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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 3 | Treatment of Displaced Calcaneus Fractures Using a Minimally Invasive Sinus Tarsi Approach显示文摘 | Hospodar Paul Guzman Camilo Johnson Paul Uhl Richard | 2008 | Orthopedics (Online)2008，，11： | 3 |
| 4 | Management of infection in acute pancreatitis显示文摘 | Werner Hartwig Jens Werner Waldemar Uhl Markus W. Büchler | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，4： | 3 |
| 5 | Scale invariant texture descriptors for classifying celiac disease显示文摘 | G. Wimmer S. Hegenbart A. Uhl A. Vécsei | 2013 | Medical Image Analysis2013，，： | 2 |
| 6 | Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging显示文摘BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited. | Georg Wimmer Michael Gadermayr Gernot Wolkersdorfer Roland Kwitt Toru Tamaki Jens Tischendorf Michael Hafner Shigeto Yoshida Shinji Tanaka Dorit Merhof Andreas Uhl | 2019 | World Journal of Gastroenterology2019，25，10： | 2 |
| 7 | Automated classification of duodenal imagery in celiac disease using evolved Fourier feature vectors显示文摘 | Andreas Vécsei Thomas Fuhrmann Michael Liedlgruber Leonhard Brunauer Hannes Payer Andreas Uhl | 2009 | Computer Methods and Programs in Biomedicine2009，，2： | 2 |
| 8 | Mangement of Sterrte neerosis in instances of severeacute Pancreatitis显示文摘 | Ran B Pralle U Uhl W | 1995 | Jan Cell Sing1995，181，4： | 2 |
| 9 | Repeated occurrence of palaeo-wildfires during deposition of the Bahariya Formation(early Cenomanian) of Egypt显示文摘The Upper Cretaceous(early Cenomanian)Bahariya Formation of Egypt has an outstanding reputation for its wealth of vertebrate remains,including a variety of iconic dinosaurs,like the carnivorous Spinosaurus and Carcharodontosaurus,as well as the herbivorous Aegyptosaurus and Paralititan.Besides these dinosaur fossils,the Bahariya Formation yielded also a wealth of invertebrate and plant remains,but even today many aspects concerning the continental palaeoenvironments reflected in these deposits(including the occurrence of palaeo-wildfires)have not been studied in detail.So far six distinct macro-charcoal bearing levels could be identified within the type section of the Bahariya Formation at Gabal El Dist profile,one of the most prolific outcrops of this formation in terms of fossil occurrence located in the north of the Bahariya Oasis,Western Desert,Egypt.Most of the charcoal investigated by means of SEM originates from ferns,pointing to a considerable proportion of this plant group within the palaeo-ecosystems that experienced fires.Gymnosperms and(putative)angiosperms have less frequently been identified.The collected data present evidence that the landscapes at the northern shores of Gondwana repeatedly experienced palaeo-wildfires,adding extra proof to previous statements that the Late Cretaceous was a fiery world on a global scale. | Haytham El Atfy Tarek Anan Andre Jasper Dieter Uhl | 2019 | Journal of Palaeogeography2019，8，4： | 2 |
| 10 | Surgical treatment of infected necrosis显示文摘 | B. Rau W. Uhl M. W. Buchler H. G. Beger | 1997 | World Journal of Surgery1997，，2： | 2 |
| 11 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 12 | Comparison of MR sequences in quantifying in vitro cartilage degeneration in osteoarthritis of the knee显示文摘 | Uhl M Allmann KH Tauer U | 1998 | The British Journal of Radiology1998，71，3： | 1 |
| 13 | Preparation of nanocomposites from styrene and modified graphite oxide显示文摘 | Uhl F M Wilkie C A | 2004 | Polymer Degradation and Stability2004，84，2： | 1 |
| 14 | Myocardial infarction in young adults:risk factors and natural history显示文摘 | Uhl GS Farrell PW | 1983 | Am Heary J1983，105，4： | 1 |
| 15 | Useful markers for predieting severity and monitoring progression of acute pancreatitis显示文摘 | Wernet J Hartwig W Uhl W | 2003 | Pancreatology2003，3，： | 1 |
| 16 | Measurement of lumbar multifidus muscle contraction with rehabilitative ultrasound imaging显示文摘 | KIESEL K B UHL T L UNDERWOOD D W | | 0，，02： | 1 |
| 17 | Loudness dependence of auditor evoked potentials (LDAEP) in t lilical monitoring of suicidal patients with major depression: a pilot study 显示文摘 | Uhl I II1 es E Gral3nickel V | 2012 | Eur Arch Psychiatry Clin Neurosci2012，262，6： | 1 |
| 18 | Chronic neurohptic treatment enhances neurotensin receptor binding in human and rat substantia nigra 显示文摘 | Uhl GR Kuhar MJ | 1984 | Nature1984，309，5966： | 1 |
| 19 | Differential diagnosis of benign tumors and tumor - like lesions in the spine: Own cases and review of the literature 显示文摘 | Knoeller SM Uhl M Adler CP | 2004 | Neoplasam2004，51，2： | 1 |
| 20 | The Mono- wheel Robot with Dynamic Stabilization 显示文摘 | Cieslak P Buratowski T Uhl T | 2011 | Ro- botics and Autonomous Systems2011，59，9： | 1 |
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