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| 1 | Family integrated care:Supporting parents as primary caregivers in the neonatal intensive care unit显示文摘Family integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psychological, educational, communication, and environmental strategies to support parents to cope with the NICU environment and to prepare them to be able to emotionally, cognitively, and physically care for their infant. FICare has been associated with improved infant feeding, growth, and parent wellbeing and self-efficacy;important mediators for long-term improved infant neurodevelopmental and behavioural outcomes. FICare implementation requires multi-disciplinary commitment, staff motivation, and sufficient time for preparation and readiness for change as professionals relinquish power and control to instead develop collaborative partnerships with parents. Successful FICare implementation and culture change have been applied by neonatal teams internationally, using practical approaches suited to their local environments. Strategies such as parent and staff meetings and relational communication help to break down barriers to change by providing space for the co-creation of knowledge, the negotiation of caregiving roles and the development of trusting relationships. The COVID-19 pandemic highlighted the vulnerability within programs supporting parental presence in neonatal units and the profound impacts of parent-infant separation. New technologies and digital innovations can help to mitigate these challenges, and support renewed efforts to embed FICare philosophy and practice in neonatal care during the COVID-19 recovery and beyond. | Chandra Waddington Nicole Rvan Veenendaal Karel O’Brien Neil Patel for the International Steering Committee for Family Integrated Care | 2021 | Pediatric Investigation2021，5，2： | 9 |
| 2 | Degenerative meniscus: Pathogenesis, diagnosis, and treatment options显示文摘The symptomatic degenerative meniscus continues to be a source of discomfort for a significant number of patients. With vascular penetration of less than onethird of the adult meniscus, healing potential in the setting of chronic degeneration remains low. Continued hoop and shear stresses upon the degenerative meniscus results in gross failure, often in the form of complex tears in the posterior horn and midbody. Patient history and physical examination are critical to determine the true source of pain, particularly with the significant incidence of simultaneous articular pathology. Joint line tenderness, a positive Mc Murray test, and mechanical catching or locking can be highly suggestive of a meniscal source of knee pain and dysfunction. Radiographs and magnetic resonance imaging are frequently utilized to examine for osteoarthritis and to verify the presence of meniscal tears, in addition to ruling out other sources of pain. Non-operative therapy focused on nonsteroidal anti-inflammatory drugs and physical therapy may be able to provide pain relief as well as improve mechanical function of the knee joint. For patients re-fractory to conservative therapy, arthroscopic partial meniscectomy can provide short-term gains regarding pain relief, especially when combined with an effective, regular physiotherapy program. Patients with clear mechanical symptoms and meniscal pathology may benefit from arthroscopic partial meniscectomy, but surgery is not a guaranteed success, especially with concomitant articular pathology. Ultimately, the long-term outcomes of either treatment arm provide similar results for most patients. Further study is needed regarding the short and long-term outcomes regarding conservative and surgical therapy, with a particular focus on the economic impact of treatment as well. | Richard Howell Neil S Kumar Nimit Patel James Tom | 2014 | World Journal of Orthopedics2014，5，5： | 8 |
| 3 | High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases显示文摘RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and Crohn's disease), and irritable bowel syndrome. | Mamie Gao Allen Zhong Neil Patel Chiraag Alur Dinesh Vyas | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 4 | Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease显示文摘Atrial fibrillation(AF) is the most common type of sustained arrhythmia,which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac and major non-cardiac diseases. Morbidity and mortality associated with AF makes it a major healthcare burden. The objective of our article is to determine the prognostic impact of AF on acute coronary syndromes,heart failure and chronic kidney disease. Multiple studies have been conducted to determine if AF has an independent role in the overall mortality of such patients. Our review suggests that AF has an independent adverse prognostic impact on the clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease. | Nileshkumar J Patel Aashay Patel Kanishk Agnihotri Dhaval Pau Samir Patel Badal Thakkar Nikhil Nalluri Deepak Asti Ritesh Kanotra Sabeeda Kadavath Shilpkumar Arora Nilay Patel Achint Patel Azfar Sheikh Neil Patel Apurva O Badheka Abhishek Deshmukh Hakan Paydak Juan Viles-Gonzalez | 2015 | World Journal of Cardiology2015，7，7： | 2 |
| 5 | A community-based multicenter trial of pharmacokinetically guided 5-fluorouracil dosing for personalized colorectal cancer therapy显示文摘 | Patel J N O’Neil B H Deal A M | 2014 | Oncologist2014，19，9： | 1 |
| 6 | Longitudinal Strain Delay Index by Speckle Tracking Imaging: A New Marker of Response to Cardiac Resynchronization Therapy显示文摘 | Pascal Lim Adisai Buakhamsri Zoran B. Popovic Neil L. Greenberg Dimpi Patel James D. Thomas Richard A. Grimm | 2008 | Circulation2008，，11： | 1 |
| 7 | Neuropsychological differences between sur- vivors of supratentorial and infratentorial brain tumottrs 显示文摘 | Patel SK Mullins WA O'Neil SH | 2011 | J Intellect Disabil Res2011，55，： | 1 |
| 8 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 9 | Investigating the utilization of pharmacokinetic-guided fluorouracil in colorectal cancer显示文摘 | Patel J N O’Neil B H Mc Leod H L | 2012 | J Clin Oncol2012，30，15： | 1 |
| 10 | Longitudinal Strain Delay Index by Speckle Tracking Imaging: A New Marker of Response to Cardiac Resynchronization Therapy显示文摘 | Pascal Lim Adisai Buakhamsri Zoran B. Popovic Neil L. Greenberg Dimpi Patel James D. Thomas Richard A. Grimm | 2008 | Circulation2008，，： | 1 |
| 11 | Effects of Visit-to-Visit Variability in Systolic Blood Pressure on Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes Mellitus显示文摘 | Jun Hata Hisatomi Arima Peter M. Rothwell Mark Woodward Sophia Zoungas Craig Anderson Anushka Patel Bruce Neal Paul Glasziou Pavel Hamet Giuseppe Mancia Neil Poulter Bryan Williams Stephen MacMahon John Chalmers | 2013 | Circulation2013，，12： | 1 |
| 12 | Dasatinib inhibits mammary tumour development in a genetically engineered mouse model显示文摘 | Saadia A Karim Helen Creedon Hitesh Patel Neil O Carragher Jennifer P Morton William J Muller Thomas RJ Evans Barry Gusterson Owen J Sansom Valerie G Brunton | 2013 | J. Pathol2013，，： | 1 |
| 13 | Use of Milrinone to Treat Cardiac Dysfunction in Infants with Pulmonary Hypertension Secondary to Congenital Diaphragmatic Hernia: A Review of Six Patients显示文摘 | Patel Neil | 2012 | Neonatology2012，，2： | 1 |
| 14 | GDNF, NGF and BDNF as therapeutic options for neurodegeneration显示文摘 | Shelley J. Allen Judy J. Watson Deborah K. Shoemark Neil U. Barua Nikunj K. Patel | 2013 | Pharmacology and Therapeutics2013，，2： | 1 |
| 15 | Impact of obesity on the survival of patients with early‐stage squamous cell carcinoma of the oral tongue显示文摘 | Neil M. Iyengar Amit Kochhar Patrick G. Morris Luc G. Morris Xi K. Zhou Ronald A. Ghossein Alejandro Pino Matthew G. Fury David G. Pfister Snehal G. Patel Jay O. Boyle Clifford A. Hudis Andrew J. Dannenberg | 2014 | Cancer2014，，7： | 1 |
| 16 | Long-term, in vivo therapeutic effects of a single dose of miR-145 micelles for atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease that is characterized by the build-up of lipid-rich plaques in the arterial walls. The standard treatment for patients with atherosclerosis is statin therapy aimed to lower serum lipid levels. Despite its widespread use, many patients taking statins continue to experience acute events. Thus, to develop improved and alternative therapies, we previously reported on microRNA-145 (miR-145 micelles) and its ability to inhibit atherosclerosis by targeting vascular smooth muscle cells (VSMCs). Importantly, one dose of miR-145 micelles significantly abrogated disease progression when evaluated two weeks post-administration. Thus, in this study, to evaluate how long the sustained effects of miR-145 micelles can be maintained and towards identifying a dosing regimen that is practical for patients with chronic disease, the therapeutic effects of a single dose of miR-145 micelles were evaluated for up to two months in vivo. After one and two months post-treatment, miR-145 micelles were found to reduce plaque size and overall lesion area compared to all other controls including statins without causing adverse effects. Furthermore, a single dose of miR-145 micelle treatment inhibited VSMC transdifferentiation into pathogenic macrophage-like and osteogenic cells in plaques. Together, our data shows the long-term efficacy and sustained effects of miR-145 micelles that is amenable using a dosing frequency relevant to chronic disease patients. | Deborah D.Chin Neil Patel Woori Lee Sonali Kanaya Jackson Cook Eun Ji Chung | 2023 | Bioactive Materials2023，，9： | 0 |
| 17 | 面对亚马逊的“5步杀法”显示文摘亚马逊是全球首屈一指的电商巨头,但这并不意味着你根本没有机会与之抗衡。要知道,亚马逊的庞大规模恰恰是它的阿喀琉斯之踵,而这也正是你进入某个细分市场的切入点。 | Neil Patel | 2015 | 销售与管理2015，0，2： | 0 |
| 18 | Carotid artery stenting in the elderly: the time has come显示文摘 Introduction
Affecting over half a million people per year, stroke is the third leading cause of death in the United States. Approximately 30% of strokes are caused by carotid occlusive disease.…… | Dipsu Patel Neil E Strickman | 2007 | Journal of Geriatric Cardiology2007，4，2： | 0 |
| 19 | 常染色体隐形遗传扁平角膜家族的临床和分子学特征显示文摘背景:常染色体隐形遗传扁平角膜特点是角膜表面扁平,伴远视和各种前节异常。突变定位在角膜基因(KERA),是一个小的富亮氨酸蛋白聚糖家族中的一员。 | Neil D. Ebenezer Chetankumar B. Patel Seenu M. Hariprasad Li L. Chen Reshma J. Patel Alison J. Hardcastle Richard C.Allen 扬帆(译) 雷嘉启(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 0 |
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