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| 1 | Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples显示文摘AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. | Satoshi Mamori Keisuke Nagatsuma Tomokazu Matsuura Kiyoshi Ohkawa Hiroshi Hano Masaharu Fukunaga Masato Matsushima Yoshifumi Masui Nao Fushiya Hiroshi Onoda Yasuyuki Searashi Ichiro Takagi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，21： | 20 |
| 2 | Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease显示文摘AIM: To determine factors predictive for esophageal varices in severe alcoholic disease (SAD). METHODS: Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS: Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type Ⅳ collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78. CONCLUSION: This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD. | Satoshi Mamori Yasuyuki Searashi Masato Matsushima Kenichi Hashimoto Shinichiro Uetake Hiroshi Matsudaira Shuji Ito Hisato Nakajima Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 3 | 玉米大斑病菌(Exserohilum turcicum)原生质体的分离及转化显示文摘玉米大斑病是严重危害玉米生产的一个世界性真菌病害。由于玉米大斑病菌 (Exserohilumturcicum)在无性生长过程中迅速产生黑色素 ,致使原生质体难以分离。测试了包括Fungase、Funcelase、Novozyme、Glucanex、Driselase、Uskizyme、Kitalase在内的 7种细胞壁降解酶及其组合、病原菌菌株和培养基对原生质体分离效果的影响。结果表明菌株的培养形态和菌丝的生长状态显著影响原生质体的分离效率 ;酶组合Kitalase +Glucanex +Driselase ,Kitalase+Glucanex和Kitalase +Uskizyme能够有效地分离玉米大斑病菌的原生质体。初步的转化试验表明 ,质粒pAN71可以用于该病原菌的转化。这些结果将为E . | 周永力 TANAKA Chihiro MATSUSHIMA Satoshi TSUDA Mitsuya | 2003 | 生物工程学报2003，19，3： | 4 |
| 4 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 5 | Linkage of Familial Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis) to Chromosome 17q25显示文摘 | Tohru Yamauchi Mitsuhiro Tada Kiyohiro Houkin Toshihiro Tanaka Yusuke Nakamura Satoshi Kuroda Hiroshi Abe Takuya Inoue Kiyonobu Ikezaki Toshio Matsushima Masashi Fukui | 2000 | Stroke: Journal of the American Heart Association2000，，： | 1 |
| 6 | A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients显示文摘 | Keita Matsubara Miyuki Morozumi Takafumi Okada Takahiro Matsushima Osamu Komiyama Michi Shoji Takashi Ebihara Kimiko Ubukata Yoshitake Sato Hironobu Akita Keisuke Sunakawa Satoshi Iwata | 2009 | Journal of Infection and Chemotherapy2009，，6： | 1 |
| 7 | Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu显示文摘The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,2018.During its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in history.The Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth line.This orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the asteroid.This paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping operation.First,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is introduced.Following the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first report.Consequently,this paper states that the HP.keeping operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period. | Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru Takahashi Hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki Satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda Takanobu Shimada Masanobu Ozaki Masanao Abe Satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki Kato Seiji Yasuda Kota Matsushima Tetsuya Masuda Makoto Yoshikawa Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 0 |
| 8 | Implementation of an educational program for pancreaticoduodenectomy in a university hospital: a retrospective observational study显示文摘Objective:No ideal training system exists for pancreaticoduodenectomy(PD).We developed an educational system that uses an objective structured assessment of technical skills.Methods:This retrospective observational study was conducted using the data of consecutive trainees and patients who underwent PD from 2007 to 2013 in Kansai Medical University Hospital.The total score on the task checklist(21 parameters)for measuring technical performance during PD by self assessment and instructor assessment was compared between junior(JN)and hepatobiliary pancreatic(HBP)trainees at a university hospital.Surgical outcomes of 303 PDs(2007-2013)were also compared among JN trainees,HBP trainees,and instructors,and the present position of the trainees was investigated.This study was approved by the institutional review board of Kansai Medical University on May 26,2020.Results:The self-assessment score on the task checklist was significantly higher for the HBP trainees than for the JN trainees on all parts of PD(P<.001).The discrepancy between self-assessment and instructor assessment improved in 3 JN trainees after experience with the first 5 PDs.Although total score curves rose to the right in the JN group,scores in the HBP group were stable,at 70 or higher,which correlated with the instructor assessment.The 90-day and 30-day mortality rates were 1.6%and 0.3%,respectively.Mortality and morbidity after PD did not differ between the JN and HBP trainees or between the instructors and the trainees.Four of 10 trainees became board-certified expert surgeons of the Japanese Society of Hepatobiliary Pancreatic Surgery.Conclusion:These results indicated good construct validity of the task checklist system.This program was safely and effectively implemented in terms of surgical outcomes and final outcomes of trainees becoming board-certified expert surgeons. | Sohei Satoi Tomohisa Yamamoto So Yamaki Satoshi Hirooka Daisuke Hashimoto Tatsuma Sakaguchi Hironori Ryota Rintaro Yui Kazuto Sakuramoto Hideyuki Matsushima Hiroaki Yanagimoto Hideyoshi Toyokawa Taku Michiura Kentaro Inoue Mitsugu Sekimoto | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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