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| 1 | Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?显示文摘BACKGROUND Distant metastases are found in approximately 35%of patients with gastric cancer at their first clinical observation,and of these,4%-14%involves the liver.Unfortunately,only 0.4%-2.3%of patients with metastatic gastric cancer are eligible for radical surgery.Although surgical resection for gastric cancer metastases is still debated,there have been changes in recent years,although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The study protocol was based on identifying studies with clearly defined purpose,eligibility criteria,methodological analysis,and patient outcome.RESULTS We selected 47 studies pertaining to the purpose of the review,which involved a total of 2304 patients.Median survival was 7-52.3 mo,median disease-free survival was 4.7-18 mo.The 1-,2-,3-,and 5-year overall survival(OS)was 33%-90.1%,10%-60%,6%-70.4%,and 0%-40.1%,respectively.Only five papers reported the 10-year OS,which was 5.5%–31.5%.The general recurrence rate was between 55.5%and 96%,and that for hepatic recurrence was between 15%and 94%.CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis,while the presence of single metastasis or≤3 metastases associated with a size of<5 cm may be considered data that do not contraindicate liver resection. | Fabio Uggeri Lorenzo Ripamonti Enrico Pinotti Mauro Alessandro Scotti Simone Famularo Mattia Garancini Luca Gianotti Marco Braga Fabrizio Romano | 2020 | World Journal of Clinical Oncology2020，11，7： | 3 |
| 2 | Mesenteric and portal vein thrombosis associated with hyperhomocysteinemia and heterozygosity for factor V Leiden mutation显示文摘TO THE EDITOR
A 79-year-old man was hospitalized because of worsening upper abdominal pain which started two days before admission and was continuously present. His personal and family historywas uneventful, he did not smoke and denied toxic habits or using any medications, including over the-counter medications, herbal remedies or any vitamin supplements. | Giuseppe Famularo Giovanni Minisola Giulio Cesare Nicotra Claudio De Simone | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | A patient with cerebral Whipple's disease and a stroke-like syndrome 显示文摘 | Famularo G Minisola G Simone C | 2005 | Scand J Gastroenterol2005，40，： | 1 |
| 4 | A patient with cerebral Whipple's disease and a stroke - like syndrome 显示文摘 | Famularo G Minisola G Simone C | 2005 | Scand J Gastroenterol2005，40，： | 1 |
| 5 | Probiotic lactobacilli an innovative tool to correct the malabsorption syndrone of vegetarians显示文摘 | Famularo G De Simone C Pandey V | 2005 | Medical Hypotheses2005，65，6： | 1 |
| 6 | A patient with cerebral Whipple's disease and a stroke-like syndrome显示文摘 | Famularo G Minisola G De Simone C | 2005 | Scand J Gastroenterol2005，40，5： | 1 |
| 7 | Inflammatory bowel disease显示文摘 | Famularo G Trinchieri V De Simone C | | 0，，24： | 1 |
| 8 | Inosine pranobex in the treatment of HIV infection: a review显示文摘 | De Simone C Famularo G Tzantzoglou S | 1991 | Int J Immunopharmacol1991，131，： | 1 |
| 9 | Camitines and its congeners:a metabolic pathway to the regulation of immune response and inflammation显示文摘 | Famularo G De Simone C Trinchieri V | 2004 | Ann N Y Acad Sci2004，1033，： | 1 |
| 10 | Pneumonia and sepsis caused by Gemella morbiUorum: an unusual association显示文摘 | Famularo G De Simone C Minisola G | 2006 | Intern Med2006，45，21： | 1 |
| 11 | Carnitine stands on its own in HIV infection treatment显示文摘 | Famularo G De Simone C Cifone G | 1999 | Archives of Internal Medicine1999，159，10： | 1 |
| 12 | Carnitines and its congeners:a metabolic pathway to the regulation of immune response and inflammation显示文摘 | FAMULARO G DE SIMONE C TRINCHIERI V | 2004 | Ann N Y Acad Sci2004，1033，： | 1 |
| 13 | Jaundice and the sepsissyndrome: a neglected link显示文摘 | Famularo G De Simone C Nicotra GC | 2003 | Eue J Intern Med2003，14，4： | 1 |
| 14 | Carnitine depletion in peripheral blood mononuclear cells from patients with AIDS: effect of oral carnitine 显示文摘 | DE SIMONE C FAMULARO G TZANTZOGLOU S | 1994 | AIDS1994，8，： | 1 |
| 15 | High dose L-carnitine improves immunologic and metabolic parameters in aids patients 显示文摘 | DE SIMONE C TZANTZOGLOU S FAMULARO G | 1993 | Immunopharmacol Immunotoxicol1993，15，： | 1 |
| 16 | Nephrotoxicity and purpura associated with levofloxacin 显示文摘 | Famularo G De Simone C | 2002 | Ann Pharmacother2002，36，9： | 1 |
| 17 | Acute cholecystitis and pan- creatitis in a patient with biliary sludge associated with the use of ceftriaxone :a rare but potentially severe complication显示文摘 | Famularo G Polchi S De Simone C | 1999 | Ann hal Med Int1999，14，3： | 1 |
| 18 | Carnitines and its congeners:a metabolic pathway to the reguration of immune response and inflammation显示文摘 | Famularo G De Simone C Trinchieri V | 2004 | Ann N Y Acad Sci2004，1033，： | 1 |
| 19 | Carnitine and septic shock patients显示文摘 | Famularo G De Simone C Arrigoni-Martelli E | 1995 | AIDS1995，6，： | 1 |
| 20 | A new era for carnitine显示文摘 | Famularo G De Simone C | 1995 | Immunology Today1995，16，： | 1 |
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