|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 2 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | VanillinI 显示文摘 | Velavan R Sureshkumar P Sivakumar K | 1995 | Acta Crystallographica Section C : Crystal Structure Communications1995，51，6： | 1 |
| 4 | Predictors of short term mortality in heart failure-insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Cardiol2010，138，1： | 1 |
| 5 | Molecular char- acterization of regulatory polymorphisms in the promoter region of the STAT6 in a Gabonese population 显示文摘 | VELAVAN T P BECHLARS S TOMIUK J | 2011 | Mere Inst Oswaldo Cruz2011，106，1： | 1 |
| 6 | Development and characterization of novel microsatellite markers from the olive ridley sea turtle ( Lepidochelys olivacea) 显示文摘 | Aggarwal R K Velavan T P Udaykumar D | 2004 | Mol Ecol Notes2004，4，1： | 1 |
| 7 | How should I treat an entrapped rotational atherectomy burr显示文摘 | Vroey FD Velavan P Jack SE | | 0，，： | 1 |
| 8 | Predictors of short term mortality in heart failure-insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Cardiol2010，138，1： | 1 |
| 9 | Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J CardioI2010，138，： | 1 |
| 10 | Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Car- diol2010，138，1： | 1 |
| 11 | Predictors of short term mortality in heart failure -insights from the Euro Heart Fail- ure survey 显示文摘 | VELAVAN P KHAN N K GOODE K | 2010 | lnt J Cardiol2010，138，1： | 1 |
| 12 | Predictors of short term mortality in heart failure-Insights from the Euro Heart Failure survey显示文摘 | VELAVAN P KHAN N K GOODE K | 2010 | Int J Cardiol2010，138，： | 1 |
| 13 | Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey显示文摘 | Velavan P Khan NK Goode K | 2010 | Int J Cardiol2010，138，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员