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| 1 | Colorectal carcinogenesis:Insights into the cell death and signal transduction pathways:A review显示文摘Colorectal carcinogenesis(CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APC^(min/+) mouse model, Azoxymethane, Dimethyl hydrazine, and a combination of Dextran sodium sulphate and dimethyl hydrazine. During CRC progression, several signal transduction pathways are activated. Among the major signal transduction pathways are p53, Transforming growth factor beta, Wnt/β-catenin, Delta Notch, Hippo signalling, nuclear factor erythroid 2-related factor 2 and Kelch-like ECH-associated protein 1 pathways. These signalling pathways collaborate with cell death mechanisms, which include apoptosis, necroptosis and autophagy, to determine cell fate. Extensive research has been carried out in our laboratory to investigate these signal transduction and cell death mechanistic pathways in CRC. This review summarizes CRC pathogenesis and the related cell death and signal transduction pathways. | Ashok kumar Pandurangan Thomas Divya Kalaivani Kumar Vadivel Dineshbabu Bakthavatchalam Velavan Ganapasam Sudhandiran | 2018 | World Journal of Gastrointestinal Oncology2018，10，9： | 10 |
| 2 | Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy显示文摘 | Ankit Saxena Sam Khosraviani Sanjeev Noel Divya Mohan Thomas Donner Abdel Rahim A. Hamad | 2014 | Cytokine2014，，： | 1 |
| 3 | Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis显示文摘 | Thomas Divya Vadivel Dineshbabu Syamala Soumyakrishnan Anandasadagopan Sureshkumar Ganapasam Sudhandiran | 2016 | Chemico-Biological Interactions2016，，： | 1 |
| 4 | Structural,magnetic,and acidic properties of cobalt ferrite nanoparticles synthesised by wet chemical methods显示文摘A detailed investigation on the effect of preparation method on the structural,magnetic,and acidic properties of cobalt ferrite nanoparticles prepared by sol-gel and co-precipitation is presented.Citric acid and ethylene glycol were used as gelling agents,while sodium hydroxide and aqueous ammonia were used as precipitating agents.The resulting ferrites were calcined at 450℃ and 750℃.Sharper X-ray diffraction(XRD)peaks were observed for the samples calcined at 750℃,indicating greater crystallinity of the samples calcined at higher temperature.Average crystallite sizes fell in the ranges of 7.1-21.1 nm and 30.4-42.1 nm for the samples calcined at 450℃ and 750℃,respectively.The infrared spectra revealed two main absorption bands,the high frequency bandν1 around 600 cm^(-1) and the low frequency bandν2 around 400 cm^(-1) arising from stretching vibrations of the oxygen bond with the metal in the tetrahedral(A)and octahedral(B)sites in the spinel lattice.Agglomeration of particles was observed in the scanning electron microscopy(SEM)images.Magnetic parameters of CoFe_(2)O_(4) nanoparticles greatly depended on calcination temperature and preparation techniques.Ammonia temperature programmed desorption(TPD)measurements indicated that weak acid sites predominate medium strength sites,while the number of strong acid sites is the least.Cumulative acidity decreased for the samples calcined at higher temperature.The results underline the effect of preparation conditions on the morphology,crystallite size,and magnetic properties of nano ferrites. | Manju KURIAN Smitha THANKACHAN Divya S.NAIR Aswathy E.K. Aswathy BABU Arathy THOMAS Binu KRISHNA K.T. | 2015 | Journal of Advanced Ceramics2015，4，3： | 0 |
| 5 | 氨基酸表面活性剂的合成、性质及工业应用(续完)显示文摘7毒性传统表面活性剂,特别是阳离子表面活性剂对水生生物具有很强的毒性。其急性毒性是由于表面活性剂在细胞-水界面处的吸附-离子相互作用现象。降低表面活性剂的cmc通常导致表面活性剂更强的界面吸附,通常导致其急性毒性升高。表面活性剂疏水链的长度增加也导致表面活性剂急性毒性增大。大部分AAS为对人体和环境(特别是对海洋生物)低毒或无毒,使其适合做为食品成分、药物和化妆品[107-113]。很多研究者证明氨基酸表面活性剂对皮肤温和且无刺激[110]。 | 肖进新(编译) Divya B.Tripathy Anuradha Mishra James Clark Thomas Farmer | 2018 | 日用化学品科学2018，41，12： | 0 |
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