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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | 增施氮肥和地面管理对酸樱桃园土壤营养状况的影响显示文摘在一个连续进行了 8年N肥定位试验的酸樱桃园,调查了每年施用 N60 kg· hm^(-2)和行间生草制对土壤营养状况的影响。结果表明:在肥沃土壤里NH_4~+是速效N的主要存在形式,而NO_3~-的含量很低。生草地土壤中含有较多的 NH_4~-,而清耕带土壤中含有较多的 NO_3~-。施肥增加土壤速效 N的含量。土壤 NO_3~-的季节性变化表明 5至 6月份土壤中 NO_3~-的含量高,而花前和 7月份土壤中 NO_3~-含量低。 P、K在清耕带 10 cm以下土壤的含量低于生草地土壤,但在 0~ 10cm土层中K的含量高于生草地。P的含量不受影响。施N减少了土壤P、K的含量。土壤中Mg的含量分布均匀,不受施N和地面管理制度的影响。 | 杨朝选 Andrzej Sadowski Ewa Jadczuk | 2000 | 果树科学2000，17，1： | 14 |
| 3 | 开放式创新网络形成及演化的探索性案例研究显示文摘企业如何在战略阶段演进中构建与战略网络与商业生态系统相互融合与共同演化的开放式创新网络,已成为开放式创新能否取得成效的关键。本文揭示了开放式创新网络与战略网络、商业生态系统的关联性及内在逻辑,运用探索性案例研究方法,以'每20分钟产生一项专利'的荷兰埃因霍芬高科技园区为研究对象,将园区开放式创新网络形成及演化3阶段的开放式创新网络概括为'1+0'、'1+N'、'N+N'3种形式,得出开放式创新网络的形成及演化取决于战略网络的类型和动态变化趋势以及商业生态系统中核心物种的生态位进化。 | 彭华涛 Bert Sadowski | 2014 | 科研管理2014，35，8： | 10 |
| 4 | 阿特拉津降解菌株Alcalegenes sp.SG1的分离鉴定和降解特性研究显示文摘用富集培养法,从农药厂的工业废水中分离到降解除草剂阿特拉津的SG1菌株,经16S rRNA基因序列分析,该菌株被鉴定为产碱杆菌(Alcalegenes sp.).Alcalegenes sp.SG1能以葡萄糖、果糖、蔗糖、麦芽糖、丙酮酸钠或柠檬酸钠为碳源,以阿特拉津为唯一氮源生长,将阿特拉津完全矿化.PCR分析表明,SG1菌株含有阿特拉津降解基因atzA、atzB、atzC和trzD.生物降解实验表明,与模式菌株Pseudomonas sp.ADP不同,额外加入氮源NH_4Cl或KNO_3,并不影响SG1菌株对阿特拉津的降解,30℃震荡培养16 h后阿特拉津降解率在98%以上,这一特性使其成为应用于阿特拉津污染土壤生物修复的优良候选菌株. | 李清艳 Boundy-Mills K L Sadowsky M J Wackett L P 蔡宝立 | 2010 | 南开大学学报(自然科学版)2010，43，3： | 9 |
| 5 | Arabidopsis Protein Phosphatase 2C ABI1 Interacts with Type I ACC Synthases and Is Involved in the Regulation of Ozone-Induced Ethylene Biosynthesis显示文摘它的生合成严格地是的在各种各样的生物过程并且因此的一个关键角色由 multiplemechanisms 调整了的乙烯戏。Posttranslational 规定,在控制乙烯生合成枢轴,经由特定的因素的复杂相互影响影响 1-aminocyclopropane1-carboxylate synthase (交流) 蛋白质稳定性。这里,我们证明 Arabidopsis thaliana 蛋白质磷酸酶打 2C, ABI1, abscisic 酸发信号的一个否定管理者,在氧化压力条件下面涉及 ethylenebiosynthesis 的规定。我们发现 ABI1 与 ACS6 和 dephosphorylates 交往它的 C-terminalfragment,压力应答的激活 mitogen 的蛋白质 kinase 的一个目标, MPK6。另外, ABI1 控制 MPK6 也 activitydirectly 并且由这个工具影响 ACS6 phosphorylation 水平。一致地与这,在 ABI1 猛烈紧张(abi1td ) 显著地更高的导致臭氧的乙烯 productionwas 比在野类型的植物。重要地,在 abi1td 异种的导致压力的乙烯生产的增加由一个更高的 ascorbate 氧化还原作用状态被补偿并且提高了抗氧化剂活动。总的来说, thisstudy 的结果提供 ABI1 由影响 ACS6 的活动限制乙烯合成的证据。ABI1 贡献 tostress 显型支撑它在在 abscisic 酸(骆驼毛的织物) 和表明 pathways.Key 词的乙烯之间的相互影响的角色: | Agnieszka Ludwikow Agata Ciesla Anna Kasprowicz-Malusk Filip Mitula Malgorzata Tajdel lukasz Gaigarnski Piotr A. Ziolkowski Piotr Kubiak Arleta Malecka Aneta Piechalak Marta Szabat Alicja Gorska Maciej Dabrowskia Izabela Ibragimow Jan Sadowski | 2014 | Molecular Plant2014，7，6： | 6 |
| 6 | Bone density of the radius, spine, and hip in relation to percent of ideal body weight in postmenopausal women显示文摘 | Bess Dawson-Hughes M.D. Clanton Shipp Laura Sadowski Gerard Dallal | 1987 | Calcified Tissue International1987，，6： | 2 |
| 7 | Gas–liquid two-phase flow in microchannels Part I: two-phase flow patterns显示文摘 | K.A. Triplett S.M. Ghiaasiaan S.I. Abdel-Khalik D.L. Sadowski | 1999 | International Journal of Multiphase Flow1999，，3： | 2 |
| 8 | 考虑技术体制和需求结构下破坏性创新与产业演化显示文摘通过构建考虑技术体制与需求结构下破坏性创新与产业演化多主体仿真模型,考察技术体制与需求结构在破坏性创新驱动产业演化中的作用。研究发现,随着技术机会不断增加、专有性不断下降,市场结构趋于竞争,破坏性创新对市场的颠覆程度更高,在位企业存活数目和市场份额不断减少,企业的平均年龄不断下降。并且,在需求异质性较高的市场,破坏性创新对产业演化的影响更加显著。 | 郁培丽 石俊国 Bert Sadowski 向涛 | 2019 | 系统管理学报2019，28，3： | 2 |
| 9 | Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study显示文摘 | Henry Krum Markus Schlaich Rob Whitbourn Paul A Sobotka Jerzy Sadowski Krzysztof Bartus Boguslaw Kapelak Anthony Walton Horst Sievert Suku Thambar William T Abraham Murray Esler | 2009 | The Lancet2009，，9671： | 2 |
| 10 | Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study显示文摘 | Henry Krum Markus Schlaich Rob Whitbourn Paul A Sobotka Jerzy Sadowski Krzysztof Bartus Boguslaw Kapelak Anthony Walton Horst Sievert Suku Thambar William T Abraham Murray Esler | 2009 | The Lancet . 2009 (9671)2009，，9671： | 2 |
| 11 | Effects of Rhodiola rosea supplementation on mental performance,physical capacity,and oxidative stress biomarkers in healthy men显示文摘Purpose: The objective of this study was to investigate the effects of chronic Rhodiola rosea(R. rosea) supplementation on mental and physical performance, as well as hormonal and oxidative stress biomarkers.Methods: Twenty-six healthy male students received either R. rosea extract(600 mg/day; RR) or placebo(PL) in a randomized double-blind trial. Prior to supplementation(Term I) and following 4 weeks of supplementation(Term II), the students underwent psychomotor tests for simple and choice reaction time, included in the Vienna Test System. Also, the subjects performed VO2 peaktest. Blood samples were obtained before and after the test to measure the hormonal profile(cortisol, testosterone, and growth hormone), as well as the biomarkers of oxidative stress(lipid hydroperoxides, total antioxidant capacity, and superoxide dismutase) and muscle damage(creatine kinase).Results: R. rosea ingestion shortened reaction time and total response time. Moreover, a greater relative increase in the number of correct responses was observed in RR group as compared to the PL group. No changes in endurance exercise capacity and hormonal profile were observed after R. rosea ingestion. R. rosea ingestion raised plasma total antioxidant capacity. It did not, however, affect other measured parameters.Conclusion: Chronic R. rosea ingestion does not affect physical performance, but can improve the results of some psychomotor tests(simple and choice reaction time) in young, healthy, and physically active men. The improvements in mental performance, however, at least in our study,seem not to be related to changes in cortisol release or antioxidant activity of R. rosea extract. Thus, the specific mechanisms responsible for these effects still need to be elucidated. | ewa jówko jerzy sadowski barbara dlugolecka dariusz gierczuk benedykt opaszowski igor ciesliński | 2018 | Journal of Sport and Health Science2018，7，4： | 2 |
| 12 | Gene Networks in Plant Ozone Stress Response and Tolerance显示文摘For many plant species ozone stress has become much more severe in the last decade. The accumulating evidence for the significant effects of ozone pollutant on crop and forest yield situate ozone as one of the most important environmental stress factors that limits plant productivity worldwide. Today, transcriptomic approaches seem to give the best coverage of genome level responses. Therefore, microarray serves as an invaluable tool for global gene expression analyses, unravelling new information about gene pathways, in-species and cross-species gene expression comparison, and for the characterization of unknown relationships between genes. In this review we summarize the recent progress in the transcriptomics of ozone to demonstrate the benefits that can be harvested from the application of integrative and systematic analytical approaches to study ozone stress response. We focused our consideration on microarray analyses identifying gene networks responsible for response and tolerance to elevated ozone concentration. From these analyses it is now possible to notice how plant ozone defense responses depend on the interplay between many complex signaling pathways and metabolite signals. | Agnieszka Ludwikow Jan Sadowski | 2008 | Journal of Integrative Plant Biology2008，50，10： | 2 |
| 13 | Systemic regulation of vascular NAD(P)H oxidase activity and Nox isoform expression in human arteries and veins 显示文摘 | Guzik TJ Sadowski J Kapelak B | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 14 | Nephrogenic systemic fibrosis:risk factors and incidence estimation显示文摘 | Bennett LK Chan MR | 2007 | Radiology2007，243，1： | 1 |
| 15 | Treatment of reverse o6-lique and transverse interochanteric fractures with the use of an intr-amedullary nail or a 95 0 screw-plate显示文摘 | Sadowski C Lubbeke A Saudan M | 2002 | J Bone Joint Surg(Am)2002，84，3： | 1 |
| 16 | Breast cancer显示文摘 | Sadowsky N Kopans DB | 1983 | Raeliol Clin North Am1983，21，1： | 1 |
| 17 | Growth and early bearing of apple trees as affected by the type of nursery trees used for planting 显示文摘 | Sadowski A Mackiewicz M Dziuban R | 2007 | Acta Horticulturae2007，732，： | 1 |
| 18 | A model of thermal contact conduct- ance at high real contact area fractions 显示文摘 | Sadowski P Stupkiewicz S | 2010 | Wear2010，268，： | 1 |
| 19 | Blood oxygen level-dependent and pufusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys 显示文摘 | Sadowski E A Djamali A Wentland A L | 2010 | Magn Reson Imaging2010，28，1： | 1 |
| 20 | Treatment of re- verse oblique and transverse intertrochanteric fractures with use of an intramedullary nail or a 95 degrees screw - plate : a prosepec- tive, randomized study 显示文摘 | Sadowski C Lubbeke A Saudan M | 2002 | J Bone Joint Surg (Am)2002，84，： | 1 |
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