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| 1 | Linkage of microbiota and osteoporosis:A mini literature review显示文摘The gut microbiota(GM) has become a recent topic of interest in the role of many disease states. Assessing patients with osteoporosis(OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation.Investigation of microbial profile relative to normal gut microbiomes, assessment of inflammatory markers such as interleukin-1(IL-1), IL-6, and tumor necrosis factor-alpha. Therapies to normalize GM in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant. | David Yatsonsky Ⅱ Karen Pan Vithal B Shendge Jiayong Liu Nabil A Ebraheim | 2019 | World Journal of Orthopedics2019，10，3： | 7 |
| 2 | Semiconductor metal oxide compounds based gas sensors: A literature review显示文摘 | Sunil Jagannath PATIL Arun Vithal PATIL Chandrakant Govindrao DIGHAVKAR Kashinath Shravan THAKARE Ratan Yadav BORASE Sachin Jayaram NANDRE Nishad Gopal DESHPANDE Rajendra Ramdas AHIRE | 2015 | Frontiers of Materials Science2015，9，1： | 5 |
| 3 | Effect ofFortifier on the Cure Kinetics and Thermal Stability of N,N,N',N'-tetraglycidyl Ether of 4,4'-diaminodiphenyl Methane UsingAmines as Curing Agents显示文摘 | Hitesh K Soni Vithal S Patel Ranjan G Patel | 1992 | Thermochimica Acta1992，196，2： | 1 |
| 4 | Double-Blind, Placebo-Controlled Study of the Effects of Carvedilol in Patients With Moderate to Severe Heart Failure: The Precise Trial显示文摘 | Milton Packer Wilson S. Colucci Jonathan D. Sackner-Bernstein Chang-seng Liang David A. Goldscher Israel Freeman Marrick L. Kukin Vithal Kinhal James E. Udelson Marc Klapholz Stephen S. Gottlieb David Pearle Robert J. Cody John J. Gregory Nikki E. Kantrow | 1996 | Circulation1996，，： | 1 |
| 5 | Preparation and Characterization of Bulk and Nano Particles of La2Zr2O7 and Nd2Zr2O7 by Sol-gel Method显示文摘 | KOTESWARA R K BANU T VITHAL M | 2002 | Mater Lett2002，54，23： | 1 |
| 6 | Thiadiazole- Based Monomeric and Polymeric Dyes for Cellulose Triacetate Fiber 显示文摘 | Hari R Maradiya Vithal S Patel | 2002 | International Journal of Polymer Analysis and Characterization2002，7，： | 1 |
| 7 | Monomeric and Polymeric Disperse Dyes Based on Heterocyclic Fabric 显示文摘 | Hari R Maradiya Vithal S Patel | 2002 | Polymer-Plastics Technology and Engineering2002，41，： | 1 |
| 8 | Preparation and characterization of bulk and nano particles of La2 Zr2 07 and Nd2Zr207 by sol-gel method 显示文摘 | RAO K K BANU T VITHAL M | 2002 | Materials Letters2002，54，23： | 1 |
| 9 | Preparation, characterization, impedance and thermal expansion studies of Mn 0.5 MSb(PO 4 ) 3 (M显示文摘 | Navulla Anantharamulu K. Koteswara Rao M. Vithal G. Prasad | 2009 | Journal of Alloys and Compounds2009，，1： | 1 |
| 10 | Safety and efficacy of carvedilol in severe heart failure显示文摘 | Jay N. Cohn Michael B. Fowler Michael R. Bristow Wilson S. Colucci Edward M. Gilbert Vithal Kinhal Steven K. Krueger Thierry Lejemtel Kenneth A. Narahara Milton Packer Sarah T. Young Terry L. Holcslaw Mary Ann Lukas | 1997 | Journal of Cardiac Failure1997，，： | 1 |
| 11 | Preparation and charac- terization of bulk and nano particles La2 Zr2 07 and Nd2 Zr2 07 by sol-gel method 显示文摘 | Rao K K Banu T Vithal M | 2002 | Mater Lett2002，54，： | 1 |
| 12 | 查看详情显示文摘 | Venkataiah G Krishna D C Vithal M Rao S S Bhat S V Prasad V Subramanyam S V Venugopal Reddy P | | 0，，： | 1 |
| 13 | Preparation and characterization of bulk and nano particles of La2 Zr2 O7 and Nd2 Zr2 O7 by sol-gel method显示文摘 | RAO K K BANU T VITHAL M | 2002 | Mater Lett2002，54，： | 1 |
| 14 | Effect of Bi 2 O 3 on physical, optical and structural studies of ZnO–Bi 2 O 3 –B 2 O 3 glasses显示文摘 | D. Saritha Y. Markandeya M. Salagram M. Vithal A.K. Singh G. Bhikshamaiah | 2008 | Journal of Non-Crystalline Solids2008，，52： | 1 |
| 15 | Utility of MPT64 antigen detection for rapid confirmation of mycobacterium tuberculosis complex显示文摘 | Jyoti Arora Gavish Kumar Ajoy Verma Manpreet Bhalla Rohit Sarin Vithal Myneedu | 2015 | Journal of Global Infectious Diseases2015，，2： | 1 |
| 16 | Multidrug-resistant tuberculosis among different types of suspected cases: Study from New Delhi显示文摘 | Ritu Singhal Neeta Singla Vithal Prasad Myneedu Niti Singh Rohit Sarin | 2015 | Indian Journal of Tuberculosis2015，，： | 1 |
| 17 | Complexes of Manganese(Ⅱ),Iron(Ⅱ),Cobalt(Ⅱ),Nickel(Ⅱ) and Copper(Ⅱ) with o-Aminobenzoic Acid显示文摘 | Vithal M Centre P G Mirzapur M | 1989 | Indian Chem Seet A1989，28，： | 1 |
| 18 | 显示文摘 | Raghavender M Kumar G S Vithal M | 2005 | Ferroelectrics2005，324，： | 1 |
| 19 | A wide-ranging review on NASICON type materials显示文摘 | Anantharamulu N Rao K K Rambabu G Kumar B V Radha V Vithal M | 2011 | Journal of Materials Science2011，46，9： | 1 |
| 20 | Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation显示文摘AIM To overcome the hazardous effects on liver caused by long-term use of antitubercular agent isoniazid(INH) by developing a novel hepatoprotective prodrug strategy by conjugating INH with aminothiols as antioxidant promoities for probable synergistic effect.METHODS INH was conjugated with N-acetyl cysteine(NAC) and N-(2)-mercaptopropionyl glycine using the SchottenBaumann reaction and with L-methionine using Boc-anhydride through a biocleavable amide linkage. Synthesized prodrugs were characterized by spectral analysis, and in vitro and in vivo release studies were carried out using HPLC. Their hepatoprotective potential was evaluated in male Wistar rats by performing liver function tests, measuring markers of oxidative stress and carrying out histopathology studies.RESULTS Prodrugs were found to be stable in acidic(pH 1.2) and basic(pH 7.4) buffers and in rat stomach homogenates, whereas they were hydrolysed significantly(59.43%-94.93%) in intestinal homogenates over a period of 6 h. Upon oral administration of prodrug NI to rats, 52.4%-61.3% INH and 47.4%-56.8% of NAC were recovered in blood in 8-10 h. Urine and faeces samples pooled over a period of 24 h exhibited 1.3%-2.5% and 0.94%-0.9% of NAC, respectively, without any presence of intact NI or INH. Prodrugs were biologically evaluated for hepatoprotective activity. All the prodrugs were effective in abating oxidative stress and re-establishing the normal hepatic physiology. The effect of prodrug of INH with NAC in restoring the levels of the enzymes superoxide dismutase and glutathione peroxidase and abrogating liver damage was noteworthy especially. CONCLUSION The findings of this investigation demonstrated that the reported prodrugs can add safety and efficacy to future clinical protocols of tuberculosis treatment. | Neha Vithal Bhilare Suneela Sunil Dhaneshwar Kakasaheb Ramoo Mahadik | 2018 | World Journal of Hepatology2018，10，7： | 0 |
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