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| 1 | 超重和肥胖的全球趋势及其与心血管疾病发生率之间的关系显示文摘虽然超重和肥胖的全球发病率逐日上升,但在不同地区、国家和性别中的发病趋势仍存在差异。据世界卫生组织报道,全球多个地区由体质量指数(body mass index,BMI)≥25kg/m2定义的超重/肥胖发生率几乎接近一半人口,有的甚至超过了一半,如美洲(61.1%),欧洲(54.8%)和东地中海地区(46.0%),然而,在非洲(26.9%),东南亚(13.7%)和西太平洋地区(25.4%),超重/肥胖发生率较低。 | 刘莉 叶鹏 Yatsuya H Li Y Hilawe EH Ota A Wang C Chiang C Zhang Y Uemura M Osako A Ozaki Y Aoyama A Circ J | 2014 | 中华高血压杂志2014，22，12： | 8 |
| 2 | Vitamin D for the prevention and treatment of pancreatic cancer显示文摘Pancreatic cancer is ranked fi fth among cancer-related deaths worldwide with a 5-year survival rate of less than 5%. Currently, surgery is the only effective therapy. However, most patients are diagnosed in the late stage and are not suitable for receiving curative surgery. Moreover, pancreatic cancer doesn't respond well to traditional chemotherapy and radiotherapy, leaving little effective treatment for advanced pancreatic cancer cases. 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], the biologically active form of vitamin D3, was originally identifi ed during studies of calcium and bone metabolism, though it is now recognized that it exerts biological effects in almost every tissue in the body. Abundant evidence has shown that 1α,25(OH)2D3 has antiproliferative, apoptotic, pro-differentiation and antiangiogensis effects in many types of cancer cells in vivo and in vitro, including breast, prostate, and colon. Similarly, the antitumor growth effect of 1α,25(OH)2D3 on pancreatic cells has been demonstrated. The clinical use of 1α,25(OH)2D3 is impeded by the lethal side effects of hypercalcemia and hypercalciuria. Therefore, 1α,25(OH)2D3 analogs, which are either equipotent or more potent than 1α,25(OH)2D3 in inhibiting tumor cell growth but with fewer hypercalcemic and hypercalciuric side effects, have been developed for the treatment of different cancers. Recently, a pre-clinical study demonstrated that a less calcemic analog of 1α,25(OH)2D3, 19-nor-1α,25(OH)2D2 (Paricalcitol), is effective in inhibiting tumor growth in vitro and in vivo , via upregulation of p21 and p27 tumor suppressor genes. Studies on the anti-tumor effects of a more potent analog of Paricalcitol are underway.1α,25(OH)2D3 and its analogs are potentially attractive novel therapies for pancreatic cancer. | Kun-Chun Chiang Tai C Chen | 2009 | World Journal of Gastroenterology2009，15，27： | 7 |
| 3 | Prostate cancer metastasis-driving genes: hurdles and potential approaches in their identification显示文摘变形前列腺癌症当前是医不好的。转移被认为在 nonmetastatic 前列腺癌症织物从变化导致特定的驾驶转移的基因的表示,导致设置了在运动的变形过程的激活的下游的基因的串联。如此的基因能潜在地为疾病的改进管理用作有效治疗学的目标。他们能被基因表示侧面的比较分析识别导出病人变形并且指出基因出现的 nonmetastatic 前列腺癌症纸巾改变了表示,由决定如此的基因的 silencing 是否能导致变形性质的抑制列在后面。在这条途径遇到的各种各样的障碍被讨论,包括(i) 对的需要临床上相关, nonmetastatic 和变形前列腺癌症纸巾象 patients’ 的异种皮移植那样;前列腺癌症经由 subrenal 囊 grafting 技术发展了并且(ii ) 在为鉴定的当前可得到的方法论的限制掌握规章的基因。 | Yan Ting Chiang Peter W Gout Colin C Collins Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 4 | Cytotoxicity and antihepatitis B virus activities of saikosaponins from Bupleurum species 显示文摘 | Chiang L C Ng L T Liu L T | 2003 | Planta Med2003，69，8： | 2 |
| 5 | Adsorption and diffusion of aromatics in AIPO4-5显示文摘 | CHIANG A S T LEE C K CHANG Z H | 1991 | Zeolites1991，11，4： | 1 |
| 6 | Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats显示文摘 | Kuo K L Weng M S Chiang C T | 2005 | Journal of Agricultural and Food Chemistry2005，53，2： | 1 |
| 7 | Co-expression of in-terleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice显示文摘 | Chiang C S Zell R | 2004 | Antiviral Res2004，64，： | 1 |
| 8 | Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA binding 显示文摘 | Hou S Y Wu S Y Chiang C M | 2002 | J Biol Chem2002，277，45： | 1 |
| 9 | Wind-induced vibration of high-rise building with tuned mass damper including soil-structure interaction显示文摘 | Liu M Y Chiang W L Hwang J H Chu C R | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 10 | Pu-erh tea supple-mentation suppresses fatty acid synthase expression in the rat liverthrough downregulating Akt and JNK signalings as demonstrated inhuman hepatoma HepG2 cells显示文摘 | CHIANG C T WENG M S LIN-SHIAU S Y | 2006 | Oncology Research Featuring Pre-clinical and Clinical Cancer Therapeutics2006，16，3： | 1 |
| 11 | Mathematical model for parametric tooth profile of spur gear using line of action显示文摘 | FONG Z H CHIANG T W TSAI C W | 2002 | Mathematical and Computer Modeling2002，36，45： | 1 |
| 12 | Cytotoxicity andanti-hepatitis B virus activities of saikosaponins fromBupleurumspeies显示文摘 | Chiang L C Nq L T Liu L T | 2003 | Planta Medica2003，69，8： | 1 |
| 13 | Evaluating intertwined effects in E-Learning programs:a novel hybrid MCDM model based onfactor analysis and DEMATEL显示文摘 | Tzeng G Chiang C Li C | 2007 | Expert System with Applications2007，32，4： | 1 |
| 14 | Polyaniline: Protonic acid doping to the metallic regime 显示文摘 | MacDiannid A G Chiang J C Huang W | 1985 | Molecular Crystals & Liquid Crystals1985，125，： | 1 |
| 15 | Norm-Conserving Pseudopotentials 显示文摘 | Hamann D R Schlüter M Chiang C | 1979 | Phys Rev Lett1979，43，： | 1 |
| 16 | Butachlor,thiobencarb and chlomethoxyfen movement in suntropical soils显示文摘 | Chiang H C Duh J R Wang Y S | 2001 | Bull Environ Contam Toxicol2001，66，： | 1 |
| 17 | Dechlorination of pentachlorophenol in anaerobic sewage sludge显示文摘 | Chang B V Chiang C W Yuan S Y | 1998 | Cheosphere1998，36，3： | 1 |
| 18 | Modeling VOCs adsorption onto activated carbon 显示文摘 | C L Chuang P C Chiang and E E Chang | 2003 | Chemosphere2003，53，1： | 1 |
| 19 | Ethyl caffeate suppresses NF-kappa B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin显示文摘 | Chiang Y M Lo C P Chen Y P | 2005 | Br J Pharmacol2005，146，3： | 1 |
| 20 | Experimental antitumor agents from Solanum indicum L 显示文摘 | Chiang H C Tseng T H Wang C J | 1991 | Anticancer Res1991，11，5： | 1 |
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