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| 1 | Human papillomavirus does not have a causal role in colorectal carcinogenesis显示文摘AIM: To investigate the presence of human papillomavirus(HPV) DNA along with the integration,the quantification and the expression of the HPV16 in colorectal cancers.METHODS: A prospective series of colorectal tumors were genotyped for HPV DNA.The clinical and pathological variables of the HPV-positive tumors were compared to those of HPV-negative samples.The integration status of HPV16 was evaluated by calculating E2/E6 ng ratios.HPV16-positive tumors were also evaluated for(1) E2,E4,E5,E6 and E7 viral gene ng quantification;(2) relative quantification compared to W12 cells; and(3) viral E2,E4,E5,E6 and E7 mR NA transcripts by real-time polymerase chain reaction.RESULTS: HPV infection was detected in 16.9% of all tumors examined,and HPV16 was the most frequent type detected(63.6% of positive tissues).Notably,the clinical and pathological features of HPV-positive colorectal cancers were not significantly different than those of HPV-negative cancers(χ2 and t-test for all clinical and pathological features of HPV-positive vs HPV-negative colorectal cancers: p ns).HPV16 DNA was present exclusively in episomal form,and the HPV16 E2,E4,E5,E6 and E7 genes were detected in tracenanogram quantities.Furthermore,the HPV16 genes ranged from 10-3 to 10-9 compared to W12 cells at an episomal stage.Although the extractions were validated by housekeeping gene expression,all the HPV16 positive tissues were transcriptionally inactive for the E2,E4,E5,E6 and E7 mR NAs.CONCLUSION: Based on our results,HPV is unlikely involved in colorectal carcinogenesis. | Laura Lorenzon Francesca Mazzetta Emanuela Pilozzi Giordana Uggeri Maria Rosaria Torrisi Mario Ferri Vincenzo Ziparo Deborah French | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 2 | Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?显示文摘BACKGROUND Distant metastases are found in approximately 35%of patients with gastric cancer at their first clinical observation,and of these,4%-14%involves the liver.Unfortunately,only 0.4%-2.3%of patients with metastatic gastric cancer are eligible for radical surgery.Although surgical resection for gastric cancer metastases is still debated,there have been changes in recent years,although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The study protocol was based on identifying studies with clearly defined purpose,eligibility criteria,methodological analysis,and patient outcome.RESULTS We selected 47 studies pertaining to the purpose of the review,which involved a total of 2304 patients.Median survival was 7-52.3 mo,median disease-free survival was 4.7-18 mo.The 1-,2-,3-,and 5-year overall survival(OS)was 33%-90.1%,10%-60%,6%-70.4%,and 0%-40.1%,respectively.Only five papers reported the 10-year OS,which was 5.5%–31.5%.The general recurrence rate was between 55.5%and 96%,and that for hepatic recurrence was between 15%and 94%.CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis,while the presence of single metastasis or≤3 metastases associated with a size of<5 cm may be considered data that do not contraindicate liver resection. | Fabio Uggeri Lorenzo Ripamonti Enrico Pinotti Mauro Alessandro Scotti Simone Famularo Mattia Garancini Luca Gianotti Marco Braga Fabrizio Romano | 2020 | World Journal of Clinical Oncology2020，11，7： | 3 |
| 3 | Recurrent Giant Hemangioma Causing Severe Respiratory Distress显示文摘 | Fabrizio Romano Grazia Messinesi Francesco Tana Franco Uggeri | 2007 | Digestive Diseases and Sciences2007，，12： | 2 |
| 4 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa MD Carlo Angelini MD Chiara Mussi Claudia Bonardi MD Fabrizio Romano MD Paola Sartori MD Franco Uggeri MD Giorgio Bovo MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 5 | Colorectal cancer with neuroendocrine differentiation in a child显示文摘 | Carlo Angelini Stefano Crippa Fabio Uggeri Claudia Bonardi Paola Sartori Franco Uggeri | 2005 | Pediatric Surgery International2005，，10： | 1 |
| 6 | Halothane, enflurane, and isoflurane attenuate both receptor-and non-receptor-mediated EDRF production in rat thoracic aorta显示文摘 | Uggeri M J Proctor G J Johns RA | 1992 | Anesthesiology1992，76，6： | 1 |
| 7 | Hepatic Surgery Using the Ligasure Vessel Sealing System显示文摘 | Fabrizio Romano M.D. Claudio Franciosi M.D. Roberto Caprotti M.D. Fabio Uggeri M.D. Franco Uggeri M.D | 2005 | World Journal of Surgery2005，，1： | 1 |
| 8 | Laparoscopic splenectomy using ligasure显示文摘 | F. Romano R. Caprotti C. Franciosi S. Fina G. Colombo F. Uggeri | 2002 | Surgical Endoscopy2002，，11： | 1 |
| 9 | New paramagnetic supramolecular adducts for MRI applications based on non-covalent interactions between Gd(Ⅲ)-complexes and ,β- or γ-cyclodextrin units anchored to chitosan 显示文摘 | Silvio Aime Eliana Gianolio Fulvio Uggeri | 2006 | Journal of Inorganic Biochemistry2006，100，： | 1 |
| 10 | Synthesis ofct-arylproponic acids via 1,2-arylshift显示文摘 | Giordono C Castaldi G Uggeri F | 1984 | AngewChem1984，96，6： | 1 |
| 11 | Identification of immnodominant hepatitis C virus (HCV) -specific cytotoxic T-cell epitopes by stimulation with endogenously synthesized HCV antigens显示文摘 | Uggeri J Matsuura Y | 2001 | Hepatology2001，33，6： | 1 |
| 12 | Adhesion of human osteoblasts to titanium: A morpho-functional analysis with confo- col microscopy显示文摘 | Uggeri J Guizzardi S Scandroglio R | 2010 | Micron2010，41，3： | 1 |
| 13 | Colorectal cancer with neuroendociine differentiation in a child 显示文摘 | Angelini C Crippa S Uggeri F | 2005 | Pediatr Surg Int2005，21，10： | 1 |
| 14 | Identification of immunodominant hepatitis C virus (HCV)-specific cytotoxic Tcell epitopes by stimulation with endogenously synthesized HCV antigens 显示文摘 | Uggeri J Matsuura Y | 2001 | Hepatology2001，33，6： | 1 |
| 15 | The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase 显示文摘 | Tardito S Uggeri J Bozzetti C | 2007 | Cancer Chemother Pharmacol2007，60，5： | 1 |
| 16 | Laparoscopic splenectomy using ligasure显示文摘 | F. Romano R. Caprotti C. Franciosi S. Fina G. Colombo F. Uggeri | 2002 | Surgical Endoscopy2002，，11： | 1 |
| 17 | Dose-dependent effects of platelet gel releasate on activities of human osteoblasts显示文摘 | Uggeri J | | 0，，10： | 1 |
| 18 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa Carlo Angelini Chiara Mussi Claudia Bonardi Fabrizio Romano Paola Sartori Franco Uggeri Giorgio Bovo | 2006 | World Journal of Surgery2006，，： | 1 |
| 19 | Henoch-Sch?nlein purpura due to methicillin-sensitive Staphylococcus aureus bacteremia from central venous catheterization显示文摘 | Uggeri S Fabbian F Catizone L | 2008 | Clin Exp Nephro2008，12，3： | 1 |
| 20 | Dose-dependent effects of platelet gel releasate on activities of human osteoblasts显示文摘 | Uggeri J Bel etti S Guizzardi S | | 0，，10： | 1 |
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