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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | 斯洛伐克西喀尔巴阡山脉内侧Veporicum地区的地球动力学演化序列与菱镁矿和滑石矿床成因(英文)显示文摘本文总结并报导了斯洛伐克西喀尔巴阡山脉内侧的石炭纪岩石中产出的菱镁矿和滑石成因的最新资料.这些矿床赋存于Veporicum构造超单元中和该超单元与Gemericum的接触带中.北部Sinec成矿带是主要的菱镁矿和滑石矿化区,产出的主要矿床有Kokava,Sinec,Samo,Hnsta-Mutnik等矿床.而南部的Ochtina成矿带只产有菱镁矿床,主要矿床包括在Dubrava地体上的Dubrava,Mikov?JedL'vec;Luben韐,Ochtina,Kosice-Bankov,Banisko,Medvedia等矿床.菱镁矿形成于变质M1期石炭系中方解石被白云石和菱镁矿连续交代过程(北矿带成矿温度为280~400℃,南矿带成矿温度为370~420℃;Radvanec&Prochska,2001;Kodera&Radvanec,2002).Permoscythian蒸发卤水提供了Mg.成矿事件和华力西期碰撞后运动有关.拉伸构造和高热流值促使成矿热液系统的产生.滑石矿化则形成于稍晚的不同期变质事件(M2),成矿流体来源也与菱镁矿化不同.构造的、微构造的、变质的以及地质年代学的数据将滑石成矿作用和阿尔卑斯上白垩系的构造地热事件AD2联系在一起.AD2事件是阿尔卑斯碰撞(AD1)地壳加厚和变质核杂岩体起源的结果,体现在地壳不整合面上的区域拉伸,及开放系统中大规模热液流动.这一过程在更靠近Veporic热穹的北带区域(Sinec剪切带)很显著,而向着Veporic热穹的周围部分(南Ochtina带),M2变质过程和块滑石化则逐渐减弱.Sinec剪切带是北Sinec带中突出的AD2-AD3结构,白云石/菱镁矿透镜体(在M1期交代造成的)和相伴随的岩石夹杂在AD1中更坚硬的基底岩石之中.本研究证明了AD2中块滑石化的普遍性,滑石和白云石2形成于拉伸显微构造中(变质过程M2;温度为490~540℃,压力为240~330MPa).在Sinec带中AD3阶段的对偶剪切作用形成了该带中的滑石矿.它是AD2事件从去顶到区域扭压剪切的动力学转变过程的逐步延续.北Sinec带使AD3变形处于由坚硬岩石包围的软岩石的狭窄的剪切带中,而在南Ochtina带中AD3变形产生在由里面漂浮着坚硬碳酸盐块的软的岩石柱中.在Ochtina带中,在AD2和AD3阶段由于M2期较低的P-T条件和变形梯度导致了该区有经济价值的滑石矿化不发育.总之,现有的研究结果能用作阿尔卑斯型地体中菱镁矿和滑石找矿的基本标志. | Zoltán NMETH Walter PROCHASKA Martin RADVANEC Martin KOV■IK Ján MADARAS Peter KOD■RA L'ubomír HRA■KO | 2004 | 岩石学报2004，20，4： | 2 |
| 3 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 4 | Persistence and growth of faecal culturable bacterial indicators in water column and sediments of Vidy Bay,Lake Geneva,Switzerland显示文摘The aims of this study was to investigate the persistence and the growth of culturable bacterial indicators(CBI) including total coliforms(TC) and faecal coliforms represented by Escherichia coli,enterococcus(ENT) ,and aerobic mesophilic bacteria(AMB) in the surface sediments and the water column of Vidy Bay(Lake Geneva,City of Lausanne,Switzerland) . The study was carried out for 60 d using microcosms containing Sewage Treatment Plant(STP) effuent and nonsterile water without CBI,as well as contaminated and non-contaminated sediments. The effects of water temperature and of organic matter associated with sediments on the survival of CBI in the sediments and the water column were observed. The number of CBI colonies in the contaminated sediments of Vidy Bay and in the STP effuent was almost identical in the order of 105-107,104-106,103-105,and 104-107 CFU/100 g sediment or /100 mL water for TC,E. coli,ENT,and AMB respectively. A degradation of CBI was observed in the sediments where organic mater content was low and in the water column at a temperature of 10°C after 5 d of experimentation. In addition,a growth of CBI was observed in the sediment which is rich in organic matter at 20°C. The results of this study indicate:(1) the higher concentrations of the CBI observed in dierent points in the water column of Vidy Bay may not be explained only by the recent contribution of the three potential sources of the Bay contamination including STP and the Chamberonne and Flon Rivers,but also by the persistence,removal from sediment and multiplication of CBI in the sediment and water column;(2) the sediment of Vidy Bay constitute a reservoir of CBI and can even support their growth;and(3) the CBI not only survive in sediments,but also can be remobilized and increased in the water column,therefore,it become a permanent microbiological pollution in Vidy Bay. | POTE John HALLER Laurence KOTTELAT Régis SASTRE Vincent ARPAGAUS Philippe WILDI Walter | 2009 | Journal of Environmental Sciences2009，21，1： | 2 |
| 5 | The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis显示文摘 | Mitchell M. Levy R Phillip Dellinger Sean R. Townsend Walter T. Linde-Zwirble John C. Marshall Julian Bion Christa Schorr Antonio Artigas Graham Ramsay Richard Beale Margaret M. Parker Herwig Gerlach Konrad Reinhart Eliezer Silva Maurene Harvey Susan Rega | 2010 | Critical Care Medicine2010，，2： | 2 |
| 6 | Systemic inflammation and copd: the framing, ham heart study 显示文摘 | Walter R E Wilk J B Larson M G | 2008 | Chest2008，133，1： | 1 |
| 7 | Mercury speciation in fluorescent lamps by thermal release analysis显示文摘 | CLAUDIO R CLAUDIO C WALTER A D J | 2003 | Waste Management2003，23，10： | 1 |
| 8 | Cellular composition and viability of demi-and quarter-embryos made from bisected bovine morulae and blastocysts显示文摘 | Gyu-Jin R Walter H J | 1998 | Theriogenology1998，50，： | 1 |
| 9 | The quantitive determination of dihydroxyacetone显示文摘 | Walter R Campbell | 1926 | J Biol Chem1926，67，1： | 1 |
| 10 | Use of random amplified polymorphic DNA ( RAPD ) for identification of largemouth bass subspecies and their intergrades显示文摘 | Williams D J Kazianis S Walter R B | 1998 | Transactions of the American Fisheries Society1998，127，： | 1 |
| 11 | Matured-endritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicitEBV-specific CD4+ and CD8T lymphocyte responses 显示文摘 | WOLFGANG H ELENA R WALTER O | 2000 | Blood2000，7，96： | 1 |
| 12 | A siliconbased electrical source of surface plasmon polaritons显示文摘 | Walters RJ van Loon R V A Brunets I | 2009 | Nature Materials2009，，： | 1 |
| 13 | Effects of high- altitude exposure on vascular endothelial growth factor levels in man显示文摘 | Walter R Maggiorini M Scherrer U | 2001 | Eur J Appl Physiol2001，85，12： | 1 |
| 14 | SOX4,(prognostic ) marker for the aggressiveness of neuroendo-crine tumors of the lung by using next-generation expres-sion analysis (NanoString) 显示文摘 | Walter RF Mairinger FD Werner R | 2015 | Future Oncol2015，11，： | 1 |
| 15 | Inhibition of nitrification by acetylene显示文摘 | Walter H M Keeney D R Fillery I R | 1979 | Soil Science Society of America Journal1979，43，1： | 1 |
| 16 | Workflow optimization through task redesign in business information processes显示文摘 | DEWAN R SEIDMANN A WALTER Z P | 1998 | Collaboration Systems and Technology Track1998，1，1： | 1 |
| 17 | The MAFT architecture for distributed fault - tolerance 显示文摘 | Kieckhafer R M Walter C J Finn A M | 1988 | IEEE Trans Computers1988，37，4： | 1 |
| 18 | Secretoneurinan angiogenic neuropeptide,induces postnatal vasculogenesis显示文摘 | Kirchmair R Egger M Walter D H | 2004 | Circulation2004，110，9： | 1 |
| 19 | Induction of systemic resistance to rust in Vicia faba by pho-sphates and EDTA:effects of calcium显示文摘 | WAlTERS D R MURRAY D C | 1992 | Plant Pathol1992，41，： | 1 |
| 20 | Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A α subunit gene显示文摘 | Ruediger R Pham HT Walter G | 2001 | Oncogene2001，20，15： | 1 |
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