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| 1 | Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies显示文摘Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy. | Sahil Gambhir Dinesh Vyas Michael Hollis Apporva Aekka Arpita Vyas | 2015 | World Journal of Gastroenterology2015，21，11： | 24 |
| 2 | Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity显示文摘Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC. | Michael Hollis Kavitha Nair Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 3 | Association between serum vitamin D levels and gastric cancer:A retrospective chart analysis显示文摘AIM To determine whether there is an increased risk of gastric adenocarcinoma associated with vitamin D deficiency(VDd).METHODS A retrospective case control study was performed of all patients diagnosed with gastric adenocarcinoma between 2005 and 2015.After we excluded the patients without a documented vitamin D level,49 patients were included in our study.RESULTS The average age of patients with gastric adenocarcinoma and documented vitamin D level was 64 years old(95%CI: 27-86) and average vitamin D level was 20.8 mg/d L(95%CI: 4-44).Compared to a matched control group,the prevalence of VDd/insufficiency in patients with gastric adenocarcinoma was significantly higher than normal vitamin D levels(83.7% vs 16.3%).Forty-one patients(83.7%) with adenocarcinoma showed VDd/insufficiency compared to 18(37%) patients with normal vitamin D level without gastric cancer(OR: 8.8,95%CI: 5-22,P value < 0.0001).The average age of males with gastric adenocarcinoma diagnosis was 60 years old vs 68 years old for females(P = 0.01).StageⅡ gastric adenocarcinoma was the most prevalent in our study(37%).CONCLUSION We reported a positive relationship between VDd and gastric adenocarcinoma,that is to say,patients with decreased VDd levels have an increased propensity for gastric adenocarcinoma. | Neil Vyas Rafael Ching Companioni Melik Tiba Hassan Alkhawam Carmine Catalano Robert Sogomonian Joel Baum Aaron Walfish | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 10 |
| 4 | 搅拌摩擦加工制备石墨烯和碳纳米管增强Al6061-SiC复合材料的显微组织演变及表面性能(英文)显示文摘对比研究多壁碳纳米管(CNT)和石墨烯纳米片(GNP)对Al-SiC基复合材料表面性能的影响,用搅拌摩擦法分别制备Al-SiC-CNT和Al-SiC-GNP复合材料。显微组织表征表明,与CNTs相比,GNPs在铝基体中的分散更加均匀。此外,还观察到SiC和GNP颗粒对位错的阻碍以及基体与增强材料之间的无缺陷界面。纳米压痕结果表明,与Al6061合金相比,Al-SiC-GNP和Al-SiC-CNT复合材料的表面纳米硬度分别显著提高约207%和27%,显微硬度分别提高了约36%和17%。摩擦学分析表明,Al-SiC-GNP复合材料的比磨损率降低约56%,而Al-SiC-CNT复合材料的比磨损率提高约122%。Al-SiC-GNP复合材料的高强度是由于在SiC存在下,GNPs会机械剥离成几层石墨烯(FLG)。此外,热失配、晶粒细化和Orowan循环等多种机制对复合材料的增强也有重要作用。而摩擦性能提升的主要原因是其表面挤出的GNP形成摩擦层,拉曼光谱和其他表征方法证实这一结果。 | Abhishek SHARMA Vyas Mani SHARMA Jinu PAUL | 2019 | Transactions of Nonferrous Metals Society of China2019，29，10： | 7 |
| 5 | 活性干酵母和灭活干酵母对肉用小母牛亚急性瘤胃酸中毒、瘤胃发酵及营养物质消化率的影响显示文摘本研究探讨了酵母菌对于减少亚急性瘤胃酸中毒的发生率(sARA)和改善肉用母牛全消化道养分消化率的重要性。试验选用6头安装有瘤胃瘘管牛的肉用小母牛(680kg±50kg),采用3×3拉丁方试验设计,饲喂日粮中含有40%大麦青贮、10%干草和50%大麦为基础的精料(DM基础)。试验处理如下:①对照组(无酵母);②活性干酵母(ADY,4g提供10^19CFU/g;ABVista,马尔堡,英国);③灭活干酵母(KDY,4g经蒸压处理的ADY)。 | Vyas D 孙鹏 | 2014 | 中国畜牧兽医2014，41，5： | 6 |
| 6 | Pharmacological cyclin dependent kinase inhibitors: Implications for colorectal cancer显示文摘Colorectal cancer accounts for a significant proportion of cancer deaths worldwide. The need to develop more chemotherapeutic agents to combat this disease is critical. Cyclin dependent kinases(CDKs), along with its binding partner cyclins, serve to control the growth of cells through the cell cycle. A new class of drugs, termed CDK inhibitors, has been studied in preclinical and now clinical trials. These inhibitors are believed to act as an anti-cancer drug by blocking CDKs to block the uncontrolled cellular proliferation that is hallmark of cancers like colorectal cancer. CDK article provides overview of the emerging drug class of CDK inhibitors and provides a list of ones that are currently in clinical trials. | Archana Balakrishnan Arpita Vyas Kaivalya Deshpande Dinesh Vyas | 2016 | World Journal of Gastroenterology2016，22，7： | 5 |
| 7 | Therapeutic potential of snake venom in cancer therapy:current perspectives显示文摘Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer.Snake venom toxins coutributed significantly to the treatment of many medical conditions.There are many published studies describing and elucidating the anti-cancer potential of snake venom.Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species.Some of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes,affecting the migration and proliferation of these cells.Some of substances found in the snake venom present a great potential as anti-tumor agent.In this review,we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity. | Vivek Kumar Vyas Keyur Brahmbhatt Hardik Bhatt Utsav Parmar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 5 |
| 8 | Fecal transplant policy and legislation显示文摘Fecal microbiota transplantation(FMT) has garnered significant attention in recent years in the face of a reemerging Clostridium difficile(C.difficile) epidemic.Positive results from the first randomized control trial evaluating FMT have encouraged the medical community to explore the process further and expand its application beyond C.difficile infections and even the gastrointestinal domain.However promising and numerous the prospects of FMT appear,the method remains limited in scope today due to several important barriers,most notably a poorly defined federal regulatory policy.The Food and Drug Administrationhas found it difficult to standardize and regulate the administration of inherently variable,metabolically active,and ubiquitously available fecal material.The current cumbersome policy,which classifies human feces as a drug,has prevented physicians from providing FMT and deserving patients from accessing FMT in a timely fashion,and subsequent modifications seem only to be temporary.The argument for reclassifying fecal material as human tissue is well supported.Essentially,this would allow for a regulatory framework that is sufficiently flexible to expand access to care and facilitate research,but also appropriately restrictive and centralized to ensure patient safety.Such an approach can facilitate the advancement of FMT to a more refined,controlled,and aesthetic process,perhaps in the form of a customized and wellcharacterized stool substitute therapy. | Dinesh Vyas Apoorva Aekka Arpita Vyas | 2015 | World Journal of Gastroenterology2015，21，1： | 4 |
| 9 | Stool therapy may become a preferred treatment of recurrent Clostridium difficile?显示文摘Fecal enemas were first reported to successfully treat life threatening enterocolitis in 1958, but fecal therapy to treat Clostridium difficile (C. difficile ) infection has remained esoteric and not well investigated until recently. In the past few years, systematic reviews of case series and case reports of fecal microbiota transplant for recurrent C. difficile infection have become available and validate use of fecal transplant for C. difficile enterocolitis. Methods of fecal transplant reported in the literature include: nasogastric tube, gastroscope, duodenal tube, colonoscopy, rectal tube, and fecal enemas administered at home; no method has been shown to be superior. A recent randomized study published in New England Journal of Medicine found fecal transplant to be superior to oral vancomycin alone in treatment of recurrent C. difficile enterocolitis. The significance of this trial cannot be underestimated as it lends credibility to the idea of intentionally using microbes to combat disease, providing an alternative to the older paradigm of disease eradication through use of antimicrobials. | Dinesh Vyas Heidi E L'Esperance Arpita Vyas | 2013 | World Journal of Gastroenterology2013，19，29： | 4 |
| 10 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 11 | Anisotropy Properties of Tissues: A Basis for Fabrication of Biomimetic Anisotropic Scaffolds for Tissue Engineering显示文摘Tissue engineering has been a subject of extensive scientific exploration in the last two decades making gradual inroads into clinical studies as well.Along with regenerative cells and growth factors,biomaterial scaffolds are integral to the development of a tissue engi neered construct.It is now appreciated that scaffolds should mimic the target tissue properties intimately in order to provide a micro-environment milieu that allows the seeded cells to differentiate into the desired tissue.Even from a structural viewpoint,mismatch between scaffold and native matrix properties can cause cell necrosis through mechanisms such as stress shielding.One of the key prop erties of most body tissues is that they exhib社anisotropy.However,most fabrication methods generate isotropic scaffolds and require specific modifications to produce anisotropic scaffolds.In the last decade,the advent of additive manufacturing and bioprinting has provided facile tools to fabricate scaffolds with desired anisotropy.On the other hand,a biomimetic scaffold can be designed only when target tissue anisotropy is well known to the tissue engineer.This review presents an overview of the anisotropic properties of different tissues,which will be critical for developing biomimetic engineered constructs.The traditional anatomical records do not adequately present these properties from the perspective of designing tissue engineering scaffolds.Subsequently,present state-of-the art in devel opment of anisotropic scaffolds as well as tissue constructs using different conventional and emerging fabrication techniques is discussed.It is expected that the readers will obtain a comprehensive reference on the research area by examining these two aspects juxtaposed to each other and gain key trends for fabrication of anisotropic scaffolds,plausibly with improved regenerative outcomes. | Pallab Datta Veena Vyas Santanu Dhara Amit Roy Chowdhury Ananya Barui | 2019 | Journal of Bionic Engineering2019，16，5： | 4 |
| 12 | High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases显示文摘RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and Crohn's disease), and irritable bowel syndrome. | Mamie Gao Allen Zhong Neil Patel Chiraag Alur Dinesh Vyas | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 13 | Antioxidant activity and total phenolic content of ethanolic extract of Caesalpinia bonducella seeds显示文摘 | Shruti Shukla Archana Mehta Jinu John Siddharth Singh Pradeep Mehta Suresh Prasad Vyas | 2009 | Food and Chemical Toxicology2009，，8： | 3 |
| 14 | SIMPLE-fying middlebox policy enforcement using SDN显示文摘 | Zafar Ayyub Qazi Cheng-Chun Tu Luis Chiang Rui Miao Vyas Sekar Minlan Yu | 2013 | ACM SIGCOMM Computer Communication Review2013，，4： | 3 |
| 15 | Circadian rhythm and drug delivery design 显示文摘 | Vyas SP Sood A Venugopalan P | 1997 | Pharrnazine1997，52，11： | 2 |
| 16 | Circadian rhythm and drug delivery design 显示文摘 | Vyas SP Sood A Venugopalan P | 1997 | Pharmazie1997，52，11： | 2 |
| 17 | Screening colonoscopy:The present and the future显示文摘In the United States,colorectal cancer(CRC)is the second leading cause of mortality in men and women.We are now seeing an increasing number of patients with advanced-stage diagnosis and mortality from colorectal cancer before 50 years of age,which requires earlier screening.With the increasing need for CRC screening through colonoscopy,and thus endoscopists,easier and simpler techniques are needed to train proficient endoscopists.The most widely used approach by endoscopists is air insufflation colonoscopy,where air distends the colon to allow visualization of the colonic mucosa.This technique is uncomfortable for patients and requires an anesthetist to administer sedation.In addition,patients commonly complain about discomfort post-op as air escapes into the small bowel and cannot be adequately removed.Current research into the use of water insufflation colonoscopies has proved promising in reducing the need for sedation,decreasing discomfort,and increasing the visibility of the colonic mucosa.Future direction into water insufflation colonoscopies which have shown to be simpler and easier to teach may increase the number of proficient endoscopists in training to serve our aging population. | Chelsea V Hayman Dinesh Vyas | 2021 | World Journal of Gastroenterology2021，27，3： | 2 |
| 18 | Making middleboxes someone else’s problem显示文摘 | Justine Sherry Shaddi Hasan Colin Scott Arvind Krishnamurthy Sylvia Ratnasamy Vyas Sekar | 2012 | ACM SIGCOMM Computer Communication Review2012，，： | 2 |
| 19 | 两个热带树种(柚木和印度实竹)叶面积指数估测异速生长方程(英文)显示文摘通过破坏性抽样、相片网格法和落叶采受器法,获得了印度Shoolpaneshwar野生动物禁猎区内生长的柚木和印度实竹叶面积指数。建立了一个异速生长方程来决定两个树种的叶面积指数。结果表明,异速生长方程获得的叶面积指数与破坏性抽样、相片网格法和落叶采受器法评估得到的指数值相近;2种测定方式下,柚木的均方根误差分别是0.90和1.15,印度实竹的均方根误差分别为0.38和0.46。估计的和计算获得的叶面积指数值匹配性较好,说明用建立的方程计算得到的2个树种叶面积指数的准确性较好。总之,冠幅伸展是一个估计树木叶面积较好的且敏感的参数。本文所提出的方程可以用作估计热带柚木和印度实竹叶面积指数。图4表1参22。 | Dhaval Vyas Nirav mehta J.Dina-karan N.S.R.Krishnayya | 2010 | Journal of Forestry Research2010，21，2： | 2 |
| 20 | Measurement of tracheal tube cuff pressure in critical care 显示文摘 | Vyas D Inweregbu K Pittard A | 2002 | Anaesthesia2002，57，3： | 2 |
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