with HBV, and viral gene expression, replication,and host response was monitored.RESULTS: HBV DNA was detectable in serum for at least 60 days. HBsAg levels rose steadily for 3 weeks postinoculation and then plateaued at a level of about 0.6 pg/mi. HBV RNA was also found in liver at levels that remained constant through the time course. Immunofluorescence revealed clusters of hepatocytes that stained positive for HBcAg. The presence of HBV covalently closed circular DNA (cccDNA) in liver was demonstrated using nuclease digestion of single-stranded DNA followed by PCR. Serum ALT levels rose and reached a peak level of 180 IU/L on day 18, but remained elevated for 60 days. Histology revealed a progressive predominantly mononuclear lobular hepatitis.CONCLUSION: These data indicate that human hepatocytestransplanted into rats rendered tolerant to these cells, when infected by HBV, results in biochemical as well as histological evidence of hepatitis that accompanies viral gene expression,and DNA replication. | Catherine H.Wu Edwin C.Ouyang Cherie Walton Kittichai Promrat Faripour Forouhar George Y. Wu | 2003 | World Journal of Gastroenterology2003，9，5： | 19 |
| 2 | 车联网环境下的高速公路合流区协调控制方法及效果评价显示文摘高速公路合流区是事故的多发区域,车联网技术为提高合流区的安全提供了有效的手段。提出了一种新的车联网环境下合流区的车辆控制协调方法。首先,对合流区的安全隐患进行了分析。其次,针对货运车辆的行驶特点,计算了匝道大货车到达合流区冲突区域的时间范围,以此时间段为约束条件,计算了主路车辆在同一时间段到达合流区的速度区间。在考虑安全和效率的条件下选择最优主路车速值,通过对车辆进行预警,使主路车辆避开可能发生冲突的区域。最后,利用仿真软件Vissim二次开发了车车通信模块,从安全性、通行效率等指标评价了安全协调控制效果。 | 王东柱 陈艳艳 马建明 C.Michael WALTON | 2016 | 公路交通科技2016，33，9： | 13 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | 改进医疗服务质量、确保病人安全的教学方法显示文摘提高医疗服务质量、确保病人安全是当前医学教育及培训面临的巨大挑战。今天的医生及医务工作者应具备良好的沟通能力,掌握如何在临床实践中鉴别、预防和处理不良事件及接近过失事件(nearmisses),如何使用当前获得的证据及相关信息,如何安全有效地在团队中工作,如何在实践中教授和学习病人安全知识,如何根据认可的伦理原则服务公众。 | Merrilyn M Walton Bruce H Barraclough Samantha A Van Staalduinen Susan L Elliott 段玉蓉(译) 张鸣明(审校) | 2009 | 中国循证医学杂志2009，9，9： | 7 |
| 5 | Understanding roof deformation mechanics and parametric sensitivities of coal mine entries using the discrete element method显示文摘Although conventional coal mine designs are conservative regarding pillar strength,local failures such as roof-falls and pillar bursts still affect mine safety and operations.Previous studies have identified that discontinuous,layered roof materials have some self-supporting capacity.This research is a preliminary step towards understanding these mechanics in coal-measure rocks.Although others have considered broad conceptual models and simplified analogs for mine roof behavior,this study presents a unique numerical model that more completely represents in-situ roof conditions.The discrete element method(DEM)is utilized to conduct a parametric analysis considering a range of in-situ stress ratios,material properties,and joint networks to determine the parameters controlling the stability of single-entries modeled in two-dimensions.Model results are compared to empirical observations of roof-support effectiveness(ARBS)in the context of the coal mine roof rating(CMRR)system.Results such as immediate roof displacement,overall stability,and statistical relationships between model parameters and outcomes are presented herein.Potential practical applications of this line of research include:(1)roof-support optimization for a range of coal-measure rocks,(2)establishment of a relationship between roof stability and pillar stress,and(3)determination of which parameters are most critical to roof stability and therefore require concentrated evaluation. | Rami Abousleiman Gabriel Walton Sankhaneel Sinha | 2020 | International Journal of Mining Science and Technology2020，30，1： | 7 |
| 6 | Intramedullary devices in the management of Judet III and IV paediatric radial neck fractures显示文摘这研究的 PurposeThe 目的是讨论在儿科学的光线的颈破裂的管理使用的不同 intramedullary 设备的结果并且建议方法与孤立的 Judet III 避免 technique.MethodsThirty 病人的陷井, IV 破裂在这未来的研究被包括。我和 II 破裂和光线的颈破裂与另外的损害联系了的 Judet 被排除。最后的结果用 Metaizeau 功能的得分系统被分级,牛津肘 Score.ResultsThe 功能的结果对好在 30 个盒子(80%) 中的 24 个中优秀。吝啬的牛津肘分数是 44.32。吝啬的后续是 40.11 个月。看见的复杂并发症是 radiocapitellar 关节穿入 - 在平均数 4.87 星期的 6 个盒子,排水量 - 6,光线的 epiphyseal 硬化 - 5,并且 heterotopic 骨化 - 1 根 case.ConclusionIntramedullary K 电线可以导致 radiocapitellar 关节穿入。钛有弹性的钉子系统不应该是被使用完全他们不能阻止排水量的固定设备。常规后续是直到至少 6 个星期必要的。有 Judet IV 破裂并且需要打开减小的病人应该被给看守预后。纸加亮这种技术的陷井并且关于类型做建议植入,在 Judet IV 的后续和耐心的 counselling 断裂。 | Manish Kiran Colin Bruce Harvey George Neeraj Garg Roger Walton | 2018 | Chinese Journal of Traumatology2018，21，1： | 5 |
| 7 | Particle size dependent sinterability and magnetic properties of recycled HDDR Nd-Fe-B powders consolidated with spark plasma sintering显示文摘The dependence of the magnetic properties on the particle size of recycled HDDR Nd-Fe-B powders was investigated,with the aim to assess the reprocessing potential of the end-of-life scrap magnets via spark plasma sintering(SPS).The as received recycled HDDR powder has coercivity(Hci)=830 kA/m and particles in the range from 30 to 700 μm(average 220 μm).After burr milling,the average particle size is reduced to 120 μm and subsequently the Hci of fine(milled) powder was 595 kA/m.Spark plasma sintering was exploited to consolidate the nanograined HDDR powders and limit the abnormal grain coarsening.The optimal SPS-ing of coarse HDDR powder at 750℃for 1 min produces fully dense magnets with Hci=950±100 kA/m which further increases to 1200 kA/m via thermal treatment at 750℃for 15 min.The burr milled fine HDDR powder under similar SPS conditions and after thermal treatment results in Hci=940 kA/m.The fine powder is further sieved down from 630 to less than 50 μm mesh size,to evaluate the possible reduction in Hci in relation to the particle size.The gain in oxygen content doubles for <50 μm sized particles as compared with coarser fractions(>200 μm).The XRD analysis for fractionated powder indicates an increase in Nd2O3 phase peaks in the finer(<100 μm)fractions.Similarly,the Hci reduces from 820 kA/m in the coarse particles(>200 μm) to 460 kA/m in the fine sized particles(<100μm).SPS was done on each HDDR powder fraction under the optimal conditions to measure the variation in Hci and density.The Hci of SPS-ed coarse fraction(>200 μm) is higher than 930 kA/m and it falls abruptly to just 70 kA/m for the fine sized particles(<100 μm).The thermal treatment further improves the Hci to>1000 kA/m only up to 100 μm sized fractions with>90% sintered density.The full densification(>99%) is observed only in the coarse fractions.The loss of coercivity and lack of sinterability in the fine sized particles(<100 μm) are attributed to a very high oxygen content.This implies that during recycling,if good magnetic properties are to be maintained or even increase the HDDR powder particles can be sized down only up to≥100 μm. | Awais Ikram Farhan Mehmood Richard Stuart Sheridan Muhammad Awais Allan Walton Anas Eldosouky Saso Sturm Spomenka Kobe Kristina Zuzek Rozman | 2020 | Journal of Rare Earths2020，38，1： | 5 |
| 8 | Investigation of factors influencing roof stability at a Western U.S.longwall coal mine显示文摘The coal mine roof rating(CMRR) was developed to bridge the gap between geological variation in underground coal mines and engineering design. The CMRR accounts for the compressive strength of the immediate roof, the shear strength and intensity of any discontinuities present, and the moisture sensitivity of the immediate roof. The CMRR has been widely used and validated in Eastern US coal mines, but it has seen limited application in the Western US. This study focuses on roof behavior at a Western coal mine(Mine A). Mine A shows significant lateral geological variation, along with localized faulting and a laterally extensive sandstone channel network. The CMRR is not used to predict roof instability at the mine. It is, therefore, hypothesized that there are other factors that are correlated with roof instability in underground coal mines that could potentially also be considered in conjunction with the CMRR.This hypothesis was tested by collecting 30 CMRR measurements at Mine A. At each measurement location, a binary record of the roof condition(stable or unstable) was made, and other parameters such as depth of cover, presence of faulting, and sandstone channels were also recorded. ANOVA tests showed that the CMRR values and the roof conditions were not strongly correlated, indicating that the CMRR input criteria are not fully predictive of roof stability at this mine. The CMRR values showed statistically significant correlations(p less than 0.05) with faulting as well as with location at an intersection. For areas that had previously experienced roof fall but were currently stable, faulting was correlated with roof condition(p less than 0.05) only when the condition was classified as unstable. | Meriel Young Gabriel Walton Elizabeth Holley | 2019 | International Journal of Mining Science and Technology2019，29，1： | 3 |
| 9 | Cognitive Deterioration and Associated Pathology Induced by Chronic Low-LevelAluminum Ingestion in a Translational Rat Model Provides an Explanation ofAlzheimer’s Disease, Tests for Susceptibility and Avenues for Treatment显示文摘 | J. R. Walton Peter Rapp | 2012 | International Journal of Alzheimer’s Disease2012，，： | 2 |
| 10 | Angle-closure Glaucoma: The Role of the Lens in the Pathogenesis, Prevention, and Treatment显示文摘 | Pamela Tarongoy Ching Lin Ho David S. Walton | 2009 | Survey of Ophthalmology2009，，2： | 2 |
| 11 | 日粮磷脂对大西洋鲑鱼早期发育和生长性能的影响显示文摘研究旨在证实大西洋鲑鱼对日粮磷脂的需求,更好地确定其需要水平和时期。因此,通过给大西洋鲑鱼提供磷虾或大豆卵磷脂探讨磷脂对其的影响。首先饲喂鱼苗含蛋白质55%和脂肪17%的饲粮,通过添加磷虾油或大豆磷脂补充脂肪.根据回归分析设计5个水平,分别为总磷脂1.5%(未添加)、2.6%、3.2%、3.6%和4.2%。在1g(受精后1400°dpf)、2.5g(1990°ape)、5g(2350°dpf)、10-20g(2850°dpf)和二龄鲑(3800°dpf)时进行取样。整体存活率高,说明存活率和饲粮磷脂添加水平呈正相关(r2=0.59—0.72)。磷脂促进了鱼苗的生长,且饲喂磷虾磷脂2.6%和大豆磷脂3.6%的鱼增长最快。鱼苗达到2.5g之前与之后生长模式不同,0-2.5g鱼补充磷虾磷脂2.6%和大豆磷脂3.6%后的生长速率(SGR)显著高于基础日粮(P〈0.05),而2.5g-二龄鲑期间,各处理之间没有差异。饲喂未补充磷脂的日粮,2.5g时发现鱼肠道脂肪变性,患病率达20%,饲喂低水平大豆磷脂日粮的鱼肠道脂肪变性患病率达10%,而喂食磷虾油和高水平大豆磷脂(≥3.2%)后以及在后期阶段,肠邋脂肪变性情况开始消失。在生命早期阶段,鲑鱼对日粮磷脂的要求是一致的。 | Taylor J F Martinez-Rubio L Pozo J D Walton J M Tinch A E Migaud H Tocher D R | 2015 | 饲料博览2015，0，8： | 2 |
| 12 | Calculation of transient motion of submerged cables显示文摘 | Thomas S. Walton Harry Polachek | 1960 | Mathematics of Computation1960，，69： | 2 |
| 13 | Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study显示文摘 | Henry Krum Markus Schlaich Rob Whitbourn Paul A Sobotka Jerzy Sadowski Krzysztof Bartus Boguslaw Kapelak Anthony Walton Horst Sievert Suku Thambar William T Abraham Murray Esler | 2009 | The Lancet2009，，9671： | 2 |
| 14 | Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study显示文摘 | Henry Krum Markus Schlaich Rob Whitbourn Paul A Sobotka Jerzy Sadowski Krzysztof Bartus Boguslaw Kapelak Anthony Walton Horst Sievert Suku Thambar William T Abraham Murray Esler | 2009 | The Lancet . 2009 (9671)2009，，9671： | 2 |
| 15 | Neuronal death and survival in two models of hypoxic-ischemic brain damage 显示文摘 | Walton M Connor B Lawlor P | 1999 | Brain Res Rev1999，29，23： | 2 |
| 16 | A DNA delivery system containing listeriolys in Oresults in enhanced hepatocytedirected gene expression显示文摘AIM To determine whether incorporation of the pH dependent bacterial toxin listeriolysin O (LLO) into the DNA carrier system could increase the endosomal escape of internalized DNA and result gene expression. METHODS A multi component delivery system was prepared consisting of asialoglycoprotein (ASG), poly L lysine (PL), and LLO. Two marker genes, luciferase and β galactosidase in plasmids were complexed and administered in vitro to Huh7[ASG receptor (+) ] and SK Hep1[ASG receptor (-) ] cells. Purity, hemolytic activity, gene expression, specificity, and toxicity were evaluated. RESULTS An LLO containing conjugate retained cell targeting specificity and membranolytic activity. In ASG receptor (+) cells, luciferase gene expression was enhanced by more than 7 fold over that of conjugates without the incorporation of listeriolysin O. No significant expression occurred in ASG receptor (-) cells. Enhancement of β galactosidase gene expression was less, but still significantly increased over controls. There was no detectable toxicity at concentrations shown to be effective in transfection studies. CONCLUSIONS ASOR PL can be coupled to LLO using disulfide bonds, and successfully target and increase the gene expression of foreign DNA. | Cherie M. Walton, Catherine H. Wu and George Y. Wu | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 17 | 先天性白内障手术后无晶状体性青光眼显示文摘目的:描述先天性白内障晶状体切开摘除术后发生无晶状体性青光眼的最大一组患者。方法:对1970年10月1日至2002年11月30日期间1位儿童青光眼专科医生经治的所有患者作回顾性复习。晶状体切开摘除术后眼压高于25mmHg(1kPa=7.5mmHg)的患者被纳入研究。晶状体摘除术前具有与青光眼任何独立相关疾病的患者或者有任何青光眼体征的患者均被剔除。结果:我们研究了117例患者的170只眼。随访时间均数±标准差为(8.6±7.6)年。最常见的白内障类型为完全性(40.8%)和核性(22.5%)。103只眼采用现代玻璃体切除技术行晶状体切开摘除术。10只眼采用较过时的技术。80.6%的眼在1岁之前做晶状体切开摘除术。晶状体切开摘除术后1年、6年和33年后分别有37.1%、75.9%和100%的眼发生青光眼。经前房角镜检查的患眼中。93.9%为开角型。57.1%的眼需要做青光眼手术。最终视力中位数为20/400。结论:大部分无晶状体性青光眼病例为开角型。要考虑多种危险因素。其预后是有保留的。需要终生随访筛查青光眼。 | Teresa C. Chen David S. Walton Lini S. Bhatia 耿韶辉(译) 申敏如(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，2： | 2 |
| 18 | Numerical analyses of pillar behavior with variation in yield criterion,dilatancy, rock heterogeneity and length to width ratio显示文摘With recent advances in numerical modeling, design of underground structures increasingly relies on numerical modeling-based analysis approaches. While modeling tools like the discrete element method(DEM) and the combined finite-discrete element method(FDEM) are useful for investigating small-scale damage processes, continuum models remain the primary practical tool for most field-scale problems.The results obtained from such models are significantly dependent on the selection of an appropriate yield criterion and dilation angle. Towards improving its capabilities in handling mining-related problems, the authors have previously developed a new yield criterion(called progressive S-shaped criterion). The focus of the current study is to demonstrate its use in modeling rock pillars through a comparative analysis against four other yield criteria. In addition to the progressive S-shaped criterion,only one out of the four other criteria predicted a trend in strength consistent with an empirical pillar strength database compiled from the literature. Given the closely-knit relationship between yield criteria and dilation angle in controlling the overall damage process, a separate comparison was conducted using a mobilized dilation model, a zero degree dilation angle and a constant non-zero dilation angle. This study also investigates the impact of meso-scale heterogeneity in mechanical properties on the overall model response by assigning probability distributions to the input parameters. The comparisons revealed that an isotropic model using a combination of progressive S-shaped criterion and mobilized dilation angle model is sufficient in capturing the behaviors of rock pillars. Subsequently, the pillar model was used to assess the effect of L/W(length/width) ratio on the peak strength. | Sankhaneel Sinha Gabriel Walton | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，1： | 2 |
| 19 | Coronal leakage of mixed anaerobic bacteria after obturation and post space preparation 显示文摘 | Barrieshi KM Walton RE Johnson WT | 1997 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod1997，84，3： | 1 |
| 20 | Optimization and implementation of periodic cruise for a hypersonic vehicle 显示文摘 | Chen Robert H Williamson Walton R Speyer Jason L | 2006 | Journal of Guidance Control and Dynamics2006，29，5： | 1 |
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