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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Molecular aspects of intestinal calcium absorption显示文摘Intestinal Ca2+ absorption is a crucial physiological process for maintaining bone mineralization and Ca2+ homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3steps: the entrance of Ca2+ across the brush border membranes(BBM) of enterocytes through epithelial Ca2+ channels TRPV6, TRPV5, and Cav1.3; Ca2+ movement from the BBM to the basolateral membranes by binding proteins with high Ca2+ affinity(such as CB9k); and Ca2+ extrusion into the blood. Plasma membrane Ca2+ ATPase(PMCA1b) and sodium calcium exchanger(NCX1) are mainly involved in the exit of Ca2+ from enterocytes. A novel molecule, the 4.1R protein, seems to be a partner of PMCA1 b, since both molecules colocalize and interact. The paracellular pathway consists of Ca2+ transport through transmembrane proteins of tight junction structures, such as claudins 2, 12, and 15. There is evidence of crosstalk between the transcellular and paracellular pathways in intestinal Ca2+ transport. When intestinal oxidative stress is triggered, there is a decrease in the expression of several molecules of both pathways that inhibit intestinal Ca2+ absorption. Normalization of redox status in the intestine with drugs such as quercetin, ursodeoxycholic acid, or melatonin return intestinal Ca2+ transport to control values. Calcitriol [1,25(OH)2D3] is the major controlling hormone of intestinal Ca2+ transport. It increases the gene and protein expression of most of the molecules involved in both pathways. PTH, thyroid hormones, estrogens, p ro l a c t i n, g ro w t h h o r m o n e, a n d g l u c o c o r t i c o i d s apparently also regulate Ca2+ transport by direct action, indirect mechanism mediated by the increase of renal 1,25(OH)2D3 production, or both. Different physiological conditions, such as growth, pregnancy, lactation, and aging, adjust intestinal Ca2+ absorption according to Ca2+ demands. Better knowledge of the molecular details of intestinal Ca2+ absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal Ca2+ absorption and preventing osteoporosis and other pathologies related to Ca2+ metabolism. | Gabriela Diaz de Barboza Solange Guizzardi Nori Tolosa de Talamoni | 2015 | World Journal of Gastroenterology2015，21，23： | 20 |
| 3 | Oxidative stress, antioxidants and intestinal calcium absorption显示文摘The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders. | Gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni | 2017 | World Journal of Gastroenterology2017，23，16： | 18 |
| 4 | 关于孤立特发性中枢性性腺功能低下(ICH)遗传病因的新发现显示文摘特发性低促性腺激素性性功能减退症(IHH)是一种罕见的疾病,它的病症表现为青春期的推迟或者缺失,以及(或者)不育症。这些病症是由于促性腺激素释放激素(GnRH)的作用未能对正常的垂体.性腺轴产生足够的刺激。由于罹患该病的患者体内的促卯泡激素(FSH)和黄体生成素(LH)的水平偏低或正常,所以采用孤立特发性中枢性性腺功能低下(ICH)这一术语定义该疾病可能更为合适。该疾病应区别于伴有其它垂体缺陷的中枢性性腺功能减退。孤立特发性中枢性性腺功能低下的发病机制比较复杂,且在男性中的发病率比中枢性性腺功能减退多5倍。大部分情况下,该病的患病人群比较分散,但也曾经报道过几例家族病例。这一发现加上其它很多致病基因突变的调查,以及一些基因敲除模型的出现,证明了该疾病的发病可能有一个强大的遗传学因素存在。孤立特发性中枢性性腺功能低下可能与一些包含锇缺乏在内的形态遗传学异常有关联,而锇缺乏与孤立特发性中枢性性腺功能低下构成了卡尔曼氏综合症(KS)的主要病征。在全部的孤立特发性中枢性性腺功能低下病例中,卡尔曼氏综合症约占40%,也被视作一个特殊的患者子群体。然而,经过对患有孤立的锇缺陷或者卡尔曼氏综合症(KS)亦或孤立特发性中枢性性腺功能低下的包含亲戚在内的几个家族谱系内部的病患的调查,证明孤立特发性中枢性性腺功能低下是一种复杂的遗传性疾病,它具有复杂多样的表征以及显性。由此得出,不管是多个基因变异还是环境因素或者核外遗传的变化都有可能导致复杂多样的病征。本文综述了己知的、与孤立特发性中枢性性腺功能低下的发病机制相关的遗传机制,并且对由意大利孤立特发性中枢性性腺功能低下网络合作中心所收集的227例病例作出临床概述。 | Marco Bonomi Domenico Vladimiro Libri Fabiana Guizzardi Elena Guarducci Elisabetta Maiolo Elisa Pignatti Roberta Asci Luca Persani | 2012 | Asian Journal of Andrology2012，14，1： | 10 |
| 5 | Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin(CT)-induced apoptosis显示文摘细胞生长和增长上的霍乱毒素(CT ) 的不同效果可以在细胞膜和触发的不同信号 transduction 机制取决于 ganglioside 受体的类型,但是其它与药抵抗机制有关工作不能被排除。CT 处理在上的效果“在 vitro ”, clonogenicity,人口双倍工资(太平洋夏季时间) , apoptosis, PKA 激活和 Bax 和 Bcl-2 表示在 WEHI-3B 房间线和它的 CT 抵抗的潜水艇克隆(WEHI-3B/CTRES ) 被评估。在 WEHI-3B 父母房间, CT 导致的营地的戏剧的累积与 PKA 激活相关很好,增加的太平洋夏季时间价值, clonogenicity 和 apoptosis 的抑制。H-89 处理由 CT 禁止了 PKA 激活但是没保护房间免受 apoptosis 和生长抑制的伤害。在 WEHI-3B/CTRES,营地的重要 CT 依赖的累积都没随 PKA 活动和太平洋夏季时间的任何增加发生。在 CT 抵抗房间(WEHI-3B/CTRES ) , Bcl-2 表示低由 CT 或药处理调整了(例如, ciprofloxacin, CPX ) 尽管这些房间被保护免受 CT 依赖的 apoptosis 的伤害然而并非从导致药的 apoptosis。不同地,从另外的房间,模型描述了,在 Bcl-2 的规定下面被证明在营地累积和 PKA 激活上独立。我们的观察在 WEHI-3B 细胞生长的抑制支持营地依赖者 kinase (PKA ) 的含意并且建议在 WEHI-3B/CTRES, Bcl-2 表示能被 CT 当营地累积不在时调制。另外,在许多的考虑,矛盾的数据在文学报导了,我们的房间模型(有到 CT 和 CPX 的不同使不交叉的特定的抵抗的一个敏感父母房间种类和二克隆)为更好调查在 CT 信号 transduction 机制和 Bcl-2 表示和函数之间的关系提供一个新、有趣的工具。 | Augusto Pessina Cristina Croera Nicoletta Savalli Arianna Bonomi Loredana Cavicchini Elisa Turlizzi Fabiana Guizzardi Lucia Guido Laura Daprai Maria GraziaNeri | 2006 | Cell Research2006，16，3： | 4 |
| 6 | Biological control of gray mold in pears by antagonistic bacteria显示文摘 | Marl M Guizzardi M Pratella G C | 1996 | Biologiel Control1996，7，1： | 1 |
| 7 | Idiopathic thrombocytope-nic purpura,Helicobacter pylori infection,and HLA class Ⅱ alleles显示文摘 | Veneri D Gottardi M Guizzardi E | 2002 | Blood2002，100，5： | 1 |
| 8 | Transforming OntoUML into Alloy:Towards Conceptual Model Validation Using a Lightweight Formal Method显示文摘 | Braga B F B Almeida J P A Guizzardi G | | 0，，01： | 1 |
| 9 | Idiopathic thrombocytopenic purpura,Helicobacter pylori infection,and HLA class Ⅱ alleles显示文摘 | Veneri D Gottardi M Guizzardi E | 2002 | Blood2002，100，5： | 1 |
| 10 | Biological control of gray mold in pears by antagonistic bacteria 显示文摘 | Marl M Guizzardi M PrateUa G C | 1996 | Biological Control1996，7，： | 1 |
| 11 | Ontology,Ontologies and the“I”of FAIR显示文摘According to the FAIR guiding principles,one of the central attributes for maximizing the added value of information artifacts is interoperability.In this paper,I discuss the importance,and propose a characterization of the notion of Semantic Interoperability.Moreover,I show that a direct consequence of this view is that Semantic Interoperability cannot be achieved without the support of,on one hand,(i)ontologies,as meaning contracts capturing the conceptualizations represented in information artifacts and,on the other hand,of(ii)Ontology,as a discipline proposing formal meth-ods and theories for clarifying these conceptualizations and articulating their representations.In particular,I discuss the fundamental role of formal ontological theories(in the latter sense)to properly ground the construction of representation languages,as well as methodological and computational tools for supporting the engineering of ontologies(in the former sense)in the context of FAIR. | Giancarlo Guizzardi | 2020 | Data Intelligence2020，2，1： | 1 |
| 12 | Relationship between volatile components of citrus fruit essential oils and antimicrobial action on Penicillium digitatum and Penicillium italicum显示文摘 | Caccioni D R L Guizzardi M Biondi D M Renda A Ruberto C | 1998 | Int J Food Microbiol1998，43，12： | 1 |
| 13 | Rela- tionship between volatile components of citrus fruit essential oils and antimicrobial action on Penicillium digitatum and Penicillium italicum 显示文摘 | Caccioni D R L Guizzardi M Biondi D M | 1998 | Int J Food Microbiol1998，43，12： | 1 |
| 14 | Adhesion of human osteoblasts to titanium: A morpho-functional analysis with confo- col microscopy显示文摘 | Uggeri J Guizzardi S Scandroglio R | 2010 | Micron2010，41，3： | 1 |
| 15 | Relationship between volatile components of citrus fruit essential oils and antimicrobial action on Penicillium digitatum and Penicillium italicum显示文摘 | Duccio R.L Caccioni Monica Guizzardi Daniela M Biondi Agatino Renda Giuseppe Ruberto | 1998 | International Journal of Food Microbiology1998，，1： | 1 |
| 16 | Inhibition of germination and growth of fruit and vegetable postharvest pathogenic fungi by essential oil components 显示文摘 | Caccioni D R L Guizzardi M | 1994 | J Essent Oil Res1994，6，2： | 1 |
| 17 | Idiopathic thrombocypenic purpura,Helicobacter pylori infection and HLA class Ⅱ alleles显示文摘 | Veneri D Gottardi M Guizzardi E | 2002 | Blood2002，100，： | 1 |
| 18 | Anfithrombotic and thrombolytic activity of sulodexide in rats显示文摘 | Miriam Barbanti Stefano Guizzardi Fiorella Calanni | 1992 | Int J Clin Lab Res1992，，22： | 1 |
| 19 | Idiopathic thrombocytopenic purpura,Helicobacter pylori infection,and HLA class Ⅱ alleles显示文摘 | Veneri D Gottardi M Guizzardi E | 2002 | Blood2002，100，： | 1 |
| 20 | Effects of heat deproteinate bone and polynucleotides on bone regeneration:an experimental study on rat显示文摘 | Guizzardi S Martini D Bacchelli B | | 0，，07： | 1 |
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