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| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma显示文摘 | Masatoshi Kudo Kazuho Imanaka Nobuyuki Chida Kohei Nakachi Won-Young Tak Tadatoshi Takayama Jung-Hwan Yoon Takeshi Hori Hiromitsu Kumada Norio Hayashi Shuichi Kaneko Hirohito Tsubouchi Dong Jin Suh Junji Furuse Takuji Okusaka Katsuaki Tanaka Osamu Matsui | 2011 | European Journal of Cancer2011，，14： | 5 |
| 3 | Simeprevir with Peginterferon/Ribavirin for Treatment-Na?ve Hepatitis C Genotype 1 Patients in Japan: CONCERTO-1, a Phase III Trial显示文摘 | Norio Hayashi Namiki Izumi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Hepatology2014，，： | 3 |
| 4 | Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012显示文摘 | Hirotaka Ohara Kazuichi Okazaki Hirohito Tsubouchi Kazuo Inui Shigeyuki Kawa Terumi Kamisawa Susumu Tazuma Kazushige Uchida Kenji Hirano Hitoshi Yoshida Takayoshi Nishino Shigeru Ko Nobumasa Mizuno Hideaki Hamano Atsushi Kanno Kenji Notohara Osamu Hasebe | 2012 | Journal of Hepato-Biliary-Pancreatic Sciences2012，，5： | 3 |
| 5 | Meloxicam inhibits the growth of non-small cell lung cancer 显示文摘 | Tsubouchi Y Mukai S Kawahito Y | 2000 | Anticancer Res2000，20，5： | 2 |
| 6 | Catalytic effects of Na and Ca from inexpensive materials on in-situ steam gasification of char from rapid pyrolysis of low rank coal in a drop-tube reactor显示文摘 | Li-xin Zhang Shinji Kudo Naoto Tsubouchi Jun-ichiro Hayashi Yasuo Ohtsuka Koyo Norinaga | 2013 | Fuel Processing Technology2013，，： | 2 |
| 7 | Development of a new tool material to ensure high performance in hot steel rolling显示文摘 | Tsubouchi K Akiyama M Yamamoto E | 1999 | Journal of tribology1999，121，4： | 2 |
| 8 | Nitrogen release during high temperature pyrolysis of coals and catalytic role of calcium in N2 formation 显示文摘 | Tsubouchi N Ohtsuka Y | 2002 | Fuel2002，81，18： | 1 |
| 9 | Detection of early esophageal and gastric cancers bymass screening显示文摘 | Mitsunaga N Tsubouchi H | 1996 | Nippon-Rinsho1996，54，5： | 1 |
| 10 | Development and integration of an immunoaffinity monolithic diskfor the on-line solid-phase extraction and HPLC determination withfluorescence detection of aflatoxin B 1 in aqueous solutions显示文摘 | TERADA H TSUBOUCHI H YAMAMOTO K | 1998 | Assoc Off Anal Chem1998，69，： | 1 |
| 11 | Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6—a role of NAD(P)H oxidase in β-cells显示文摘 | Hirotaka Tsubouchi Toyoshi Inoguchi Mieko Inuo Maiko Kakimoto Toshiyo Sonta Noriyuki Sonoda Shuji Sasaki Kunihisa Kobayashi Hideki Sumimoto Hajime Nawata | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 12 | Eruption speed and rate of angulation change of a cyst-associated mandibular second premolar after marsupialization of a dentigerous cyst 显示文摘 | Miyawaki S Hyomoto M Tsubouchi J | 1999 | Am J Orthod Dentofacial Orthop1999，116，5： | 1 |
| 13 | Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice显示文摘 | Tsubouchi H Yanagi S Miura A | 2014 | EurJPharmacol2014，15，743： | 1 |
| 14 | Clinical diagnostic criteria ofIgG4 - related sclerosing cholangitis 显示文摘 | OharaH Okazaki K Tsubouchi H | 2012 | Journal of Hepato - Biliary-Pancreatic Sciences2012，19，5： | 1 |
| 15 | Nitrogen release during high temperature pyrolysis of coals and catalytic role of calcium in N2 formation显示文摘 | Tsubouchi N Ohtsuka Y | 2002 | Fuel2002，81，18： | 1 |
| 16 | Effect of nitrogen-containing compounds on polychlorinated dibenzo-p- dioxin/dibenzofuran formation through de novo synthesis 显示文摘 | Shunsuke Kuzuhara Hiroshi Sato Naoto Tsubouchi | 2005 | Environmental Science and Technology2005，39，： | 1 |
| 17 | Determination of cationic surfactants by two-phase titration显示文摘 | TSUBOUCHI M MITSUSHIO H YAMASAKI N | 1981 | Analytical Chemistry1981，53，12： | 1 |
| 18 | IAC application in beanut detection显示文摘 | NAKAJIMA P M TSUBOUCHI H MIYABE M | 1999 | JAOAC Int1999，82，： | 1 |
| 19 | Enhancement of N2 Formation from the Nitrogen in Carbon and Coal by Calcium显示文摘 | Tsubouchi N Ohtsuka Y Xu C | | 0，，01： | 1 |
| 20 | Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studies显示文摘 | Namiki Izumi Norio Hayashi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Gastroenterology2014，，5： | 1 |
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