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| 1 | Magnesium based implants for functional bone tissue regeneration–A review显示文摘Magnesium(Mg)has emerged as one of the third-generation biomaterials for regeneration and support of functional bone tissue.Mg is a better choice over permanent implants such as titanium,stainless steel,cobalt-chrome as magnesium is biodegradable and does not require a second surgery for its removal after bone tissue recovery.It also reduces the risk of stress shielding as its elastic modulus is closer to human bone in comparison to permanent implants and other biodegradable metallic implants based on Iron and Zinc.Most importantly,Mg is osteoconductive thus stimulates new bone formation and possess anti-bacterial properties hence reducing the risk of failure due to infection.Despite its advantages,a major concern with pure Mg is its rapid bio-corrosion in presence of body fluids due to which the mechanical integrity of the implant deteriorates before healing of the tissue is complete.Mechanical properties of Mg-based implants can be enhanced by mechanical processing,alloying,and topology optimization.To reduce the corrosion/degradation rate,Mg has been alloyed with metals,reinforced with ceramics,and surface coatings have been applied so that the degradation rate of Mg-based implant matches with that of healing rate of bone tissue.The present review discusses the effect of alloying elements and reinforcing ceramics on microstructure,mechanical,and corrosion properties of Mg-based orthopedic implants.In addition,the biocompatibility of Mg-based alloys,composites,and coatings applied on Mg implants has been highlighted.Further,different methods of fabricating porous implants have been highlighted as making the implant porous facilitates the growth of new bone tissue through the pores. | Gavish Uppal Amit Thakur Amit Chauhan Saroj Bala | 2022 | Journal of Magnesium and Alloys2022，10，2： | 4 |
| 2 | Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats显示文摘AIM:To examine whether the administration of atorvastatin and rosuvastatin would prevent experimentallyinduced hepatic cirrhosis in rats.METHODS:Liver cirrhosis was induced by injections of thioacetamide(TAA).Rats were treated concurrently with TAA alone or TAA and either atorvastatin(1,10 and 20 mg/kg) or rosuvastatin(1,2.5,5,10 and 20 mg/kg) given daily by nasogastric gavage.RESULTS:Liver fibrosis and hepatic hydroxyproline content,in the TAA-treated group was significantly higher than those of the controls [11.5 ± 3.2 vs 2.6 ± 0.6 mg/g protein(P = 0.02)].There were no differences in serum aminotransferase levels in the TAA controls compared to all the groups treated concomitantly by statins.Both statins used in our study did not prevent liver fibrosis or reduce portal hypertension,and had no effect on hepatic oxidative stress.Accordingly,the hepatic level of malondialdehyde was not lower in those groups treated by TAA + statins compared to TAA only.In vitro studies,using the BrdU method have shown that atorvastatin had no effect of hepatic stellate cells proliferation.Nevertheless,statin treatment was not associated with worsening of liver damage,portal hypertension or survival rate.CONCLUSION:Atorvastatin or rosuvastatin did not inhibit TAA-induced liver cirrhosis or oxidative stress in rats.Whether statins may have therapeutic applications in hepatic fibrosis due to other etiologies deserve further investigation. | Haim Shirin Efrat Sharvit Hussein Aeed Dov Gavish Rafael Bruck | 2013 | World Journal of Gastroenterology2013，19，2： | 2 |
| 3 | Linear relationship between systolic and diastolic blood pressure monitored over 24 h: Assess ment and eorrelates显示文摘 | Gavish B Ben- Dov IZ Bursztyn M | 2008 | J Hypertens2008，26，2： | 1 |
| 4 | Solubilization of histamine H-1, GABA and benzodiazepine receptors 显示文摘 | GAVISH M CHANG R S L SNYDER S H | 1979 | Life Sci1979，25，9： | 1 |
| 5 | An algorithm for optimal route selection in SNA networks 显示文摘 | Gavish B Hantler S L | 1983 | IEEE Transaction on Commtmication1983，31，10： | 1 |
| 6 | Lipoprotein (a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis显示文摘 | Hajjar KA Gavish D Breslow JL | 1989 | Nature1989，339，6222： | 1 |
| 7 | Nth order dynamics target observability from angle measurements 显示文摘 | FOGEL ELl GAVISH MOTH | 1988 | Transactions on Aerospace and Electronic System1988，24，30： | 1 |
| 8 | Effect of a stabiliza tion splint therapy on pain during chewing in patients suffer ing from myofascial pain 显示文摘 | Gavish A Winocur E Ventura YS | 2002 | J Oral Rehabil2002，29，12： | 1 |
| 9 | Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis显示文摘 | Gavish D Breslow JL | 1989 | Nature1989，339，303： | 1 |
| 10 | Cloning of cDNAs for Fanconi's anaemia by functional complementation显示文摘 | Strathdee CA Gavish H Shannon WR | 1992 | Nature1992，358，6385： | 1 |
| 11 | Paralled savings based heuristic for the deliv- er y problem显示文摘 | Ahinkemer K Gavish B | 1991 | Operations Research1991，39，： | 1 |
| 12 | Nth-order dynamics target observability from angle measurements显示文摘 | Gavish M | 1998 | IEEE Transaction on Aerospace and Electronic Systems1998，24，3： | 1 |
| 13 | An approach to the optimal positioning of a new product显示文摘 | Gavish B Horsky D Srikanth K | 1983 | Management Science1983，29，11： | 1 |
| 14 | Liprotein (a) modulation of endothelial cell surface fibrinolysis and its potential role in atheroselerosis显示文摘 | Hajjar KA Gavish D Breslow JL | 1989 | Natu re1989，339，： | 1 |
| 15 | Parallel savings based heuristic for the delivery problem显示文摘 | Altinkemer K Gavish B | 1991 | Operations Research1991，39，： | 1 |
| 16 | Production/inventory systems with a sto- chastic production rate under a continuous review policy显示文摘 | Gavish B Graves S C | 2005 | Computers & Operations Research2005，32，5： | 1 |
| 17 | Experiences in a family with the upshaw-schulman syndrome over a 44-year period显示文摘 | Bennett Michael Chubar Yevgeni Gavish Israel | 2014 | Clin Appl Thromb Hemost2014，20，3： | 1 |
| 18 | Nth-order Dynamics Target Observ- ability from Angle Measurements 显示文摘 | Fogel E Gavish M | 1988 | IEEE Transactions on Aerospace and Electronic Systems1988，24，3： | 1 |
| 19 | Nth-Order Dynamics Target Observability from Angle Measurements显示文摘 | FOGEL E GAVISH M | 1988 | IEEE Transactions on Aerospace and Electronic Systems1988，24，3： | 1 |
| 20 | Compu- tationally efficient optimal solutions to the lot-sizing problem in multistage assembly systems 显示文摘 | AFENTAKIS P GAVISH B KARMARKAR U | 1984 | Manage- ment Science1984，30，2： | 1 |
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