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| 1 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 2 | Metastatic atypical choroid plexus papilloma: a case report 显示文摘 | Uff CE Galloway M Bradford R | 2007 | J Neurooncol2007，82，1： | 1 |
| 3 | Functional characterisation of the human α1 glycine receptor in a fluorescence-based membrane potential assay显示文摘 | Anders AJ Uffe K | 2005 | Eur J Pharmacol2005，521，13： | 1 |
| 4 | Emissions of NOx, particle mass and particle numbers from aircraft main engines, APU's and handing equipment at Copenhagen Airport显示文摘 | Morten W Uffe K Thomas E | 2015 | Atmospheric Environment2015，100，： | 1 |
| 5 | Bone bruise in the acutely injured knee显示文摘 | Thomas Bretlau Jon Tux?e Lone Larsen Uffe J?rgensen Henrik S. Thomsen Gunnar Lausten | 2002 | Knee Surgery, Sports Traumatology, Arthroscopy2002，，2： | 1 |
| 6 | A full periodic table force field for molecular mechanics and molecular dynamics simulations 显示文摘 | Rappe A K Casewit C J UFF K S | 1992 | J Am Chem Soc1992，11，4： | 1 |
| 7 | CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, slasma membrane domains显示文摘 | Neame S J Uff CR Sheikh H | 1995 | J Cell Sci1995，108，9： | 1 |
| 8 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 9 | Management of acutehydrocephalus following aneurysmal subarachnoid haemorrhage :the role of serial lumbar puncture and continuous lumbar drainage显示文摘 | Marcus H Uff C Murphy M | 2011 | Br J Neurosurg2011，25，4： | 1 |
| 10 | Theincidence and prognostic significance of new-onset atrial fibrillation inpatients with acute myocardial infarction and left ventricular systolicdysfunction: A CARISMA substudy显示文摘 | Christian Jons Uffe G Jacobsen Rikke Moerch Joergensen | 2011 | Heart Rhythm2011，8，3： | 1 |
| 11 | Trends and perspectives in industrial maintenance management显示文摘 | James T Luxhoj Jens O Riis Uffe Thorsteinsson | 1997 | Journal of Manufacturing Systems1997，16，3： | 1 |
| 12 | Granulomatous prostatitis显示文摘 | Uzoh CC Uff JS Okeke AA | | 0，，03： | 1 |
| 13 | Crystal structure of the platelet glycoprotein Ⅰ bα N-terminal domain reveals an unmasking mechanism for receptor activation显示文摘 | Uff S Clemetson JM Harrison T | 2002 | J Biol Chem2002，277，35： | 1 |
| 14 | Mutated Desmoglein‐2 Proteins are Incorporated into Desmosomes and Exhibit Dominant‐Negative Effects in Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Torsten B. Rasmussen Johan Palmfeldt Peter H. Nissen Raffaela Magnoni S?ren Dalager Uffe B. Jensen Won Y. Kim Lene Heickendorff Henning M?lgaard Henrik K. Jensen Ulrik T. Baandrup Peter Bross Jens Mogensen | 2013 | Human Mutation2013，，5： | 1 |
| 15 | A Categorization of the 'Whys' and 'Hows' of Using History in Mathematics Education 显示文摘 | Uffe Thomas Jankvist | 2009 | Educ Stud Math2009，，23： | 1 |
| 16 | Rad52显示文摘 | Uffe H. Mortensen Michael Lisby Rodney Rothstein | 2009 | Current Biology2009，，16： | 1 |
| 17 | A categorization of the ' whys' and 'hows' of using history in mathematics education显示文摘 | Uffe Thomas Jankvist | 2009 | Educ Stud Math2009，71，： | 1 |
| 18 | Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study显示文摘OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 years.In addition,one-year all-cause mortality and AF relapse were compared.METHODS&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide registries.Patients aged 65−74 years served as the reference group for patients≥75 years.Relapse of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within follow-up.The composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age. | Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi | 2021 | Journal of Geriatric Cardiology2021，18，11： | 1 |
| 19 | Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin显示文摘 | Krarup A Uffe BS Rensen S | 2005 | Infection and Immunity2005，73，2： | 1 |
| 20 | A fresh look at shifting cultivation: Fallow length an uncertain indicator of productivity显示文摘 | Ole Mertz Reed L. Wadley Uffe Nielsen Thilde B. Bruun Carol J.P. Colfer Andreas de Neergaard Martin R. Jepsen Torben Martinussen Qiang Zhao Gabriel T. Noweg Jakob Magid | 2007 | Agricultural Systems2007，，1： | 1 |
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