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| 1 | Defining the Mitochondrial Stress Response in Arabidopsis thaliana显示文摘获得的全球概述线粒体对应力作出回应,我们试图定义工厂 mitochondrial 压力反应(MSR ) 。由联合通常认为地与压力相关的条件的 16 个 microarray 实验编码 mitochondrial 蛋白质的一套 1196 Arabidopsis thaliana 基因, 45 原子编码基因被定义为广泛地压力应答。用绿色荧光灯蛋白质(GFP ) 熔化试金,很多这些指向蛋白质的 mitochondrial 被测试,在是的总数 26 蛋白质证实 mitochondrially 指向了。几这些蛋白质被观察双指向了到线粒体和质体,包括小热吃惊蛋白质 sHSP23.5 和 sHSP23.6。除了线粒体的明确的压力部件,例如其他的 oxidases,菸碱腺嘌 dinucleotide (NAD (P) H ) 脱氢酶,和热震惊蛋白质,许多另外的蛋白质,许多与未知功能,被识别。mitochondrial 搬运人蛋白质家庭在压力应答的基因是过去代表的,建议那个压力越过 mitochondrial 为代谢物运输导致改变的需要内部膜。尽管这些蛋白质编码许多的基因包含普通行动 cis 规章的元素,很多个不同规章的过程或信号多半触发了 MSR,是明显的。因此,这些基因提供新模型系统学习 mitochondrial 后退规定,除了广泛地使用的其他的 oxidase 模型。另外,当在对应力应答的蛋白质的变化没在一个抄本与变化相关很好,铺平,它建议 post-transcriptional 机制也在定义 MSR 起一个重要作用。 | Olivier Van Aken Botao Zhang Chris Carrie Vindya Uggalla Ellen Paynter Estelle Giraud James Whelan | 2009 | Molecular Plant2009，2，6： | 4 |
| 2 | C1q nephropathy in children: clinical characteristics and outcome显示文摘 | Vindya N. Gunasekara Neil J. Sebire Kjell Tullus | 2014 | Pediatric Nephrology2014，，： | 1 |
| 3 | Tubulins - The Target for Anticancer Therapy显示文摘 | N.G. Vindya Nishant Sharma Mukesh Yadav K.R. Ethiraj | 2015 | Current Topics in Medicinal Chemistry2015，，1： | 1 |
| 4 | Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cisplatin-induced neurotoxicity in rats显示文摘Background: The aim of the present study was to evaluate the neuroprotective effect of allantoin in cisplatin‐induced toxicity in rats. Methods: Adult male Wistar rats weighing 160‐200 g were used. Neuropathy was induced by injecting cisplatin (2 mg/kg, ip, twice a week for 6 weeks) and the rats were concurrently treated with allantoin (200 and 400 mg/kg, po) for 8 weeks. At the end of the study, body weight and hemogram were measured. Behavioural tests were performed, including tests for cold and hot hyperalgesia, motor co‐ordination, locomotor activity, mechano‐tactile allodynia and mechanical hyperalgesia. The rats were then sacrificed and sciatic nerve conduction velocity was determined. The antioxidant enzyme and nitric oxide levels in sciatic nerve homogenates were measured. Results: In this study, allantoin restored the motor nerve conduction velocity deficits induced by cisplatin, and the allantoin‐treated rats showed improvement in cold and thermal hyperalgesia, mechano‐tactile allodynia, and mechanical hyperalgesia. Allantoin treatment also improved the rats’ hematological status, increasing haemoglobin, platelet and RBC counts compared to the cisplatin‐treated group. Allantoin treatment also mitigated the functional abnormalities seen in the cisplatin neuropathy group, protecting neurons from the neurotoxic effects of cisplatin. Conclusion: Allantoin shows promise for use as an adjuvant drug in cancer treatment to protect against cisplatin‐induced neuropathy. | Vindya N S Aqib Mohamad Rema Razdan | 2019 | Animal Models and Experimental Medicine2019，2，2： | 1 |
| 5 | Association Between Child Maltreatment and Constipation: A School-Based Survey Using Rome III Criteria显示文摘 | Shaman Rajindrajith Niranga M. Devanarayana Chamila Lakmini Vindya Subasinghe D.G. Harendra de Silva Marc A. Benninga | 2014 | Journal of Pediatric Gastroenterology and Nutrition2014，，4： | 1 |
| 6 | Subcritical dynamo and hysteresis in a Babcock-Leighton type kinematic dynamo model显示文摘In the Sun and Sun-like stars,it is believed that cycles of the large-scale magnetic field are produced due to the existence of differential rotation and helicity in the plasma flows in their convection zones(CZs).Hence,it is expected that for each star,there is a critical dynamo number for the operation of a large-scale dynamo.As a star slows down,it is expected that the large-scale dynamo ceases to operate above a critical rotation period.In our study,we explore the possibility of the operation of the dynamo in the subcritical region using the Babcock–Leighton type kinematic dynamo model.In some parameter regimes,we find that the dynamo shows hysteresis behavior,i.e.,two dynamo solutions are possible depending on the initial parameters—decaying solution if starting with weak field and strong oscillatory solution(subcritical dynamo)when starting with a strong field.However,under large fluctuations in the dynamo parameter,the subcritical dynamo mode is unstable in some parameter regimes.Therefore,our study supports the possible existence of subcritical dynamo in some stars which was previously demonstrated in a mean-field dynamo model with distributedαand MHD turbulent dynamo simulations. | Vindya Vashishth Bidya Binay Karak Leonid Kitchatinov | 2021 | Research in Astronomy and Astrophysics2021，21，10： | 0 |
| 7 | Effects of USPSTF guidelines on patterns of screening and treatment outcomes for prostate cancer显示文摘The updated United States Preventive Services Task Force(USPSTF) for prostate cancer in 2012 recommends against prostate-specific antigen(PSA) based screening for men of all ages. Prostate cancer is the second most common and second most deadly cancer in American men. PSA screening for prostate cancer has been present since 1994 leading to an over diagnosis and over treatment of low volume disease. There is an overall agreement of men towards the guidelines but even with the understanding of the USPSTF, these men tend to follow more personal beliefs that have been influenced by their knowledge of the disease process and physician influence. Physicians also followed the directions of the patients and opted not to change their current practice of PSA screening despite the new guidelines. Time, legal, and ethical issues were some of the barriers that physicians faced in tailoring their practice towards screening. The importance of informed consent is highlighted by both the patients and the physicians and clearly more effective when the patient was pre-informed of the disease processand prompted the physicians to initiate conversation of informed screening. Younger patients were inclined towards aggressive treatment and older patients opted towards watchful waiting both with emphasis on the importance of evidence-based information provided by the physician. Decision aids were useful in making informed decisions and could be used to educate patients on screening purposes and treatment options. However, even with well-created decision aids and physician influence, patients' own belief system played a major part in healthcare decision making in either screening or treatment for prostate cancer. | Vindya Gunawardena Jeanny B Aragon-Ching | 2014 | World Journal of Translational Medicine2014，3，2： | 0 |
| 8 | Secondary metabolites from an endophytic fungus Aspergillus fumigatus from Solanum insanum L.显示文摘An endophytic fungus Aspergillus fumigatus,isolated from the fruits of Solanum insanum L.,was cultured in potato dextrose broth medium.Chromatographic separation of the EtOAc extract led to the isolation of six secondary metabolites,identified as pseurotin A(1),fumigaclavine C(2),monomethylsulochrin(3),trypacidin(4),fumiquinazoline C(5)and guignasulfide(6)by spectral means.Compounds 2 and 3 showed brine shrimp toxicity with IC50 values of 147 and 74.2μM,respectively,while compounds 4 and 5 showed slight inhibition on the growth of fungal pathogen Cladosporium cladosporioides.This is the first report of the isolation of guignasulfide(6)from A.fumigatus,which has been previously isolated only from an endophytic fungus Guignardia sp. | Vindya Kanthi Munasinghe N.Savitri Kumar Nimal Adikaram Lalith Jayasinghe Hiroshi Araya Yoshinori Fujimoto | 2021 | Asian Journal of Traditional Medicines2021，16，2： | 0 |
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