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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 3 | The maximum reservoir capacity of soils for persistent organic pollutants: implications for global cycling 显示文摘 | Valle M D Jurado E Dachs J | 2005 | Environmental Pollution2005，134，1： | 1 |
| 4 | Effects of galanin on growth hormone and prolactin secretion in anorexia nervosa 显示文摘 | Maneini A Valle D | 2000 | Metabolism2000，49，： | 1 |
| 5 | Joint LDPC Decoding and Timing Recovery Using Code Constraint Feedback显示文摘 | Lee D U Valles E L Villasenor J D | 2006 | IEEE Communication Letters2006，10，03： | 1 |
| 6 | Provocative hypothalamopituitary axis tests in severe head injury:correlations with severity and prognosis显示文摘 | Della Corte F Mancini A Valle D | 1998 | Crit Care Med1998，26，8： | 1 |
| 7 | MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster 显示文摘 | Xu S Witmer PD Lumayag S Kovacs B Valle D | 2007 | J Biol Chem2007，282，25： | 1 |
| 8 | Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis显示文摘Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of cirrhosis.It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors identified.For HCC screening in NAFLD,a valid precision-based screening is needed.Currently,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program.Hence,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Giovana D P Sartori Livia Villela Nogueira Gustavo Tovo Both Cristiane A Villela-Nogueira Angelo A de Mattos | 2023 | World Journal of Gastroenterology2023，29，2： | 1 |
| 9 | The etiology of pleural effusions in an area with high incidence of tuberculosis显示文摘 | Valdes L Alvarez D Valle JM | 1996 | Chest1996，109，： | 1 |
| 10 | Serotonergic neurons in the caudal raphe nuclei discharge in association with activity of masticatory muscles显示文摘 | Ribeiro D O Valle L E | 1997 | Braz J Med Biol Res1997，30，1： | 1 |
| 11 | A 7-year study ofsevere hospital-acquired pneumonia requiting ICU admission显示文摘 | Valles J Mesalles E Mafiscal D | 2003 | Intensive Care Med2003，29，11： | 1 |
| 12 | Understanding the Effects of Government Spending on Consumption 显示文摘 | GALl' J LOPEZ-SALIDO J D VALLES J | 2007 | Journal of the European Economics Association2007，5，1： | 1 |
| 13 | Could HRM sup- port organizational innovation 显示文摘 | Jimenez- Jimenez D Sanz -Valle R | 2008 | International Journal Of Human Resource Management2008，19，7： | 1 |
| 14 | An identikit of patients seeking treatment for erectile dysfunction in Italy:results from the EDOS Italian database显示文摘 | FUSCO F SICUTERI R VALLE D | 2007 | Arch Ital Urol Androl2007，79，1： | 1 |
| 15 | Droplets formation in turbulent mixing of two immiscible fluids in a new type of static mixer 显示文摘 | Lemenand T Della Valle D Zellouf Y Peerhossaini H | 2003 | International Journal of Multiphase Flow2003，29，5： | 1 |
| 16 | Biochemical and pharmacological properties of clopidogrel:a new ADP receptor antagonist显示文摘 | Herbert JM Frehel D Valle E | 1999 | Eur Heart J1999，，： | 1 |
| 17 | Effects of galanin on growth hormone and prolactin secretion in anorexia nervosa显示文摘 | De Marinis L Mancini A Valle D | 2000 | Metabolism2000，49，2： | 1 |
| 18 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 19 | Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids 显示文摘 | ALVAREZ-LOPEZ M PEREDA M D DEL VALLE J A FERNANDEZ-LORENZO M GARCIA-ALONSO M C RUANO OA ESCUDERO M L | 2010 | Acta Biomaterialia2010，6，： | 1 |
| 20 | An Ontology-Based Measure to Compute Semantic Similarity in Biomedicine 显示文摘 | Batet M Sanchez D Valls A | 2011 | Journal of Biomedical Informatics2011，44，1： | 1 |
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