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| 1 | Colorectal carcinogenesis:Insights into the cell death and signal transduction pathways:A review显示文摘Colorectal carcinogenesis(CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APC^(min/+) mouse model, Azoxymethane, Dimethyl hydrazine, and a combination of Dextran sodium sulphate and dimethyl hydrazine. During CRC progression, several signal transduction pathways are activated. Among the major signal transduction pathways are p53, Transforming growth factor beta, Wnt/β-catenin, Delta Notch, Hippo signalling, nuclear factor erythroid 2-related factor 2 and Kelch-like ECH-associated protein 1 pathways. These signalling pathways collaborate with cell death mechanisms, which include apoptosis, necroptosis and autophagy, to determine cell fate. Extensive research has been carried out in our laboratory to investigate these signal transduction and cell death mechanistic pathways in CRC. This review summarizes CRC pathogenesis and the related cell death and signal transduction pathways. | Ashok kumar Pandurangan Thomas Divya Kalaivani Kumar Vadivel Dineshbabu Bakthavatchalam Velavan Ganapasam Sudhandiran | 2018 | World Journal of Gastrointestinal Oncology2018，10，9： | 10 |
| 2 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 3 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 4 | Predictors of short term mortality in heart failure — Insights from the Euro Heart Failure survey显示文摘 | Periaswamy Velavan Nasrin K. Khan Kevin Goode Alan S. Rigby Poay H. Loh Michel Komajda Ferenc Follath Karl Swedberg Hugo Madeira John G.F. Cleland | 2008 | International Journal of Cardiology2008，，1： | 2 |
| 5 | Genetic insights on host and hepatitis B virus in liver diseases显示文摘 | Hoang van Tong C. Thomas Bock Thirumalaisamy P. Velavan | 2014 | Mutation Research-Reviews in Mutation Research2014，，： | 2 |
| 6 | VanillinI 显示文摘 | Velavan R Sureshkumar P Sivakumar K | 1995 | Acta Crystallographica Section C : Crystal Structure Communications1995，51，6： | 1 |
| 7 | Predictors of short term mortality in heart failure-insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Cardiol2010，138，1： | 1 |
| 8 | in vitro Antioxidant Activity and Total Polyphenolic Content of Cyperus rotundus Rhizomes显示文摘 | KR. Nagulendran S. Velavan R. Mahesh V. Hazeena Begum | 2007 | E-Journal of Chemistry2007，，3： | 1 |
| 9 | Observation of three sites for vanadyl in a biomineral,zinc sodium phosphate hexahydrate:an EPR investigation显示文摘 | Velavan K Sougandi I Venkatesan V | 2005 | Journal of Physics and Chemistry of Solids2005，66，： | 1 |
| 10 | Regulatory T cells and parasites显示文摘 | Velavan TP Ojurongbe O | 2011 | J Biomed Bioteehnol2011，2011，52： | 1 |
| 11 | Molecular char- acterization of regulatory polymorphisms in the promoter region of the STAT6 in a Gabonese population 显示文摘 | VELAVAN T P BECHLARS S TOMIUK J | 2011 | Mere Inst Oswaldo Cruz2011，106，1： | 1 |
| 12 | Detection of multiple infections by monocystis strains in a single earthworm host using ribosomal internal transcribed spacer sequence variation 显示文摘 | Velavan TP Sehulenburg H Miehiels NK | 2010 | Par- asitology2010，137，1： | 1 |
| 13 | Development and characterization of novel microsatellite markers from the olive ridley sea turtle ( Lepidochelys olivacea) 显示文摘 | Aggarwal R K Velavan T P Udaykumar D | 2004 | Mol Ecol Notes2004，4，1： | 1 |
| 14 | How should I treat an entrapped rotational atherectomy burr显示文摘 | Vroey FD Velavan P Jack SE | | 0，，： | 1 |
| 15 | Predictors of short term mortality in heart failure-insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Cardiol2010，138，1： | 1 |
| 16 | Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J CardioI2010，138，： | 1 |
| 17 | Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Car- diol2010，138，1： | 1 |
| 18 | Predictors of short term mortality in heart failure -insights from the Euro Heart Fail- ure survey 显示文摘 | VELAVAN P KHAN N K GOODE K | 2010 | lnt J Cardiol2010，138，1： | 1 |
| 19 | External beam radiotherapy and intraluminal brachytherapy in advanced inoperable esophageal cancer: JIPMER experience 显示文摘 | Reddy KS Velavan K | 2001 | Am J Clin Oncol2001，24，2： | 1 |
| 20 | Predictors of short term mortality in heart failure-Insights from the Euro Heart Failure survey显示文摘 | VELAVAN P KHAN N K GOODE K | 2010 | Int J Cardiol2010，138，： | 1 |
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