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| 1 | 半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用显示文摘目的研究半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用PI-Hoechst荧光双染法和TUNEL法检测细胞凋亡;流式细胞仪检测5F对DNA含量的影响。结果5F抑制NCI-H460细胞的生长,其效果与5F的浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/ml;荧光双染色法显示经5F作用后细胞出现变形,染色质浓缩,产生凋亡小体;细胞被阻滞在G2/M期。结论5F在体外能有效地抑制NCI-H460细胞的生长,其作用可能是通过诱导其凋亡产生的。 | 刘义 吴科锋 李立 George G CHEN Michael KY HSIN Malcolm J UNDERWOOD 梁念慈 | 2009 | 肿瘤防治研究2009，36，1： | 9 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | 半边旗活性物质5F对非小细胞肺癌NCI-H460细胞IκKβ、IκB、p65及p50 mRNA表达的影响显示文摘目的从NF-κB信号通路着手探讨半边旗活性物质5F诱导非小细胞肺癌NCI-H460细胞凋亡发生的机制。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用半定量RT-PCR方法检测NCI-H460细胞IκKβ、IκB、p65及p50mRNA表达水平的变化。结果5F抑制NCI-H460细胞的生长,其效果与5F的质量浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/mL;100μg/mL5F作用NCI-H460细胞6h后能引起IκKβ和IκBmRNA表达水平显著降低(P<0.05);p65和p50mRNA水平在作用3h就发生明显减少(P<0.05)。结论5F诱导NCI-H460细胞凋亡的机制可能是通过抑制核因子-κB(NF-κB)信号通路来实现的。 | 刘义 CHEN George G 吕应年 HSIN Michael K Y UNDERWOOD Malcolm J 梁念慈 | 2010 | 中草药2010，41，3： | 3 |
| 4 | AMP-activated protein kinase is negatively associated with intramuscular fat content in longissimus dorsi muscle of beef cattle显示文摘 | K.R. Underwood W.J. Means M.J. Zhu S.P. Ford B.W. Hess M. Du | 2007 | Meat Science2007，，2： | 3 |
| 5 | Top Ten Pressing Questions About the Development of Emotion Regulation显示文摘 | Marion K. Underwood | 1997 | Motivation and Emotion1997，，1： | 2 |
| 6 | Prevention of spinal cord ischaemia during descending thoracic and thoracoabdominal aortic surgery显示文摘 | Wan IY Angelini GD Bryan AJ Ryder I Underwood MJ | 2001 | Eur J Cardiothorac Surg2001，19，2： | 2 |
| 7 | Experiment Comparison of Mechanically Ruled and Holographiclly Recorded Plane Varied-line Spacing Gratings显示文摘 | UNDERWOOD J H DEVILLE B | 1997 | SPIE1997，3150，： | 2 |
| 8 | OARSI guidelines for the non-surgical management of knee osteoarthritis显示文摘 | T.E. McAlindon R.R. Bannuru M.C. Sullivan N.K. Arden F. Berenbaum S.M. Bierma-Zeinstra G.A. Hawker Y. Henrotin D.J. Hunter H. Kawaguchi K. Kwoh S. Lohmander F. Rannou E.M. Roos M. Underwood | 2014 | Osteoarthritis and Cartilage2014，，： | 2 |
| 9 | Inflammatory response after coronary revascularization with or without cardiopulmonary bypass显示文摘 | Lloyd CT Underwood MJ | 2000 | Ann Thorac Surg2000，69，： | 1 |
| 10 | Changes in activity of the Cu-Zn superoxide dismutase enzyme in tissues of the rat with changes in dietary copper显示文摘 | Paynter DI Moir R J Underwood EJ | 1979 | J Nutr1979，109，： | 1 |
| 11 | Exercise to improve gait velocity 显示文摘 | Judge JO Underwood M Gennosa T | 2008 | Arch Phys Med Rehabil2008，74，： | 1 |
| 12 | Review of thermo-mechanical cracking and wear mechanisms in largecaliber guns 显示文摘 | Underwood J H Vigilante G N Mulligan C P | 2007 | Wear2007，263，712： | 1 |
| 13 | The potential for phosphorus release across the sediment–water interface in an eutrophic reservoir dosed with ferric sulphate显示文摘 | R.G. Perkins G.J.C. Underwood | 2001 | Water Research2001，，6： | 1 |
| 14 | Basement membrane and repair of injury to peripheral nerve:defining a potential role for macrophages,matrix metalloproteinases,and tissue inhibitor of metalloproteinases1显示文摘 | La Fleur M Underwood J L Rappolee D A | 1996 | J Exp Med1996，184，6： | 1 |
| 15 | Sensor Registration and Calibration Using Moving Targets显示文摘 | Kodagoda K R S Alempijevic A Underwood J | | 0，，01： | 1 |
| 16 | Measurement of lumbar multifidus muscle contraction with rehabilitative ultrasound imaging显示文摘 | KIESEL K B UHL T L UNDERWOOD D W | | 0，，02： | 1 |
| 17 | Disinhibition of ag- gression through diffusion of responsibility and dehumanization of victims 显示文摘 | Bandura A Underwood B Fromson ME | 1975 | J Res Pers1975，9，： | 1 |
| 18 | Two design patterns for facilitating building information model-based synchronous collaboration显示文摘 | ISIKDAG U UNDERWOOD J | 2010 | Automation in construction2010，19，5： | 1 |
| 19 | SB 239063,a p38 MAPK inhibitor,reduces neutrophilia,inflammatory cytokines,MMP-9,and fibrosis in lung显示文摘 | Underwood D C Osborn R R Bochnowicz S | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，5： | 1 |
| 20 | Radiation environment measurements with the comic ray experiments on-board the KITSAT-1 and PoSAT-1 micro-sattellites显示文摘 | Brock D J Williams P S | 1994 | IEEE TransNuclSci1994，41，6： | 1 |
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